Flask is a microframework for Python that provides common tools and patterns for building web applications but does not enforce any specific project structure. It includes the Werkzeug WSGI toolkit and Jinja templating engine. Flask emphasizes simplicity and flexibility by providing basic application object and request context while allowing developers to choose extensions and build application-specific solutions. It is well-suited for Google App Engine by providing a Flask application object that can be deployed to GAE and extensions that integrate authentication and maps.