Global Journal of Infectious Diseases and Clinical Research is an international peer-reviewed journal founded by a network of experts across the globe recognized as the International Infectiologists Network. The mission of GJIDCR is to promote and publish infectious diseases research in areas of basic sciences, clinical medicine and public health.
GJIDCR encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.
The impact of Chemical, Biological, Radiological, Nuclear and Explosive event...Jamie Ranse
Ranse J. (2021). The impact of Chemical, Biological, Radiological, Nuclear and Explosive events on Emergency Departments: An integrative review; invited speaker for Qatar Health 2021, Doha, Qatar, 22nd January. [online]
Risk assessment and health research in Vietnam: A first special issue of the ...ILRI
Poster prepared by Hung Nguyen-Viet and Tran Thi Tuyet Hanh for the 6th Asian Pig Veterinary Society Congress, Ho Chi Minh City, Vietnam, 23-25 September 2013.
Covid 19 Pandemic A Challenge, A Menace for Nursesijtsrd
As we all knows COVID 19 is a Pandemic that affect more than 176 million people and 3.8 million deaths. In this Pandemic our Frontline workers i.e. Doctors, Nurses and Other Healthcare Staff also suffers emotionally as well as Physically due to more duty hours and overload of work. This Article includes a survey data that was conducted in US by American Nurses Association, To know about the concern and experiences, facing problems during Pandemic by Nursing Staff. In this Article mainly we are focusing on Nursing staff during pandemic situation and how we can encourage them. Miss. Preeti Bala | Dr. Priyanka Chaudhary | Dr. Rajwant Kaur Randhawa "Covid-19 Pandemic (A Challenge, A Menace for Nurses)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45085.pdf Paper URL: https://www.ijtsrd.com/medicine/nursing/45085/covid19-pandemic-a-challenge-a-menace-for-nurses/miss-preeti-bala
Impact of mass gatherings on ambulance services and emergency departmentsJamie Ranse
Ranse J. (2020). Impact of mass gatherings on ambulance services and emergency departments; invited speaker for Qatar Health 2020, Doha, Qatar, 17th January
Ranse J. (2019). The 2018 Commonwealth Games Experience; invited speaker for 4th International Conference for Mass Gathering Medicine, Jeddah, Saudi Arabia, 16th December.
The impact of Chemical, Biological, Radiological, Nuclear and Explosive event...Jamie Ranse
Ranse J. (2021). The impact of Chemical, Biological, Radiological, Nuclear and Explosive events on Emergency Departments: An integrative review; invited speaker for Qatar Health 2021, Doha, Qatar, 22nd January. [online]
Risk assessment and health research in Vietnam: A first special issue of the ...ILRI
Poster prepared by Hung Nguyen-Viet and Tran Thi Tuyet Hanh for the 6th Asian Pig Veterinary Society Congress, Ho Chi Minh City, Vietnam, 23-25 September 2013.
Covid 19 Pandemic A Challenge, A Menace for Nursesijtsrd
As we all knows COVID 19 is a Pandemic that affect more than 176 million people and 3.8 million deaths. In this Pandemic our Frontline workers i.e. Doctors, Nurses and Other Healthcare Staff also suffers emotionally as well as Physically due to more duty hours and overload of work. This Article includes a survey data that was conducted in US by American Nurses Association, To know about the concern and experiences, facing problems during Pandemic by Nursing Staff. In this Article mainly we are focusing on Nursing staff during pandemic situation and how we can encourage them. Miss. Preeti Bala | Dr. Priyanka Chaudhary | Dr. Rajwant Kaur Randhawa "Covid-19 Pandemic (A Challenge, A Menace for Nurses)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45085.pdf Paper URL: https://www.ijtsrd.com/medicine/nursing/45085/covid19-pandemic-a-challenge-a-menace-for-nurses/miss-preeti-bala
Impact of mass gatherings on ambulance services and emergency departmentsJamie Ranse
Ranse J. (2020). Impact of mass gatherings on ambulance services and emergency departments; invited speaker for Qatar Health 2020, Doha, Qatar, 17th January
Ranse J. (2019). The 2018 Commonwealth Games Experience; invited speaker for 4th International Conference for Mass Gathering Medicine, Jeddah, Saudi Arabia, 16th December.
NEW GENERATIONS OF DRUG-ELUTING
STENTS - A BRIEF REVIEW
*Aleksander Ernst, Joško Bulum
Department of Ischemic Heart Disease, Medical Faculty University of Zagreb,
University Hospital Centre Zagreb, Zagreb, Croatia
*Correspondence to aleksanderernst@gmail.com
The Neglected Dimension of Global Security: A Framework to Counter Infectious...The Rockefeller Foundation
The Ebola crisis in West Africa was both a tragedy and a wakeup call, revealing dangerous deficiencies across global systems to prevent, prepare, and respond to infectious disease crises. To address these shortcomings and inform a more effective response in the future, the National Academy of Medicine convened the Commission on a Global Health Risk Framework for the Future (GHRF Commission)—an independent, international group of experts in finance, governance, R&D, health systems, and the social sciences.
The Commission’s report highlights the essential role of pandemic preparedness in national security and economic stability—a critical but often under-examined dimension of the global conversation post-Ebola. Importantly, the report demonstrates that the impact of infectious disease crises goes far beyond human health alone—and that mitigation, likewise, requires the mobilization and long-term commitment of multiple sectors.
20 topics for a biology literature review – pubricaPubrica
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Epidemiological Studies Essay
Questions On Epidemiology Paper : Epidemiology
Personal Statement Of Epidemiology
Research And Determinants Of Epidemiology Essay
Epidemiology: Casual Reasoning And Science
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The life, medical, and health sciences represent a broad array of disciplines that generally involve the biology and health of people, plants, and animals. These fields, especially when the provision of medical care is included, make up an important and growing part of Michigan’s economy. Approximately 533,000 Michiganders were employed in one of these sectors in 2015, representing approximately one in eight jobs. Between 2011 and 2015, the sector added 21,000 jobs, with growth of 4.2 percent. While this growth is slower than the overall economy during this period, this slower growth is misleading. Michigan’s economy is still recovering from the sharp employment declines that occurred in the 2000s, a decline that the life, medical, and health sciences did not experience. Compared to its 2000 level, employment in the life, medical and health sciences is up 18.9 percent, while overall Michigan employment is still down 9.3 percent.1 The ability of the sector to grow while the rest of Michigan’s economy was contracting represents an important stabilizing force for the economy.
I hope you have found this issue to be informative and helpful in your work. Please send me any information you'd like posted in upcoming issues.
Any recommendations to improve this communique would be most appreciated!
And if you’d like to support the Center’s work with a tax deductible donation, that would be fantastic and do a great deal: http://centerforglobalinitiatives.org/donateNow.cfm
Cheers, and thank you for your work,
Chris
From Discovery to Delivery: Benchwork to Global Health: Corey CasperUWGlobalHealth
Explores relationships and discrepancies between important research-based medical advancements and subsequent real world implementation. Advancements in the management and potential elimination of infectious diseases such as HIV and TB will be addressed, as related to development and implementation of effective diagnostics, vaccines, or treatments.
Week 4: Week 4 - Epidemiology—Introduction
Epidemiology—Introduction
The study of epidemics is epidemiology. Its primary focus is on the distribution and causes of disease in populations. Epidemiology involves developing and testing ways to prevent and control disease by studying its origin, spread, and vulnerabilities.
As a discipline, epidemiologic research addresses a variety of health-related questions of societal importance. Epidemiologic research methods are used by clinical investigators and scientists who conduct observational and experimental research on the prevention and treatment of disease.
The Cholera epidemic, a case from the 19th century, was enabled by the global movement of people. Having appeared in India in 1817, it spread throughout Asia and the Middle East within a decade. It was reported in Moscow in 1830 and then spread to Warsaw, Hamburg, Berlin, and London in 1831 (Snow, 1855, 2002). When it crossed the Atlantic to reach North America, Cholera gained the notoriety of the first truly global disease.
The modern day world is dominated by free trade and rapid transportation. An unprecedented rate of global interchange of food, consumer products, and organisms—including humans—is occurring. The threat of pandemics in the 21st century has heightened the importance of epidemiology at national and international levels.
Although diseases such as Influenza A (H1N1), Severe Acute Respiratory Syndrome (SARS), Acquired Immunodeficiency Syndrome (AIDS), West Nile Virus, Salmonella, are commonly recognized as epidemics, as they cause large scale disruption of health in populations. The field of epidemiology also addresses epidemics of obesity (Ogden et al., 2007), diabetes (Zimmet, 2001), mental health (Insel & Fenton, 2005), and any other disease that may cause large scale disruption of health in populations.
In general, there are ten stages to an outbreak investigation:
1. Investigation preparation
2. Outbreak confirmation
3. Case definition
4. Case identification
5. Descriptive epidemiology
6. Hypothesis generation
7. Hypothesis evaluation
8. Environmental studies
9. Control measures
10. Information dissemination
Investigation preparation requires a health crisis manager to identify a team of professionals who will lead the outbreak investigation, review the scientific literature, and notify local, state, and national organizations of the potential outbreak.
Outbreak confirmation requires actual laboratory confirmation of the disease, which may involve the collection of blood, urine, and stool samples from ill people and performing bacteriologic, virologic, or parasitic testing of those samples.
Case definition is the process by which we establish a set of standard criteria to determine who is and is not infected with respect to a specific outbreak; that is, a protocol is developed to determine case patients.
Case identification requires the health crisis manager and team of professionals to conduct a systematic and organize.
Development Challenges, South-South Solutions is the monthly e-newsletter for the United Nations Development Programme’s South-South Cooperation Unit (www.southerninnovator.org). It has been published every month since 2006.
Stories by David South
Design and Layout: UNDP South-South Cooperation Unit
A World United Against Infectious Diseases: Connecting Organizations for Regi...The Rockefeller Foundation
The world has made significant strides in tackling major public health challenges over the last several decades. We have eradicated one disease, smallpox, and are close to doing so with polio and guinea worm. We continue to make significant progress on other debilitating illnesses, including malaria, tuberculosis and HIV/AIDS. Yet, even as our technology and practices improve, new threats arise. In the last two decades, we have seen some 30 new zoonotic diseases emerge, from SARS to hantavirus to Ebola and more. Population pressures and economic growth push humans into ever closer contact with animals, disturbing ecosystems, and creating ripe conditions for new pathogens to jump from animals to humans. Add to this the incredible growth in global travel and trade and the risk of new diseases quickly spreading worldwide has never been greater. So while our ability to respond continually improves, the challenges we face increase as well.
Many factors make up the successful fight against emerging infectious diseases. But one factor trumps all* early detection and rapid identification of novel infections. If we can find a new pathogen early, we can often isolate it to the area in which it emerges. Conversely, failure to find the disease early allows the pathogen to propagate to new regions, countries and continents, making the response much more difficult and costly. Imagine if we had found HIV/AIDS when it was still contained to its region of origin*many of today’s 35 million people infected worldwide would have never been exposed. Our tools of detection, including point-of-care diagnostics and digital surveillance, continue to improve. However, the global infectious disease surveillance system is disjointed. Practices and protocols vary, and inefficiencies abound. The initiative we are jointly supporting*Connecting Organizations for Regional Disease Surveillance (CORDS)*tackles this challenge by building trust and collaboration across national borders.
CORDS unites regional disease surveillance networks from critical hotspots around the world to promote exchanges of best practices in surveillance and catalyze innovation in early disease detection. By working together with international bodies, including the World Health Organization (WHO), World Organization for Animal Health (IOE), and the Food and Agriculture Organization of the United Nations (FAO), CORDS will speed the development, capabilities and sustainability of all its network members to improve global surveillance and mitigate the potential impact of disease outbreaks both from epidemic diseases and from the recrudescence of endemic diseases.
Each of our organizations comes to this issue with equal commitment but different perspectives ranging from global health to disaster management to biosecurity and more. We are all united in our dedication to this effort, which fills a critical gap in global public health capacity. We look forward to CORDS contributing to improve health o
All Crimson publishers scientific journals are open access and constantly updated to keep the knowledge flowing. Our articles are also met with the highest standards of publishing and go through a peer review before being considered for publishing. Crimson Publishing Group provides Journal publishing services in the diversified academic disciplines such as Science, Technology and Medicine available Online via Open Access ensuring the quality by reputed editors and high quality peer-reviewing. We strive towards betterment of societal conditions benefitting global humanity by advancing innovations in the fields of scientific research. We inspire upcoming researchers and scientists nurturing the essential temper and we are motivated to be significant role players for offering due recognition and rewards for their works.
Our global Open Access platform makes sure that there are no barriers in sharing the knowledge and evolving through it.
OMICS Publishing Group, Journal of General Medicine is an Open Access, peer-reviewed journal which aims to provide the most rapid and reliable source of information on current developments in the field of General Medicine.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
The ASGCT Annual Meeting was packed with exciting progress in the field advan...
Global Journal of Infectious Diseases and Clinical Research
1. Global Journal of Infectious
Diseases and Clinical Research
ISSN: 2455-5363
2. About Journal
Global Journal of Infectious Diseases and Clinical Research is an international peer-
reviewed journal founded by a network of experts across the globe recognized as the
International Infectiologists Network. The mission of GJIDCR is to promote and publish
infectious diseases research in areas of basic sciences, clinical medicine and public
health.
GJIDCR encourages research, education and dissemination of knowledge in the field of
Infectious Diseases across the world thus promoting translational research by striking a
synergy between basic science, clinical medicine and public health. The Journal intends
to bring together scientists and academicians in Infectious Diseases to promote
translational synergy between Laboratory Science, Clinical Medicine and Public Health.
The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis,
Data Protocols, Case Reports, Clinical Photographs, review articles and special
commentaries. Students, Residents, Academicians, Public Health experts and scientists
are all encouraged to be a part of this initiative by contributing, reviewing and
promoting scientific works and science.
3. Aims & Scope
The Global Journal of Infectious Diseases and Clinical Research is a peer-reviewed,
global journal that publishes original research, reviews and case studies on infectious
diseases. We encourage research on infectious diseases that remain key agent of
poverty and social inequity of the majority world today.
Global Journal of Infectious Diseases and Clinical Research provides a forum for
Classification:
Bacterial Infections
Cross Infection
Eye Infections
Fungal Infections
Focal Infection Gingivitis,
5. Reviewer Board
Gabriel Trueba, Professor, Universidad San Francisco de Quito, USA.
Prashant Jain, Assistant Professor, Clinical Mental Health Counseling, USA.
Ashley C. Banyard, Animal and Plant Health Agency (APHA), UK
Dra Maria teresa Rosanova, Doctora de la Universidad de Buenos Aires,
Argentina
Mariana A. Rivero, "Universidad Nacional del Centro de la Provincia de
Buenoa Aires, Argentina "
Tang Thean Hock, Profesor, Universiti Sains Malaysia, Malaysia
Munir Aktas, Professor, Firat university, Turkey
Myat Phone Kyaw, Deputy Director General, Mentor of Mahidol University,
Burma.
6. Thank you for watching…
For more about Journal Visit:
http://www.peertechz.com/Infectious-Diseases/
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