The document outlines a presentation by Martin Kirk Christensen regarding the NOBLE CTO trial, which investigates chronic total coronary occlusions (CTOs) and their association with arrhythmias. It discusses two studies focused on the evaluation of percutaneous coronary intervention (PCI) in CTOs, assessing outcomes like quality of life and complication rates. Christensen also mentions his lack of financial conflicts of interest and invites further contact for inquiries.

1. NOBLE CTO TRIAL

2. I, Martin Kirk Christensen DO SADLY NOT have a
financial interest/arrangement or affiliation with one
or more organizations that could be perceived as a
real or apparent conflict of interest in the context of
the subject of this presentation
Disclosure Statement of Financial Interest

3. Participating centers

4. The questions
• What to do in everyday practice
• CTOs and arythmias are related, but does opening CTOs help?
• How often does CTOs help on symptoms other than classic
angina?
• In an all-comer setting, what is the succesrate and
complication rate?

5. Actually 2 studies
• Step 1
– The NOrdic-Baltic Randomized Registry Study for Evaluation
of PCI in Chronic Total Coronary Occlusion (NOBLE-CTO)
• Step 2
– The Nordic Baltic Chronic Total Occlusion (CTO) Arrhythmia
Study

6. Setup
• NOBLE CTO
– Stabile disease and only untreated CTO
• Quality of life
• Echocardiography
• MR perfusion
• NOBLE Arrhythmia
– Loop recorder

7. Status
• NOBLE 138 included
• NOBLE Arrythmia 103 included

8. Thank you
If interested please contact me:
Martin Kirk Christensen
Aalborg University Hospital
Denmark
m.kirk@rn.dk