This document discusses 5 upcoming trends in cardiovascular research: 1) recognizing pleiotropic drug effects, 2) initiating personalized/precision medicine, 3) investigating the effects of epigenetic and miRNA antisense oligonucleotide therapeutics, 4) developing innovative trial methods for innovative interventions, and 5) increasing academic, CRO, and pharma collaboration. It provides examples for each trend, such as exploring the cardiovascular effects of diabetic drugs beyond their primary targets, using gene therapy treatments in precision medicine, linking epigenetic changes like DNA methylation to increased cardiovascular disease risk, considering geographic and cultural factors in trial designs, and fostering collaboration between basic researchers, drug developers, and clinical research organizations.