This document discusses fatigue, including its definition, types, causes, symptoms, and assessment. It defines fatigue as tiredness or diminished energy that interferes with normal activities. Fatigue can be acute or chronic, and local or general. Common causes include lack of sleep, stress, illness, and advancing age. Symptoms include forgetfulness and lack of interest. Assessment involves history, physical exam, and potentially blood tests and imaging. Tests evaluate things like anaerobic capacity, aerobic capacity, and muscle strength and fatigue. Questionnaires can also assess fatigue severity.