Ethan Cumbler discusses guerrilla leadership in healthcare and the need for front-line teams and change. He describes how initially creating an educational service at his hospital failed due to a lack of system organization and support. Effective change requires system redesign including standardized protocols, interprofessional rounds, and geographic concentration of expertise. This creates the potential for high-functioning interprofessional teams that can drive measurable improvements in outcomes like staff satisfaction and quality metrics. Culture change towards continuous quality improvement is motivated when data is provided to front-line teams and recognition is given.