The document examines the effects of simultaneous kidney-pancreas transplantation (KP) versus kidney alone transplantation (KD) on diabetic enteropathy in patients with type 1 diabetes over a 7-year period, finding that KP but not KD improved biochemical markers, gastrointestinal symptoms, anorectal manometry results, and microscopic pathology of the rectal mucosa.
Evidence: Describing my kitchen. ENGLISH DOT WORKS 2. SENA... ..
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actividad 3 semana 1. ENGLISH DOT WORKS 2.
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2. describing cities and places. ENGLISH DOT WORKS 2. SENA. semana 4 acitivda..... ..
Evidence: describing cities and places.ENGLISH DOT WORKS 2. SENA. ENGLISH DOT WORKS 2.
semana 4 acitivdad 2.ENGLISH DOT WORKS 2.
week 4 acitivty 2. ENGLISH DOT WORKS 2.
3.Evidence: Getting to Bogota.ENGLISH DOT WORKS 2. SENA.semana 4 actividad 3... ..
vidence: Getting to Bogota / Evidencia: Llegando a Bogotá.
ENGLISH DOT WORKS 2. SENA.
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semana 4 actividad 3.ENGLISH DOT WORKS 2.
week 4 activity 3.ENGLISH DOT WORKS 2. SENA.
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actividad 2 Semana 1. Evidence: Going to the restaurant .
Activity 2 Week 1. Evidence: Going to the restaurant .
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week 2 activity 2.ENGLISH DOT WORKS 2.
semana 2 actividad 2. ENGLISH DOT WORKS 2.
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semana 4 actividad 1.ENGLISH DOT WORKS 2.
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La presente guía tiene como finalidad orientar a los responsables del tratamiento de datos personales en la elaboración, diseño y difusión del aviso de privacidad respecto de su contenido y alcance al que refiere la Ley Federal de Protección de Datos Personales en Posesión de los Particulares, en lo sucesivo la Ley.
La guía se divide en seis grandes secciones: la primera establece las características generales de todo aviso de privacidad; la segunda orienta a los responsables para la elaboración de avisos de privacidad que cumplan con lo dispuesto por la Ley; la tercera contiene recomendaciones para el contenido del aviso de privacidad; la cuarta refiere a las medidas compensatorias que contempla la Ley en su artículo dieciocho, la quinta presenta diez consejos prácticos para la elaboración de un aviso de privacidad y la sexta presenta modelos tipo de aviso de privacidad.
Mini Gastric Bypass: initial Experience
British Obesity Metabolic Surgery Society
4 th Annual Scientific Meeting
Jan 23-25, 2013 Glasgow
SPIRE Hospital Southampton
Department of Bariatric Surgery
M Van den Bossche, I Bailey, J Kelly
J Byrne, R Sutherland*
2. describing cities and places. ENGLISH DOT WORKS 2. SENA. semana 4 acitivda..... ..
Evidence: describing cities and places.ENGLISH DOT WORKS 2. SENA. ENGLISH DOT WORKS 2.
semana 4 acitivdad 2.ENGLISH DOT WORKS 2.
week 4 acitivty 2. ENGLISH DOT WORKS 2.
3.Evidence: Getting to Bogota.ENGLISH DOT WORKS 2. SENA.semana 4 actividad 3... ..
vidence: Getting to Bogota / Evidencia: Llegando a Bogotá.
ENGLISH DOT WORKS 2. SENA.
ENGLISH DOT WORKS 2.
semana 4 actividad 3.ENGLISH DOT WORKS 2.
week 4 activity 3.ENGLISH DOT WORKS 2. SENA.
Evidence: Going to the restaurant . ENGLISH DOT WORKS 2. SENA... ..
Evidence: Going to the restaurant .
ENGLISH DOT WORKS 2. SENA.
actividad 2 Semana 1. Evidence: Going to the restaurant .
Activity 2 Week 1. Evidence: Going to the restaurant .
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Evidence: I can’t believe it.ENGLISH DOT WORKS 2. SENA.
ENGLISH DOT WORKS 2.
semana 3 actividad 1.ENGLISH DOT WORKS 2.
week 3 activity 1.ENGLISH DOT WORKS 2.
Evidence: I can’t believe it. SENA.
Evidence: Memorable moments.ENGLISH DOT WORKS 2. SENA. semana 2 actividad 2... ..
Evidence: Memorable moments.ENGLISH DOT WORKS 2. SENA. ENGLISH DOT WORKS 2.
week 2 activity 2.ENGLISH DOT WORKS 2.
semana 2 actividad 2. ENGLISH DOT WORKS 2.
Evidence: Planning my trip. ENGLISH DOT WORKS 2. SENA. semana 4 actividad 1... ..
Evidence: Planning my trip. ENGLISH DOT WORKS 2. SENA.
ENGLISH DOT WORKS 2.
semana 4 actividad 1.ENGLISH DOT WORKS 2.
week 4 activity 1.ENGLISH DOT WORKS 2.
3. Your next holiday destination ACTIVIDAD 3 SEMANA 3 ENGLISH DOT WORKS 2... ..
3. Your next holiday destination. ACTIVIDAD 3 SEMANA 3 ENGLISH DOT WORKS 2.SENA.
ENGLISH DOT WORKS 2. week 3 activity 3.
ENGLISH DOT WORKS 2. ACTIVIDAD 3 SEMANA 3
Your next holiday destination. ENGLISH DOT WORKS 2.
La presente guía tiene como finalidad orientar a los responsables del tratamiento de datos personales en la elaboración, diseño y difusión del aviso de privacidad respecto de su contenido y alcance al que refiere la Ley Federal de Protección de Datos Personales en Posesión de los Particulares, en lo sucesivo la Ley.
La guía se divide en seis grandes secciones: la primera establece las características generales de todo aviso de privacidad; la segunda orienta a los responsables para la elaboración de avisos de privacidad que cumplan con lo dispuesto por la Ley; la tercera contiene recomendaciones para el contenido del aviso de privacidad; la cuarta refiere a las medidas compensatorias que contempla la Ley en su artículo dieciocho, la quinta presenta diez consejos prácticos para la elaboración de un aviso de privacidad y la sexta presenta modelos tipo de aviso de privacidad.
Mini Gastric Bypass: initial Experience
British Obesity Metabolic Surgery Society
4 th Annual Scientific Meeting
Jan 23-25, 2013 Glasgow
SPIRE Hospital Southampton
Department of Bariatric Surgery
M Van den Bossche, I Bailey, J Kelly
J Byrne, R Sutherland*
Journal Club about the Phase 2 study of Selonsertib in Diabetic Kidney Disease to Our Division on 12/9/19.
Also an intro about the Phase 3 study (MOSAIC) we will be launching before the end of the year
Erik Boot - Studying Psychosis in 22q11 Deletion Syndromewef
Presentation made July 28, 2016 at the live webinar hosted by the Schizophrenia Research Forum and titled Studying Psychosis in 22q11 Deletion Syndrome. More details and video recording at http://www.schizophreniaforum.org/for/live/detail.asp?liveID=100
Effects of Prenatal Exposure to Hydoxylated PCB & Brominated Flame Retardants v2zq
Effects of Prenatal Exposure to Hydoxylated PCB & Brominated Flame Retardants - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Effects of Simultaneous KP transplantation VS KD single in type 2 diabetics: seven years follow-up
1. Università Vita-Salute San Raffaele
Effects of Simultaneous Kidney-Pancreas and
Kidney Alone Transplantation on Diabetic
Enteropathy: a 7-year Follow-up Study
Scuola di Specializzazione Chirurgia dell’Apparato Digerente
Direttore Prof. Carlo Staudacher
Diploma di Specializzazione del Dott.:
Francesco LUPARINI
matr. 001443
2. Background
• DEFINITION: All gastrointestinal disorders associated with hyperglycaemia
• EPIDEMIOLOGY: Ranging from 20-76%
Janatuinen (1993) Scan J Gastroenterol; Bytzer (2001) Arch Intern Med. ;
Feldman (1983) Ann Intern Med; Maleki (2000) Arch Intern Med
• ETIOLOGY: Autonomic Neuropathy and Vasculopathy.
Bjornsson (1994) Scand J. Gastroenterol ; Koch (1999) Dig Dis Sci
• SYMPTOMS:
• Upper GI: Early satiety; Nausea; Vomiting; Heartburn ; Dysphagia;
Gastroparesis.
• Lower GI: Constipation; Abdominal Pain; Diarrhea; Fecal incontinence.
• DIAGNOSIS IMAGING: Esophageal Manometry; Electrogastrography; Gastric
Emptying Scintigraphy; Anorectal Manometry; Defecography; Electromiography
• THERAPY: only symptomatic and poorly effective
Francesco Luparini MD
3. Aims of the Study
1) To evaluate the effects of Kidney-Pancreas
Transplantation (KP) or Kidney Alone (KD) through:
- Laboratory/Blood Pressure values
- Specimen of rectal mucosa
- Gastrointestinal symptoms/fecal incontinence
2) To correlate biochemical,functional and microscopic
data in Kidney-Pancreas or Kidney transplantation
toward Diabetic Enteropathy
Francesco Luparini MD
4. Patients
• Patients: Type 1 Diabetic undergoing renal
substitutive therapy
• Observation Period: 06/2000 – 06/2010
• Follow-up: 7 years (mean)
Francesco Luparini MD
5. Methods
Evaluation during Recovery:
Haematic samples for biochemical, metabolic values and
plasma sample for Ghrelin Elisa assay
Interview-based Questionnaire consisting of 15 items (GSRS;
Rating Scale for Gastrointestinal Symptoms)
Svedlund (1988) Dig Dis Sci
Anorectal Manometry
Rectal mucosa biopsies for optical and electronic microscopy
Francesco Luparini MD
6. Patients’ Characteristics I
Baseline
KP (n=26) KD (n=20)
Age (yrs)* 37.3±3.7 Age (yrs)* 43.4±7.0
Duration of Diabetes (yrs) 27.6 ±6.2 Duration of Diabetes (yrs) 31.3±12.7
HbA1c (%) 8.3±1.7 HbA1c (%) 8.5±1.6
Gender (male/female) 17/9 Gender (male/female) 13/7
Time of Dialysis (months) 53.4±30.2 Time of Dialysis (months) 43.8±25.9
Laser-treated Retinopathy (%) 72% Laser-treated Retinopathy (%) 61%
Kidney Warm Ischemia (min) 40.0±19.6 Kidney Warm Ischemia (min) 45.2±21.3
Kidney Cold Ischemia (h) 7.0±4.6 Kidney Cold Ischemia (h) 7.6±9.5
BMI 22.9±2.3 BMI 23.7±3.1
Creatinine (mg/dl) 8.4±2.6 Creatinine (mg/dl) 8.7±2.5
eGFR (ml/min/1.73m2) 7.9±2.9 eGFR (ml/min/1.73m2) 7.0±2.4
yrs= years ; Hb1Ac=Glycated hemoglobin; min= minutes
BMI= body mass index; * p= 0.004 Francesco Luparini MD
7. Patients’ Characteristics II
Baseline
KP (n=26) KD (n=20)
BUN (mg/dl) 142.0±44.0 BUN (mg/dl) 147.1±51.8
Uric Acid (mg/dl) 6.9±1.3 Uric Acid (mg/dl) 6.7±1.5
EIR (UI/die) 37.4±11.0 EIR (UI/die) 39.1±17.2
Systolic BP 143.5±12.9 Systolic BP 146.3±18.7
Diastolic BP 83.7±8.3 Diastolic BP 82.8±8.5
TG (mg/dl) 162.5±92.7 TG (mg/dl) 191.7±119.2
Chol (mg/dl) 201.0±45.7 Chol (mg/dl) 198.4±50.3
LDL (mg/dl) 116.3±40.3 LDL (mg/dl) 109.7±37.1
HDL (mg/dl) 48.1±14.4 HDL (mg/dl) 47.9±12.1
eGFR= glomerular filtration rate; BUN= blood urea nitrogen;
EIR= exogen insulin requirement; UI= international unit; BP= blood pressure; TG= Tryglicerids;
Chol= cholesterol; LDL= low density lipoprotein; HDL= high density lipoprotein
Francesco Luparini MD
8. Biochemistry
KP KD
*
* p<0.01 vs. all
*
* p<0.01 vs. all
Basal 2 yrs 7 yrs Basal 2 yrs 7 yrs
(n=26) (n=25) (n=22) Francesco Luparini MD (n=20) (n=15) (n=8)
9. Biochemistry
KP KD
* *
* p<0.01 vs. all * p<0.01 vs. all
* *
* p<0.01 vs. all * p<0.01 vs. all
Basal 2 yrs 7 yrs Basal 2 yrs 7 yrs
(n=26) (n=26) (n=23) (n=20) (n=14) (n=12)
Francesco Luparini MD
34. Conclusions
KP tx, but not KD, improves diabetic enteropathy
• Effect on Biochemistry: improves glycemic and TG profile
• Effect on Symptoms: reduces abdominal pain
• Effect on Manometry: stabilises continence
• Effect on Ultrastructures: improves mitosis, nerves vesicles,
endothelial and Schwann cells
Further studies are requested to confirm our observation
in larger pool of kidney–pancreas recipients
Francesco Luparini MD