The number of electrons in an atom's outermost shell determines its reactivity. Atoms are most stable when their outer shell is full. The periodic table arranges elements based on their electron configuration and properties. Elements in the same column generally have the same number of valence electrons and similar reactivity, with reactivity increasing as you move left to right within a period. Noble gases have full outer shells and are highly stable as single atoms, while group 1 elements have one valence electron and tend to lose or share it to become stable.