Scott Webster is a Senior Research Scientist at the University of Central Florida's College of Optics and Photonics. He specializes in nonlinear optics and characterization of optical materials using techniques like Z-scan and pump-probe spectroscopy. He has successfully led research teams, published over 50 journal articles, and maintains multiple laser systems for experiments.
It has been almost decades since the “war on cancer” was declared. It is now generally
believed that personalized medicine is the future for cancer patient management.
Possessing unprecedented potential for early detection, accurate diagnosis, and
personalized treatment of cancer, nanoparticles have been extensively studied over the last
decade. In this report, I will try to summarize the current state-of-the-art nanoparticles in
biomedical applications targeting cancer. Multi- functionality nanoparticle-based agents.
Targeting ligands, imaging labels, therapeutic Drugs, and other. And the Role of Chemical
Engineers in this field and the promise that it holds for future.
It has been almost decades since the “war on cancer” was declared. It is now generally
believed that personalized medicine is the future for cancer patient management.
Possessing unprecedented potential for early detection, accurate diagnosis, and
personalized treatment of cancer, nanoparticles have been extensively studied over the last
decade. In this report, I will try to summarize the current state-of-the-art nanoparticles in
biomedical applications targeting cancer. Multi- functionality nanoparticle-based agents.
Targeting ligands, imaging labels, therapeutic Drugs, and other. And the Role of Chemical
Engineers in this field and the promise that it holds for future.
1. Done by: Dr. Mohamad Ghazi Kassem
2. What is Nanotechnology An engineered DNA strandtiny motor pRNA Semiconducting metal junction formed by two carbon nanotubes Nanotechnology is the creation of functional materials, devices and systems, through the understanding and control of matter at dimensions in the nanometer scale length (1-100 nm), where new functionalities and properties of matter are observed and harnessed for a broad range of applications.
3. What is Nanoscale Fullerenes C60 22 cm 12,756 Km 1.27 × 107 m 0.22 m 10 millions times smaller 0.7 nm 0.7 × 10-9 m 1 billion times smaller
4. What Are Gold Nanoparticles? • Gold nanoparticles (‘nanogold’) occur as clusters of gold atoms up to 100nm in diameter. Gold nanoparticle • Nanogold has unusual visible properties because the particles are small enough to scatter visible light. - in contrast, mass gold reflects light. 5nm gold clusters
5. • Gold nanoparticles appear yellow to deep red to in solution. - colour depends on size of nanoparticles • The distance between particles also affects colour - surface plasmon resonance is the term used by nanotechnologists to describe this effect.
6. Why Gold Nanoparticles Cancer is a difficult disease to treat, contain, and identify. There are many different ways for treating cancer such as surgery, chemotherapy, radiation and many others. These methods are effective if the cancer tumor is caught soon enough. However, these treatments are not effective enough because they do not only target the affected cells, they also affect healthy cells. But • Gold Nanoparticles are non toxic • With Gold Nanoparticles we can detecting cancer cells and even destroy them without affect healthy cells.
7. Mostafa A. El-Sayed Julius Brown Chair and Regents Professor; Director, Laser Dynamics Laboratory “Gold nanoparticles are very good at scattering and absorbing light,” said Mostafa El-Sayed, director of the Laser Dyanamics Laboratory and chemistry professor at Georgia Tech. “We wanted to see if we could harness that scattering property in a living cell to make cancer detection easier. So far, the results are extremely promising.”
8. Gold Nanoparticle Tumor Detection The common strategy to detect the tumor is the functionalization of the nanoparticle with an antibody specific to the tumor antigens, and then detect the nanoparticle by some spectroscopic technique B. Tumor photograph Imaging with gold nanoparticles as contrast agent
9. Many cancer cells have a protein, known as Epidermal Growth Factor Receptor (EFGR), all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody for EFGR, suitably named antiEFGR, researchers were able to get the nanoparticles to attach themselves to the cancer cells. Electrostatically + + + + - - - + + + - + -+ - - + + + + Covalently S S S S S S S S
10. Gold Nanoparticles Nanoshells
1. Done by: Dr. Mohamad Ghazi Kassem
2. What is Nanotechnology An engineered DNA strandtiny motor pRNA Semiconducting metal junction formed by two carbon nanotubes Nanotechnology is the creation of functional materials, devices and systems, through the understanding and control of matter at dimensions in the nanometer scale length (1-100 nm), where new functionalities and properties of matter are observed and harnessed for a broad range of applications.
3. What is Nanoscale Fullerenes C60 22 cm 12,756 Km 1.27 × 107 m 0.22 m 10 millions times smaller 0.7 nm 0.7 × 10-9 m 1 billion times smaller
4. What Are Gold Nanoparticles? • Gold nanoparticles (‘nanogold’) occur as clusters of gold atoms up to 100nm in diameter. Gold nanoparticle • Nanogold has unusual visible properties because the particles are small enough to scatter visible light. - in contrast, mass gold reflects light. 5nm gold clusters
5. • Gold nanoparticles appear yellow to deep red to in solution. - colour depends on size of nanoparticles • The distance between particles also affects colour - surface plasmon resonance is the term used by nanotechnologists to describe this effect.
6. Why Gold Nanoparticles Cancer is a difficult disease to treat, contain, and identify. There are many different ways for treating cancer such as surgery, chemotherapy, radiation and many others. These methods are effective if the cancer tumor is caught soon enough. However, these treatments are not effective enough because they do not only target the affected cells, they also affect healthy cells. But • Gold Nanoparticles are non toxic • With Gold Nanoparticles we can detecting cancer cells and even destroy them without affect healthy cells.
7. Mostafa A. El-Sayed Julius Brown Chair and Regents Professor; Director, Laser Dynamics Laboratory “Gold nanoparticles are very good at scattering and absorbing light,” said Mostafa El-Sayed, director of the Laser Dyanamics Laboratory and chemistry professor at Georgia Tech. “We wanted to see if we could harness that scattering property in a living cell to make cancer detection easier. So far, the results are extremely promising.”
8. Gold Nanoparticle Tumor Detection The common strategy to detect the tumor is the functionalization of the nanoparticle with an antibody specific to the tumor antigens, and then detect the nanoparticle by some spectroscopic technique B. Tumor photograph Imaging with gold nanoparticles as contrast agent
9. Many cancer cells have a protein, known as Epidermal Growth Factor Receptor (EFGR), all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody for EFGR, suitably named antiEFGR, researchers were able to get the nanoparticles to attach themselves to the cancer cells. Electrostatically + + + + - - - + + + - + -+ - - + + + + Covalently S S S S S S S S
10. Gold Nanoparticles Nanoshells
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TOPICS
WHAT IS UL?
– UL Standards
– UL Files for PFC Flexible Circuits
2. UL Tests for Flexible Circuit (FPC) boards
3. Summary of UL – Recognised types for PFC
4. Examples of UL – Recognised designation
UL Standards
UL 796 Standard for Printed Wiring Board
UL 796F Standard for Printed Wiring Board includes special classification for flexible printed wiring
UL 94 Tests for Flammability of Plastic Materials for Parts in Devices and Appliances
1. SCOTT WEBSTER, Ph.D.
Senior Research Scientist
University of Central Florida Cell: (407) 488-7041
CREOL, the College of Optics & Photonics Nationality: American
4000 Central Florida Blvd. Email: swebster@creol.ucf.edu
Orlando, FL 32816-2700 LinkedIn
SUMMARY OF QUALIFICATIONS
Successfully multitasks multiple programs and their respective managerial and scientific duties with the
ability to pursue fundament and applied research in nonlinear optics utilizing wavelengths from the
ultraviolet to mid-infrared with femtosecond to nanosecond pulse widths. Performs nonlinear optical
characterization with and of femtosecond white light supercontinuum generation in condensed media and
gasses. Successfully works with and helps organize numerous collaborations specializing in research fields
such as nonlinear optics, chemistry, materials science, physics, nanomaterials synthesis and
characterization, organic and inorganic device fabrication, and both modeling and simulations of light-
matter interactions. Exceptionally proficient at running the daily operations of a large research team of
scientists while stimulating colleagues to perform at their highest level of creativity to meet planned and
unplanned deadlines. Maintains multiple laser systems and laboratory operations while guiding
experimental design, setup, and acquisition.
ACADEMIC AND PROFESSIONAL EXPERIENCE
CREOL: College of Optics and Photonics, University of Central Florida, Orlando, FL
Senior Research Scientist/Group Manager, 2004 – Present
• Prioritizes the research group’s activities, including all aspects (experimentally-theoretically-
programmatically) of funded programs running in parallel (as many as five), to satisfy funded
program’s responsibilities and deliverables while planning for anticipated non-funded programs.
• Writes and implements numerical models and simulations of light-matter interactions to extract linear
and nonlinear optical parameters from experimental results.
• Conducts experimental and theoretical linear and nonlinear optical characterization of many classes
of optical materials.
• Responsible for writing manuscripts and presentations for journals, conferences, proposals, and
program reviews, with the ability to tailor each for the intended audience. Effectively communicates
complex concepts and ideas to the intended audiences’ level of understanding.
• Materials specialties include π-conjugated and non-conjugated organic systems, small molecules,
polymers, wide- and narrow-gap semiconductors including quantum dots, photochromics, organic and
inorganic nanomaterials, polymeric-nanomaterial composites, photonic band gap materials and
structures, glasses, films, and fibers.
Wake Forest University, Winston Salem, NC
Post-Doctoral Research Associate, September 2003 to September 2004
Researched and characterized various nanomaterials and organics for organic electronic devices
(OLEDs and OPVs) and their optical testing. Designed and set up the nonlinear optics lab from
inception while prioritizing ongoing experiments without significant delay.
Nanomaterials Consultant
Private consultant, 2002 – 2004
Aided clients in preparation of proposals for DoD and NIH funding by writing proposals’ technical
sections in linear and nonlinear optical characterization of nanomaterials and nanocomposites.
Clemson University, Clemson, SC
Graduate Research Assistant, May 2000 – September 2003
2. Completed Physics Ph.D. course work and passed qualifier. Responsible for designing, maintaining,
and managing the newly formed optics division of the Center for Optical Materials Science and
Engineering Technologies (COMSET).
H.C. Stark, Newton, MA
Process Engineer, June - August 1999
Internship: Responsible for manufacturing protocols and equipment controls in their Tantalum
extraction processes.
University of Virginia, Charlottesville, VA
Summer Researcher, May - August 1998
Performed basic laboratory organic chemistry and characterization for the chemical identification of
synthesized intermediates, impurities, and yields of metal-centered star block copolymers.
RESEARCH EXPERIENCE
Currently a Senior Research Scientist at the University of Central Florida in the College of Optics and
Photonics (CREOL) working in the Nonlinear Optics group directed by Drs. Eric Van Stryland and
David Hagan. From 2003 to 2004, managed and maintained the optics facility in the Center for
Nanotechnology and Molecular Materials at Wake Forest University under the direction of Dr. David L.
Carroll. From September 2000 until 2003, responsible for managing and maintaining the optics division
of the Center for Optical Materials Science and Engineering Technologies (COMSET) under the
direction of Dr. John Ballato at Clemson University.
These positions have afforded me the opportunity to participate and lead a diverse array of projects from
conception through design, implementation, and completion into a product or publishable output. My
research focus has been on the linear and nonlinear optical characterization and modeling of various
optical materials (π-conjugated and non-conjugated organics, wide/narrow gap semiconductors, glasses,
plasmonic nanostructures, etc.) and the development and analysis of new experimental techniques (white
light continuum generation for Z-scan and the double-pump probe technique for long-lived absorptions,
etc.). My work within these research groups involved projects ranging from femtosecond
supercontinuum generation in gasses and condensed media, nanomaterials growth, scanning probe
microscopy (AFM, SNOM, STM) and electron microscopy (SEM, TEM, EELS), to polymeric electro-
optical device fabrication and testing (organic-LEDs (OLEDs) and organic-photovoltaics (OPVs)). This
diverse variety of projects required frequent collaborations and provided a strong working knowledge of
many experimental techniques and scientific disciplines.
SELECT EXPERIMENTAL TECHNIQUES
Z-scan (Transmissive/Reflective) Two-photon Fluorescence Spectroscopy
White Light Continuum Generation Absorption/Reflection spectroscopy
Modeling/Programming of NLO processes FTIR Absorption/Reflection spectroscopy
Pump-probe spectroscopy Optical Microscopy (Bright, Dark, and DIC)
Nonlinear Transmission Thermo Gravimetric Analysis
Confocal Micro-Raman Differential Scanning Calorimetry
Macro-Raman Time of Flight Spectroscopy (carrier mobility)
Electroluminescence Photo-oxidation Lifetime
Photoluminescence (Spectral and Temporal) Steady State Emission/Exc. Anisotropy
PUBLICATION HIGHLIGHTS (as of 6/2011)
Peer-Reviewed Archival Journal Citations: >700
Active Reviewer for Archival Journals: 13
Book Chapters: 1
Refereed Journal Publications: 53
Refereed Conference Proceedings and Extended Abstracts: 79
Presented (Talks, Invited Lectures, and Colloquia): 36
2
3. Contributed Presentations: 79
SELECT JOURNAL AND PROCEEDINGS PUBLICATIONS
• D.A. Fishman, C.M. Cirloganu, S. Webster, L.A. Padilha, M. Monroe, D.J. Hagan, and E.W. Van Stryland,
“Sensitive mid-infrared detection in wide-gap semiconductors using extreme nondegenerate two-photon
absorption” Nature PhotonicsNature Photonics 5, 561–565 (2011). DOI:10.1038/nphoton.2011.168
• T. Ensley, D. Fishman, S. Webster, L. Padilha, D. Hagan, E. Van Stryland, "Energy and spectral enhancement
of femtosecond supercontinuum in a noble gas using a weak seed" Opt. Express 19, 757 (2011).
• P.D. Olszak, C.M. Cirloganu, S. Webster, L.A. Padilha, S. Guha, L.P. Gonzalez, S. Krishnamurthy, D.J. Hagan,
and E.W. Van Stryland, “Spectral and temperature dependence of two-photon and free-carrier absorption in
InSb” Phys. Rev. B 82, 235207 (2010).
• S. Webster, D. Peceli, H. Hu, L.A. Padilha, O.V. Przhonska, A.E. Masunov, A.O. Gerasov, A.D. Kachkovski,
Y.L. Slominsky, A.I. Tolmachev, V.V. Kurdyukov, O.O. Viniychuk, E. Barrasso, R. Lepkowicz, D.J. Hagan,
E.W. Van Stryland “Near-Unity Quantum Yields for Intersystem Crossing and Singlet Oxygen Generation in
Polymethine-like Molecules: Design and Experimental Realization” J. Phys. Chem. Lett. 1, 2354 (2010).
• S. Webster, S.A. Odom, L.A. Padilha, O.V. Przhonska, D. Peceli, H. Hu, Nootz, A.D. Kachkovski, J. Matichak,
S. Barlow, H.L. Anderson, S.R. Marder, D.J. Hagan, E.W. Van Stryland, “Linear and Nonlinear Spectroscopy of
a Porphyrin-Squaraine-Porphyrin Conjugated System” J. Phys. Chem. B 113, 14854 (2009).
• C. Cirloganu, P. Olszak, L. Padilha, S. Webster, D. Hagan, and E. Stryland, "Three-photon absorption spectra of
zinc blende semiconductors: theory and experiment" Opt. Lett. 33, 2626 (2008).
• C. Fuentes-Hernandez, L.A. Padilha, D. Owens, S-Y. Tseng, S. Webster, J-Y. Cho, D.J. Hagan, E.W. Van
Stryland, S.R. Marder and B. Kippelen, "Linear and nonlinear optical properties of highly transmissive one-
dimensional metal-organic photonic bandgap structures" Proc. SPIE 7049, 70490O (2008).
• S. Webster, M. Reyes-Reyes, X. Pedron, R. López-Sandoval, M. Terrones, and D.L. Carroll, “Enhanced
nonlinear transmittance by complimentary mechanisms: A reverse-saturable absorbing dye blended with
nonlinear-scattering carbon nanotubes” Adv. Matt. 17(10), 1239 (2005).
• S. Webster, F.C. McDonald, A. Villanger, M.J. Soileau, E.W. Van Stryland, D.J. Hagan, B. McIntosh, W.
Torruellas, J. Farroni and K. Tankala, "Optical damage measurements for high peak power ytterbium doped fiber
amplifiers" Proc. SPIE 5991, 599115 (2005).
• S. Webster, J. Maultzsch, C. Thomsen, J. Liu, R. Czerw, M. Terrones, F. Adar, C. John, A. Whitley, D. L.
Carroll, “Raman Characterization of Nitrogen Doped Multiwalled Carbon Nanotubes” MRS Proceedings 772,
M7.8 (2003).
• J. Maultzsch, S. Reich, C. Thomsen, S. Webster, R. Czerw, D.L. Carroll, S.M.C. Vieira, P.R. Birkett, C.A. Rego
“Raman characterization of boron-doped multiwalled carbon nanotubes” Appl. Phys. Lett. 81, 2647 (2002).
• H.S. Woo, R. Czerw, S. Webster, D.L. Carroll, J. Ballato, A.E. Strevens, D. O’Brien, and W.J. Blau, “Hole
blocking in carbon nanotube–polymer composite organic light-emitting diodes based on poly (m-phenylene
vinylene-co-2, 5-dioctoxy-p-phenylene vinylene)” Appl. Phys. Lett. 77, 1393 (2000).
EDUCATION
Ph.D. Wake Forest University, Physics, Advisor: David L. Carroll, 2003
Dissertation: Optical Characterization of Nanostructured Materials
B.S. Roanoke College, Physics, Advisor: Richard G. Grant, 1999
Topics: Mossbauer Spectroscopy and Numerical Modeling of nonlinear systems
Computer Skills
Business Software: Microsoft Windows 7 (x86 and x64) and Office 2010 and their previous versions,
Adobe Acrobat Pro X, and Adobe Photoshop CS5
Scientific Software: MatLab, Mathematica, Mathcad, Origin, ChemDraw, LabView (beginner)
Hardware Proficiency: Able to diagnose, fix, and build almost any PC/Server
REFERENCES
References and complete C.V. are available by request or downloadable through LinkedIn.
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