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1. Anusorn Cherdthong, PhD
137748 Applied Biochemistry in Nutritional Science
Email: anusornc@kku.ac.th
E-learning: http://ags.kku.ac.th/eLearning/137748
Metabolism of Nutrients in
Stomach and Intestine

2. Introduction
Metabolism:
Catabolism: large  small
molecule and receiving ATP
Anabolism: small large molecule
and spend ATP, NADPH

3. Metabolism in stomach
Carbohydrate: overview
Mouth: -amylase
Teeth
Esophagus
Stomach: no amylase
Small/large intestine: enzymes
Rectal: excretion

5. Metabolism in stomach
Wanapat et al. (2013)

6. Metabolism in stomach
Carbohydrate: Rumen metabolism
poly mono saccharide: extracellular
microbial enzyme:
Cellulose—cellobiose
Hemicellulose—cellobiose
Pectin—methanol and pectic acid
 Mono saccharidepyruvate
 Pyruvate---VFA, CH4
C2, C3 and C4

7. Metabolism in stomach
McDonald et al. (2011)
Carbohydrate: Rumen metabolism

8. Metabolism in stomach
McDonald et al. (2011)
VFV synthesis in rumen

9. Metabolism in stomach
Protein: overview in stomach
Gastrin hormone
HCl excretion: low pH (2.0)
Pepsinogen excretion: proenzyme
for peptide degrade

10. Metabolism in stomach
Protein: Rumen
Proteiolytic
microorganism
Bacteria
Protozoa
Fungi
McDonald et al. (2011)

11. Metabolism in stomach
Lipid: overview in stomach
No digest in non ruminant stomach
Ruminant act by rumen microbes
by:
Hydrolysis
Hydrogenation
Isomerization

12. Metabolism in intestine
Carbohydrate:
Require enzyme for pancreases:
-amylase
-glucosidase
Maltase
-dextrinase

13. Metabolism in intestine
Protein metabolism in small intestine:
Modified from Cunningham (1992)

14. Metabolism in intestine
Protein metabolism in small intestine:
Modified from Cunningham (1992)

15. Metabolism in intestine
Lipid metabolism in small intestine:
Triacyl glycerol
 Required bile salt as emulsifier
Excreate cholecystokinin and
secretin
Formulation of mixed micelle for
transfer and absorption
Bile recycle when reaction finished
Required pancreatic lipase

16. Metabolism in intestine
Lipid: Absorption
 Chylomicron: lipoprotein
 Via lymph system---
blood---tissue
 Metabolism in liver,
storage
Nelson and Cox (2000)

17. Metabolism in large intestine:
A few metabolism in this part
Digest some cellulose by-pass
Work by bacteria
Re-absorption of nutrients
Essential for equine: fiber digestion

18. Conclusion
1
2
3
Metabolism of nutrient in stomach
Utilization of nutrient in different animal
al species
Metabolism of nutrient in intestine

19. Thank you!