William E. Lewis Jr has given these tips for individuals to improve their credit score. The credit score changes continuously as new information is added to the credit report or while you handle credit in a more and less responsive manner.
Preparing for Early Stage Financing - Pedley, Millin & Gordinier - June 11, 2013almillin
Presentation from a June 11, 2013 workshop titled “Preparing for Early Stage Financing”. Topics covered include:
1. Creating a compelling investor package and preparing for investor presentations
2. Evaluating the sources of financing and legal structures for each stage of a company’s lifecycle
3. Negotiating a term sheet – a deep dive into the key legal provisions and their impact
4. Understanding the different set of documents that comprise the “Definitive Documentation”
5. Preparing for the due diligence process
6. Complying with federal and state regulatory requirements
William E. Lewis Jr has given these tips for individuals to improve their credit score. The credit score changes continuously as new information is added to the credit report or while you handle credit in a more and less responsive manner.
Preparing for Early Stage Financing - Pedley, Millin & Gordinier - June 11, 2013almillin
Presentation from a June 11, 2013 workshop titled “Preparing for Early Stage Financing”. Topics covered include:
1. Creating a compelling investor package and preparing for investor presentations
2. Evaluating the sources of financing and legal structures for each stage of a company’s lifecycle
3. Negotiating a term sheet – a deep dive into the key legal provisions and their impact
4. Understanding the different set of documents that comprise the “Definitive Documentation”
5. Preparing for the due diligence process
6. Complying with federal and state regulatory requirements
http://www.temizlik-malzemeleri.gen.tr - Temizlik Malzemeleri
emizlik sarf malzemeleri, temizlik işlerinde kullanılan sarf ürünlerinin genel grubudur. Temizlik sarf malzemeleri grubunda temizlik bezleri, cam bezleri, ıslak ve nemli mop ürünleri, yer temizlik ekipmanları, cam temizlik ekipmanları, mikrofiber ürünler, fırçalar, yer pedleri, teleskopik saplar, bulaşık eldivenleri ve bulaşık süngerleri gibi ürünler bulunmaktadır. Temizlik sarf malzemeleri, temizlik işlemlerinde kullanılan yardımcı malzeme grubudur.
I had the great opportunity to conduct a 2 hours seminar for a first year marketing class in Polytechnic University of Marche, San Benedetto del Tronto’s branch.
The lesson touched upon digital marketing basic concepts as well as more advanced ones, providing also my students with a social media strategy sample plan . Even if they were at their first class in marketing topics, from the interest and participation showed during the lesson I am really sure they will continue their studies on those topics.
I strongly wish to keep in touch with them all . #smssbt
Main topics :
- Inbound and outbound marketing
- Content and viral marketing
- Social media strategy
- Social Media Plan
Saying "Thanks!" Instead of Asking "Please?" Jann Schultz
Presented by Jann Schultz, AVP Donor Services, Operation Smile and Stacey Baxter, USA Retention and Engagement Director, Compassion International, July 2013. Two organizations with very different acquisition strategies review the results of their welcome and acknowledgement programs, sharing how thanking donors on a regular basis and expressing gratitude without an ask for a gift is an important piece of the donor relationship puzzle.
RNIB - integrating across channel and function. Integration: breaking down th...CharityComms
Natasha Dickinson, group head of marketing and communications, RNIB
Visit the CharityComms website to view slides from past events, see what events we have coming up and to check out what else we do: www.charitycomms.org.uk
http://www.temizlik-malzemeleri.gen.tr - Temizlik Malzemeleri
emizlik sarf malzemeleri, temizlik işlerinde kullanılan sarf ürünlerinin genel grubudur. Temizlik sarf malzemeleri grubunda temizlik bezleri, cam bezleri, ıslak ve nemli mop ürünleri, yer temizlik ekipmanları, cam temizlik ekipmanları, mikrofiber ürünler, fırçalar, yer pedleri, teleskopik saplar, bulaşık eldivenleri ve bulaşık süngerleri gibi ürünler bulunmaktadır. Temizlik sarf malzemeleri, temizlik işlemlerinde kullanılan yardımcı malzeme grubudur.
I had the great opportunity to conduct a 2 hours seminar for a first year marketing class in Polytechnic University of Marche, San Benedetto del Tronto’s branch.
The lesson touched upon digital marketing basic concepts as well as more advanced ones, providing also my students with a social media strategy sample plan . Even if they were at their first class in marketing topics, from the interest and participation showed during the lesson I am really sure they will continue their studies on those topics.
I strongly wish to keep in touch with them all . #smssbt
Main topics :
- Inbound and outbound marketing
- Content and viral marketing
- Social media strategy
- Social Media Plan
Saying "Thanks!" Instead of Asking "Please?" Jann Schultz
Presented by Jann Schultz, AVP Donor Services, Operation Smile and Stacey Baxter, USA Retention and Engagement Director, Compassion International, July 2013. Two organizations with very different acquisition strategies review the results of their welcome and acknowledgement programs, sharing how thanking donors on a regular basis and expressing gratitude without an ask for a gift is an important piece of the donor relationship puzzle.
RNIB - integrating across channel and function. Integration: breaking down th...CharityComms
Natasha Dickinson, group head of marketing and communications, RNIB
Visit the CharityComms website to view slides from past events, see what events we have coming up and to check out what else we do: www.charitycomms.org.uk
This publication is a collaborative effort of the Waterloo-Wellington LEAVE A LEGACY™, a program of the Canadian Association of Gift Planners (CAGP-ACPDP™), to provide valuable information to the readers on planned gifting and charitable giving.
Science of Giving - Shift Philanthropy WebinarBrady Josephson
Giving is powerful. But it's also complex. This presentation looks at some of the stats of the philanthropic sector as well as some science behind giving, fundraising, and marketing for causes. Also includes some live poll results.
Virtual Volunteering - Volunteer From Your HomeCicely Majeed
Gain some insight on what virtual volunteering is like and also prepare for any type of volunteering or community service you are interested in or required to participate in.
How altruistic and social pressure motivation drive giving by the wealthy in the United States and the Netherlands - ISTR Conference, Stockholm, Sweden.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Do donors raise their donation when they are aware of decreasing government subsidies?
1. Do donors raise their donations when they are
aware of decreasing government subsidies?
A survey experiment
Arjen de Wit & René Bekkers
7th
ERNOP Conference
July 9, 2015, Paris, France
2. In a perfectly altruistic world...
Do people value certain public goods in society
Do people see where others spend their money
on
Do people donate to public goods that are not
funded by others
4. However...
People often do not know how much subsidies an
organisation receives
And if they know, they do not change their
donations
(Horne et al. 2005)
5. Previous findings
Laboratory experiments typically find partial
crowding-out
But findings with administrative or survey data
are inconclusive
(De Wit & Bekkers 2013)
7. The current project
What if people know about actual subsidy
change?
Survey experiment
Giving in the Netherlands Panel Survey 2014
CAWI
N = 1,271
8. Experimental design
After filling out the survey, respondents get a
reward in points
They can spend their reward (partly) on a
personal voucher or (partly) on a charitable
organisation
9. Experimental design
No information:
'The Dutch charities are in need of your support.'
Information:
'The Dutch charities are in need of your support. KWF
Kankerbestrijding, for example, received € 361,000 on
government subsidies in 2011 but received no subsidies in
2012.'
10. Experimental design
No information:
'The Dutch charities are in need of your support.'
Information:
'The Dutch charities are in need of your support. KWF
Kankerbestrijding, for example, received € 361,000 on
government subsidies in 2011 but received no subsidies in
2012.'
Manipulation check:
'What do you think, did KWF Kankerbestrijding receive more,
an equal amount of, or less government susbidies in 2012
compared with 2011?'
11. Providing information on cuts does not
substantially increase number of donors
No information Information
0
2
4
6
8
10
12
14
Average
Believes that subsidy has
decreased
Believes that subsidy has
increased or has not changed
%
12. Providing information on cuts does not
substantially increase number of donors
No information Information
0
2
4
6
8
10
12
14
Average
Believes that subsidy has
decreased
Believes that subsidy has
increased or has not changed
%
13. ...nor does it increase the number of
points donated
No information Information
0
5
10
15
20
25
Average
Believes that subsidy has
decreased
Believes that subsidy has
increased or has not changed
Points
14. ...nor does it increase the number of
points donated
No information Information
0
5
10
15
20
25
Average
Believes that subsidy has
decreased
Believes that subsidy has
increased or has not changed
Points
*
*
or does it?
15. Who would be more sensitive to
information?
People who are more committed to the public
good
In this case, people who are KWF donors
16. Effect not stronger among KWF donors
No information Information
0
2
4
6
8
10
12
Non-donors
Donors
%
17. Effect not stronger among KWF donors
No information Information
0
2
4
6
8
10
12
14
16
18
Non-donors
Donors
Points
18. What if...
After decision and manipulation check:
'Imagine that you would have heard that KWF
Kankerbestrijding had received [less/an equal amount
of/more] subsidies in 2012 than in 2011. What would you
have done with your reward?'
19. Some people who did not receive
information earlier may start donating...
Imagine: decrease
Imagine: no change/increase
0
2
4
6
8
10
12
14
Actual decision
Hypothetical decision
%
20. ...but no difference in points donated
Imagine: decrease
Imagine: no change/increase
0
2
4
6
8
10
12
14
16
Actual decision
Hypothetical decision
Points
21. Three innovations
Role of information tested in novel research
design
Tested among different groups (donors vs. non-
donors) in survey experiment
Actual and hypothetical decision
22. Summing up
When provided with information about subsidy
decrease, people do not donate (more)
Effect not stronger among donors
No different effect for hypothetical situations of
changing government subsidies
23. Summing up
When provided with information about subsidy
decrease, people do not donate (more)
Effect not stronger among donors
No different effect for hypothetical situations of
changing government subsidies
Important null findings
24. What about the altruistic world?
Even if people know about a change in
government funding they are reluctant to change
donations
Previous beliefs and preferences seem to matter
more than new information
25. Thank you
Arjen de Wit
René Bekkers
Center for Philanthropic Studies
VU University Amsterdam