This document discusses open source efforts to develop new antimalarial drugs. It outlines four series of compounds that have shown potential against malaria but require further optimization. These series are not fully explored and others can utilize the open source infrastructure to investigate them further. The document also describes tools and resources available through the open source malaria initiative, including online lab books, project management, data management, and publishing. It notes student cohorts and collaborations are part of the effort to synthesize new antimalarial compounds.