Gamma amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. It is synthesized from glutamate by glutamic acid decarboxylase and acts by opening chloride channels, reducing neuronal excitability. GABA acts on three main receptor types: GABAA, GABAB, and GABAC. GABAA receptors are ligand-gated chloride channels whose activation results in neuronal inhibition. Many drugs target the GABA system, including anxiolytics, sedative-hypnotics, general anesthetics, and anticonvulsants. Drugs like benzodiazepines and barbiturates enhance the effects of GABA at GAB