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1. Focal Segmental Glomerulosclerosis
KDIGO 2021 Clinical Practice Guideline for the
Management of Glomerular Diseases
Mohammed Abdel Gawad MD Neph, ESENeph
Lecturer of Nephrology, School of Medicine, NewGiza University
Nephrology Consultant, Alexandria
Founder of NephroTube.com
Co-chair of AFRAN Web/Media Committee
ISN Education SoMe Team Member
drgawad@gmail.com
@Gawad_Nephro
17, Jul, 2022

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4. Talk Outline
• FSGS Classification
• Pathology
• Management

5. Talk Outline
• FSGS Classification
• Pathology
• Management

9. Talk Outline
• FSGS Classification
• Pathology
• Management

10. Normal glomerulus

20. Pathology Variant Prognosis & Significance
NOS the prototype
Perihilar ? Secondary
Tip variant Better prognosis
Collapsing Poor response
and prognosis
? Secondary
Cellular ? Early stage lesion

22. Talk Outline
• FSGS Classification
• Pathology
• Management

25. FSGS IN ADULTS – TREATMENT: INITIAL TREATMENT OF
PRIMARY FSGS
Practice Point 6.2.2.1: Suggested dosing schedule for glucocorticoids in the initial treatment
of primary FSGS is outlined below.
Patients who are expected to respond to
glucocorticoids usually show at least some improvement
in proteinuria within 4–8 weeks.

26. FSGS IN ADULTS – TREATMENT: INITIAL TREATMENT OF
PRIMARY FSGS
Practice Point 6.2.2.1: Suggested dosing schedule for glucocorticoids in the initial treatment
of primary FSGS is outlined below.

27. FSGS IN ADULTS – TREATMENT: INITIAL TREATMENT OF
PRIMARY FSGS
Practice Point 6.2.2.1: Suggested dosing schedule for glucocorticoids in the initial treatment of primary
FSGS is outlined below.

29. FSGS IN ADULTS – SPECIAL SITUATIONS: DOSING SCHEDULE
FOR CYCLOSPORINE AND TACROLIMUS
Practice Point 6.3.2.1: Treatment of steroid-resistant primary FSGS: Suggested dosing schedule for
cyclosporine and tacrolimus.