The document discusses the changing nature of work from routine manufacturing to knowledge work. It notes that knowledge worker productivity is one of the biggest 21st century challenges and that intellectual capital now generates most market value. The spectrum of process support is reviewed, from highly structured to unstructured. Examples of adaptive case management systems are provided. Qualities of case management that differ from workflow, like supporting innovation and knowledge worker autonomy, are discussed. The conclusion is that adaptive case management is well-suited to support unpredictable knowledge work processes that require teams of experts to adapt and innovate to accomplish goals.