MBBS Ist yeat data

1. DRUGS STIMULATING
NEUROMUSCULAR JUNCTION
Dr. Sabeen Arjumand

2. LEARNING OBJECTIVES
By the end of the lecture students will be able to
• Recall the components of neuromuscular junction
• Recognize the major neurotransmitter released at NMJ and
the receptors on which it acts
• Remember the synthesis, storage, release, metabolism and
action of Acetylcholine
• Discuss other drugs stimulating neuromuscular junction

3. • The neuromuscular junction
(NMJ) is a synaptic
connection between the
terminal end of a motor
nerve and a muscle (skeletal/
smooth/ cardiac). It is the
site for the transmission of
action potential from nerve
to the muscle.

4. What are the three components of a neuromuscular
junction?
1) Presynaptic motor nerve terminal
2) Synaptic space (synaptic cleft)
3) The postsynaptic surface of the skeletal muscle fiber.

5. What are the major neurotransmitters in the neuromuscular
junction?
Acetylcholine (ACh) is the principal neurotransmitter at the
neuromuscular junction NMJ

8. • Nicotinic ACh-receptor in
skeletal muscle
Ligand-gated Channels

9. 1/12/2024 ANS 9

11. 1/12/2024 ANS 11

12. OTHER DRUGS STIMULATING NMJ
• Nicotine
• Neostigmine
• Pyridostigmine