This document provides an overview and instructions for submitting grant applications through Grants.gov. It discusses: 1) What Grants.gov is and when to use it for submitting federal grant applications. 2) The two options - using Adobe PDF forms or the SAGE Grant Runner system - for completing application forms and assembling materials. 3) The process at the University of Washington for routing applications through the Office of Sponsored Programs (OSP) prior to formal submission through Grants.gov.