This document discusses challenges in cancer data integration and analysis. It proposes the development of open science models, standardized data elements, and sustainable informatics infrastructure. Emerging technologies like mobile devices, social media, and cloud computing create opportunities to build a national "learning health system" for cancer. The National Cancer Institute is pursuing initiatives like the Cancer Genomics Data Commons and cloud pilots to leverage large genomic and clinical datasets using these technologies and develop predictive models to improve outcomes. The ultimate goal is a system that facilitates data sharing, continuous learning from all cancer patients, and personalized, predictive oncology.
FDA NGS and Big Data Conference September 2014Warren Kibbe
Presentation for the FDA NGS and Big Data Conference September 2014 held on the NIH campus. NCI initiatives, including Cancer Genomics Data Commons, NCI Cloud Pilots, big data issues for cancer
Day 2 Big Data panel at the NIH BD2K All Hands 2016 meetingWarren Kibbe
Big data in oncology and implications for open data, open science, rapid innovation, data reuse, reproducibility and data sharing. Cancer Moonshot, Precisions Medicine Initiative (PMI), the Genomic Data Commons, NCI Cloud Pilots, NCI-DOE Pilots, and the Cancer Research Data Ecosystem.
FDA NGS and Big Data Conference September 2014Warren Kibbe
Presentation for the FDA NGS and Big Data Conference September 2014 held on the NIH campus. NCI initiatives, including Cancer Genomics Data Commons, NCI Cloud Pilots, big data issues for cancer
Day 2 Big Data panel at the NIH BD2K All Hands 2016 meetingWarren Kibbe
Big data in oncology and implications for open data, open science, rapid innovation, data reuse, reproducibility and data sharing. Cancer Moonshot, Precisions Medicine Initiative (PMI), the Genomic Data Commons, NCI Cloud Pilots, NCI-DOE Pilots, and the Cancer Research Data Ecosystem.
NCI Cancer Genomics, Open Science and PMI: FAIR Warren Kibbe
Talk given to the NLM Fellows on July 8, 2016. Touches on Cancer Genomics, Open Science and PMI: FAIR in NCI genomics thinking and projects. Includes discussion of the Genomic Data Commons (GDC), Cancer Data Ecosystem, Data sharing, and the NCI cancer clinical trials open API.
National Cancer Data Ecosystem and Data SharingWarren Kibbe
Grand Rounds at the Siteman Cancer Center at Washington University. Highlighting the Genomic Data Commons and the National Cancer Data Ecosystem defined by the Cancer Moonshot Blue Ribbon Panel
Nci clinical genomics data sharing ncra sept 2016Warren Kibbe
Gave an update on the Cancer Research Data Ecosystem, the Genomic Data Commons, Cloud Pilots, incentives for data sharing in cancer research to the NCI Council of Research Advocates (NCRA) on Monday, September 26th, 2016
Cancer Moonshot, Data sharing and the Genomic Data CommonsWarren Kibbe
Gave the inaugural Informatics Grand Rounds at City of Hope on September 8th. NIH Commons, Genomic Data Commons, NCI Cloud Pilots, Cancer Moonshot and rationale for changing incentives around data sharing all discussed.
Converged IT Summit - NCI Data SharingWarren Kibbe
Cancer Moonshot, Data Sharing, Genomic Data Commons, NCI Cloud Pilots, Cancer Research Data Ecosystem, technology advances, chemotherapy advances, MATCH, NCI Cancer Moonshot Blue Ribbon Panel Recommendations
Advancing Innovation and Convergence in Cancer Research: US Federal Cancer Mo...Jerry Lee
Special Seminar at the 8th Taiwan Biosignatures Workshop to share overall work of NCI's Center for Strategic Scientific Initiatives since 2003 as well as CSSI's influence on select projects initiated by the 2016 WH Cancer Moonshot Task Force that include Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) network, International Cancer Proteogenome Consortium, and the Blood Profiling Atlas in Cancer (BloodPAC) commons.
CI4CC Moonshot Blue Ribbon Panel Report 20161010Warren Kibbe
Presentation to the Fall CI4CC meeting in Utah. CI4CC Moonshot Blue Ribbon Panel Report. Highlights of Vice President Biden's Cancer Moonshot and the NCI Blue Ribbon Panel Recommendations.
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...Warren Kibbe
May 2016 FNLAC presentation of the DOE-NCI partnership around three pilots focused on existing projects in NCI and existing NSCI directives and activities in DOE.
NCI Cancer Imaging Program - Cancer Research Data EcosystemWarren Kibbe
Given to the NCI Cancer Imaging Program monthly telecon on January 9th, 2017. NCI Genomic Data Commons, Beau Biden Cancer Moonshot Blue Ribbon Panel, Cancer Research Data Ecosystem and the role of imaging in precision medicine
2016 Data Commons and Data Science Workshop June 7th and June 8th 2016. Genomic Data Commons, FAIR, NCI and making data more findable, publicly accessible, interoperable (machine readable), reusable and support recognition and attribution
NCI Cancer Genomics, Open Science and PMI: FAIR Warren Kibbe
Talk given to the NLM Fellows on July 8, 2016. Touches on Cancer Genomics, Open Science and PMI: FAIR in NCI genomics thinking and projects. Includes discussion of the Genomic Data Commons (GDC), Cancer Data Ecosystem, Data sharing, and the NCI cancer clinical trials open API.
National Cancer Data Ecosystem and Data SharingWarren Kibbe
Grand Rounds at the Siteman Cancer Center at Washington University. Highlighting the Genomic Data Commons and the National Cancer Data Ecosystem defined by the Cancer Moonshot Blue Ribbon Panel
Nci clinical genomics data sharing ncra sept 2016Warren Kibbe
Gave an update on the Cancer Research Data Ecosystem, the Genomic Data Commons, Cloud Pilots, incentives for data sharing in cancer research to the NCI Council of Research Advocates (NCRA) on Monday, September 26th, 2016
Cancer Moonshot, Data sharing and the Genomic Data CommonsWarren Kibbe
Gave the inaugural Informatics Grand Rounds at City of Hope on September 8th. NIH Commons, Genomic Data Commons, NCI Cloud Pilots, Cancer Moonshot and rationale for changing incentives around data sharing all discussed.
Converged IT Summit - NCI Data SharingWarren Kibbe
Cancer Moonshot, Data Sharing, Genomic Data Commons, NCI Cloud Pilots, Cancer Research Data Ecosystem, technology advances, chemotherapy advances, MATCH, NCI Cancer Moonshot Blue Ribbon Panel Recommendations
Advancing Innovation and Convergence in Cancer Research: US Federal Cancer Mo...Jerry Lee
Special Seminar at the 8th Taiwan Biosignatures Workshop to share overall work of NCI's Center for Strategic Scientific Initiatives since 2003 as well as CSSI's influence on select projects initiated by the 2016 WH Cancer Moonshot Task Force that include Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) network, International Cancer Proteogenome Consortium, and the Blood Profiling Atlas in Cancer (BloodPAC) commons.
CI4CC Moonshot Blue Ribbon Panel Report 20161010Warren Kibbe
Presentation to the Fall CI4CC meeting in Utah. CI4CC Moonshot Blue Ribbon Panel Report. Highlights of Vice President Biden's Cancer Moonshot and the NCI Blue Ribbon Panel Recommendations.
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...Warren Kibbe
May 2016 FNLAC presentation of the DOE-NCI partnership around three pilots focused on existing projects in NCI and existing NSCI directives and activities in DOE.
NCI Cancer Imaging Program - Cancer Research Data EcosystemWarren Kibbe
Given to the NCI Cancer Imaging Program monthly telecon on January 9th, 2017. NCI Genomic Data Commons, Beau Biden Cancer Moonshot Blue Ribbon Panel, Cancer Research Data Ecosystem and the role of imaging in precision medicine
2016 Data Commons and Data Science Workshop June 7th and June 8th 2016. Genomic Data Commons, FAIR, NCI and making data more findable, publicly accessible, interoperable (machine readable), reusable and support recognition and attribution
Presentation "The Impact of All Data on Healthcare"
Keith Perry
Associate VP & Deputy CIO
UT MD Anderson Cancer Center
With continuing advancement in both technology and medicine, the drive is on to make all data meaningful to drive medical discovery and create actionable outcomes. With tools and capabilities to capture more data than ever before, the challenge becomes linking existing structured and unstructured clinical data with genomic data to increase the industry’s analytical footprint.
Learning Objectives:
∙ Discuss the need to make all data meaningful in order to speed discovery of new knowledge
∙ Provide examples of an analytical direction that supports evolution in medicine
∙ Expose the challenges facing the industry with respect to ~omits
Twenty Years of Whole Slide Imaging - the Coming Phase ChangeJoel Saltz
I surveyed the development of Digital Pathology methodology beginning with the 1997 virtual microscope prototype at Hopkins (PMC2233368) to current tools, methods and algorithms designed to display, analyze and classify whole slide imaging data. I will describe the capabilities of current methods, describe how these methods are likely to evolve and how they will be likely to impact Pathology research and practice.
di Pier Giuseppe Pelicci, MD-PhD, Istituto Europeo di Oncologia IEO, Università degli Studi di Milano.
Slide per l'intervento tenuto in Fondazione Giannino Bassetti in occasione del primo incontro del ciclo "La medicina di precisione", primo progetto dalla convenzione tra Università di Pavia e Fondazione Bassetti.
12 marzo 2018
SAMSI Precision Medicine Keynote, August 2018: Data: where Precision Oncology...Warren Kibbe
The promise of precision medicine in oncology is predicated on the availability of accurate, high quality data from the clinic and the laboratory. Likewise, a Learning Health System is one in which we use data to monitor that we are following guidelines and care pathways to deliver the best care and not revert to prior practices (regression testing for care!) and also provide real world evidence to determine effectiveness and identify populations that would benefit from novel therapies. Into this mix of clinical drivers are the rapidly changing capabilities in instrumentation, computing, computation, and the pervasive use of sensors and smart devices. I will highlight a few of the obvious and perhaps not as obvious opportunities in leveraging the increasingly digital landscape in healthcare and biomedical research as we move toward a national learning health system for cancer.
Presentation that gives an overview of the impact of IT on radiology, including the growing role of biomarkers and artificial intelligence and deep learning on the (future) radiology profession. The shift to precision medicine and personalized care are explained, the reasons for a re-definition of radiology are addressed.
Big data and better health outcomes, the journey to the Ministry of Health virtual information centre, viewed from a research perspective. Presented by Professor Tony Blakely, University of Otago, Wellington, at HINZ 2014, 12 November 2014, 8.30am, Plenary Room
Data sharing drivers in precision oncology, biomedical research, and healthcare. Accelerating discovery, innovation, providing credit for all stakeholders - patients, researchers, care providers, payers.
tranSMART Community Meeting 5-7 Nov 13 - Session 3: The TraIT user stories fo...David Peyruc
tranSMART Community Meeting 5-7 Nov 13 - Session 3: The TraIT user stories for tranSMART
The TraIT user stories for tranSMART
Jan-Willem Boiten, TraIT
The Translational Research IT (TraIT) project in The Netherlands aims to organize, deploy, and manage a nationwide IT infrastructure for data and workflow management targeted specifically at the needs of translational research projects. tranSMART has been selected as the central data integration and browsing solution across the four major domains of translational research: clinical, imaging, biobanking and experimental (any-omics). For this purpose user stories from anticipated user projects are collected and mapped onto the current functionality of tranSMART. The gaps identified in this analysis are being tackled systematically as summarized in the TraIT development roadmap for tranSMART.
Presentation to the Department of Biology at the University of Windsor, Windsor, Ontario. The description and update of activities related to the International Cancer Genome Consortium (ICGC)
Similar to Federal Research & Development for the Florida system Sept 2014 (20)
Overview of the NIH-funded RADx-UP - Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP) Coordination and Data Collection Center (CDCC) with a focus on the Common Data Elements used to gather data across the RADx-UP Consortium for COVID-19 testing.
RADx-UP CDCC presentation for the NIH Disaster Interest GroupWarren Kibbe
Presentation on the RADx-Underserved Populations Coordination and Data Collection Center with an emphasis on how it will help understand and reduce the disparities associated with the COVDI-19 pandemic
Data Harmonization for a Molecularly Driven Health SystemWarren Kibbe
Maximizing the value of data, computing, data science in an academic medical center, or 'towards a molecularly informed Learning Health System. Given in October at the University of Florida in Gainesville
Data Harmonization for a Molecularly Driven Health SystemWarren Kibbe
Seminar for Dr. Min Zhang's Purdue Bioinformatics Seminar Series. Touched on learning health systems, the Gen3 Data Commons, the NCI Genomic Data Commons, Data Harmonization, FAIR, and open science.
Drivers for data sharing in funding of biomedical research. Importance of data sharing on open science, innovation, reproducibility that is enabled by digital technologies and data science.
Data in precision oncology SAMSI Precision Medicine Meeting mar 2019Warren Kibbe
Talk at the March 14-15 2019 SAMSI Advances in Precision and Personalized Medicine held as part of the Program on Statistical, Mathematical, and Computational Methods for Precision Medicine (PMED) at NCSU, Raleigh, NC
A process server is a authorized person for delivering legal documents, such as summons, complaints, subpoenas, and other court papers, to peoples involved in legal proceedings.
Many ways to support street children.pptxSERUDS INDIA
By raising awareness, providing support, advocating for change, and offering assistance to children in need, individuals can play a crucial role in improving the lives of street children and helping them realize their full potential
Donate Us
https://serudsindia.org/how-individuals-can-support-street-children-in-india/
#donatefororphan, #donateforhomelesschildren, #childeducation, #ngochildeducation, #donateforeducation, #donationforchildeducation, #sponsorforpoorchild, #sponsororphanage #sponsororphanchild, #donation, #education, #charity, #educationforchild, #seruds, #kurnool, #joyhome
This session provides a comprehensive overview of the latest updates to the Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards (commonly known as the Uniform Guidance) outlined in the 2 CFR 200.
With a focus on the 2024 revisions issued by the Office of Management and Budget (OMB), participants will gain insight into the key changes affecting federal grant recipients. The session will delve into critical regulatory updates, providing attendees with the knowledge and tools necessary to navigate and comply with the evolving landscape of federal grant management.
Learning Objectives:
- Understand the rationale behind the 2024 updates to the Uniform Guidance outlined in 2 CFR 200, and their implications for federal grant recipients.
- Identify the key changes and revisions introduced by the Office of Management and Budget (OMB) in the 2024 edition of 2 CFR 200.
- Gain proficiency in applying the updated regulations to ensure compliance with federal grant requirements and avoid potential audit findings.
- Develop strategies for effectively implementing the new guidelines within the grant management processes of their respective organizations, fostering efficiency and accountability in federal grant administration.
Up the Ratios Bylaws - a Comprehensive Process of Our Organizationuptheratios
Up the Ratios is a non-profit organization dedicated to bridging the gap in STEM education for underprivileged students by providing free, high-quality learning opportunities in robotics and other STEM fields. Our mission is to empower the next generation of innovators, thinkers, and problem-solvers by offering a range of educational programs that foster curiosity, creativity, and critical thinking.
At Up the Ratios, we believe that every student, regardless of their socio-economic background, should have access to the tools and knowledge needed to succeed in today's technology-driven world. To achieve this, we host a variety of free classes, workshops, summer camps, and live lectures tailored to students from underserved communities. Our programs are designed to be engaging and hands-on, allowing students to explore the exciting world of robotics and STEM through practical, real-world applications.
Our free classes cover fundamental concepts in robotics, coding, and engineering, providing students with a strong foundation in these critical areas. Through our interactive workshops, students can dive deeper into specific topics, working on projects that challenge them to apply what they've learned and think creatively. Our summer camps offer an immersive experience where students can collaborate on larger projects, develop their teamwork skills, and gain confidence in their abilities.
In addition to our local programs, Up the Ratios is committed to making a global impact. We take donations of new and gently used robotics parts, which we then distribute to students and educational institutions in other countries. These donations help ensure that young learners worldwide have the resources they need to explore and excel in STEM fields. By supporting education in this way, we aim to nurture a global community of future leaders and innovators.
Our live lectures feature guest speakers from various STEM disciplines, including engineers, scientists, and industry professionals who share their knowledge and experiences with our students. These lectures provide valuable insights into potential career paths and inspire students to pursue their passions in STEM.
Up the Ratios relies on the generosity of donors and volunteers to continue our work. Contributions of time, expertise, and financial support are crucial to sustaining our programs and expanding our reach. Whether you're an individual passionate about education, a professional in the STEM field, or a company looking to give back to the community, there are many ways to get involved and make a difference.
We are proud of the positive impact we've had on the lives of countless students, many of whom have gone on to pursue higher education and careers in STEM. By providing these young minds with the tools and opportunities they need to succeed, we are not only changing their futures but also contributing to the advancement of technology and innovation on a broader scale.
Understanding the Challenges of Street ChildrenSERUDS INDIA
By raising awareness, providing support, advocating for change, and offering assistance to children in need, individuals can play a crucial role in improving the lives of street children and helping them realize their full potential
Donate Us
https://serudsindia.org/how-individuals-can-support-street-children-in-india/
#donatefororphan, #donateforhomelesschildren, #childeducation, #ngochildeducation, #donateforeducation, #donationforchildeducation, #sponsorforpoorchild, #sponsororphanage #sponsororphanchild, #donation, #education, #charity, #educationforchild, #seruds, #kurnool, #joyhome
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Canadian Immigration Tracker March 2024 - Key SlidesAndrew Griffith
Highlights
Permanent Residents decrease along with percentage of TR2PR decline to 52 percent of all Permanent Residents.
March asylum claim data not issued as of May 27 (unusually late). Irregular arrivals remain very small.
Study permit applications experiencing sharp decrease as a result of announced caps over 50 percent compared to February.
Citizenship numbers remain stable.
Slide 3 has the overall numbers and change.
Canadian Immigration Tracker March 2024 - Key Slides
Federal Research & Development for the Florida system Sept 2014
1. National Cancer Institute
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
NCI Informatics
and Genomics
September 2014
2. Disclaimer
• These views are my own and do not
necessarily reflect those of the NCI
3. Overview
• National Challenges in Cancer Data
• Disruptive Technologies
• NCI Genomics Data Commons
• NCI Cloud Pilots
• Building a national learning health system
for cancer clinical genomics
4. National Challenges in Cancer
Informatics
• Lowering barriers to data access,
analysis and modeling for cancer
research
• Integration of data and learning from
basic and clinical research with
cancer care that enable prediction
and improved outcomes
5. We need:
• Open Science (Open Access, Open Data,
Open Source) and Data Liquidity for the
cancer community
• Semantic interoperability through CDEs
and Case Report Forms mapped to
standards
• Sustainable models for informatics
infrastructure, services, data
6. Where we are
Disruptive technologies
Getting social
Open access to data
7. Disruptive Technologies
• Printing
• Steam power
• Transportation
• Electricity
• Antibiotics
• Semiconductors &VLSI design
• http
• High throughput biology
Systems view - end of reductionism?
8. Precision Oncology
• The era of precision medicine and precision
oncology is predicated on the integration of
research, care, and molecular medicine and
the availability of data for modeling, risk
analysis, and optimal care
How do we re-engineer
translational research policies
that will enable a true learning
healthcare system?
9.
10. Disruptive Technologies
• Printing
• Steam power
• Transportation
• Electricity
• Antibiotics
• Semiconductors &VLSI design
• http
• High throughput biology
• Ubiquitous computing
Everyone is a data provider
Data immersion
World:
6.6B active mobile contracts
1.9B smart phone contracts
1.1B land lines
World population 7.1B
US:
345M active mobile contracts
287M smart phone contracts
US population 313M
11. What about social media?
• Social media may be one avenue for
modifying behaviors that result in cancer
• Properly orchestrated, social media can
have dramatic impact on quality of life
for patients and survivors
• It can reach into all segments of our
society, including underserved populations
12. Public Health
• These three modifiable factors -
infectious disease, smoking, and poor
nutrition and lack of exercise contribute
to at least 50% of our current cancer
burden. And the cost from loss of quality of
life, pain and suffering is incalculable.
13. Some NCI Big Data activities
• TCGA, TARGET and ICGC
– Cancer Genomics Data Commons
– NCI Cloud Pilots
• Molecular Clinical Trials:
– MPACT, MATCH, Exceptional Responders
15. From the Second Machine Age
From: The Second Machine Age: Work, Progress, and Prosperity in a Time of Brilliant
Technologies by Erik Brynjolfsson & Andrew McAfee
16. Molecular data is Big Data
• Brief trip down memory lane
• Sequencing and the Human Genome
Project
21. HGP outcomes
• $5.6B investment in 2010 dollars
• $800B economic development
• Enabled many basic discoveries, clinical
therapies and diagnostics, and applied
technologies
22. TCGA history
• About three years post-HGP
• Initiated in 2005
• Collaboration of NHGRI and NCI to
examine GBM, Lung and Ovarian cancer
using genomic techniques in 2006.
• Expanded to 20+ tumor types.
23. TCGA drivers
• Providing high quality reference sets for
20+ tissue types
• Providing a platform for systems biology
and hypothesis generation
• Providing a test bed for understanding the
real world implications of consent and data
access policies on genomic and clinical
data.
26. Focus on TCGA
• TCGA consortium slides
• Thanks to Lou Staudt and Jean Claude
Zenklusen
27. TCGA –
Lessons from
structural
genomics
Jean Claude Zenklusen,
Ph.D.
Director
TCGA Program Office
National Cancer Institute
28. The Mutational Burden of Human Cancer
Mike Lawrence and Gaddy Getz
Increasing genomic
complexity
Childhood
cancers
Carcinogens
29. Molecular Subgroups Refine Histological Diagnosis
TCGA Nature 497:67 (2013)
Of Endometrial Carcinoma
POLE
(ultra-mutated)
MSI
(hypermutated)
Copy-number low
(endometriod)
Copy-number high
(serous-like)
Mutations
Per Mb
PolE
MSI / MSH2
Copy #
PTEN
p53
Histology
Serous
misdiagnosed
as endometrioid?
Histology
Endometrioid
Serous
30. Molecular Diagnosis of Endometrial Cancer May
Surgery only?
Adjuvant
radiotherapy?
TCGA Nature 497:67 (2013)
Influence Choice of Therapy
POLE
(ultra-mutated)
MSI
(hypermutated)
Copy-number low
(endometriod)
Copy-number high
(serous-like)
Mutations
Per Mb
PolE
MSI / MSH2
Copy #
PTEN
p53
Histology
Adjuvant
chemotherapy?
31. NCI Cancer Genomics Data Commons
GDC
NCI Genomics
Data Commons
Genomic +
clinical data
. . .
32. NCI Cancer Genomics Data Commons
GDC
NCI Genomics
Data Commons
Genomic +
clinical data
. . .
Cancer
information
donor
33. Utility of a Cancer Knowledge Base
GDC
Identify
low-frequency
cancer drivers
Define genomic
determinants of response
to therapy
Compose clinical trial
cohorts sharing
Targeted genetic lesions
Cancer
information
donor
34. Driver for the Cloud Pilots
• An inflection point for TCGA is looming
2,500,000
2,000,000
1,500,000
1,000,000
500,000
0
7/1/09
1/1/10
7/1/10
1/1/11
7/1/11
1/1/12
7/1/12
1/1/13
7/1/13
1/1/14
7/1/14
Gigabytes (GB)
35. NCI Cloud Pilots
• Funding for up to 3 cloud pilots - 24
month pilots that are meant to inform the
Cancer Genomics Data Commons
– Explore models for cancer genomics APIs
– Explore cloud models for data+analysis
• Announced this week: The Institute for
Systems Biology, The Broad Institute, and
Seven Bridges will be the initial consortium
36. NCI Cloud Pilots
• A way to move computation to the data
• Sustainable models for providing access
to data
• Reproducible pipelines for QA, variant
calling, knowledge sharing
• Define genomics/phenomics APIs for
discovering new variants contributing to
cancer, enhancing response, modulating
risk
37. Relationship of the Cancer Genomics
Data Commons and NCI Cloud Pilots
GDC
NCI Cloud
Computational Centers
Periodic
Data Freezes
Search /
retrieve
Analysis
NCI Genomics
Data Commons
39. Institute of Medicine Report
Sept 10, 2013
Delivering High-Quality Cancer Care: Charting
a New Course for System in Crisis
Understanding the outcomes of individual cancer patients as
well as groups of similar patients
1
Capturing data from real-world settings that researchers
can then analyze to generate new knowledge
2
A “Learning” healthcare IT system that learns routinely and
iteratively by analyzing captured data, generating evidence,
and implementing new insights into subsequent care.
3
40. “Learning IT System”
IOM Report on Cancer Care
Search Prior Knowledge: Enable clinicians to use
previous patients’ experiences to guide future care.
1
Care Team Collaboration: Facilitate a
coordinated cancer care workforce & mechanisms for
easily sharing information with each other.
2
Cancer Research: Improve the evidence base for quality
cancer care by utilizing all of the data captured during real-world
clinical encounters and integrating it with data captured
from other sources.
3
43. Can we make a Cinematch
for cancer patients?
Netflix’s Cinematch software analyzes each customer’s film-viewing habits and
recommends other movies.
44. Patients like me
• Patients with diagnoses,
symptoms and labs like yours are
eligible for these trials…
• Patient-centered resources…
45. If we can forecast
the weather, can
we forecast
cancer?
46. Where is the weather moving?
Doppler & Map Fusion
51. Modeling Tumor Growth
Mathematical model: proliferation
of cells with the potential for
invasion and metastasis
Swanson et al., British Journal of Cancer, 2007: 1-7.
55. Population
Decision
Support
Rapid Learning Systems
Patient-level data are aggregated to achieve population-based change,
and results are applied to care of individual patients.
Predict
outcomes
56. Precision Oncology
• The era of precision medicine and precision
oncology is predicated on the integration of
research, care, and molecular medicine and
the availability of data for modeling, risk
analysis, and optimal care
How do we re-engineer
translational research policies
that will enable a true learning
healthcare system?
57. The future
• Elastic computing ‘clouds’
• Social networks
• Big Data analytics
• Precision medicine
• Measuring health
• Practicing protective medicine
Semantic and
synoptic data
Intervening
before health is
compromised
Learning systems that enable learning
from every cancer patient