Identify the most common parasitic diseases that affect the CNS.
Discuss the Imaging features of these diseases.
Clarify the significances of Imaging in diagnosis and assessment of pathological features of these diseases.
Identify the most common parasitic diseases that affect the CNS.
Discuss the Imaging features of these diseases.
Clarify the significances of Imaging in diagnosis and assessment of pathological features of these diseases.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
3. Aseptic meningitis
Refer principally to viral meningitis.
Other infection.( Lyme disease,syphlis,TB)
Parameningeal infection:
(brain abscess, epidural abscess,venus sinus empyema)
Chemical (NSAID,anti-inflamatory, IVig)
Autoimmune disorders
4. Aseptic meningitis
definition: When the CSF culture was negative.
CSF:
pressure mmh2o: normal or slightly elevated.
leukocytes : PMN early mononuclear later.rarly >1000
Protein mg /dl:20-100
Glucose mg/dl: generally normal may be depressed to40.
(15-20%)
Entroviruse recoverd by CSF culture or PCR
HSV by PCR.
CSF
5. Encephalitis
Inflammatory of brain parenchyma lead to cerebral
dysfunction .
May be diffuse , or localized
1. Usually Acute
2. Post infection encephalomyelitis
3. Chronic degenerative
4. slow viral infection.
6. Encephalitis
it has 2 mechanism.
1. Direct infection.
2. Immune mediated response in the CNS that begins
several days after the extraneural manifestation of
infection .
7. Encephalitis
Viruses are the principal causes of acute
infection encephlitis.
Metabolic.
Toxic.
Neoplastic disorder.
HIV is an important cause of enceplalitis more
commonly insidious in onset.
8. ADEM ( Acute disseminated encephalomyelitis)
ADEM abrupt development.
mutiple neurologic signs related to an inflammatory
and demyelinating disorder of brain and spinal cord .
Childhood viral infection.
( measles , chickenpox, or vaccination)
Resembles to MS.
Relapses occurred in 14% within in 1 year .
10. Laboratory
CSF shows:
lymphocytic pleocytosis.
Slight elevatin protein.
Normal glucose.
The CSF occasionally may be normal.
In HSV protein and RBC increased .
Extreme elevated of protien and reduction of glucose
(TB, carcinomatoseis, cryptococcal infection)
11. Laboratory
EEG: temporal lobe characteristic HSV
infection .
Serologic studies.
(arbovirus, EBV, mycoplasma, cat-scratch, Lyme)
culture stool and CSF ,nasopharyngeal.
PCR test for HSV,entrovirus and other virus.
The cause of encephalitis In 1/3 of cases is
undetermined.
12. Laboratory
Brain biopsy may be necessary for definitive
diagnosis.
1. in patients with focal neurologic finding
2. Severe encephalopathy with no clinical improvement
if diagnosis is obscure.
3. HSV,rabis encephalitis ,prion related disease (kuru,
jakob) diagnosed with culture of brain biopsy.
4. Identify arbovirus, entrovirus, TB, fungal infection .
5. Non infection illness ( primary CNS vasculopathies
,malignancies)
13. Differential diagnosis
Diagnosis established with :
Neurologic signs. epidemiology, evidence of
infection in CSF, EEG, brain imaging
brain biopsy diagnostic but seldom performed.
14. Treatment
There is no specific therapy exception of HSV
and HIV. Treatment is supportive
(siezure, electerolyte abnormality, airway
monitoring, increased ICP
ADEM:high-dose IV corticosteroids.
IV acyclovir is choice for HSV.
M,pneumonia may be trated with doxycycline,
erythromycin, azithromycin, clarithromycin??
15. complication
Symptoms resolve over several days to 2-3 weeks.
Recover without sequelae in 2/3 before dischrge from
hospital.
neurologic sequelae(spasticity,cognitive impairment,
weakness, ataxia, seizure.
( gradually recover some or all)
death.
Mortality is 5%