Leonardo is celebrating its 50th anniversary. It was founded in the 1960s by Frank Malina and others to foster collaboration between artists and scientists. During this time, many important institutions and events bridging the arts and sciences emerged, including the Leonardo Journal, Experiments in Art and Technology, and the Exploratorium. Leonardo helped build a global network of practitioners across disciplines. The document argues this network must now help redesign science and engineering to address modern challenges like climate change through more open, team-based, and socially embedded approaches.
Roger Malina on A Historical Perspective on the Art-Sci-Tech fieldroger malina
Presentation given by Roger Malina on July 26 2014 at Kettle's Yard, Cambridge UK at
White Heat: art, science and
social responsibility in 1960s Britain
talk title is
The Leonardo Journal at 50_ networking the arts,sciences and technology now. The talk takes the person of Frank Malina, founder of Leonardo Journal as the springboard for a historical perspective
STEAM to STEM: Redesigning Science Itself by Roger Malinaroger malina
Presented at Balance Un Balance Conference, Plymouth 2017 STEAM to STEM: How the arts, design and humanities can work with STEM to redesign science itself: The scientific method needs redesigning for the problems we are working on today. Scientific culture needs redesigning to couple better to the needed social re-design (design 4.0) for a sustainable global civilization .
roger malina presentation to the new design media and art initiative at lafayette college. title using transition design to start redesigning science itsel, part of the stem to steam motivation initiatives
Roger Malina Bogota the dark universe, making science intimateroger malina
roger malina presents arguments for our transition to a data culture which is data rich but meaning poor-presented at the Bogota Planetarium May 14 2016
presentation at the planetarium of bogota for their 50th anniversary- advocating the need for more hybrids who combine the arts, sciences, technology and design- and the need to redesign science itself-both the scientific methods and the social embedding of science
Roger Malina on A Historical Perspective on the Art-Sci-Tech fieldroger malina
Presentation given by Roger Malina on July 26 2014 at Kettle's Yard, Cambridge UK at
White Heat: art, science and
social responsibility in 1960s Britain
talk title is
The Leonardo Journal at 50_ networking the arts,sciences and technology now. The talk takes the person of Frank Malina, founder of Leonardo Journal as the springboard for a historical perspective
STEAM to STEM: Redesigning Science Itself by Roger Malinaroger malina
Presented at Balance Un Balance Conference, Plymouth 2017 STEAM to STEM: How the arts, design and humanities can work with STEM to redesign science itself: The scientific method needs redesigning for the problems we are working on today. Scientific culture needs redesigning to couple better to the needed social re-design (design 4.0) for a sustainable global civilization .
roger malina presentation to the new design media and art initiative at lafayette college. title using transition design to start redesigning science itsel, part of the stem to steam motivation initiatives
Roger Malina Bogota the dark universe, making science intimateroger malina
roger malina presents arguments for our transition to a data culture which is data rich but meaning poor-presented at the Bogota Planetarium May 14 2016
presentation at the planetarium of bogota for their 50th anniversary- advocating the need for more hybrids who combine the arts, sciences, technology and design- and the need to redesign science itself-both the scientific methods and the social embedding of science
The talk presents and overview of the ArtSciLab in the ATEC School at UTDallas and explains how the lab works withinthe framework of the ATEC strategic objectives
Roger Malina Art Science Orsay mai 2012roger malina
Art Science Relations Today: ARTSCIENCE ?
Power point presentation in FRENCH
presented at the Art Science Days at the University of Paris Sud in May 2012
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
4. Leonardo founding
networks
• Frank Malina.. J Needham..J
Brownowski.. C P Snow Max
Bill..Buckminster Fuller..C H
Waddington..E
Gombrich..Robert
Maxwell...R Arnheim. G
Kepes, John Holloway,
J.J. Gibson..Liliane Lijn..Roy
Ascott,Pauline Oliveros. Sonia
Sheridan..Jasia Reichardt
Gyorgy Kepes..Jonas Salk…
Takis.. R Arnheim, Frank
Oppenheimer, Michele Emmer,
Sheila Pinkel…………
5. 1960s interesting years
• Leonardo Journal Paris
• Gyorgy Kepes: Founds Center For Visual Arts
at MIT, led to Media Lab
• Frank Oppenheimer founds Exploratorium in
San Francisco
• Jasia Reichardt Cybernetics Serendipity
Exhibition in London
• Experiments in Art and Technology NY
• New Tendencies in Zagreb
• ……1968…..a time of cultural phase change
9. Frank Malina
1912-1981
• Born Brenham Texas
• Bohemians .. 1880s
• 1918 Czech republic
• 20s Brenham HS
• Texas A and M
• Caltech, JPL, Aerojet
• 1947 UNESCO Paris
• 1953 Kinetic Artist
• 1960 Intl Academy
Astronautics
• 1968 Leonardo Art-
Science Journal
10. The Mysterious Effectiveness of
Mathematics
Von Karman “Vortex Street”
Mathematics and Engineering..
It was a hard sell to convince
the engineers to integrate
mathematics into their practices
Now lets address the
mysterious effectiveness of the
arts in the sciences
•Thank you Michele Emmer
•Istvan Hargittai
•Jacques Mandebrojt……
11.
12. A high Tolerance for Strange
People
Jack Parsons
Amateur Chemist
Invention and patenting of
solid rocket motor fuels
Led to first human object to
reach out of space
Interest in ‘esoterica”
Aha moment on a Caltech
roof
13.
14. Tired of Painting Dead Fish
The Mysterious Effectiveness of Instruments
– Our Senses are Filters not
Windows on the World
– Other scales of size, time, other
sources of energy
– Some aspects of the world cannot
be understood until we have
invented the right instrument
– Augmented Senses
– Extended Senses
– New Senses
– The arts/design as sensory
expansion
– Thank you David Rosenboom, JJ
Gibson, Ernst Gombrich……
15. The Leonardo “Communities of
Practice” Today
• 15,000 have
published in Leonardo
• Planetary, allmedia
• All areas of science
and technology
• The villages have
become small towns
• Lets not grow them
into cities
16.
17. USA National Academies of Science,
Engineering, Medicine Report ( May 2018)
•The Integration of the Humanities and Arts with
Sciences, Engineering, and Medicine in Higher
Education: Branches from the Same Tree
•Released by the US National Academies on May 7
2018 collect evidence and models for integration of
the arts and humanities and STEM/M fields
• Welcome Ashley Bear, thank you JD Talasek
18. Leonardo 50th
Birthday
• Recommended closing Leonardo on our 50th
– Vision of the founders has been accomplished
• If you have to plug it in, it cannot be art
– Art forms enabled by new media and
technologies becoming dominant art forms
• Art is local not international
– Artists and scientists collaborate over the world
• Artists don’t use art theory
– Neuroscience,, Computer Science ,AI
• Artists don’t write, Art Critics do
– Artists and designers can now publish as well
as create and perform their art
19. Lets cut down the tree of knowledge and
enable an ecology of knowledge for the
anthropocene
20. And now==And now==
• the network of villages has helped
redesign the arts for the 21st
century
•Now lets help redesign the sciencesNow lets help redesign the sciences
and engineering and medicineand engineering and medicine
•Overcome the tragedy of the internetOvercome the tragedy of the internet
•Anticipating the traumas of climateAnticipating the traumas of climate
changeschanges
21. The Leonardo founders Context in
1950s
• A generation traumatized by WW II
• Dedicated to rebuilding Europe and
international cooperation in both sciences
and arts—UN..EU..NATO…..UNESCO
– As a force for global development and peace
• A belief that the best minds of artists and
scientists were needed ..woven together..
( C P Snow)
• Cultural optimism science and technology-
“science the endless frontier”
22. •From the individual “genius”
•to hybrid ‘genius’ teams
•train for heterogeneous
transdisciplinary collaborations
• Institutions are badly designed
•Bridging Cultures, Over
planetary distances, multilingual
•But grounded in local knowledge
•No best practices, but many
good practices
• We still award Phds to
individuals not teams…….
•From a patral to a matral culture
23. Does Science Itself Need Redesigning ?
• 1945 « Science the Endless Frontier »
report, Vannevar Bush
• "New frontiers of the mind are before us,
• and if they are pioneered with the same
vision, boldness, and drive with which we
have waged this war
• we can create a fuller and more fruitful
employment and a fuller and more fruitful
life."--FRANKLIN D. ROOSEVELT November
17, 1944.
• This vision of science: science for the
winning of “wars”.. War on Cancer… War
on Drugs… rather than co-design !!!
• The problem of the Anthropocene is not a
war but a systemic, cybernetic, complex
system collapse
23
24. Now we,you, have to help Redesign Science and
Engineering
• We need to redesign the
scientific methods
• given the sciences of
complexity. New concepts
of causality, new maths
• - existence of big data, AI
• -new instruments that can
study our own minds
• cog science can help
redesign human methods
• Citizen Science and
Professional Amateurs
• Redesign the social
embedding of science
• Helga Nowotny former
president of the
European Research
Council called for
‘socially robust science
• artists and designers
and the humanities to
help us redesign
science
• Open Science