Flutivate Cream (Generic Fluticasone Propionate Cream)

Flutivate Cream (Generic Fluticasone Propionate Cream)
© The Swiss Pharmacy

Flutivate cream (Generic Fluticasone
Propionate Cream) is a topical (for the skin)
steroid used to treat inflammation and itching
caused by a number of skin conditions such as
allergic reactions, eczema, and psoriasis.
Flutivate is not used to treat rosacea, severe
acne, or viral skin infections such as chickenpox
or herpes.

Flutivate cream is manufactured by
GlaxoSmithKline Pharmaceuticals Limited,
India in the strength of 0.005%.

Chemical Structure

The active ingredient contained in Flutivate cream
(Flutivate ointment) is Fluticasone Propionate.
Flutivate cream contains Fluticasone Propionate
0.005% w/w.

Uses of Flutivate 0.005% Cream:
Flutivate cream (Generic Fluticasone Propionate Cream) is a medium
potency corticosteroid indicated for the relief of the inflammatory and
pruritic manifestations of corticosteroid-responsive dermatoses. It
reduces swelling, redness, itching, and rashes caused by skin conditions,
such as eczema. It works by decreasing inflammation of the skin. It
belongs to a group of medications called topical steroids.
Flutivate ointment may be used with caution in pediatric patients 3
months of age or older.
The safety and efficacy of drug use for longer than 4 weeks in this
population have not been established. The safety and efficacy of
Flutivate Cream (Flutivate ointment) in pediatric patients below 3
months of age have not been established.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html

Recommended Adult Dosage
The dose of Flutivate cream (Generic Fluticasone Cream) is
given below:
Apply thinly and gently rub into affected area once or twice a
day for up to 4 weeks until improvement occurs, then reduce
frequency or change to a less potent preparation. If the
condition worsens or does not improve within 4 weeks,
treatment and diagnosis should be re-evaluated. Gradually
discontinue once controlled and use an emollient as
maintenance therapy. Rebound of pre-existing dermatoses
can occur with abrupt discontinuation.

Recommended Adult Dosage
Adults and Elderly: Re-evaluate treatment and diagnosis if
condition worsens or no improvement within 4 weeks.
Children And Infants Aged 3 Months Of Age Or Older:
Withdraw treatment and re-evaluate if no improvement
within 7 to 14 days.

Contraindications
➔
Flutivate cream is contraindicated in patients with a known
hypersensitivity to Fluticasone Propionate or any component of
the tablet.
➔
The following conditions should not be treated with Fluticasone
Propionate cream: untreated cutaneous infections, rosacea, acne
vulgaris, perioral dermatitis, perianal and genital pruritus, pruritus
without inflammation, dermatoses in infants under three months of
age, including dermatitis and nappy rash.
➔
Flutivate cream is not indicated for topical application to the eye.

Storage Instructions
Flutivate Cream (Generic Fluticasone Propionate
Cream) have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C (59° to
86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Local skin irritation, local hypersensitivity, risk of hypercortisolism
(Cushing's syndrome) and reversible hypothalamic-pituitary adrenal
(HPA) axis suppression could occur. Avoid prolonged use where
possible, especially in infants and children under 12 years of age as
adrenal suppression is more likely to occur – treatment should be
limited to 7 to 14 days.
Prolonged application to the face is undesirable. If applied to the
eyelids, care is needed to ensure that the preparation does not enter
the eye. Avoid occlusion due to risk of infection. May be associated
with a higher occurrence of local hypersensitivity reactions and an
increased risk of local infection around chronic leg ulcers.

Warnings
Close supervision required if used in psoriasis as rebound relapses,
development of tolerances, risk of generalized pustular psoriasis and
development of local or systemic toxicity due to impaired barrier
function of the skin have been reported in some cases. If used in
psoriasis, careful patient supervision is important.
Initiate antimicrobial therapy if lesions have become infected; any
spread of infection requires withdrawal of topical corticosteroid
therapy and administration of antimicrobial therapy.

Possible Side Effects
In controlled clinical trials of twice-daily administration, the total
incidence of side effects associated with the use of Fluticasone
Propionate Cream (Flutivate cream) was approximately 4%.
These side effects were usually mild; self-limiting; and
consisted primarily of pruritus, dryness, numbness of fingers,
and burning.

Two clinical studies compared once- to twice-daily administration of
Fluticasone Propionate Cream (Flutivate cream) for the treatment of
moderate to severe eczema.
The local drug-related side effects for the patients enrolled in both
studies are: Skin infection,Infected eczema, Viral warts,Herpes simplex,
Impetigo, Atopic dermatitis, Eczema, Exacerbation of eczema,
Erythema, Burning, Stinging, Skin irritation, Pruritus, Exacerbation of
pruritus, Folliculitis, Blisters and Dryness of skin.
Side effects from pediatric open-label trial include Burning, Dusky
erythema, Erythematous rash, Facial telangiectasia, Non-facial
telangiectasia and Urticaria.

The following local side effects have been reported infrequently with
topical corticosteroids, and they may occur more frequently with the
use of occlusive dressings and higher potency corticosteroids.
These reactions are listed in an approximately decreasing order of
occurrence: irritation, folliculitis, acneiform eruptions,
hypopigmentation, perioral dermatitis, allergic contact dermatitis,
secondary infection, skin atrophy, striae, hypertrichosis and miliaria.
Also, there are reports of the development of pustular psoriasis from
chronic plaque psoriasis following reduction or discontinuation of
potent topical corticosteroid products.

Flutivate Cream Overdosage
Topically applied Fluticasone Propionate Cream (Flutivate cream) can
be absorbed in sufficient amounts to produce systemic effects. In case
of chronic overdosage or misuse, the features of hypercorticism may
appear.
As with any corticosteroid, treatment should be discontinued if the
symptoms of hypercorticism appear. It is important that the treatment
is gradually withdrawn by reducing the frequency of application or by
substituting a less potent corticosteroid because of the risk of
glucocorticosteroid insufficiency. Further management should be as
clinically indicated.

Flutivate Cream During Pregnancy
Fluticasone Propionate Cream (Flutivate cream) has been classified by
the US FDA as Pregnancy Category C.
Corticosteroids have been shown to be teratogenic in laboratory
animals when administered systemically at relatively low dosage
levels. Some corticosteroids have been shown to be teratogenic after
dermal application in laboratory animals.
There are no adequate and well-controlled studies in pregnant
women. Flutivate cream should be used during pregnancy only if the
expected benefit to the mother justifies the potential risk to the fetus.
The minimum quantity should be used for the minimum duration.

Flutivate Cream (Generic Fluticasone Propionate
Cream) is manufactured by GlaxoSmithKline
Pharmaceuticals Limited, India.

Flutivate Cream (Generic Fluticasone Propionate Cream)

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