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IOP PUBLISHING                                                               PHYSICS IN MEDICINE AND BIOLOGY

Phys. Med. Biol. 52 (2007) 2267ā€“2276                                       doi:10.1088/0031-9155/52/8/015




Dose delivered from Varianā€™s CBCT to patients
receiving IMRT for prostate cancer

                   Ning Wen, Huaiqun Guan1 , Rabih Hammoud, Deepak Pradhan,
                   T Nurushev, Shidong Li and Benjamin Movsas
                   Henry Ford Health System, Detroit, MI, USA

                   E-mail: hguan1@hfhs.org

                   Received 17 August 2006, in ļ¬nal form 11 December 2006
                   Published 2 April 2007
                   Online at stacks.iop.org/PMB/52/2267

                   Abstract
                   With the increased use of cone beam CT (CBCT) for daily patient setup,
                   the accumulated dose from CBCT may be signiļ¬cantly higher than that from
                   simulation CT or portal imaging. The objective of this work is to measure
                   the dose from daily pelvic scans with ļ¬xed technical settings and collimations.
                   CBCT scans were acquired in half-fan mode using a half bowtie and x-rays were
                   delivered in pulsed-ļ¬‚uoro mode. The skin doses for seven prostate patients
                   were measured on an IRB-approved protocol. TLD capsules were placed on the
                   patientā€™s skin at the central axis of three beams: AP, left lateral (Lt Lat) and right
                   lateral (Rt Lat). To avoid the ring artefacts centred in the prostate, the treatment
                   couch was dropped 3 cm from the patientā€™s tattoo (central axis). The measured
                   AP skin doses ranged 3ā€“6 cGy for 20ā€“33 cm separation. The larger the patient
                   size the less the AP skin dose. Lateral doses did not change much with patient
                   size. The Lt Lat dose was āˆ¼4.0 cGy, which was āˆ¼40% higher than the Rt Lat
                   dose of āˆ¼2.6 cGy. To verify this dose asymmetry, surface doses on an
                   IMRT QA phantom (oval shaped, 30 cm Ɨ 20 cm) were measured at the same
                   three sites using TLD capsules with 3 cm table-drop. The dose asymmetry was
                   due to: (1) kV source rotation which always starts from the patientā€™s Lt Lat and
                   ends at Lt Lat. Gantry rotation gets much slower near the end of rotation but
                   dose rate stays constant and (2) 370ā—¦ scan rotation (10ā—¦ scan overlap on the Lt
                   Lat side). In vivo doses were measured inside a Rando pelvic heterogeneous
                   phantom using TLDs. The left hip (femoral head and neck) received the highest
                   doses of āˆ¼10ā€“11 cGy while the right hip received āˆ¼6ā€“7 cGy. The surface and
                   in vivo doses were also measured for phantoms at the central-axis setup. The
                   difference was less than āˆ¼12% to the table-drop setup.




1   Address for correspondence: Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48084, USA.

0031-9155/07/082267+10$30.00 Ā© 2007 IOP Publishing Ltd Printed in the UK                                  2267
2268                                                                                   N Wen et al

1. Introduction

Cone beam CT (CBCT) using the on-board imager (OBI) device installed on linear accelerators
(linac) allows three-dimensional (3D) online patient setup and treatment veriļ¬cation for
image guided radiation therapy (IGRT). CBCT enables soft tissue imaging providing a major
advantage for prostate localization on a daily basis. 2D localization based on pelvic bony
landmarks using either OBI or portal imaging is less accurate (Schallenkamp et al 2005).
In our institution, a protocol has been implemented to use Varianā€™s CBCT for daily prostate
patient setup. Patients were treated to a total of 78 Gy in 42 fractions using the IMRT
technique. Further, patients were educated about a bowel regimen to assure an empty rectum
prior to simulation and treatments. If the rectum was found not empty (with displacement
of prostate initially), the patient was instructed to use the restroom and a second CBCT was
acquired prior to treatment. The accumulated total-body dose delivered from CBCT can be
much higher than that from simulation CT or EPID. The goal of this study is to measure the
daily CBCT dose.
     The computed tomography dose index (CTDI) that is used to represent the diagnostic CT
dose may not be adopted for the speciļ¬cation of CBCT dose (CTDI is even considered less
adequate for multi-slice CT scanners (Dixon 2003, Brenner 2005)). The reasons are: (1) the
10 cm long ion chamber used to measure the CTDI for diagnostic CT cannot collect all scatters
from the large cone opening of CBCT; (2) the cumulative dose from CBCT may be high and
the dose distribution is better measured and added to the treatment dose and (3) CBCT is quite
different from diagnostic CT in terms of gantry rotational speed, bowtie design, etc.
     A measurement of CBCT dose has been recently reported (Islam et al 2006) for Elektaā€™s
Synergy system. In that study, patientsā€™ skin dose, phantom surface dose and phantom centre
dose (two cylindrical phantoms: 16 and 32 cm diameters) were measured at different technical
settings and different ļ¬eld-of-views using MOSFET detectors and a Farmer chamber.
     In this study, we focused our measurement of Varianā€™s CBCT dose on pelvic sites with
ļ¬xed technical and collimator setting. Skin doses for seven prostate patients were measured.
TLD capsules were placed on the patientā€™s skin at the central axis of three beams: AP, left
lateral (Lt Lat) and right lateral (Rt Lat). In order to avoid the ring artefacts centred at the
prostate, the treatment couch was dropped 3 cm from the patientā€™s tattoo (i.e. central axis). The
surface doses on an IMRT QA phantom (oval shaped: 20 cm AP and 30 cm Lat dimensions)
were then measured to verify the lateral dose asymmetry from patients. A Rando pelvic
phantom was used to measure the in vivo dose distributions along the AP and Lat central axis,
including the surface doses. Phantom dose measurements were made for both the table-drop
(3 cm) and central-axis setups in order to check the difference between the two. The absorbed
dose was determined using the data provided by AAPM TG61 and Ma and Seuntjens (1999).


2. Materials and methods

2.1. Varianā€™s OBI system and OBI-based CBCT
Varianā€™s on-board imager (OBI) device was installed on a dual energy 21EX linear accelerator
(linac). The OBI system consisted of a kV x-ray source (KVS) and an amorphous-silicon
(a-Si) ļ¬‚at panel detector (KVD) in addition to the megavoltage electronic portal imaging device
(EPID). The KVS and KVD were mounted on linac gantry via two robotically controlled arms,
which position the KVS and KVD orthogonal to the treatment beam and retract when they are
not in use. The x-ray tube (KVS) has two focal spots: smaller size of 0.4 mm and larger size
of 0.8 mm. The x-rays can be delivered in two modes: radiographic mode and pulsed-ļ¬‚uoro
Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer                               2269




                              (a)                                  (b)

                  Figure 1. CBCT acquisition mode. (a) Full-fan mode with full bowtie mounted. The KVD is
                  centred with x-ray axis. (b) Half-fan mode with half bowtie mounted. The KVD is shifted to one
                  side.

mode. The KVD panel has a detection area of 40 cm (X) Ɨ 30 cm (Y). With the panel set at
150 cm source-to-detector distance (SDD), the maximum superior/inferior coverage is 20 cm
at the isocentre plane.
     OBI-based CBCT was acquired by rotating the linac gantry from 175ā—¦ to 185ā—¦ in the
extension mode for a total of 370ā—¦ rotation. The kV source always starts from patientā€™s Lt Lat
and ends at Lt Lat resulting in a 10ā—¦ over scan on the Lt Lat side. CBCT has two acquisition
modes to offer two different ļ¬eld-of-views: full-fan mode and half-fan mode. Full-fan mode
was used to scan sites where the size is less than 24 cm (e.g., brain). KVD is centred in this
mode. Half-fan mode was used for sites larger than 24 cm (mostly for body scans) and KVD
was shifted to one side to cover more than half the patientā€™s volume. Bowtie ļ¬lters for either
mode can be mounted to the KVS to modify the beam proļ¬le for less patient dose. Figure 1
shows a schematic of the two different modes.

2.2. Setup for CBCT dose measurement
For all scans, a technical setting of 125 kV, 80 mA and 25 ms was used. X-rays were delivered
in pulsed-ļ¬‚uoro mode. CBCT scans were acquired in half-fan mode using a half bowtie. In
this mode, the ļ¬‚at panel detector was shifted to one side and the collimators were set at X1 =
5.3 cm and X2 = 24.9 cm. Y1 and Y2 were set both at 6 cm. Note that the maximum Y coverage
is 20 cm at the source-to-detector distance (SDD) of 150 cm. 12 cm scan in the longitudinal
direction was a good compromise between decreasing scatter and patient coverage for prostate
localization.
     Skin doses for seven prostate patients undergoing daily CBCT were measured. TLD
capsules were placed on the patientā€™s tattoo, i.e., the central axis of three beams: AP, left
lateral (Lt Lat) and right lateral (Rt Lat). To avoid the ring artefacts centred at the prostate2 ,
the treatment couch was dropped 3 cm from the patientā€™s tattoo (ļ¬gure 3(a) is the central-axis
setup and 3(b) is the table-drop setup. The rings around the central axis in 3(a) moved 3 cm
anterior in 3(b)). After the Lt Lat dose was found higher than the Rt Lat dose, we measured the
surface doses at the same three sites on an IMRT QA phantom (CIRS model 002H9K, 30 cm Ɨ
20 cm oval shaped) in order to conļ¬rm the asymmetry. The in vivo doses were then measured
2 The thin ring artefacts around the central axis come from the non-uniform response of ļ¬‚at-panel pixel detectors.

There is also a large ring artefact of 25 cm in diameter for which the reason is unclear. However, all ring artefacts
were much reduced in version 2.0 of CBCT.
2270                                                                                  N Wen et al




               Figure 2. The experimental setup for HVL measurement.


inside a Rando pelvic phantom by placing TLDs along the AP and Lat central axis; from skin
to skin (therefore skin doses were also measured). The absorbed dose was determined using
the data provided in AAPM TG61 and Ma and Seuntjens (1999). The skin and in vivo doses
were also measured for phantoms under the central-axis setup in order to check the difference
to the table-drop setup. Calculation of skin and in vivo doses were described in sections 2.4
and 2.5, respectively.

2.3. The x-ray beam quality K
For kV x-rays, the ļ¬rst half value layer (HVL) and kV were used to specify the beam quality.
The experimental setup for HVL measurement is shown in ļ¬gure 2. Measurement was
performed under the radiographic mode of OBI using a technical setting of 125 kV, 80 mA
and 160 ms with a half bowtie. High-purity (99.9%) Al attenuators were used. The Al
attenuator was placed 50 cm away from a parallel-plate ion chamber (Keithly model 96035)
and the x-ray collimators (blades or diaphragms) were set to 2 cm Ɨ 2 cm to make a narrow
beam measurement.
     The measured HVL at the central axis for a half bowtie was found to be 6.3 mm Al. For
the OBI, the collimators (blades) were installed only āˆ¼20 cm from the source, different from
the āˆ¼50 cm speciļ¬cation in TG61 for therapeutic kV devices. However, as long as a narrow
beam was used, the default collimation setup with OBI should be acceptable.
     It is important to note that the beam quality near the lateral beam edge can be harder than
that at the beam centre because of the higher attenuation by the half bowtie. Also, the beam
spectrum near the superior/inferior beam edge is somewhat different from that at beam centre
(Bhat et al 1999). We ignore these differences in this study.

2.4. The skin (surface) dose measurement
TLDs were used previously for the entrance surface dose (Omrane et al 2003) and the
backscatter factor (BSF) (Coudin and Marinello 1998) measurement of kV beams. In this
study, LiF TLDs were calibrated against the Keithley parallel-plate ion chamber (model 96035)
under the 125 kV x-rays with half-fan bowtie. First, TLDs of the same batch were indexed
and placed around the circle of the cylindrical sensitive volume on the surface of the parallel
chamber. The sensitivity of each individual TLD was the ratio of the TLD reading to the
average reading of all TLDs. Then TLDs having similar sensitivities were grouped and placed
in capsules for skin dose measurement. The parallel-plate ion chamber was calibrated in an
accredited dosimetry calibration laboratory (ADCL) using a 120 kV, HVL-4.15 mm Al beam
Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer                                  2271

and the air-kerma calibration factor Nk = 2.08 Ɨ 106 Gy Cāˆ’1. The chamberā€™s energy response
varies <4% in a broad energy range of 20ā€“150 kV.
     The dose on the patientā€™s skin can be derived as:
                                              skin
                                       ĀÆ
                                       Āµen
                  Dskin = DTLD
                                        Ļ     TLD air
                                                                                skin
                               RTLD āˆ’ RBG                              ĀÆ
                                                                       Āµen
                        =                            DTLD-Cali
                              RTLD-Cali āˆ’ RBG                           Ļ       TLD air
                                                                       TLD                             skin
                               RTLD āˆ’ RBG                     ĀÆ
                                                              Āµen                            ĀÆ
                                                                                             Āµen
                        =                            Dair
                              RTLD-Cali āˆ’ RBG                  Ļ       air                    Ļ        TLD air
                                                                                air
                                                                         TLD                            skin
                               RTLD āˆ’ RBG                        ĀÆ
                                                                 Āµen                             ĀÆ
                                                                                                 Āµen
                        =                            MNk
                              RTLD-Cali āˆ’ RBG                     Ļ      air                      Ļ     TLD air
                                                                                   air
                                                                         skin
                               RTLD āˆ’ RBG                        ĀÆ
                                                                 Āµen
                        =                            MNk                                                           (1)
                              RTLD-Cali āˆ’ RBG                     Ļ      air     air
where M is the free-in-air parallel chamber reading after the temperature, pressure, polarity,
ion-recombination and electrometer corrections; RTLD-Cali is the TLD reading from the
calibration and RTLD is the TLD reading from the skin dose measurement; and RBG is the
background reading of TLD. (Āµen /Ļ)skin is the ratio of mass energy absorption coefļ¬cient of
                                 ĀÆ     air
skin to air, averaged in free-air medium and it can be quoted from Ma and Seuntjens (1999,
table 2). Note that TLDsā€™ over-response (āˆ¼15ā€“20%) to kV x-rays was not involved here
because the effect was cancelled. In this study, skin doses for seven prostate patients were
measured and multiple measurements were made for each patient. Both the average dose and
per cent standard deviation (%SD) were calculated for each patient. As noted before, the
patientā€™s skin dose was only measured under the table-drop (3 cm) setup.
     Similarly, the surface dose on phantoms can be derived as
                                                                         surface
                               RTLD āˆ’ RBG                        ĀÆ
                                                                 Āµen
                  Dskin =                            MNk                                     .                     (2)
                              RTLD-Cali āˆ’ RBG                     Ļ      air           air
     The IMRT QA phantom is manufactured from proprietary materials that fully mimic water
with 1% accuracy from 50 keV to 50 MeV and therefore (Āµen /Ļ)water is used. The Rando
                                                              ĀÆ     air
phantomā€™s soft tissue was made of a proprietary urethane formulation with an effective atomic
number and mass density that closely simulates muscle tissue with randomly distributed
fat. The (Āµen /Ļ)muscle (Ma and Seuntjens (1999), table 2) was used for dose calculation.
            ĀÆ       air
Note that the surface dose is contributed by both the incident and transmitted projections.
The transmitted x-rays are harder in beam quality but the effect can be negligible because
(Āµen /Ļ)muscle in free-air varies <2% for all beams with HVL < 10.0 mm Al (Ma and Seuntjens
  ĀÆ     air
(1999), table 2, by multiplying the water/air and muscle/water ratio data). For the 30.2 cm Ɨ
12.0 cm half-fan projection (366 cm2), the (Āµen /Ļ)muscle ratio is only 0.2% less than the
                                                  ĀÆ     air
standard 10 cm Ɨ 10 cm data (Ma and Seuntjens (1999), ļ¬gure 6). The surface doses were
measured seven times for the IMRT QA phantom and four times for the Rando phantom.
Measurements were made for both the table-drop (3 cm) and central-axis setups.

2.5. The in vivo dose measurement
In vivo doses were measured inside the Rando pelvic phantom using TLDs. The slab at which
TLDs were placed has both bone and muscle-equivalent materials. TLDs were placed along
2272                                                                                                  N Wen et al




               Figure 3. Dose distributions along the AP and Lat central axis in the Rando pelvic phantom for
               (a) the central-axis (CA) and (b) the table-drop (TD) setups. The thin ring artefacts around the
               central axis in (a) were moved 3 cm anterior in (b).



the AP and Lat central-axis lines, as shown in ļ¬gure 3(a) for central-axis setup and (b) for
table-drop setup. One TLD per location and four measurements were made for each setup
for improved dose statistics. Two or three TLD cubes were placed inside the femoral head to
measure the dose to bone. Individual TLDsā€™ responses were documented.
     The in vivo doses inside the Rando phantom can be derived similarly as for equation (1),
but the (Āµen /Ļ) ratio was in muscle (or bone media) but not in air.
         ĀÆ
                                                     TLD                     muscle
             RTLD āˆ’ RBG                       ĀÆ
                                              Āµen                  ĀÆ
                                                                   Āµen
Dmuscle =                         MNk                                                             .          (3)
            RTLD-Cali āˆ’ RBG                    Ļ     air            Ļ        TLD
                                                           air                        muscle

     The (Āµen /Ļ)TLD in free-air and in muscle (water-equivalent) cannot cancel each other.
           ĀÆ      air
However, the (Āµen /Ļ)water in air and water is less than 2% per TG61 and Ma and Seuntjens
                ĀÆ      air
(1999, tables 2 and 3). Taking this āˆ¼2% difference for TLD which is nearly water-equivalent
at 125 kV, the ļ¬nal dose calculation can be simpliļ¬ed to
                                                                       muscle
                              RTLD āˆ’ RBG                         ĀÆ
                                                                 Āµen
               Dtissue =                            MNk                                           .          (4)
                             RTLD-Cali āˆ’ RBG                      Ļ    air         air or water

    We used the (Āµen /Ļ)muscle averaged in free-air and in water media for calculation.
                     ĀÆ     air
Similarly, the absorbed dose inside bone was
                                                                       bone
                              RTLD āˆ’ RBG                         ĀÆ
                                                                 Āµen
               Dtissue =                            MNk                                                      (5)
                             RTLD-Cali āˆ’ RBG                      Ļ    air      air or water

where (Āµen /Ļ)bone = (Āµen /Ļ)bone (Āµen /Ļ)water . From Ma and Seuntjens (1999, tables 2
         ĀÆ       air       ĀÆ    water ĀÆ      air
and 3), (Āµen /Ļ)bone in free-air and water for a 6.3 mm HVL beam can be āˆ¼5% different
           ĀÆ       water
by interpolating the data of 4.76 and 9.17 mm Al HVL. Again the average (Āµen /Ļ)bone ĀÆ     air
in free-air and water media was used for calculation. Also the beam quality at any TLD
location can be different from that used for TLD calibration in air. The (Āµen /Ļ)bone at 15 cm
                                                                          ĀÆ      water
depth of water was 0.93 for 100 kV and 0.99 for 150 kV. We expect the ratio for 125 kV
to be 0.96. The (Āµen /Ļ) ratio is little SSD dependent but it is ļ¬eld size dependent
                         ĀÆ
(Ma and Seuntjens 1999) for bone to water. For the half-fan ļ¬eld size of 12 cm Ɨ 30.2 cm,
the (Āµen /Ļ)bone is āˆ¼2% higher than that of the standard 10 cm Ɨ 10 cm ļ¬eld.
     ĀÆ       water
Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer                                2273

                    Table 1. AP and Lat skin doses for patients (table-drop setup).

                                 Patient separation          AP dose             Rt Lat dose       Lt Lat dose

          Total    TLDs         AP         Lateral      Average               Average             Average
Patient   trials   each trial   (cm)       (cm)         (cGy)      %SD        (cGy)      %SD      (cGy)        %SD
A         4        20           32.65      40.24        3.22        5.51%     2.68        8.75%   3.94         9.10%
B         5        20           27.18      40.07        4.54        7.75%     2.55       11.27%   4.12         8.52%
C         3        20           25.46      38.56        4.29        6.77%     2.54        6.23%          N/A
D         5        20           23.74      37.28        4.10        8.73%     2.39        3.46%   3.49         6.25%
E         6        20           22.77      34.91        5.05        8.93%     2.51        5.95%   4.25         3.77%
F         6        20           21.7       36.04        6.02        3.78%     2.34        7.06%          N/A
G         7        20           20.48      34.16        6.06       10.82%     2.78       16.78%          N/A




     kV dose measurements (using MOSFET detectors) inside a phantom consisting of soft
tissue, bone and lung-equivalent materials have been reported (Jones et al 2005). Based on
the study, dose calculation inside bones using the free-in-air (Āµen /Ļ)bone provides āˆ¼ Ā±10%
                                                                ĀÆ      air
accuracy (based on the error bars) comparing to the Monte Carlo simulation. Considering
TLDs have less energy response than MOSFET detectors, we expect that the inaccuracy of
bone dose calculation due to the approximation in equation (5) was better than 10%.


3. Results

3.1. Skin dose on patients (table-drop setup)

Table 1 shows the average skin doses and the per cent standard deviations (%SD) at AP, Rt Lat
and Lt Lat for patients of different sizes. The number of measurements (trials) was also given
for each patient. AP doses strongly depend on patientsā€™ separation, ranging from 3.2 cGy for
32.7 cm to 6.1 cGy for 20.5 cm. Lat doses had little dependence on patientsā€™ separation. Rt
Lat dose was 2ā€“3 cGy, which was lower than the Lt Lat dose of 3.5ā€“4 cGy by about āˆ¼40%.
The standard deviations range from 3.5% to 17% for all data.
     The fact that large patients received smaller AP doses is due to the decrease of transmission
from posterior and posterior oblique projections, despite that large patients actually received
more skin doses from anterior and anterior oblique projections (because of the shorter source-
to-skin distances, or SSD). For the three patients with AP separations 23.74 cm, 25.46 cm and
27.18 cm, AP doses were actually increased a few per cent with increased separation. This
means that the increased entrance doses from anterior projections outweigh the decreased
transmission from posterior projections. For very thin (<22 cm) patients, the increased
transmission outweighs the decreased entrance dose.


3.2. Surface dose on phantoms

Table 2 ļ¬rst shows the surface doses and per cent standard deviations (%SD) at the same three
sites on the IMRT QA phantom for both the central-axis (CA) and table-drop (TD) setups. For
this exactly symmetrical phantom, Lt Lat doses were measured to be āˆ¼40ā€“50% higher than the
Rt Lat doses. Comparing the table-drop setup to the central-axis setup, AP dose was increased
a few per cent but Lt Lat and Rt Lat doses were each decreased by a few per cent. The surface
doses on the Rando pelvic phantom at the same three sites were also measured (at the time for
in vivo dose measurement) and shown on the second row of table 2. With table-drop, AP dose
2274                                                                                               N Wen et al

                 Table 2. Phantom surface doses from the central-axis (CA) and table-drop (TD) setups.

                                          CA (SAD = 100 cm) (cGy)              TD (SAD = 103 cm) (cGy)

                         Sep. (cm)       AP        Lt Lat       Rt Lat         AP        Lt Lat          Rt Lat
        Num. TLDs
Phantom trials per trial AP Lat      Ave %SD Ave %SD Ave           %SD     Ave %SD Ave %SD Ave              %SD
IMRT     7     25       20    30     4.73 5.71 4.52 4.23 3.00       5.35   5.12 4.31 4.13 2.89 2.77         2.92
Rando    4     25       20    33     4.91 4.83 4.21 3.65 2.61       3.47   5.73 3.89 4.30 4.03 2.83         3.66




is also increased in this case (possibly because more side projections become incident rather
than transmitted, which offset the dose decrement from the larger anterior SSD) but the Lt Lat
and Rt Lat doses change little.


3.3. In vivo dose in phantom
The in vivo doses measured inside the Rando pelvic phantom using TLDs, along the AP and
Lat central axis (tattoo) were shown in ļ¬gure 3 for (a) the central-axis and (b) the table-drop
setups. The results were the average of all four measurements for each setup. Again, the tissue
and bone doses on the left side were higher than those on the right side. The anterior part of the
phantom also received higher doses with table-drop than with the central-axis setup. Doses at
the AP, PA and Lt Lat peripheral area (except at the Rt Lat where the dose is about the same
as the central dose āˆ¼3 cGy) were āˆ¼40ā€“50% higher than at the central. The left femoral bone
received the highest doses of 10ā€“11 cGy while the right one received āˆ¼6ā€“7 cGy.


4. Discussion

Additional measurements were made in half-fan or full-fan scan, with or without bowtie,
central-axis or table-drop setup and all conļ¬rmed that the Lt Lat dose was higher than the Rt
Lat dose. This dose asymmetry was found because: (1) the kV source always starts from Lt Lat
and ends at Lt Lat. Gantry rotation gets much slower near the end but dose rate stays constant;
and (2) 10ā—¦ scan overlaps on the Lt Lat side (start and end). In vivo dose measurement also
conļ¬rmed that the peripheral dose at AP, PA and Lt Lat is higher than the central dose by
about āˆ¼40%. The Rt Lat dose is about the same as the central dose.
     The normal tissue integral dose for a total of 42 fractions is in the range of āˆ¼130 (central)
to 200 (skin) cGy. Despite that the daily CBCT dose is only āˆ¼2% of the prescription dose, it
is, however, distributed over the whole scanned volume. Particularly, dose at the left femoral
head can be up to 11 cGy per scan and the total dose can be more than 400 cGy from the
whole treatment course. Adding this dose to the femoral dose received from treatment beams,
which is āˆ¼3400 cGy in our institution, the total dose is still under tolerance. However, the
advantage of CBCT guided RT versus the disadvantage of additional kV dose may need further
investigation, especially if low kV is used in the future. On the other hand, it is not too difļ¬cult
to consider the CBCT dose as a part of the prescription dose. Previously a model-based
treatment planning system was developed for dose computations in the kV energy range using
ADACā€™s Pinnacle system (Alaei et al 2000). It used the Monte Carlo technique to generate
photon energy deposition kernels (Alaei et al 1999). The system was applied for lung dose
calculation with kV x-rays (Alaei et al 2001) and it could be used for the calculation of kV
dose from CBCT.
Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer                              2275

     Varianā€™s current CBCT used a total of 1320 mAs (660 projections, 2 mAs per projection,
125 kV). Compared to the total 660 mAs (330 projections) used in the Synergy system at
120 kV, Varianā€™s CBCT delivers approximately doubled dose. For the Synergy system (Islam
et al 2006), the doses at the centre and the surface for a cylindrical phantom of 30 cm diameter
were 1.6 cGy and 2.3 cGy, respectively, which were about half of our measurement. Also,
the lateral dose asymmetry was not reported for the Synergy system. By evaluating the image
quality versus the number of projections for clinical needs, the number of projections for
Varianā€™s CBCT may be reduced as well despite that the current CBCT used ļ¬xed projection
number and technical settings. Dose reduction strategies like those discussed in Islam et al
(2006) could also be used for Varianā€™s CBCT.


5. Conclusion

Absolute dose measurements have been made for pelvic CBCT scans with ļ¬xed technical and
collimation settings using TLDs. These include skin doses for real patients and surface/in vivo
doses for phantoms. There were two major ļ¬ndings from the measurements: (1) the lateral
dose distribution is not symmetrical, with Lt Lat being āˆ¼40% higher than Rt Lat and (2) AP
skin dose varies with patient size, ranging from 3.2 to 6.1 cGy for patientsā€™ AP separation of
20ā€“33 cm (the larger the separation the less the skin dose), but lateral skin dose depends little
on separation (Lt Lat dose was āˆ¼4.2 cGy and Rt Lat dose was āˆ¼2.6 cGy on average). The
in vivo peripheral doses at AP, PA and Lt Lat areas were higher than the central dose (āˆ¼3 cGy)
by about āˆ¼40% but the Rt Lat dose was about the same as the central dose. The highest
in vivo dose was inside the left hip joint region where the maximum dose can be up to 11 cGy.
The CBCT dose delivered to a pelvic site for a total of 42 fractions can range from āˆ¼130 cGy
to the central tissue, āˆ¼200 cGy to most of the peripheral tissues, and more than āˆ¼400 to the
left hip joint region. The disadvantage of additional kV dose delivered with CBCT is worth
further investigation.


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Dose delivered from varian's cbct to patients receiving imrt for prostate cancer

  • 1. IOP PUBLISHING PHYSICS IN MEDICINE AND BIOLOGY Phys. Med. Biol. 52 (2007) 2267ā€“2276 doi:10.1088/0031-9155/52/8/015 Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer Ning Wen, Huaiqun Guan1 , Rabih Hammoud, Deepak Pradhan, T Nurushev, Shidong Li and Benjamin Movsas Henry Ford Health System, Detroit, MI, USA E-mail: hguan1@hfhs.org Received 17 August 2006, in ļ¬nal form 11 December 2006 Published 2 April 2007 Online at stacks.iop.org/PMB/52/2267 Abstract With the increased use of cone beam CT (CBCT) for daily patient setup, the accumulated dose from CBCT may be signiļ¬cantly higher than that from simulation CT or portal imaging. The objective of this work is to measure the dose from daily pelvic scans with ļ¬xed technical settings and collimations. CBCT scans were acquired in half-fan mode using a half bowtie and x-rays were delivered in pulsed-ļ¬‚uoro mode. The skin doses for seven prostate patients were measured on an IRB-approved protocol. TLD capsules were placed on the patientā€™s skin at the central axis of three beams: AP, left lateral (Lt Lat) and right lateral (Rt Lat). To avoid the ring artefacts centred in the prostate, the treatment couch was dropped 3 cm from the patientā€™s tattoo (central axis). The measured AP skin doses ranged 3ā€“6 cGy for 20ā€“33 cm separation. The larger the patient size the less the AP skin dose. Lateral doses did not change much with patient size. The Lt Lat dose was āˆ¼4.0 cGy, which was āˆ¼40% higher than the Rt Lat dose of āˆ¼2.6 cGy. To verify this dose asymmetry, surface doses on an IMRT QA phantom (oval shaped, 30 cm Ɨ 20 cm) were measured at the same three sites using TLD capsules with 3 cm table-drop. The dose asymmetry was due to: (1) kV source rotation which always starts from the patientā€™s Lt Lat and ends at Lt Lat. Gantry rotation gets much slower near the end of rotation but dose rate stays constant and (2) 370ā—¦ scan rotation (10ā—¦ scan overlap on the Lt Lat side). In vivo doses were measured inside a Rando pelvic heterogeneous phantom using TLDs. The left hip (femoral head and neck) received the highest doses of āˆ¼10ā€“11 cGy while the right hip received āˆ¼6ā€“7 cGy. The surface and in vivo doses were also measured for phantoms at the central-axis setup. The difference was less than āˆ¼12% to the table-drop setup. 1 Address for correspondence: Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48084, USA. 0031-9155/07/082267+10$30.00 Ā© 2007 IOP Publishing Ltd Printed in the UK 2267
  • 2. 2268 N Wen et al 1. Introduction Cone beam CT (CBCT) using the on-board imager (OBI) device installed on linear accelerators (linac) allows three-dimensional (3D) online patient setup and treatment veriļ¬cation for image guided radiation therapy (IGRT). CBCT enables soft tissue imaging providing a major advantage for prostate localization on a daily basis. 2D localization based on pelvic bony landmarks using either OBI or portal imaging is less accurate (Schallenkamp et al 2005). In our institution, a protocol has been implemented to use Varianā€™s CBCT for daily prostate patient setup. Patients were treated to a total of 78 Gy in 42 fractions using the IMRT technique. Further, patients were educated about a bowel regimen to assure an empty rectum prior to simulation and treatments. If the rectum was found not empty (with displacement of prostate initially), the patient was instructed to use the restroom and a second CBCT was acquired prior to treatment. The accumulated total-body dose delivered from CBCT can be much higher than that from simulation CT or EPID. The goal of this study is to measure the daily CBCT dose. The computed tomography dose index (CTDI) that is used to represent the diagnostic CT dose may not be adopted for the speciļ¬cation of CBCT dose (CTDI is even considered less adequate for multi-slice CT scanners (Dixon 2003, Brenner 2005)). The reasons are: (1) the 10 cm long ion chamber used to measure the CTDI for diagnostic CT cannot collect all scatters from the large cone opening of CBCT; (2) the cumulative dose from CBCT may be high and the dose distribution is better measured and added to the treatment dose and (3) CBCT is quite different from diagnostic CT in terms of gantry rotational speed, bowtie design, etc. A measurement of CBCT dose has been recently reported (Islam et al 2006) for Elektaā€™s Synergy system. In that study, patientsā€™ skin dose, phantom surface dose and phantom centre dose (two cylindrical phantoms: 16 and 32 cm diameters) were measured at different technical settings and different ļ¬eld-of-views using MOSFET detectors and a Farmer chamber. In this study, we focused our measurement of Varianā€™s CBCT dose on pelvic sites with ļ¬xed technical and collimator setting. Skin doses for seven prostate patients were measured. TLD capsules were placed on the patientā€™s skin at the central axis of three beams: AP, left lateral (Lt Lat) and right lateral (Rt Lat). In order to avoid the ring artefacts centred at the prostate, the treatment couch was dropped 3 cm from the patientā€™s tattoo (i.e. central axis). The surface doses on an IMRT QA phantom (oval shaped: 20 cm AP and 30 cm Lat dimensions) were then measured to verify the lateral dose asymmetry from patients. A Rando pelvic phantom was used to measure the in vivo dose distributions along the AP and Lat central axis, including the surface doses. Phantom dose measurements were made for both the table-drop (3 cm) and central-axis setups in order to check the difference between the two. The absorbed dose was determined using the data provided by AAPM TG61 and Ma and Seuntjens (1999). 2. Materials and methods 2.1. Varianā€™s OBI system and OBI-based CBCT Varianā€™s on-board imager (OBI) device was installed on a dual energy 21EX linear accelerator (linac). The OBI system consisted of a kV x-ray source (KVS) and an amorphous-silicon (a-Si) ļ¬‚at panel detector (KVD) in addition to the megavoltage electronic portal imaging device (EPID). The KVS and KVD were mounted on linac gantry via two robotically controlled arms, which position the KVS and KVD orthogonal to the treatment beam and retract when they are not in use. The x-ray tube (KVS) has two focal spots: smaller size of 0.4 mm and larger size of 0.8 mm. The x-rays can be delivered in two modes: radiographic mode and pulsed-ļ¬‚uoro
  • 3. Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer 2269 (a) (b) Figure 1. CBCT acquisition mode. (a) Full-fan mode with full bowtie mounted. The KVD is centred with x-ray axis. (b) Half-fan mode with half bowtie mounted. The KVD is shifted to one side. mode. The KVD panel has a detection area of 40 cm (X) Ɨ 30 cm (Y). With the panel set at 150 cm source-to-detector distance (SDD), the maximum superior/inferior coverage is 20 cm at the isocentre plane. OBI-based CBCT was acquired by rotating the linac gantry from 175ā—¦ to 185ā—¦ in the extension mode for a total of 370ā—¦ rotation. The kV source always starts from patientā€™s Lt Lat and ends at Lt Lat resulting in a 10ā—¦ over scan on the Lt Lat side. CBCT has two acquisition modes to offer two different ļ¬eld-of-views: full-fan mode and half-fan mode. Full-fan mode was used to scan sites where the size is less than 24 cm (e.g., brain). KVD is centred in this mode. Half-fan mode was used for sites larger than 24 cm (mostly for body scans) and KVD was shifted to one side to cover more than half the patientā€™s volume. Bowtie ļ¬lters for either mode can be mounted to the KVS to modify the beam proļ¬le for less patient dose. Figure 1 shows a schematic of the two different modes. 2.2. Setup for CBCT dose measurement For all scans, a technical setting of 125 kV, 80 mA and 25 ms was used. X-rays were delivered in pulsed-ļ¬‚uoro mode. CBCT scans were acquired in half-fan mode using a half bowtie. In this mode, the ļ¬‚at panel detector was shifted to one side and the collimators were set at X1 = 5.3 cm and X2 = 24.9 cm. Y1 and Y2 were set both at 6 cm. Note that the maximum Y coverage is 20 cm at the source-to-detector distance (SDD) of 150 cm. 12 cm scan in the longitudinal direction was a good compromise between decreasing scatter and patient coverage for prostate localization. Skin doses for seven prostate patients undergoing daily CBCT were measured. TLD capsules were placed on the patientā€™s tattoo, i.e., the central axis of three beams: AP, left lateral (Lt Lat) and right lateral (Rt Lat). To avoid the ring artefacts centred at the prostate2 , the treatment couch was dropped 3 cm from the patientā€™s tattoo (ļ¬gure 3(a) is the central-axis setup and 3(b) is the table-drop setup. The rings around the central axis in 3(a) moved 3 cm anterior in 3(b)). After the Lt Lat dose was found higher than the Rt Lat dose, we measured the surface doses at the same three sites on an IMRT QA phantom (CIRS model 002H9K, 30 cm Ɨ 20 cm oval shaped) in order to conļ¬rm the asymmetry. The in vivo doses were then measured 2 The thin ring artefacts around the central axis come from the non-uniform response of ļ¬‚at-panel pixel detectors. There is also a large ring artefact of 25 cm in diameter for which the reason is unclear. However, all ring artefacts were much reduced in version 2.0 of CBCT.
  • 4. 2270 N Wen et al Figure 2. The experimental setup for HVL measurement. inside a Rando pelvic phantom by placing TLDs along the AP and Lat central axis; from skin to skin (therefore skin doses were also measured). The absorbed dose was determined using the data provided in AAPM TG61 and Ma and Seuntjens (1999). The skin and in vivo doses were also measured for phantoms under the central-axis setup in order to check the difference to the table-drop setup. Calculation of skin and in vivo doses were described in sections 2.4 and 2.5, respectively. 2.3. The x-ray beam quality K For kV x-rays, the ļ¬rst half value layer (HVL) and kV were used to specify the beam quality. The experimental setup for HVL measurement is shown in ļ¬gure 2. Measurement was performed under the radiographic mode of OBI using a technical setting of 125 kV, 80 mA and 160 ms with a half bowtie. High-purity (99.9%) Al attenuators were used. The Al attenuator was placed 50 cm away from a parallel-plate ion chamber (Keithly model 96035) and the x-ray collimators (blades or diaphragms) were set to 2 cm Ɨ 2 cm to make a narrow beam measurement. The measured HVL at the central axis for a half bowtie was found to be 6.3 mm Al. For the OBI, the collimators (blades) were installed only āˆ¼20 cm from the source, different from the āˆ¼50 cm speciļ¬cation in TG61 for therapeutic kV devices. However, as long as a narrow beam was used, the default collimation setup with OBI should be acceptable. It is important to note that the beam quality near the lateral beam edge can be harder than that at the beam centre because of the higher attenuation by the half bowtie. Also, the beam spectrum near the superior/inferior beam edge is somewhat different from that at beam centre (Bhat et al 1999). We ignore these differences in this study. 2.4. The skin (surface) dose measurement TLDs were used previously for the entrance surface dose (Omrane et al 2003) and the backscatter factor (BSF) (Coudin and Marinello 1998) measurement of kV beams. In this study, LiF TLDs were calibrated against the Keithley parallel-plate ion chamber (model 96035) under the 125 kV x-rays with half-fan bowtie. First, TLDs of the same batch were indexed and placed around the circle of the cylindrical sensitive volume on the surface of the parallel chamber. The sensitivity of each individual TLD was the ratio of the TLD reading to the average reading of all TLDs. Then TLDs having similar sensitivities were grouped and placed in capsules for skin dose measurement. The parallel-plate ion chamber was calibrated in an accredited dosimetry calibration laboratory (ADCL) using a 120 kV, HVL-4.15 mm Al beam
  • 5. Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer 2271 and the air-kerma calibration factor Nk = 2.08 Ɨ 106 Gy Cāˆ’1. The chamberā€™s energy response varies <4% in a broad energy range of 20ā€“150 kV. The dose on the patientā€™s skin can be derived as: skin ĀÆ Āµen Dskin = DTLD Ļ TLD air skin RTLD āˆ’ RBG ĀÆ Āµen = DTLD-Cali RTLD-Cali āˆ’ RBG Ļ TLD air TLD skin RTLD āˆ’ RBG ĀÆ Āµen ĀÆ Āµen = Dair RTLD-Cali āˆ’ RBG Ļ air Ļ TLD air air TLD skin RTLD āˆ’ RBG ĀÆ Āµen ĀÆ Āµen = MNk RTLD-Cali āˆ’ RBG Ļ air Ļ TLD air air skin RTLD āˆ’ RBG ĀÆ Āµen = MNk (1) RTLD-Cali āˆ’ RBG Ļ air air where M is the free-in-air parallel chamber reading after the temperature, pressure, polarity, ion-recombination and electrometer corrections; RTLD-Cali is the TLD reading from the calibration and RTLD is the TLD reading from the skin dose measurement; and RBG is the background reading of TLD. (Āµen /Ļ)skin is the ratio of mass energy absorption coefļ¬cient of ĀÆ air skin to air, averaged in free-air medium and it can be quoted from Ma and Seuntjens (1999, table 2). Note that TLDsā€™ over-response (āˆ¼15ā€“20%) to kV x-rays was not involved here because the effect was cancelled. In this study, skin doses for seven prostate patients were measured and multiple measurements were made for each patient. Both the average dose and per cent standard deviation (%SD) were calculated for each patient. As noted before, the patientā€™s skin dose was only measured under the table-drop (3 cm) setup. Similarly, the surface dose on phantoms can be derived as surface RTLD āˆ’ RBG ĀÆ Āµen Dskin = MNk . (2) RTLD-Cali āˆ’ RBG Ļ air air The IMRT QA phantom is manufactured from proprietary materials that fully mimic water with 1% accuracy from 50 keV to 50 MeV and therefore (Āµen /Ļ)water is used. The Rando ĀÆ air phantomā€™s soft tissue was made of a proprietary urethane formulation with an effective atomic number and mass density that closely simulates muscle tissue with randomly distributed fat. The (Āµen /Ļ)muscle (Ma and Seuntjens (1999), table 2) was used for dose calculation. ĀÆ air Note that the surface dose is contributed by both the incident and transmitted projections. The transmitted x-rays are harder in beam quality but the effect can be negligible because (Āµen /Ļ)muscle in free-air varies <2% for all beams with HVL < 10.0 mm Al (Ma and Seuntjens ĀÆ air (1999), table 2, by multiplying the water/air and muscle/water ratio data). For the 30.2 cm Ɨ 12.0 cm half-fan projection (366 cm2), the (Āµen /Ļ)muscle ratio is only 0.2% less than the ĀÆ air standard 10 cm Ɨ 10 cm data (Ma and Seuntjens (1999), ļ¬gure 6). The surface doses were measured seven times for the IMRT QA phantom and four times for the Rando phantom. Measurements were made for both the table-drop (3 cm) and central-axis setups. 2.5. The in vivo dose measurement In vivo doses were measured inside the Rando pelvic phantom using TLDs. The slab at which TLDs were placed has both bone and muscle-equivalent materials. TLDs were placed along
  • 6. 2272 N Wen et al Figure 3. Dose distributions along the AP and Lat central axis in the Rando pelvic phantom for (a) the central-axis (CA) and (b) the table-drop (TD) setups. The thin ring artefacts around the central axis in (a) were moved 3 cm anterior in (b). the AP and Lat central-axis lines, as shown in ļ¬gure 3(a) for central-axis setup and (b) for table-drop setup. One TLD per location and four measurements were made for each setup for improved dose statistics. Two or three TLD cubes were placed inside the femoral head to measure the dose to bone. Individual TLDsā€™ responses were documented. The in vivo doses inside the Rando phantom can be derived similarly as for equation (1), but the (Āµen /Ļ) ratio was in muscle (or bone media) but not in air. ĀÆ TLD muscle RTLD āˆ’ RBG ĀÆ Āµen ĀÆ Āµen Dmuscle = MNk . (3) RTLD-Cali āˆ’ RBG Ļ air Ļ TLD air muscle The (Āµen /Ļ)TLD in free-air and in muscle (water-equivalent) cannot cancel each other. ĀÆ air However, the (Āµen /Ļ)water in air and water is less than 2% per TG61 and Ma and Seuntjens ĀÆ air (1999, tables 2 and 3). Taking this āˆ¼2% difference for TLD which is nearly water-equivalent at 125 kV, the ļ¬nal dose calculation can be simpliļ¬ed to muscle RTLD āˆ’ RBG ĀÆ Āµen Dtissue = MNk . (4) RTLD-Cali āˆ’ RBG Ļ air air or water We used the (Āµen /Ļ)muscle averaged in free-air and in water media for calculation. ĀÆ air Similarly, the absorbed dose inside bone was bone RTLD āˆ’ RBG ĀÆ Āµen Dtissue = MNk (5) RTLD-Cali āˆ’ RBG Ļ air air or water where (Āµen /Ļ)bone = (Āµen /Ļ)bone (Āµen /Ļ)water . From Ma and Seuntjens (1999, tables 2 ĀÆ air ĀÆ water ĀÆ air and 3), (Āµen /Ļ)bone in free-air and water for a 6.3 mm HVL beam can be āˆ¼5% different ĀÆ water by interpolating the data of 4.76 and 9.17 mm Al HVL. Again the average (Āµen /Ļ)bone ĀÆ air in free-air and water media was used for calculation. Also the beam quality at any TLD location can be different from that used for TLD calibration in air. The (Āµen /Ļ)bone at 15 cm ĀÆ water depth of water was 0.93 for 100 kV and 0.99 for 150 kV. We expect the ratio for 125 kV to be 0.96. The (Āµen /Ļ) ratio is little SSD dependent but it is ļ¬eld size dependent ĀÆ (Ma and Seuntjens 1999) for bone to water. For the half-fan ļ¬eld size of 12 cm Ɨ 30.2 cm, the (Āµen /Ļ)bone is āˆ¼2% higher than that of the standard 10 cm Ɨ 10 cm ļ¬eld. ĀÆ water
  • 7. Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer 2273 Table 1. AP and Lat skin doses for patients (table-drop setup). Patient separation AP dose Rt Lat dose Lt Lat dose Total TLDs AP Lateral Average Average Average Patient trials each trial (cm) (cm) (cGy) %SD (cGy) %SD (cGy) %SD A 4 20 32.65 40.24 3.22 5.51% 2.68 8.75% 3.94 9.10% B 5 20 27.18 40.07 4.54 7.75% 2.55 11.27% 4.12 8.52% C 3 20 25.46 38.56 4.29 6.77% 2.54 6.23% N/A D 5 20 23.74 37.28 4.10 8.73% 2.39 3.46% 3.49 6.25% E 6 20 22.77 34.91 5.05 8.93% 2.51 5.95% 4.25 3.77% F 6 20 21.7 36.04 6.02 3.78% 2.34 7.06% N/A G 7 20 20.48 34.16 6.06 10.82% 2.78 16.78% N/A kV dose measurements (using MOSFET detectors) inside a phantom consisting of soft tissue, bone and lung-equivalent materials have been reported (Jones et al 2005). Based on the study, dose calculation inside bones using the free-in-air (Āµen /Ļ)bone provides āˆ¼ Ā±10% ĀÆ air accuracy (based on the error bars) comparing to the Monte Carlo simulation. Considering TLDs have less energy response than MOSFET detectors, we expect that the inaccuracy of bone dose calculation due to the approximation in equation (5) was better than 10%. 3. Results 3.1. Skin dose on patients (table-drop setup) Table 1 shows the average skin doses and the per cent standard deviations (%SD) at AP, Rt Lat and Lt Lat for patients of different sizes. The number of measurements (trials) was also given for each patient. AP doses strongly depend on patientsā€™ separation, ranging from 3.2 cGy for 32.7 cm to 6.1 cGy for 20.5 cm. Lat doses had little dependence on patientsā€™ separation. Rt Lat dose was 2ā€“3 cGy, which was lower than the Lt Lat dose of 3.5ā€“4 cGy by about āˆ¼40%. The standard deviations range from 3.5% to 17% for all data. The fact that large patients received smaller AP doses is due to the decrease of transmission from posterior and posterior oblique projections, despite that large patients actually received more skin doses from anterior and anterior oblique projections (because of the shorter source- to-skin distances, or SSD). For the three patients with AP separations 23.74 cm, 25.46 cm and 27.18 cm, AP doses were actually increased a few per cent with increased separation. This means that the increased entrance doses from anterior projections outweigh the decreased transmission from posterior projections. For very thin (<22 cm) patients, the increased transmission outweighs the decreased entrance dose. 3.2. Surface dose on phantoms Table 2 ļ¬rst shows the surface doses and per cent standard deviations (%SD) at the same three sites on the IMRT QA phantom for both the central-axis (CA) and table-drop (TD) setups. For this exactly symmetrical phantom, Lt Lat doses were measured to be āˆ¼40ā€“50% higher than the Rt Lat doses. Comparing the table-drop setup to the central-axis setup, AP dose was increased a few per cent but Lt Lat and Rt Lat doses were each decreased by a few per cent. The surface doses on the Rando pelvic phantom at the same three sites were also measured (at the time for in vivo dose measurement) and shown on the second row of table 2. With table-drop, AP dose
  • 8. 2274 N Wen et al Table 2. Phantom surface doses from the central-axis (CA) and table-drop (TD) setups. CA (SAD = 100 cm) (cGy) TD (SAD = 103 cm) (cGy) Sep. (cm) AP Lt Lat Rt Lat AP Lt Lat Rt Lat Num. TLDs Phantom trials per trial AP Lat Ave %SD Ave %SD Ave %SD Ave %SD Ave %SD Ave %SD IMRT 7 25 20 30 4.73 5.71 4.52 4.23 3.00 5.35 5.12 4.31 4.13 2.89 2.77 2.92 Rando 4 25 20 33 4.91 4.83 4.21 3.65 2.61 3.47 5.73 3.89 4.30 4.03 2.83 3.66 is also increased in this case (possibly because more side projections become incident rather than transmitted, which offset the dose decrement from the larger anterior SSD) but the Lt Lat and Rt Lat doses change little. 3.3. In vivo dose in phantom The in vivo doses measured inside the Rando pelvic phantom using TLDs, along the AP and Lat central axis (tattoo) were shown in ļ¬gure 3 for (a) the central-axis and (b) the table-drop setups. The results were the average of all four measurements for each setup. Again, the tissue and bone doses on the left side were higher than those on the right side. The anterior part of the phantom also received higher doses with table-drop than with the central-axis setup. Doses at the AP, PA and Lt Lat peripheral area (except at the Rt Lat where the dose is about the same as the central dose āˆ¼3 cGy) were āˆ¼40ā€“50% higher than at the central. The left femoral bone received the highest doses of 10ā€“11 cGy while the right one received āˆ¼6ā€“7 cGy. 4. Discussion Additional measurements were made in half-fan or full-fan scan, with or without bowtie, central-axis or table-drop setup and all conļ¬rmed that the Lt Lat dose was higher than the Rt Lat dose. This dose asymmetry was found because: (1) the kV source always starts from Lt Lat and ends at Lt Lat. Gantry rotation gets much slower near the end but dose rate stays constant; and (2) 10ā—¦ scan overlaps on the Lt Lat side (start and end). In vivo dose measurement also conļ¬rmed that the peripheral dose at AP, PA and Lt Lat is higher than the central dose by about āˆ¼40%. The Rt Lat dose is about the same as the central dose. The normal tissue integral dose for a total of 42 fractions is in the range of āˆ¼130 (central) to 200 (skin) cGy. Despite that the daily CBCT dose is only āˆ¼2% of the prescription dose, it is, however, distributed over the whole scanned volume. Particularly, dose at the left femoral head can be up to 11 cGy per scan and the total dose can be more than 400 cGy from the whole treatment course. Adding this dose to the femoral dose received from treatment beams, which is āˆ¼3400 cGy in our institution, the total dose is still under tolerance. However, the advantage of CBCT guided RT versus the disadvantage of additional kV dose may need further investigation, especially if low kV is used in the future. On the other hand, it is not too difļ¬cult to consider the CBCT dose as a part of the prescription dose. Previously a model-based treatment planning system was developed for dose computations in the kV energy range using ADACā€™s Pinnacle system (Alaei et al 2000). It used the Monte Carlo technique to generate photon energy deposition kernels (Alaei et al 1999). The system was applied for lung dose calculation with kV x-rays (Alaei et al 2001) and it could be used for the calculation of kV dose from CBCT.
  • 9. Dose delivered from Varianā€™s CBCT to patients receiving IMRT for prostate cancer 2275 Varianā€™s current CBCT used a total of 1320 mAs (660 projections, 2 mAs per projection, 125 kV). Compared to the total 660 mAs (330 projections) used in the Synergy system at 120 kV, Varianā€™s CBCT delivers approximately doubled dose. For the Synergy system (Islam et al 2006), the doses at the centre and the surface for a cylindrical phantom of 30 cm diameter were 1.6 cGy and 2.3 cGy, respectively, which were about half of our measurement. Also, the lateral dose asymmetry was not reported for the Synergy system. By evaluating the image quality versus the number of projections for clinical needs, the number of projections for Varianā€™s CBCT may be reduced as well despite that the current CBCT used ļ¬xed projection number and technical settings. Dose reduction strategies like those discussed in Islam et al (2006) could also be used for Varianā€™s CBCT. 5. Conclusion Absolute dose measurements have been made for pelvic CBCT scans with ļ¬xed technical and collimation settings using TLDs. These include skin doses for real patients and surface/in vivo doses for phantoms. There were two major ļ¬ndings from the measurements: (1) the lateral dose distribution is not symmetrical, with Lt Lat being āˆ¼40% higher than Rt Lat and (2) AP skin dose varies with patient size, ranging from 3.2 to 6.1 cGy for patientsā€™ AP separation of 20ā€“33 cm (the larger the separation the less the skin dose), but lateral skin dose depends little on separation (Lt Lat dose was āˆ¼4.2 cGy and Rt Lat dose was āˆ¼2.6 cGy on average). The in vivo peripheral doses at AP, PA and Lt Lat areas were higher than the central dose (āˆ¼3 cGy) by about āˆ¼40% but the Rt Lat dose was about the same as the central dose. The highest in vivo dose was inside the left hip joint region where the maximum dose can be up to 11 cGy. The CBCT dose delivered to a pelvic site for a total of 42 fractions can range from āˆ¼130 cGy to the central tissue, āˆ¼200 cGy to most of the peripheral tissues, and more than āˆ¼400 to the left hip joint region. The disadvantage of additional kV dose delivered with CBCT is worth further investigation. References Alaei P, Gerbi B J and Geise R A 1999 Generation and use of photon energy deposition kernels for diagnostic quality x-rays Med. Phys. 26 1687ā€“97 Alaei P, Gerbi B J and Geise R A 2000 Evaluation of a model-based treatment planning system for dose computations in the kilovoltage energy range Med. Phys. 27 2821ā€“6 Alaei P, Gerbi B J and Geise R A 2001 Lung dose calculations at kilovoltage x-ray energies using a model-based treatment planning system Med. Phys. 28 194ā€“8 Bhat M, Pattison J, Bibbo G and Caon M 1999 Off-axis x-ray spectra: a comparison of Monte Carlo simulated and computed x-ray spectra with measured spectra Med. Phys. 26 303ā€“9 Brenner D J 2005 Is it time to retire the CTDI for CT quality assurance and dose optimization? Med. Phys. 32 3225ā€“6 Coudin D and Marinello Ginette 1998 Lithium borate TLD for determining the backscatter factors for low-energy x-rays: Comparison with chamber-based and Monte Carlo derived values Med. Phys. 25 347ā€“53 Dixon R L 2003 A new look at CT dose measurement: beyond C T DI Med. Phys. 30 1272ā€“80 Ioppolo J L, Price R I, Tuchyna T and Buckley C E 2002 Diagnostic x-ray dosimetry using Monte Carlo simulation Phys. Med. Biol. 47 1707ā€“20 Islam M K, Purdie T G, Norrlinger B D, Alasti H, Moseley D J, Sharpe M B, Siewerdsen J H and Jaffray D A 2006 Patient dose from kilovoltage cone beam computed tomography imaging in radiation therapy Med. Phys. 33 1573ā€“82 Jones A K, Pazik F D, Hintenlang D E and Bolck W E 2005 MOSFET dosimeter depth-dose measurements in heterogeneous tissue-equivalent phantoms at diagnostic x-ray energies Med. Phys. 32 3209ā€“13 Ma C-M, Coffey C W, DeWerd L A, Liu C, Nath R, Seltzer S M and Seuntjens J P 2001 AAPM protocol for 40ā€“300 kV x-ray beam dosimetry in radiotherapy and radiobiology Med. Phys. 28 868ā€“93
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