This study investigated relationships between life satisfaction, meaning in life, hope, and COVID-19 fear in Turkish adults during the COVID-19 outbreak. The study included 1,186 adults with a mean age of 41.04 from different cities and regions of Turkey. Participants completed scales measuring life satisfaction, meaning in life, dispositional hope, and COVID-19 fear. Results showed that meaning in life, hope (in terms of goal-setting and alternative ways of thinking), were significant positive predictors of life satisfaction. However, COVID-19 fear, age, gender, and knowing someone infected with COVID-19 were not significant predictors of life satisfaction in adults.