This document summarizes a clinical trial that tested the effects of a glutathione patch on cellular physiological function in different organs. The trial found that wearing the patch for 12 hours per day for 4 weeks significantly improved cellular physiological status in the pancreas, liver, gallbladder, intestines, adrenal glands, hypothalamus and pituitary gland, as measured by bioelectrical impedance data. This suggests the patch is effective at enhancing glutathione levels and positively impacting organ function. The technology provides a safe, convenient and affordable way to boost glutathione compared to previous intravenous methods.
This document summarizes new randomized controlled trials in critical care nutrition published between 2009-2011 and their impact on existing clinical practice guidelines. It discusses several new RCTs on probiotics, fish oils, arginine, glutamine, and lipid emulsions. For probiotics and fish oils, the new evidence strengthens recommendations for their use. However, for arginine and glutamine, the new RCTs did not clearly support benefits. Overall, the new data impacts some recommendations and highlights areas requiring further research.
Potential role of bioactive peptides in prevention and treatment of chronic d...NxFxProducerDJ
This review analyzes studies and clinical trials on bioactive peptides and their potential roles in preventing and treating chronic diseases. The review focuses on cardiovascular diseases, immunity, cancer, and other areas. Bioactive peptides from various food sources like fish, milk, meat, and plants have shown effects like lowering blood pressure and lipids in clinical trials. Some peptides also demonstrate anticancer activity in vitro and in vivo as well as immunomodulatory and antimicrobial effects. However, more clinical evidence and standardized extraction procedures are still needed to confirm these effects and enable use of bioactive peptides as preventive or therapeutic treatments.
This document summarizes key considerations for nutrition in intensive care patients. It addresses questions like which patients should be fed, when feeding should start, what route is best, how much to feed, and what the feed should contain. The document discusses evidence that early enteral feeding within 48 hours is preferable to delaying feeding. It also notes that enteral feeding is generally better than parenteral feeding when possible due to lower risks, though parenteral may be necessary in some cases. The optimal amount of feeding is also addressed.
Product Overview
Viasil uses 100% natural ingredients for a safe and clinically tested
erectile dysfunction formula. Revolutionising bedroom
performance, Viasil increases energy levels, reawakens sexual
desire, supports hard powerful erections and extra stamina and
endurance.
Now even better than before thanks to the complementary Viasil -
Instant Erection Gel.
The document summarizes the evaluation of anti-obesity drugs. It discusses various in vitro and in vivo preclinical models used to evaluate potential anti-obesity compounds, including receptor binding assays, determination of hormone levels, food intake studies in rodents, and diet-induced and genetic obesity models. It also outlines the advantages and limitations of different acute and chronic in vivo models for assessing drug effects on obesity.
Herbal medicine safety studies at the NTPAbraham Nyska
The document discusses several 2-year cancer studies conducted by the National Toxicology Program (NTP) on common herbal supplements. The studies found:
1) Goldenseal caused liver cancer in rats and mice. Its active component berberine tested positive for genetic toxicity.
2) Ginkgo biloba extract caused liver and thyroid cancer in mice and thyroid tumors in rats. It contains compounds that tested positive for mutagenicity.
3) Kava kava extract study results are not discussed but the study was conducted similarly to the others.
The document provides details on the study designs and tumor findings for each supplement. It emphasizes that herbal medicines contain complex mixtures that can have carcin
The document discusses the effects of green tea on weight loss and cardiovascular health. It finds that green tea catechins have cardiovascular benefits by inhibiting LDL oxidation and cellular oxidation. Studies show a dose-dependent relationship between green tea and lowering total and free cholesterol, resulting in reduced fat mass. Green tea was also found to up-regulate LDL receptors in a dose-dependent manner relative to the catechin EGCG. More research is still needed to fully understand the clinical benefits of green tea for humans.
This document summarizes new randomized controlled trials in critical care nutrition published between 2009-2011 and their impact on existing clinical practice guidelines. It discusses several new RCTs on probiotics, fish oils, arginine, glutamine, and lipid emulsions. For probiotics and fish oils, the new evidence strengthens recommendations for their use. However, for arginine and glutamine, the new RCTs did not clearly support benefits. Overall, the new data impacts some recommendations and highlights areas requiring further research.
Potential role of bioactive peptides in prevention and treatment of chronic d...NxFxProducerDJ
This review analyzes studies and clinical trials on bioactive peptides and their potential roles in preventing and treating chronic diseases. The review focuses on cardiovascular diseases, immunity, cancer, and other areas. Bioactive peptides from various food sources like fish, milk, meat, and plants have shown effects like lowering blood pressure and lipids in clinical trials. Some peptides also demonstrate anticancer activity in vitro and in vivo as well as immunomodulatory and antimicrobial effects. However, more clinical evidence and standardized extraction procedures are still needed to confirm these effects and enable use of bioactive peptides as preventive or therapeutic treatments.
This document summarizes key considerations for nutrition in intensive care patients. It addresses questions like which patients should be fed, when feeding should start, what route is best, how much to feed, and what the feed should contain. The document discusses evidence that early enteral feeding within 48 hours is preferable to delaying feeding. It also notes that enteral feeding is generally better than parenteral feeding when possible due to lower risks, though parenteral may be necessary in some cases. The optimal amount of feeding is also addressed.
Product Overview
Viasil uses 100% natural ingredients for a safe and clinically tested
erectile dysfunction formula. Revolutionising bedroom
performance, Viasil increases energy levels, reawakens sexual
desire, supports hard powerful erections and extra stamina and
endurance.
Now even better than before thanks to the complementary Viasil -
Instant Erection Gel.
The document summarizes the evaluation of anti-obesity drugs. It discusses various in vitro and in vivo preclinical models used to evaluate potential anti-obesity compounds, including receptor binding assays, determination of hormone levels, food intake studies in rodents, and diet-induced and genetic obesity models. It also outlines the advantages and limitations of different acute and chronic in vivo models for assessing drug effects on obesity.
Herbal medicine safety studies at the NTPAbraham Nyska
The document discusses several 2-year cancer studies conducted by the National Toxicology Program (NTP) on common herbal supplements. The studies found:
1) Goldenseal caused liver cancer in rats and mice. Its active component berberine tested positive for genetic toxicity.
2) Ginkgo biloba extract caused liver and thyroid cancer in mice and thyroid tumors in rats. It contains compounds that tested positive for mutagenicity.
3) Kava kava extract study results are not discussed but the study was conducted similarly to the others.
The document provides details on the study designs and tumor findings for each supplement. It emphasizes that herbal medicines contain complex mixtures that can have carcin
The document discusses the effects of green tea on weight loss and cardiovascular health. It finds that green tea catechins have cardiovascular benefits by inhibiting LDL oxidation and cellular oxidation. Studies show a dose-dependent relationship between green tea and lowering total and free cholesterol, resulting in reduced fat mass. Green tea was also found to up-regulate LDL receptors in a dose-dependent manner relative to the catechin EGCG. More research is still needed to fully understand the clinical benefits of green tea for humans.
Effect of Piper crocatum Extract Against Weight Loss and Liver Enzyme Levels ...iosrphr_editor
Piper crocatum is one of Indonesian medicinal plant that contain flavonoids, tannins, alkaloids, and saponins. Aims of this study were to evaluate the effect of Piper crocatum aqueous extract against a decrease in body weight (BW) and the activity of enzymes involved in lipid metabolism (AMPK, ACC, FAS) in liver obese rats. This study used four groups of Sprague dawley rat (n = 6), including normal group (N), obese controls (OC), Piper crocatum extract dose 1260 mg/kgBW (PcA), and Piper crocatum extract dose of 1890 mg/kgBW (PcB). Measurement of metabolic liver enzyme levels (AMPK, ACC, FAS) are using ELISA kit (CusabioTM). Results of this study showed that the PcA group produce the highest reduction in body weight (4.52%), and the lowest levels of ACC (9.13 ng/g) and FAS (360.68 ng/g) which was significantly different from obese control group (95% CI). Piper crocatum extract can't activate AMPK. The highest levels in rat liver AMPK is in N group with 8.42 ng/g, but this value is not significantly different from other groups.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Dietary Supplementation with Calcium in Healthy Rats Administered with Artemi...IOSR Journals
Reports on the role of calcium on predisposition to cardiovascular disease have been rather inconsistent while studies on its interaction with other medications are ongoing. We therefore investigated the effect of separate and combine administration of calcium supplement with artemisinin-based combination drug on hepatic and serum lipid profile. Thirty two male wistar rats were randomly assigned into four groups of eight rats each. The control (group A) received normal saline. Group B and D were placed on 10mg/Kg calcium twice daily for four weeks. On the thirtieth day, therapeutic dose of artemisinin-based combination was simultaneously administered to group C and group D twice daily for three days. All the rats were then sacrificed after 12 hours fasting, blood was withdrawn and the liver removed and homogenized in an appropriate buffer. Biochemical analysis showed no significant (p>0.05) variation in hepatic triaacylglycerol in all the treated groups whereas calcium supplementation was observed to induce a significant (p<0.05) reduction in hepatic cholesterol. Significant elevations due to calcium supplementation were also observed in serum total cholesterol, LDL cholesterol level and atherogenic risk index with a concomitant reduction in serum HDL cholesterol. No significant change was observed in serum total cholesterol, triacylglycerol and serum lipoproteins in all other treatment groups. Our study suggests that calcium supplementation may predispose to cardiovascular disease and that its co administration with ACT may not aggravate nor reduced the predisposition risk.
Efficacy of Omeg-3 Fatty Acids in Preventing Cancer Induced CachexiaJosh Nooner
This document provides an overview of cancer-induced cachexia and the potential role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing or treating it. Cancer-induced cachexia is defined as an ongoing loss of skeletal muscle mass that cannot be fully reversed by nutritional support and leads to impaired function. It is caused by chronic inflammation, hypermetabolism, and alterations in gene expression and protein levels. Studies show omega-3 PUFAs may alleviate cachexia by suppressing the ubiquitin-proteasome pathway and inflammatory cytokines, as well as through their anti-inflammatory and metabolic effects. The document reviews several studies that have investigated the efficacy and safety of omega-3 supplementation for cachexia treatment
Pumpkin seed oil extracted from cucurbita maxima improves urinary disorder in...Younis I Munshi
This document summarizes a study that evaluated the effects of pumpkin seed oil extracted from Cucurbita maxima on urinary dysfunction in human overactive bladder. Forty-five subjects took 10 grams per day of pumpkin seed oil from C. maxima for 12 weeks. Urinary function was evaluated at baseline and after 6 and 12 weeks using the Overactive Bladder Symptom Score. The results showed that pumpkin seed oil from C. maxima significantly reduced OABSS scores after both 6 and 12 weeks, suggesting it may be effective for treating urinary disorders like overactive bladder in humans.
- The document discusses cachexia, a wasting syndrome seen in many cancer patients, and the potential role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing or treating cancer-induced cachexia.
- It reviews the definition, etiology, complications, and current treatments for cachexia. It also discusses the roles, mechanisms, and early studies investigating omega-3 PUFAs for treating cachexia.
- The document provides background information on cachexia and omega-3 PUFAs to introduce and support the review of literature on efficacy of omega-3 PUFAs in preventing cancer-induced cachexia.
Comparative evaluation of the effects of artemisinin based combination therap...Alexander Decker
This study compared the effects of artemisinin-based combination therapy (ACT) and amodiaquine monotherapy on glucose-6-phosphate dehydrogenase (G6PD) activity, fasting glucose levels, and parasite clearance rates in malaria-infected adults in Nigeria. Twenty subjects were divided into two groups, with one group receiving ACT and the other receiving amodiaquine monotherapy. Blood samples collected before and after treatment were analyzed for G6PD activity, glucose levels, and parasite density. There were no significant differences between the treatment groups in G6PD activity or fasting glucose levels. However, the ACT group had a significantly higher parasite clearance rate compared to the amodiaquine monotherapy group.
In this presentation i have tried to explain in details about the Total Parenteral Nutrition (TPN) , what is it, who needs it, and how to prepare it and the necessary procedure with instructions. It is very useful for the individuals from Nutrition, Nursing, Pharmacists, and Medical background.
This document discusses optimal nutrition strategies for critically ill patients. It emphasizes the importance of early enteral nutrition within 48 hours of admission, and achieving adequate calorie and protein intake levels. Higher calorie and protein intake levels are associated with better outcomes like reduced infections, shorter hospital stays and lower mortality. The development of the NUTRIC risk score is summarized, which can help identify patients most likely to benefit from aggressive nutrition therapy based on factors like age, illness severity and comorbidities. Validation studies showed higher risk patients based on NUTRIC score had worse outcomes with low nutrition adequacy levels. Nurse-directed feeding protocols are recommended to help optimize enteral nutrition delivery.
Proper Nutrition: The Cornerstone to WellnessKordonowy
The biophotonic scanner is revolutionizing how patients think about nutrition. It provides a quantitative measure of a person's antioxidant status and helps motivate individuals to obtain optimal nutritional status, something that is critical to wellness and improved outcomes.
MaxGXL is a patented formula that accelerates the body's production of glutathione, an important antioxidant that declines with age. Glutathione fights inflammation, boosts energy and mental function. MaxGXL has been shown to significantly increase intracellular glutathione levels in clinical tests. Increasing glutathione through MaxGXL can dramatically raise energy, strengthen the immune system, slow aging, and improve health and well-being. The product was awarded a rare composition patent for its ability to boost glutathione levels and recycling.
Medical technology encompasses healthcare products that diagnose, monitor, or treat diseases. Medical technologists perform complex scientific tests on blood and body fluids to analyze results. The mitochondria in cells convert food into usable energy in the form of ATP through a process similar to combustion. Medical technologists perform various tests involving biological energy production and mitochondria, such as muscle biopsy testing to measure enzyme activities and oxygen consumption, blood tests to check lactate/pyruvate levels and creatine kinase, and genetic tests to identify mitochondrial mutations.
Glutathione is the essential antioxidant for body health help, a strengthener, and Immune stimulant. This small protein, naturally produced in the body, keeps these three protective functions.
Efficacy of Anti-Melanogenic and Anti-Ageing Properties of Glutathione with A...IJSRP Journal
Widespread concerns regarding the rise in prevalence of skin cancer and the adverse effects of both acute and chronic photo-damage due to exposure to UV rays, has led to various modes of treatment. The latest development in this regard is the findings about Glutathione and Polypodium dry extract as potential treatment components for skin conditions. Glutathione plays pivotal role in protecting cells against oxidative stressinduced cellular damage and in detoxifying Xenobiotics and drug metabolism. The added photo-protective effects of oral Polypodium with its antioxidant, immunoregulatory and antiinflammatory properties aid also in prevention of chronic skin damage, photoaging, and skin cancer led by UV exposure. Its decreased levels are associated with the common features of aging as well as of a wide range of pathological conditions, including neurodegenerative disorders.
1. The document discusses using vitamins, supplements, and herbs to support hormone health, specifically in augmenting bioidentical hormone replacement therapy (BHRT).
2. It provides examples of nutraceuticals and their roles in supporting estrogen metabolism, thyroid function, and liver detoxification which are important for hormone balance.
3. The document emphasizes that estrogen metabolism is important and outlines strategies like diet, exercise, and supporting the liver and bowel to help metabolize and clear estrogens in a healthy way.
This randomized, double-blinded, placebo-controlled study assessed the effects of Oxytocin FactorTM for weight loss over 45 days. 45 participants were randomized to receive either a placebo or Oxytocin FactorTM twice daily. Results showed that the Oxytocin FactorTM group lost more weight (14.89 lbs), body fat (4.72%), and waist circumference (4.31 inches) on average compared to the placebo group, though statistical significance was not achieved due to the small sample size. Larger studies are needed to determine the statistical significance of Oxytocin FactorTM as a safe and effective weight loss tool.
The document discusses several topics related to proteins and medical research. It describes the structure of proteins, the protein RAF-1 which is essential for blood vessel formation, the process of angiogenesis, and how this relates to tumor development. It also discusses the protein PGC-1 alpha and the hormone irisin which are linked to exercise and health benefits, and how isolating these proteins could lead to new treatment methods for diseases like obesity and cancer. Finally, it talks about how recent medical advances and research using body proteins/molecules could help promote healthier lifestyles and reduce disease rates.
The Aura PTL II Clinical System uses low-level laser therapy, acupoint stimulation, homeopathy, and nutrition to assess substance sensitivities and reduce symptoms. It consists of testing to identify sensitivities, laser treatment of acupoints to reduce stress responses, harmonic imprinting for customization, and supplements. While light therapy has been used for centuries and lasers are generally safe, more rigorous randomized controlled trials would be needed to validate the specific clinical claims of the Aura PTL II System.
The AURA PTL II Clinical System combines testing for substance sensitivities, low level light therapy, harmonic imprinting, and homeopathy to provide holistic treatment. It uses a non-invasive scan to identify substances causing neurological stress and applies low-level lasers to acupuncture points to reduce sensitivity and symptoms. While light therapy has historical uses and mechanisms are known, limited research specifically examines AURA's clinical effects. Further controlled studies are needed to validate its wide-ranging claims and non-specific marketing approach.
1) A study evaluated a novel closed-loop gastric electrical stimulation system called abiliti for treating obesity. 34 obese participants were implanted with the device.
2) At 12 months, participants experienced a mean excess weight loss of 28.7% and a mean BMI reduction of 4.8 kg/m2. Weight loss was stable through 27 months for those who remained in follow up.
3) The device led to significant alterations in eating behavior including reduced disinhibition and hunger, and increased physical activity and cognition around eating. The gastric electrical stimulation treatment was well tolerated and resulted in significant weight loss and behavioral changes.
Effect of Piper crocatum Extract Against Weight Loss and Liver Enzyme Levels ...iosrphr_editor
Piper crocatum is one of Indonesian medicinal plant that contain flavonoids, tannins, alkaloids, and saponins. Aims of this study were to evaluate the effect of Piper crocatum aqueous extract against a decrease in body weight (BW) and the activity of enzymes involved in lipid metabolism (AMPK, ACC, FAS) in liver obese rats. This study used four groups of Sprague dawley rat (n = 6), including normal group (N), obese controls (OC), Piper crocatum extract dose 1260 mg/kgBW (PcA), and Piper crocatum extract dose of 1890 mg/kgBW (PcB). Measurement of metabolic liver enzyme levels (AMPK, ACC, FAS) are using ELISA kit (CusabioTM). Results of this study showed that the PcA group produce the highest reduction in body weight (4.52%), and the lowest levels of ACC (9.13 ng/g) and FAS (360.68 ng/g) which was significantly different from obese control group (95% CI). Piper crocatum extract can't activate AMPK. The highest levels in rat liver AMPK is in N group with 8.42 ng/g, but this value is not significantly different from other groups.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Dietary Supplementation with Calcium in Healthy Rats Administered with Artemi...IOSR Journals
Reports on the role of calcium on predisposition to cardiovascular disease have been rather inconsistent while studies on its interaction with other medications are ongoing. We therefore investigated the effect of separate and combine administration of calcium supplement with artemisinin-based combination drug on hepatic and serum lipid profile. Thirty two male wistar rats were randomly assigned into four groups of eight rats each. The control (group A) received normal saline. Group B and D were placed on 10mg/Kg calcium twice daily for four weeks. On the thirtieth day, therapeutic dose of artemisinin-based combination was simultaneously administered to group C and group D twice daily for three days. All the rats were then sacrificed after 12 hours fasting, blood was withdrawn and the liver removed and homogenized in an appropriate buffer. Biochemical analysis showed no significant (p>0.05) variation in hepatic triaacylglycerol in all the treated groups whereas calcium supplementation was observed to induce a significant (p<0.05) reduction in hepatic cholesterol. Significant elevations due to calcium supplementation were also observed in serum total cholesterol, LDL cholesterol level and atherogenic risk index with a concomitant reduction in serum HDL cholesterol. No significant change was observed in serum total cholesterol, triacylglycerol and serum lipoproteins in all other treatment groups. Our study suggests that calcium supplementation may predispose to cardiovascular disease and that its co administration with ACT may not aggravate nor reduced the predisposition risk.
Efficacy of Omeg-3 Fatty Acids in Preventing Cancer Induced CachexiaJosh Nooner
This document provides an overview of cancer-induced cachexia and the potential role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing or treating it. Cancer-induced cachexia is defined as an ongoing loss of skeletal muscle mass that cannot be fully reversed by nutritional support and leads to impaired function. It is caused by chronic inflammation, hypermetabolism, and alterations in gene expression and protein levels. Studies show omega-3 PUFAs may alleviate cachexia by suppressing the ubiquitin-proteasome pathway and inflammatory cytokines, as well as through their anti-inflammatory and metabolic effects. The document reviews several studies that have investigated the efficacy and safety of omega-3 supplementation for cachexia treatment
Pumpkin seed oil extracted from cucurbita maxima improves urinary disorder in...Younis I Munshi
This document summarizes a study that evaluated the effects of pumpkin seed oil extracted from Cucurbita maxima on urinary dysfunction in human overactive bladder. Forty-five subjects took 10 grams per day of pumpkin seed oil from C. maxima for 12 weeks. Urinary function was evaluated at baseline and after 6 and 12 weeks using the Overactive Bladder Symptom Score. The results showed that pumpkin seed oil from C. maxima significantly reduced OABSS scores after both 6 and 12 weeks, suggesting it may be effective for treating urinary disorders like overactive bladder in humans.
- The document discusses cachexia, a wasting syndrome seen in many cancer patients, and the potential role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing or treating cancer-induced cachexia.
- It reviews the definition, etiology, complications, and current treatments for cachexia. It also discusses the roles, mechanisms, and early studies investigating omega-3 PUFAs for treating cachexia.
- The document provides background information on cachexia and omega-3 PUFAs to introduce and support the review of literature on efficacy of omega-3 PUFAs in preventing cancer-induced cachexia.
Comparative evaluation of the effects of artemisinin based combination therap...Alexander Decker
This study compared the effects of artemisinin-based combination therapy (ACT) and amodiaquine monotherapy on glucose-6-phosphate dehydrogenase (G6PD) activity, fasting glucose levels, and parasite clearance rates in malaria-infected adults in Nigeria. Twenty subjects were divided into two groups, with one group receiving ACT and the other receiving amodiaquine monotherapy. Blood samples collected before and after treatment were analyzed for G6PD activity, glucose levels, and parasite density. There were no significant differences between the treatment groups in G6PD activity or fasting glucose levels. However, the ACT group had a significantly higher parasite clearance rate compared to the amodiaquine monotherapy group.
In this presentation i have tried to explain in details about the Total Parenteral Nutrition (TPN) , what is it, who needs it, and how to prepare it and the necessary procedure with instructions. It is very useful for the individuals from Nutrition, Nursing, Pharmacists, and Medical background.
This document discusses optimal nutrition strategies for critically ill patients. It emphasizes the importance of early enteral nutrition within 48 hours of admission, and achieving adequate calorie and protein intake levels. Higher calorie and protein intake levels are associated with better outcomes like reduced infections, shorter hospital stays and lower mortality. The development of the NUTRIC risk score is summarized, which can help identify patients most likely to benefit from aggressive nutrition therapy based on factors like age, illness severity and comorbidities. Validation studies showed higher risk patients based on NUTRIC score had worse outcomes with low nutrition adequacy levels. Nurse-directed feeding protocols are recommended to help optimize enteral nutrition delivery.
Proper Nutrition: The Cornerstone to WellnessKordonowy
The biophotonic scanner is revolutionizing how patients think about nutrition. It provides a quantitative measure of a person's antioxidant status and helps motivate individuals to obtain optimal nutritional status, something that is critical to wellness and improved outcomes.
MaxGXL is a patented formula that accelerates the body's production of glutathione, an important antioxidant that declines with age. Glutathione fights inflammation, boosts energy and mental function. MaxGXL has been shown to significantly increase intracellular glutathione levels in clinical tests. Increasing glutathione through MaxGXL can dramatically raise energy, strengthen the immune system, slow aging, and improve health and well-being. The product was awarded a rare composition patent for its ability to boost glutathione levels and recycling.
Medical technology encompasses healthcare products that diagnose, monitor, or treat diseases. Medical technologists perform complex scientific tests on blood and body fluids to analyze results. The mitochondria in cells convert food into usable energy in the form of ATP through a process similar to combustion. Medical technologists perform various tests involving biological energy production and mitochondria, such as muscle biopsy testing to measure enzyme activities and oxygen consumption, blood tests to check lactate/pyruvate levels and creatine kinase, and genetic tests to identify mitochondrial mutations.
Glutathione is the essential antioxidant for body health help, a strengthener, and Immune stimulant. This small protein, naturally produced in the body, keeps these three protective functions.
Efficacy of Anti-Melanogenic and Anti-Ageing Properties of Glutathione with A...IJSRP Journal
Widespread concerns regarding the rise in prevalence of skin cancer and the adverse effects of both acute and chronic photo-damage due to exposure to UV rays, has led to various modes of treatment. The latest development in this regard is the findings about Glutathione and Polypodium dry extract as potential treatment components for skin conditions. Glutathione plays pivotal role in protecting cells against oxidative stressinduced cellular damage and in detoxifying Xenobiotics and drug metabolism. The added photo-protective effects of oral Polypodium with its antioxidant, immunoregulatory and antiinflammatory properties aid also in prevention of chronic skin damage, photoaging, and skin cancer led by UV exposure. Its decreased levels are associated with the common features of aging as well as of a wide range of pathological conditions, including neurodegenerative disorders.
1. The document discusses using vitamins, supplements, and herbs to support hormone health, specifically in augmenting bioidentical hormone replacement therapy (BHRT).
2. It provides examples of nutraceuticals and their roles in supporting estrogen metabolism, thyroid function, and liver detoxification which are important for hormone balance.
3. The document emphasizes that estrogen metabolism is important and outlines strategies like diet, exercise, and supporting the liver and bowel to help metabolize and clear estrogens in a healthy way.
This randomized, double-blinded, placebo-controlled study assessed the effects of Oxytocin FactorTM for weight loss over 45 days. 45 participants were randomized to receive either a placebo or Oxytocin FactorTM twice daily. Results showed that the Oxytocin FactorTM group lost more weight (14.89 lbs), body fat (4.72%), and waist circumference (4.31 inches) on average compared to the placebo group, though statistical significance was not achieved due to the small sample size. Larger studies are needed to determine the statistical significance of Oxytocin FactorTM as a safe and effective weight loss tool.
The document discusses several topics related to proteins and medical research. It describes the structure of proteins, the protein RAF-1 which is essential for blood vessel formation, the process of angiogenesis, and how this relates to tumor development. It also discusses the protein PGC-1 alpha and the hormone irisin which are linked to exercise and health benefits, and how isolating these proteins could lead to new treatment methods for diseases like obesity and cancer. Finally, it talks about how recent medical advances and research using body proteins/molecules could help promote healthier lifestyles and reduce disease rates.
The Aura PTL II Clinical System uses low-level laser therapy, acupoint stimulation, homeopathy, and nutrition to assess substance sensitivities and reduce symptoms. It consists of testing to identify sensitivities, laser treatment of acupoints to reduce stress responses, harmonic imprinting for customization, and supplements. While light therapy has been used for centuries and lasers are generally safe, more rigorous randomized controlled trials would be needed to validate the specific clinical claims of the Aura PTL II System.
The AURA PTL II Clinical System combines testing for substance sensitivities, low level light therapy, harmonic imprinting, and homeopathy to provide holistic treatment. It uses a non-invasive scan to identify substances causing neurological stress and applies low-level lasers to acupuncture points to reduce sensitivity and symptoms. While light therapy has historical uses and mechanisms are known, limited research specifically examines AURA's clinical effects. Further controlled studies are needed to validate its wide-ranging claims and non-specific marketing approach.
1) A study evaluated a novel closed-loop gastric electrical stimulation system called abiliti for treating obesity. 34 obese participants were implanted with the device.
2) At 12 months, participants experienced a mean excess weight loss of 28.7% and a mean BMI reduction of 4.8 kg/m2. Weight loss was stable through 27 months for those who remained in follow up.
3) The device led to significant alterations in eating behavior including reduced disinhibition and hunger, and increased physical activity and cognition around eating. The gastric electrical stimulation treatment was well tolerated and resulted in significant weight loss and behavioral changes.
פירוט הרכיבים הטבעיים שנמצאים ב Cane תוסף תזונה טבעי המסייע לחולי סוכרת להגיע לאיזון ברמות הסוכר שלהם. Cane הוא תוסף תזונה מבית קיורהלייף, חברה הדואגת לאיכות חייהם של החולים במחלות כרוניות.
http://www.cane-curalife.com/
1. Phytosterols are plant compounds similar in structure to cholesterol that have shown promise in treating various cancers. Studies in animal models and cell cultures have found that phytosterol supplementation reduced tumor growth and progression of breast, prostate, colon and other cancers.
2. Mechanisms by which phytosterols may treat cancer include inducing apoptosis of cancer cells, reducing oxidative stress, decreasing inflammatory cytokines and angiogenesis to cancer cells. Doses of 300mg per day have shown benefits, though most Americans consume only 80mg daily.
3. Further research is still needed to better understand long term effects and interactions with drugs, but initial animal and cell studies provide evidence that phytosterols may be a potential dietary intervention
1. Phytosterols are plant compounds similar in structure to cholesterol that have shown promise in treating various cancers. Studies in animal models and cell cultures have found that phytosterol supplementation reduced tumor growth and progression of breast, prostate, colon and other cancers.
2. Mechanisms by which phytosterols may treat cancer include inducing apoptosis of cancer cells, reducing oxidative stress, decreasing inflammatory cytokines and angiogenesis to cancer cells. Doses of 300mg per day have shown benefits, though most Americans consume only 80mg daily.
3. Further research is still needed to better understand long term effects and interactions with medications, but initial animal and cell studies provide evidence that phytosterols may serve as a dietary intervention
A study was conducted using Immunocal protein supplementation as part of a prehabilitation program for patients scheduled for colorectal surgery. The prehabilitation program, which included exercise, nutrition counseling and Immunocal, began 4 weeks before surgery. Patients who completed the prehabilitation program were able to walk significantly further in a 6-minute walking test compared to those who began rehabilitation only after surgery. The prehabilitation program helped to improve patients' functional capacity and physical strength before surgery, allowing for better recovery outcomes.
This document provides background information on protein supplement use among gym-goers in Lebanon. It begins with acknowledging those who helped with the project and providing a table of contents that outlines the abstract, introduction, literature review, methodology, results, discussion, limitations, ethics, and conclusion sections. The introduction discusses the increased popularity of protein supplements globally and reviews different types of supplements and their purposes. The literature review summarizes several previous studies that examined protein supplement use among athletes and gym-goers. The methodology section describes the study design, sampling, data collection, analysis, and ethics. The results and discussion sections will analyze survey responses from 50 gym-goers in Lebanon on their protein supplement use.
The document discusses the growing problem of obesity around the world and in the UAE specifically. Some key points:
- Over 30% of the global population is now overweight or obese.
- In the UAE, over 60% of men and 66% of women are overweight or obese, which is double the world average.
- Obesity-related diseases like diabetes are rising sharply in the UAE, with nearly 1 in 5 people affected and projections that over 1.8 million people could have diabetes within a few years.
safe and clinically tested erectile dysfunction formula. Revolutionising bedroom performance it increases energy levels, reawakens sexual desire, supports hard powerful erections, stamina and endurance. Now even better with the NEW complementary Viasil – Instant Erection Gel to support instant erection better than ever.
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This document outlines several diabetes risk reduction programs:
1. A quality improvement program at community health centers that significantly improved processes of care for diabetes and asthma but not outcomes.
2. A lifestyle intervention program and metformin treatment that both reduced incidence of type 2 diabetes, with lifestyle changes proving more effective.
3. A study finding that increased colonic propionate reduced brain responses to high-calorie foods and led to less food appeal and calorie intake.
4. A nutrition education program tailored for low-literacy adults that significantly improved fat-related knowledge and behaviors over general nutrition classes.
5. An online health promotion program for older workers that significantly improved diet and exercise self-effic
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
1. New Advances In
Glutathione Enhancement Therapy
Clinical trials show that the science, implications and economics of
glutathione enhancement therapy have changed with a new technology:
• Standard protocols for intravenous IV glutathione therapy and nutritional intervention
may be a modality of the past.
• A new “light-based” technology shows clinical results for safely raising glutathione
levels up to an average increase of 300%.
• Improvement in and availability of effective glutathione therapy now holds huge
implications for the health/medical industry.
• New medical technology created by LifeWave delivers this optimal glutathione
enhancement through an FDA-registered medical device.
Highlights of Recent Clinical Trials:
A. Clinical trial of LifeWave product shows subjects achieved increased blood-level
glutathione averages of 15 times higher than typical IV therapy results.
B. Clinical trial of LifeWave product shows these sustained, high levels to be safe and
profoundly beneficial in improved function of eight major organs within 30 days. (The
glutathione patch worn 12 hours daily for 4 weeks significantly improves cellular
physiologic functional status in different organs.)
C. Ramifications for Medical Practitioners:
• For IV therapy clinics, economic changes caused by this technology are affecting
business models.
• For non-IV clinics, a more effective and convenient glutathione enhancement
product is now available to all types of practices and is a safe, convenient and
affordable option for patients.
For more information, contact:
2. New Advances In Glutathione Enhancement Therapy
2
New Advances In
Glutathione Enhancement Therapy
Introduction
In 1999, the U.S. Navy funded a three-year research project with a goal of creating or discovering a
different medical modality for extending life expectancy with a focus on energy enhancement. The end
result goal was to keep personnel alert and physically able to sustain long periods of duty without sleep
and while maintaining a high level of mental and physical function. An additional goal was to eliminate
the typical use of stimulants, amphetamines and other chemical modes.
The result was the development of a new technology that makes use of various frequencies of light
which, when directed to the body, provoke specific responses by use of photo-receptors on and within
human cells. A product called Energy Enhancer was developed to assist the body in more efficient fat
burning and to enhance energy production within the cell mitocondria.
After several scientific studies and clinical trials, the technology was registered with the FDA by
Lifewave Corporation of La Jolla, California, and the patenting process proceeded in earnest.
The technology was then further developed to include five additional devices specifically designed
for other medical applications:
1. Glutathione enhancer - sends a light signal to the cells allowing the body to produce as high or low a
level of glutathione as it requires for optimal physiologic function.
2. Carnosine enhancer - sends a light signal to the cells allowing the body to produce as high or low a
level of carnosine as it requires for optimal physiologic function.
3. Pain reliever - assists the body in reducing inflammation temperatures by 4 degrees in less than five
minutes, immediately reducing or eliminating pain regardless of the cause of the pain or inflammation.
4. Sleep enhancer - sends a light signal to the cells allowing the body to produce as high or low a level of
melatonin as it requires for optimal physiologic function. Assists the body to easily achieve delta level
sleep.
5. Appetite and craving control - assists the hypothalamus gland with improved function to bring
cravings for food and other substances into normal range.
Development of the Glutathione Enhancer at its early stage included a double-blind placebo
controlled clinical trial (see attached, page 4: Hippocrates Health Institute, “A New Way To Increase
Glutathione Levels In The Body”) to determine what blood levels of glutathione were being achieved.
Prior to this study, it was expected that if very high levels existed, a high level expelling of heavy metals
and other toxins would accompany the experience; therefore, stress markers related to kidney function
were tracked on a daily basis for safety reasons. The assumption was that these markers would show an
increase but, quite surprisingly, in this study, the opposite was found.
This single finding spurred the researchers on to further testing to determine the specific effect this
very high level of glutathione production had on the major organs of the body. A double-blind, placebo
controlled clinical trial (See attached, page 7: University of Texas, “Glutathione Patches Improve Cellular
Physiologic Functional Status In Different Organ’s) was conducted in 2009 which confirmed the
hypothesis that the LifeWave Glutathione Enhancer patch would hold profound benefits for the users in
the area of organ function.
3. New Advances In Glutathione Enhancement Therapy
3
Glutathione Therapy
More than 80,000 studies and trials exist today related to glutathione. From as early as 1964,
glutathione has been applied in cancer therapy as well as for many other chronic conditions.
Blood Glutathione levels have been identified as being one of the most important indicators of overall
health. As the master antioxidant in the body, Glutathione has a range of diverse metabolic functions,
including:
• Acting as a free radical scavenger
• “Recharging” depleted antioxidants back into their active state (Vitamin C, Vitamin E,
Vitamin A, etc.)
• Maintaining the immune system
• Supporting protein structures
• Removing heavy metals such as mercury through the liver
Because glutathione is a large molecule and thus difficult to introduce into the cells, effective
supplementation has been a challenge. Roughly 40% of the available research relates to the topic of how
to increase glutathione blood-levels. Dietary precursors are known to achieve as much as a 10% increase,
allowing intra-cellular benefits while IV therapy, conducted several times weekly can bring as much as an
18% rise but is challenged by molecule size and other factors.
The use of the new light technology developed by LifeWave renders these challenges mute in that it
does not introduce any glutathione or other compound into the body. A specific frequency of light is
directed to the body allowing appropriate photo receptors in and on the cells to initiate the chemical
functions needed to produce, whatever levels are required by the body for its optimal physiologic
function.
The results of the first trial confirmed a 300% average increase in glutathione blood-levels, with
production achieved by the body’s own physiology and without the addition of dietary precursors.
Until recently, IV therapy had been accepted as the best available mode of glutathione therapy. Most
all research showing the effectiveness of glutathione in treatment of chronic conditions is based upon this
18% increase.
The LifeWave light technology devices are now showing profound results of sustained 300% average
increases, in trials and in clinical therapy applications.
Treatment, Economics and Markets
Treatment with glutathione has required both complex protocols related to dietary precursors and
economic barriers regarding multiple sessions needed for IV therapy.
The new light technology by LifeWave allows a simplified application, making it a therapy which can
be applied through any medical and healing practice or by the patient, and at a cost that is well within
most budgets.
The implications for clinics which rely upon IV glutathione therapy as a component of their medical
practice is likely to be a sharp decrease in services requested and offered due to expense, convenience
and, ultimately the ineffectiveness of IV therapy in comparison to this new technology.
The Lifewave Glutathione Enhancer patch is covered under the Medicare “Flex” plan, bringing
additional economic benefits for its use in the marketplace.
4.
5.
6.
7. New Advances In Glutathione Enhancement Therapy
7
GLUTATHIONE PATCHES IMPROVE CELLULAR
PHYSIOLOGIC FUNCTIONAL STATUS IN DIFFERENT
ORGANS
Sherry Blake-Greenberg ND, MA, HMD, and
Homer Nazeran PhD, CPEng (Biomed.)*
Health Integration Therapy, Palos Verdes Estates, California 90274, USA
*Electrical and Computer Engineering, University of Texas at El Paso,
El Paso Texas 79968, USA
ABSTRACT
Glutathione, termed the “ultimate” or “master” antioxidant, is a vital intracellular tripeptide
molecule and plays a central role in cellular physiologic functions. It is very important in cellular
detoxification and protection from damage caused by free radicals, peroxides and toxins. Blood
glutathione levels are indicative of overall health. Glutathione metabolism and its cause and
effect relationship to diseases such as cancer, neurodegenerative diseases, cystic fibrosis, HIV,
aging and others have been shown in biomedical literature. Currently the undeniable connection
between glutathione and good health is very well established.
Bioelectrical impedance data indicative of cellular physiologic organ function (status),
using an Electro Interstitial Scanning (EIS) system, were acquired from two cohort volunteers
after giving informed consent. Cohort 1 comprised of 10 subjects: 1 male and 9 females, 18-86
years of age while Cohort 2 were 20 subjects: 4 males and 16 females, 18-86 years of age.
Cellular hysiologic function in subjects were evaluated in 8 organs (pancreas, liver, gall bladder,
intestines, left and right adrenal glands, hypothalamus and pituitary gland) while wearing the
glutathione patch for a period of 4 weeks. Physiologic function testing was repeated each week.
Cohort 1 wore the glutathione patch for 12 hours/day daily, while Cohort 2 wore the glutathione
patch for 12 hours/day on weekdays. Cellular physiologic function baseline data were acquired
from all subjects at the beginning of the study period before the glutathione patch was worn.
Subjects were instructed to keep well hydrated during the study period. All subjects served as
their own control. The hypothesis to be tested was: The glutathione patch worn 12 hours daily
for four weeks significantly improves cellular physiologic functional status in different organs.
Statistical analyses were carried out in both cohorts comparing the cumulative averages of the
net changes in cellular physiologic functional status of each organ at the end of the study period
with corresponding baseline data. The results in Cohort 1 showed a highly significant (p <
0.001) improvement in physiologic functional status of all organs tested except in pancreas that
showed a very significant improvement (p < 0.01). Average statistical power considering the
effect size (% improvement in physiologic function, sample number, and level of significance)
was at least 72% in Cohort 1. The results in Cohort 2 showed a significant (p < 0.05)
improvement in physiologic functional status of fours organs (adrenal glands, hypothalamus and
pituitary gland). Average statistical power considering the effect size (% improvement in
physiologic function, sample number, and level of significance) for these organs was at least
76% in these tests. No significance improvement in cellular physiologic status was observed in
pancreas, liver, gall bladder and intestines in Cohort 2. This could be attributed to the fact that
by not using the patches for 2 days in a week (about 30% less exposure to glutathione), the
8. New Advances In Glutathione Enhancement Therapy
8
subjects in Cohort 2 did not achieve adequate stimulated detoxification in all organs by
glutathione over the study period.
The overall data in Cohort 1 in this study demonstrated that glutathione patches worn 12
hours daily over a period of 4 weeks produced a highly significant improvement in physiologic
functional status of pancreas, liver, gall bladder, intestines, left and right adrenals,
hypothalamus and pituitary gland and very significant improvement in pancreas with a statistical
power of at least 72%. Stated differently all organs achieved significant cellular physiologic
functional status improvement compared to baseline with a statistical power of at least 91%.
Keywords: Glutathione patch, Cellular physiologic function measurements, Electro
interstitial scan (EIS) system 2
INTRODUCTION
Glutathione is a vital intracellular tripeptide molecule comprised of 3 nonessential
amino acids: cysteine, glutamic acid and glycine (g-glutamyl-cysteinyl-glycine
abbreviated as GSH). These 3 building blocks in turn are made from different
combinations of essential amino acids. The –SH suffix in GSH (reduced form of
glutathione) indicates that it contains a sulfhydryl group. This group comes from sulfur-
containing amino acids cysteine and methionine. Glutathione is produced naturally in
abundance in the body and circulates constantly in the bloodstream neutralizing free
radicals (dangerous by-products of normal metabolic processes converting food to
energy) and removing environmental poisons such as heavy metals, harmful waste
products and toxins to protect cells against oxidative stress. Free radicals are unstable
oxygen-containing molecules which are hungry for electrons to quench their insatiable
desire for cell destruction. Glutathione is a powerful antioxidant (created by the same
energy-producing processes that create free radicals) which serves as a built-in defense
against the harmful effects of free radicals, by rapidly quenching the destructive free
electrons in these molecules. The balancing act between free radicals and antioxidants
could be easily disrupted for any reason such as when the body is under stress, fighting
an infection or inflammation or healing from an injury, in which case more free radicals
are generated. Free radicals are also created when the body is exposed to cigarette
smoke, alcohol, ultraviolet light, heavy metals, air pollution, pesticides, food additives,
and other environmental toxins. Free radicals are the underlying cause of a variety of
illnesses in the body [1].
Lyons et al, described that glutathione serves diverse physiologic functions such
as detoxification of xenobiotics, protection of cells from oxidative stress, and acts as a
storage and a transport form of cysteine. They explained that reduced tissue levels of
GSH are thought to compromise cell function, promote tissue damage, and increase
morbidity under various disease conditions [2].
Wu et al, studied glutathione metabolism and its implications for health. They
described that glutathione plays important roles in antioxidant defense, nutrient
metabolism, and regulation of a variety of cellular events. They also explained that
glutathione deficiency contributes to oxidative stress playing a key role in aging and the
pathogenesis of many diseases. These diseases include: seizure, Alzheimer’s,
9. New Advances In Glutathione Enhancement Therapy
9
Parkinson’s, liver disease, cystic fibrosis, sickle cell anemia, human immunodeficiency
virus (HIV), acquired immunodeficiency syndrome (AIDS), cancer, heart attack, stroke,
and diabetes. They emphasized the need for new understanding of the nutritional
regulation of GSH metabolism as a critical step for development of effective health
improvement and disease treatment strategies [3].
Townsend et al, provided an overview of the biological importance of GSH at
cellular and organism level and showed cause and effect relationships between GSH
metabolism and diseases such as cancer, neurodegenerative diseases, cystic fibrosis
(CF), HIV, and aging. They also showed how the enzymes involved in GSH regulation
and control influence susceptibility and progression of these conditions. They concluded
that there seemed to be no harm in supplementing a diet with GSH as “perhaps the
product will provide a supply of the constituent amino acids, where, in particular,
cysteine may be useful in stimulating gastrointestinal synthesis of GSH” [4].
The current methods of oral supplementation with glutathione or its amino acid
precursors have not been effective in significantly elevating the blood levels of this
antioxidant due to stomach acid destruction of L-Glutathione and unpredictability of
results with precursor amino acids. Direct daily injection of glutathione has been more
effective in producing short term elevation of glutathione, however this approach is
unreliable due to expense and inconvenience. Preliminary clinical data from blood and 3
urine samples collected every 24 hours over a period of 5 days from 15 volunteers
wearing the glutathione patch have shown a 3 to 4 fold increase in blood levels of
glutathione compared to baseline levels [5].
This is the first study of its kind to investigate the effect of the glutathione patch
on organ physiologic function. Bioelectrical impedance data indicative of cellular
physiologic function, using and EIS system, were acquired from two cohort volunteers.
Cohort 1 comprised of 10 subjects: 1 male and 9 females, 18-86 years of age while
Cohort 2 comprised of 20 subjects: 4 males and 16 females, 18-86 years of age.
Cellular physiologic function in subjects were evaluated in 8 organs (pancreas, liver, gall
bladder, intestines, left and right adrenal glands, hypothalamus and pituitary gland)
while wearing the glutathione patch for a period of 4 weeks. Physiologic function testing
was repeated each week. Each visit was approximately 1 hour in duration for the
testing. Cohort 1 wore the glutathione patch for 12 hours daily, while Cohort 2 wore the
patch for 12 hours/day on weekdays only. Physiologic function baseline data were
acquired from all subjects at the beginning of the study period before the glutathione
patch was worn. Subjects were instructed to keep well hydrated during the study period.
All subjects served as their own control.
The overall data in this study demonstrated that glutathione patches worn 12
hours daily over a period of 4 weeks caused highly significant improvement in
physiologic functional status of pancreas, liver, gall bladder, intestines, left and right
adrenals, hypothalamus and pituitary gland and very significant improvement in
pancreas with a statistical power of at least 72%. Stated differently all organs achieved
10. New Advances In Glutathione Enhancement Therapy
10
significant cellular physiologic functional improvement with a statistical power of at least
91%.
MATERIALS AND METHODS
For this investigation, the glutathione patch (LifeWave, La Jolla, California, USA) was
used. The glutathione patch is described as “a new method for increasing glutathione
levels by stimulating acupuncture points on the body with a combination of pressure and
infrared energy. The LifeWave glutathione patch is a non-transdermal patch that does
not put any chemicals or drugs into the body. The LifeWave glutathione patch contains
natural nontoxic crystals that absorb body heat to generate infrared signals that cause
the body to produce more endemic glutathione. Clinical studies utilizing blood analyses
indicate an average rise of more than triple the blood glutathione over a period of 24
hours” [5]. For a comprehensive discussion of the LifeWave glutathione patch please
see reference [6].
An EIS (Electro Interstitial Scan, U.S. patent No. US 61/194,509) system was
deployed to acquire bioelectrical impedance data indicative of cellular physiologic
functional status in 8 organs. “The EIS provides an electrical signal corresponding to the
status of a patient's physiological parameters: Na+/K+ATPase pump activity, tissue
pCO2, sympathetic system activity and microcirculation blood flow.” [7]. The EIS
System uses chronoamperometry based on Cottrel’s equation [8]. It is based on
bioelectrical impedance and physiology of the interstitial fluid. It introduces low intensity
direct currents at 1.2 V into the body to measure only one compartment of the interstitial
fluid. “The EIS System with world wide patents (No 06/09878 and 065217) is the only
commercially available device utilizing a Direct Current, allowing in vivo analysis of the
physiological parameters at the cellular level via the interstitial fluid. The 3 minute test is
free of any operator bias. The EIS system using Chronoamperometry, models human
body systems with measurements of physiological data.” [9].
The EIS is a hardware/software computerized system that applies precise
algorithms and proprietary formulas to generate on-screen, 3-D modeling
representations of the human body's systems;4 with specific intended uses. EIS system
is a French electrochemical device, classified as a medical device in Europe and the
United States. Its main functions are to read the different processes going on in the
body, hyper-activity and hypo-activity in the organs. EIS measures the biochemistry and
hormone levels. It also measures pH, body composition and the sympathetic and
parasympathetic system. Even emotional traumas can be detected by measuring the
biochemistry and cellular activity in various areas of the brain. It is measuring by
sending harmless, low voltage frequencies to and from 6 electrodes connected to the
body. The computer software calculates everything based on the changes made to
these signals on their path through the body. Most measurements are done based on
the extracellular fluids, which is the environment of all cells. This is where the
biochemistry is most important, and where cellular activity can be measured by looking
at what goes into and out of the cells. EIS scans the whole body in 3 minutes. It is a
biofeedback device in the United States with pending FDA approval.
11. New Advances In Glutathione Enhancement Therapy
11
Inclusion criteria for participation in this study were functional individuals who
were willing to wear the glutathione patch and participate in the study for a period of four
weeks. Participants also agreed to not commence with any other new therapy or
methods of healing and/or make any major changes in their daily life that could alter the
efficacy of the study. Subjects must not have worn the glutathione patch prior to the
study. Subjects were recruited from the local area of Palos Verdes and may or may not
have been previous patients of Health Integration Therapy. Two cohort of volunteer
subjects participated in this study. Cohort 1 comprised of 10 subjects: 1 male and 9
females, 18-86 years old while Cohort 2 were 20 subjects: 4 males and 16 females, 18-
86 years old. Cohort 1 wore the glutathione patch for 12 hours daily, while Cohort 2
wore the glutathione patch for 12 hours/day on weekdays only. After giving informed
consent, cellular physiologic function baseline data were acquired from all subjects at
the
beginning of the study period before the glutathione patch was worn and weekly
afterwards for 4 weeks. Subjects were instructed to keep well hydrated during the study
period. All subjects served as their own control. The subjects were instructed to place
the glutathione patch 2 inches inferior to the navel (below belly button) or on CV6.
Figure 1 shows the glutathione patch and figure 2 shows the anatomical position for
wearing the glutathione patch.
RESULTS
The Electro Interstitial Scan (EIS) System used in this investigation measured cellular
physiologic function on a scale of -100 to 0 for under-function and 0 to +100 for over-
function. A reading in the -20 to + 20 is range indicative of normal values for organ
function.
Table 1 shows typical EIS System readings (cellular function physiologic status) for a
female subject, while Table 2 shows typical EIS System readings for a male subject as
examples. Functional status changes from week to week are noted as D1, D2, D3 and
12. New Advances In Glutathione Enhancement Therapy
12
D4, for the 4-week period showing cellular physiologic changes in the organs. Davg
shows the average value of changes for the 4-week period, and Dtotal represents the
average total physiologic change after 4 weeks with respect to baseline readings.
Table 3 shows the overall mean values and standard deviations for baseline and total
change in physiologic function for each of the organs in Cohort 1 (n =10).
DISCUSSION AND CONCLUSION
Statistical analyses were carried out in both cohorts comparing the cumulative averages
of the net changes in physiologic functional status of each organ at the end of the study
period with corresponding baseline data. The results in Cohort 1 showed a highly
significant (p < 0.001) improvement in physiologic functional status of all organs tested
13. New Advances In Glutathione Enhancement Therapy
13
except in pancreas that showed a very significant improvement (p < 0.01). Average
statistical power considering the effect size (% improvement in physiologic function,
sample number, and level of significance) was at least 72% in Cohort 1. The results in
Cohort 2 showed a significant (p < 0.05) improvement in physiologic functional status of
four organs (adrenal glands, hypothalamus and pituitary gland). Average statistical
power considering the effect size (% improvement in physiologic function, sample
number, and level of significance) was at least 76% in these tests. No significance
improvement in cellular physiologic status was observed in pancreas, liver, gall bladder
and intestines in Cohort 2. This could be attributed to the fact that discontinue use and
not wearing the
glutathione patch for 2 days in a week (about 30% less exposure to glutathione) the
subjects in Cohort 2 did not have adequate stimulated detoxification in all organs by
glutathione over the study period.
More detailed statistical analyses of the EIS data enabled us to make the
following observations:
1. In Cohort 1 (n =10), the average statistical power was more than 72%
for all organs showing a highly significant (p < 0.001) improvement in
cellular physiologic function. The average statistical power without
considering the pituitary gland was more than 82%. The average statistical
power, without considering pituitary and intestine was more than 90%.
2. In Cohort 1 (n = 10), the average statistical power was more than 84%
for all organs showing a very significant (p< 0.01) improvement in cellular
physiologic function. The average statistical power without considering the
pituitary gland was more than 91%. The average statistical power without
excluding the pituitary gland and intestine was more than 97%.
3. In Cohort 1 (n = 10), the average statistical power was more than 91%
for all organs showing a significant (p< 0.05) improvement in cellular
physiologic function. The average statistical power without considering the
pituitary gland was more than 96%. The average statistical power without
excluding the pituitary gland and intestine was more than 99%.
4. In Cohort 2 (n = 20), 4 organs (adrenal glands, hypothalamus and
pituitary gland) showed a significant (p< 0.05) improvement in cellular
physiologic function.
In summary, the overall data in Cohort 1 demonstrated that the glutathione patch
worn 12 hours daily over a period of 4 weeks produced a highly significant improvement
in physiologic functional status of liver, gall bladder, intestines, adrenals, hypothalamus
and pituitary gland and a very significant improvement in pancreas with a statistical
power of at least 72%. Stated differently, it could be concluded that the glutathione
patch caused a significant improvement in cellular physiologic functional status of
pancreas, liver, gall bladder, intestines, adrenals, hypothalamus and pituitary gland with
a statistical power > 91%. Therefore, the hypothesis that: The glutathione patch worn 12
hours daily for 4 weeks significantly improves cellular physiologic functional status in
different organs was accepted as true.
14. New Advances In Glutathione Enhancement Therapy
14
REFERENCES
1. A. H. Pressman A H. Glutathione: The Ultimate Antioxidant. St. Martin’s Press, New
York, NY,
1997.
2. J. Lyons, A. Rauh-Pfeiffer, Y. M. Yu, X.-M. Lu, D. Zurakowsk, R. G. Tompkins, A. M.
Ajamii, V. R. Young and L. Castillo. Blood glutathione synthesis rates in healthy adults
receiving a sulfur amino acid-free diet. Proceedings of the National Academy of
Sciences, May 9, 2000 vol. 97, No. 10, 5071-5076.
3. G. Wu, Y. Fang, S. Yang, J. R. Lupton, and N. D. Turner. Glutathione Metabolism
and Its Implications for Health. The Journal of Nutrition, 134: 489–492, 2004.
4. D. M. Townsend, K. D. Tew, H. Tapiero. The importance of glutathione in human
disease. Biomedicine & Pharmacotherapy 57, 145–155, 2003.
5. Haltiwanger, S. A New Way to Increase Glutathione Levels in the Body. Hippocrates
Magazine. Vol 28, Issue 1, 48-49, Feb. 2009.
6. Haltiwanger, S. LifeWave Skin Care Patch Instructions.
http://www.lifewave.com/pdf/Papers/SciencePaper004-GlutathioneSkinPatch.pdf.
Retrieved June
2009
7. Electro Interstitial Scan (EIS) System. http://www.ldtechnologies.com/. Retrieved
June 2009.
8. Bard, A. J.; Faulkner, L. R. “Electrochemical Methods. Fundamentals and
Applications” 2nd Ed. Wiley, New York. 2001.
9. We are Listening to the body Signals! http://www.eisunitedstates.com/. Retrieved
June 2009.