ANAESTHESIA DEFINITION
• insensitivityto pain, especially as artificially
induced by the administration of gases or
the injection of drugs before surgical
operations
4.
HISTORY OF ANESTHESIA
•General anesthesia was absent until the mid- 1800s.
• Ether used as anesthetic in 1842 by Dr. Crawford W.long
• Ether publicized as anesthetic in 1846 by Dr. William Morton.
• Ether is no longer used in modern practice, yet considered to be the first
ideal' anesthetic
• Chloroform used as anesthetic in 1853 by Dr. John Snow
• Endotracheal tube discovered in 1878
• Thiopental first used in 1934
6.
General anesthesia -for surgical procedure to render the patient
unaware/unresponsive to the painful stimuli.
Drugs producing General Anesthesia - are called GENERAL
ANAESTHETICS
Regional and Local anesthesia - reversible inhibition of impulse
generation and propagation in nerves. Drugs producing local
anaesthesia - are called LOCAL ANAESTHETICS
• General anaesthetics(GAs) are drugs which produce reversible
loss of all sensations and consciousness. It usually involves a
loss of memory and awareness with insensitivity to painful
stimuli, during a surgical procedure
12.
Classic Stages ofAnesthesia
Stage 1: Analgesia
decreased awareness of pain, amnesia ,without loss of consciousness
Stage 2:excitation
delirium & excitation, enhanced reflexes,retching, incontinence,
irregular respiration
Stage 3: Surgical Anaesthesia
Unconscious, no pain reflexes, regular respiration
Stage 4: Medullary Depression
Respiratory and CV depression requiring ventilation ad
pharmacological support
• A localanaesthetic is injected to block or
anaesthetise a nerve or nerve fibers
• Implies a major nerve block administered by
an anesthesiologist (such as spinal, epidural,
caudal, or major peripheral block)
Mechanism of Action
•Principle site of action - Nerve Root
• LA bathes the nerve root in subarachnoid or epidural space
• Spinal Anaesthesia- direct injection of LA into CSF, with lesser
volume of drugs
• Epidural Anaesthesia- LA injected in epidural space at nerve
roots, with higher volume of drugs
29.
• Local anestheticsolutions block sensory,
autonomic and motor impulses as the
anterior and posterior nerve roots pass
through the CSF. It is NOT the spinal cord!
• The site of action includes the spinal nerve
roots and the dorsal root ganglion.
• Spinal needleis inserted with the stylet through the introducer
• Needle should be inserted in the midline and directed cranially
at an angle of less than 50 degrees to the longitudinal axis of the
vertebral column
• Bevel of the spinal needle should be kept parallel to the
longitudinal axis of the spine
• Loss of resistances can be felt after puncturing ligamentum
flavum and the duramater
33.
PERIPHERAL NERVE BLOCKS
•Surgery limited to one extremity (ideally one nerve
distribution)
• Moderate to severe postoperative pain anticipated
• Facilitate same-day discharge and avoid hospitalization for
pain management
• Improve vascular supply
• Early physical therapy and rehabilitations
• Employed forminor procedures in which the
surgical site is infiltrated with a local anesthetic
• May inject drugs such as lidocaine or
bupivacaine
• Can be done on OPD basis or daycare surgery
38.
MECHANISM OF ACTION
•Local anaesthetics reversibly block impulse
conduction along axons and other excitable
membranes that utilize sodium channels as the
primary means of action potential generation.
• This action can be used clinically to block pain
sensation.
39.
INDICATIONS
• Incision anddrainage of incised abscess.
• Removal of cysts, residual infection areas, neoplastic growths,
ranula and salivary calculi.
• Most dental procedures.
• Suturing of open wound.