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FluSurge Modeling of the COVID-19 Pandemic
Contributors:
Jonathan Adam A. Rico, MSc.
Pia Regina Fatima C. Zamora, M.D., Ph.D.
Jiye Kwon
Raphael Nelo S. Aguila
Jesus Emmanuel A. Sevilleja, M.D., MPhil
Romulo de Castro, Ph.D.
University of San Agustin
Center for Informatics
Iloilo City, 5000
April 10, 2020
Estimating the Sufficiency of Panay and Guimaras Islands’ Hospital Resources during the COVID-19 Pandemic
March 20
Iloilo City
ECQ
March 22
Antique
ECQ
March 25
Capiz
1st case
April 1
Panay-wide
Quarantine
March 25
Capiz
ECQ
March 15
Capiz, Iloilo
CQ
March 17
Antique
CQ
March 23
Aklan
ECQ
March 21
Iloilo
1st case
March 27
Aklan
3 cases
CoViD-19 Timeline: Panay and Guimaras
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
Input Variable
COVID-19
(Panay Island + Guimaras)
Population 4,730,508
0-19 years old 1,797,417
20-64 years old 2,587,126
65 years old and above 345,965
Basic Hospital Resources
Total licensed non-ICU beds 1780
Licensed non-ICU beds staffed (%) 100%
Total licensed ICU beds 112
Licensed ICU beds staffed (%) 100%
Total number of ventilators 112
Ventilators available (%) 100%
Assumptions
Pandemic duration (6, 8, 12) 8 weeks
Gross clinical attack rate (15%, 25%, 35%) 25%
Average length of non-ICU hospital stay (1-14 days) 14 days
Average length of ICU stay (1-20 days) 8 days
Average length of ventilator usage (1-20 days) 7 days
Average proportion of admitted patients will need ICU care
(%) 20%
Average proportion of admitted patients will need ventilators
(%) 5%
Average proportion of deaths assumed to be hospitalized (%) 90%
Daily percentage increase in cases arriving compared to
preceding day (0.1% - 20%) 17%
SUMMARY OF INPUTS TO THE FLUSURGE TOOL
Based on
Wuhan, Hubei
Experience
Data from
DOH, WVMC,
TMCI
Projected Data
from PSA
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
ASSUMPTIONS
FluSurge 2.0 operates under
non-quarantine conditions
FULL CAPACITY of
DOH-retained hospitals
Utilize 50% of the capacity
of other Level II and Level
III hospitals
Pandemic duration of at
least 8 weeks (March 20 –
May 15)
Gross clinical attack rate
(AR) = 25%
Pandemic Impact/ Attack Rate 25%
Total Hospital Admissions
Most Likely Scenario 13,437
Minimum Scenario 4,713
Maximum Scenario 19,327
Total Deaths
Most Likely Scenario 2341
Minimum Scenario 1137
Maximum Scenario 4355
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
At the end of 8 weeks,
Peak of hospital admissions: Weeks 4 and 5
Accumulated hospital admissions: 13,437
Accumulated deaths: 2,341
CoViD-19 Impact
Weeks
1 2 3 4 5 6 7 8
Hospital Admission Weekly admissions 806 1344 2016 2553 2553 2016 1344 806
Peak admissions / day 556 556
Non-ICU Bed
Capacity
Total = 1780
CoViD-19 PUIs/cases in
non-ICU facilities
806 2150 3359 4569 5474 5474 4305 3096
% non-ICU capacity
needed
45% 121% 189% 257% 308% 308% 242% 174%
ICU Bed Capacity
Total = 112
CoViD-19 PUIs/cases in
the ICU
161 304 462 598 714 598 462 304
% ICU capacity needed 144% 271% 412% 534% 638% 534% 412% 271%
Ventilator Capacity
Total = 112
CoViD-19 PUIs/cases on
ventilators
40 67 101 128 161 122 93 61
% ventilator usage 36% 60% 90% 114% 144% 109% 83% 55%
peak
Admissions vs Capacity
Week 1
ICU admissions >
hospital capacity
Week 2
Non-ICU admissions >
hospital capacity
Weeks 4-6
Ventilator use >
hospital capacity
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
Peak of CoViD-19 outbreak vs Hospital capacity:
Other simulations (pandemic duration = 6, 8, 12, weeks; AR = 15%, 25%,35%)
Impact on Hospital Resources/
Duration, Attack Rate
6 Weeks 8 Weeks 12 Weeks
15% 25% 35% 15% 25% 35% 15% 25% 35%
Hospital capacity needed
(%)
205% 342% 478% 185% 308% 431% 149% 248% 347%
ICU capacity needed (%) 423% 705% 987% 383% 638% 893% 302% 503% 705%
Ventilator capacity needed
(%)
95% 159% 223% 86% 144% 201% 68% 114% 159%
Hospital admissions will exceed hospital capacity in Panay and Guimaras
(except ventilator capacity at AR = 15%)
RECOMMENDATIONS
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
Extension of the ECQ in Panay and Guimaras
beyond April 14, 2020 to prevent a surge of cases and
deaths, and/or set up other mitigating measures to
keep the number of cases below hospital capacity.
Augment hospital capacity quickly
- add non-ICU beds
- add ICU beds
- add ventilators
- add personnel
Enhance CoViD-19 testing and contact tracing
Protect the frontliners
- provision of adequate PPEs
- routine testing of hospital personnel,
even when they do not show
symptoms
This model simulates the impact of
the CoViD-19 outbreak in Panay
and Guimaras, if no preventive
measures are in place.
If the ECQ were to be lifted without
any mitigating measures, it is
possible to experience the disease
trajectory projected here.
SUMMARY
April 04, 2020
Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
ACKNOWLEDGEMENTS
REFERENCES
[1] Baker, et. al. (September 9, 2011). Epidemiologic Modeling with FluSurge for Pandemic (H1N1) 2009, Outbreak, Queensland, Australia.
[2] Feng Z, et. al. (February 17, 2020). Vital Surveillances: The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020. China CDC Weekly, 2020, 2(8): 113-122.
Accessed from http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51.
[3] Grasseli, et. al. (March 13, 2020). Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response. Journal of the American Medical Association
(JAMA) Network. doi:10.1001/jama.2020.4031. Accessed from https://jamanetwork.com/journals/jama/fullarticle/2763188.
[4] Guan, et. al. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. DOI: 10.1056/NEJMoa2002032
[5] Momblan, Gail. (March 21, 2020). Iloilo province confirms 1st Covid-19-positive patient. Retrieved from https://www.pna.gov.ph/articles/1097383
[6] Qun Li, et. al. (January 29, 2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine. doi Baker, et. al. (September 9, 2011). Epidemiologic
Modeling with FluSurge for Pandemic (H1N1) 2009 a2001316.
[7] Tang B, Xia F, Tang S, Bragazzi NL, Li Q, Sun X, Liang J, Xiao Y, Wu J, The effectiveness of quarantine and isolation determine the trend of the COVID-19 epidemics in the final phase of the current
outbreak in China, International Journal of Infectious Diseases (2020), doi: https://doi.org/10.1016/j.ijid.2020.03.018
[8] Tantuco, V. (March 28, 2020). Philippine hospital capacity data https://www.rappler.com/newsbreak/in-depth/256133-numbers-what-hospitals-need-treat-coronavirus.
[9] Wu Z and McGoogan J. (February 24, 2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center
for Disease Control and Prevention. Journal of the American Medical Association (JAMA) Network. doi:10.1001/jama.2020.2648. Accessed from Baker, et. al. (September 9, 2011). Epidemiologic Modeling
with FluSurge for Pandemic (H1N1) 2009 https://jamanetwork.com/journals/jama/article-abstract/2762130.
[10] Zhang, et. al. (2006). FluSurge—A Tool to Estimate Demand for Hospital Services during the Next Pandemic Influenza. DOI: 10.1177/0272989X06295359.
[11] Zhou, et. al. (March 11, 2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. doi: 10.1016/S0140-3. Accessed from
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30566-3/fulltext
[12]https://www.rappler.com/nation/254904-list-areas-visayas-under-community-quarantine-
curfews-state-calamity-coronavirus
[13] Iloilo City Mar 20: https://www.rappler.com/nation/255350-iloilo-city-under-community-
quarantine
[14] Antique Mar 22: https://www.pna.gov.ph/articles/1097530
[15] Capiz Mar 25: https://pia.gov.ph/news/articles/1037135
[16] Capiz, ECQ: https://dailyguardian.com.ph/capiz-under-enhanced-community-quarantine/
[17] Panay-wide ECQ Apr 1: https://www.pna.gov.ph/articles/1096857
[18] China reports zero new cases in coronavirus epicenter Hubei. Retrieved from:
https://www.latimes.com/world-nation/story/2020-03-19/coronavirus-china-cases-hubei.
[19] Philippine Health Atlas. Accessed from http://healthatlas.doh.gov.ph/. March 29, 2020.
[20] Population Projection Statistics. Accessed from https://psa.gov.ph/statistics/census/projected-
population. March 27, 2020
Dr. Sarah De Leon (IMH)
Dr. Al Jeson Chin (WVMC)
Mr. Patrick B. Jalandoni (TMCI)

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FluSurge Modeling of the COVID-19 Pandemic for the Panay and Guimaras Islands

  • 1. FluSurge Modeling of the COVID-19 Pandemic Contributors: Jonathan Adam A. Rico, MSc. Pia Regina Fatima C. Zamora, M.D., Ph.D. Jiye Kwon Raphael Nelo S. Aguila Jesus Emmanuel A. Sevilleja, M.D., MPhil Romulo de Castro, Ph.D. University of San Agustin Center for Informatics Iloilo City, 5000 April 10, 2020 Estimating the Sufficiency of Panay and Guimaras Islands’ Hospital Resources during the COVID-19 Pandemic
  • 2. March 20 Iloilo City ECQ March 22 Antique ECQ March 25 Capiz 1st case April 1 Panay-wide Quarantine March 25 Capiz ECQ March 15 Capiz, Iloilo CQ March 17 Antique CQ March 23 Aklan ECQ March 21 Iloilo 1st case March 27 Aklan 3 cases CoViD-19 Timeline: Panay and Guimaras April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
  • 3. Input Variable COVID-19 (Panay Island + Guimaras) Population 4,730,508 0-19 years old 1,797,417 20-64 years old 2,587,126 65 years old and above 345,965 Basic Hospital Resources Total licensed non-ICU beds 1780 Licensed non-ICU beds staffed (%) 100% Total licensed ICU beds 112 Licensed ICU beds staffed (%) 100% Total number of ventilators 112 Ventilators available (%) 100% Assumptions Pandemic duration (6, 8, 12) 8 weeks Gross clinical attack rate (15%, 25%, 35%) 25% Average length of non-ICU hospital stay (1-14 days) 14 days Average length of ICU stay (1-20 days) 8 days Average length of ventilator usage (1-20 days) 7 days Average proportion of admitted patients will need ICU care (%) 20% Average proportion of admitted patients will need ventilators (%) 5% Average proportion of deaths assumed to be hospitalized (%) 90% Daily percentage increase in cases arriving compared to preceding day (0.1% - 20%) 17% SUMMARY OF INPUTS TO THE FLUSURGE TOOL Based on Wuhan, Hubei Experience Data from DOH, WVMC, TMCI Projected Data from PSA April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph ASSUMPTIONS FluSurge 2.0 operates under non-quarantine conditions FULL CAPACITY of DOH-retained hospitals Utilize 50% of the capacity of other Level II and Level III hospitals Pandemic duration of at least 8 weeks (March 20 – May 15) Gross clinical attack rate (AR) = 25%
  • 4. Pandemic Impact/ Attack Rate 25% Total Hospital Admissions Most Likely Scenario 13,437 Minimum Scenario 4,713 Maximum Scenario 19,327 Total Deaths Most Likely Scenario 2341 Minimum Scenario 1137 Maximum Scenario 4355 April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph At the end of 8 weeks, Peak of hospital admissions: Weeks 4 and 5 Accumulated hospital admissions: 13,437 Accumulated deaths: 2,341
  • 5. CoViD-19 Impact Weeks 1 2 3 4 5 6 7 8 Hospital Admission Weekly admissions 806 1344 2016 2553 2553 2016 1344 806 Peak admissions / day 556 556 Non-ICU Bed Capacity Total = 1780 CoViD-19 PUIs/cases in non-ICU facilities 806 2150 3359 4569 5474 5474 4305 3096 % non-ICU capacity needed 45% 121% 189% 257% 308% 308% 242% 174% ICU Bed Capacity Total = 112 CoViD-19 PUIs/cases in the ICU 161 304 462 598 714 598 462 304 % ICU capacity needed 144% 271% 412% 534% 638% 534% 412% 271% Ventilator Capacity Total = 112 CoViD-19 PUIs/cases on ventilators 40 67 101 128 161 122 93 61 % ventilator usage 36% 60% 90% 114% 144% 109% 83% 55% peak Admissions vs Capacity Week 1 ICU admissions > hospital capacity Week 2 Non-ICU admissions > hospital capacity Weeks 4-6 Ventilator use > hospital capacity April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph
  • 6. April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph Peak of CoViD-19 outbreak vs Hospital capacity: Other simulations (pandemic duration = 6, 8, 12, weeks; AR = 15%, 25%,35%) Impact on Hospital Resources/ Duration, Attack Rate 6 Weeks 8 Weeks 12 Weeks 15% 25% 35% 15% 25% 35% 15% 25% 35% Hospital capacity needed (%) 205% 342% 478% 185% 308% 431% 149% 248% 347% ICU capacity needed (%) 423% 705% 987% 383% 638% 893% 302% 503% 705% Ventilator capacity needed (%) 95% 159% 223% 86% 144% 201% 68% 114% 159% Hospital admissions will exceed hospital capacity in Panay and Guimaras (except ventilator capacity at AR = 15%)
  • 7. RECOMMENDATIONS April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph Extension of the ECQ in Panay and Guimaras beyond April 14, 2020 to prevent a surge of cases and deaths, and/or set up other mitigating measures to keep the number of cases below hospital capacity. Augment hospital capacity quickly - add non-ICU beds - add ICU beds - add ventilators - add personnel Enhance CoViD-19 testing and contact tracing Protect the frontliners - provision of adequate PPEs - routine testing of hospital personnel, even when they do not show symptoms This model simulates the impact of the CoViD-19 outbreak in Panay and Guimaras, if no preventive measures are in place. If the ECQ were to be lifted without any mitigating measures, it is possible to experience the disease trajectory projected here. SUMMARY
  • 8. April 04, 2020 Center for Informatics, University of San Agustin, Iloilo City/ informatics@usa.edu.ph ACKNOWLEDGEMENTS REFERENCES [1] Baker, et. al. (September 9, 2011). Epidemiologic Modeling with FluSurge for Pandemic (H1N1) 2009, Outbreak, Queensland, Australia. [2] Feng Z, et. al. (February 17, 2020). Vital Surveillances: The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020. China CDC Weekly, 2020, 2(8): 113-122. Accessed from http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51. [3] Grasseli, et. al. (March 13, 2020). Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response. Journal of the American Medical Association (JAMA) Network. doi:10.1001/jama.2020.4031. Accessed from https://jamanetwork.com/journals/jama/fullarticle/2763188. [4] Guan, et. al. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. DOI: 10.1056/NEJMoa2002032 [5] Momblan, Gail. (March 21, 2020). Iloilo province confirms 1st Covid-19-positive patient. Retrieved from https://www.pna.gov.ph/articles/1097383 [6] Qun Li, et. al. (January 29, 2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine. doi Baker, et. al. (September 9, 2011). Epidemiologic Modeling with FluSurge for Pandemic (H1N1) 2009 a2001316. [7] Tang B, Xia F, Tang S, Bragazzi NL, Li Q, Sun X, Liang J, Xiao Y, Wu J, The effectiveness of quarantine and isolation determine the trend of the COVID-19 epidemics in the final phase of the current outbreak in China, International Journal of Infectious Diseases (2020), doi: https://doi.org/10.1016/j.ijid.2020.03.018 [8] Tantuco, V. (March 28, 2020). Philippine hospital capacity data https://www.rappler.com/newsbreak/in-depth/256133-numbers-what-hospitals-need-treat-coronavirus. [9] Wu Z and McGoogan J. (February 24, 2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Journal of the American Medical Association (JAMA) Network. doi:10.1001/jama.2020.2648. Accessed from Baker, et. al. (September 9, 2011). Epidemiologic Modeling with FluSurge for Pandemic (H1N1) 2009 https://jamanetwork.com/journals/jama/article-abstract/2762130. [10] Zhang, et. al. (2006). FluSurge—A Tool to Estimate Demand for Hospital Services during the Next Pandemic Influenza. DOI: 10.1177/0272989X06295359. [11] Zhou, et. al. (March 11, 2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. doi: 10.1016/S0140-3. Accessed from https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30566-3/fulltext [12]https://www.rappler.com/nation/254904-list-areas-visayas-under-community-quarantine- curfews-state-calamity-coronavirus [13] Iloilo City Mar 20: https://www.rappler.com/nation/255350-iloilo-city-under-community- quarantine [14] Antique Mar 22: https://www.pna.gov.ph/articles/1097530 [15] Capiz Mar 25: https://pia.gov.ph/news/articles/1037135 [16] Capiz, ECQ: https://dailyguardian.com.ph/capiz-under-enhanced-community-quarantine/ [17] Panay-wide ECQ Apr 1: https://www.pna.gov.ph/articles/1096857 [18] China reports zero new cases in coronavirus epicenter Hubei. Retrieved from: https://www.latimes.com/world-nation/story/2020-03-19/coronavirus-china-cases-hubei. [19] Philippine Health Atlas. Accessed from http://healthatlas.doh.gov.ph/. March 29, 2020. [20] Population Projection Statistics. Accessed from https://psa.gov.ph/statistics/census/projected- population. March 27, 2020 Dr. Sarah De Leon (IMH) Dr. Al Jeson Chin (WVMC) Mr. Patrick B. Jalandoni (TMCI)