Mojito is a model-view-controller framework built on YUI 3 that allows developers to create cross-platform applications using JavaScript. It uses a single language across both server-side and client-side runtimes and supports progressive enhancement and localization. A Mojito application is organized using a directory structure that separates code by mojits. Configuration files define settings for different devices and routes. Controllers handle data and views display it using templating. Major companies like AT&T and Yahoo! use Mojito to build mobile and web applications.