This document discusses early onset scoliosis (EOS) and various treatment options. EOS is defined as scoliosis beginning before age 5 or 10. Treatment options include observation, bracing, casting, growing rods, VEPTER, and fusion surgery. Growing rods and VEPTER involve periodic lengthening to allow continued spine and lung growth while correcting the curvature. Magenetically controlled growing rods are a newer option that can be lengthened in the office without surgery. Both have benefits but also risks like infection and premature fusion. The goals are to improve spine and lung development while avoiding early fusion when possible for EOS patients.
Complex Fractures and Instability of the Elbow joint: Advances in Mechanism and Pathophysiology, Injury paterns, Treatment principals and Results are discussed in this presentation.
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Guided Growth for Angular Knee Deformities in Nutritional Rickets ChildrenTamer El-Sobky
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Nutritional rickets in children is a global health concern. It manifests in generalized skeletal deformities including angular or coronal plane knee deformities. Guided growth surgery is a recognized treatment option for angular knee deformities in general. However, there is insufficient citations on its use in the treatment of angular knee deformities in children with nutritional rickets. Rachitic lower limb deformities can be complex. They are usually multiostotic, multiapex and multiplane and require extensive corrective osteotomies. However osteotomies are fraught with complications and can be technically demanding. In this presentation we present our experience with the use of surgical guided growth as a minimally invasive treatment option to correct angular knee deformities in children with nutritional rickets.
Total elbow arthroplasty for distal humerus fractures provided similar outcom...BipulBorthakur
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Total elbow arthroplasty for distal humerus fractures provided similar outcomes when performed as a primary procedure or after failed internal fixation by Dr Bipul Borthakur
A spinal fusion surgery is a procedure that is used to join two or more vertebrae together. Spinal Fusion Surgery India has a high success rate and you can be one of the many people who recover from a serious illness and live a long and happy life.
Neck of femur and Distal end radius fracture case... evidence based #dr_azankiAbdallah El-Azanki
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a 46 years old patient with ipsilateral neck femur and distal end radius fracture, the aim of this lecture is to highlight the deficit of evidence base or literature for such combined cases and to stimulate orthopedic surgeons in reporting how did they manage their cases.
#dr_azanki
Complex Fractures and Instability of the Elbow joint: Advances in Mechanism and Pathophysiology, Injury paterns, Treatment principals and Results are discussed in this presentation.
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Guided Growth for Angular Knee Deformities in Nutritional Rickets ChildrenTamer El-Sobky
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Nutritional rickets in children is a global health concern. It manifests in generalized skeletal deformities including angular or coronal plane knee deformities. Guided growth surgery is a recognized treatment option for angular knee deformities in general. However, there is insufficient citations on its use in the treatment of angular knee deformities in children with nutritional rickets. Rachitic lower limb deformities can be complex. They are usually multiostotic, multiapex and multiplane and require extensive corrective osteotomies. However osteotomies are fraught with complications and can be technically demanding. In this presentation we present our experience with the use of surgical guided growth as a minimally invasive treatment option to correct angular knee deformities in children with nutritional rickets.
Total elbow arthroplasty for distal humerus fractures provided similar outcom...BipulBorthakur
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Total elbow arthroplasty for distal humerus fractures provided similar outcomes when performed as a primary procedure or after failed internal fixation by Dr Bipul Borthakur
A spinal fusion surgery is a procedure that is used to join two or more vertebrae together. Spinal Fusion Surgery India has a high success rate and you can be one of the many people who recover from a serious illness and live a long and happy life.
Neck of femur and Distal end radius fracture case... evidence based #dr_azankiAbdallah El-Azanki
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a 46 years old patient with ipsilateral neck femur and distal end radius fracture, the aim of this lecture is to highlight the deficit of evidence base or literature for such combined cases and to stimulate orthopedic surgeons in reporting how did they manage their cases.
#dr_azanki
congenital pseudoarthrosis of tibia or anterolateral bowing of tibia is cause of major morbidity in children with no definitive or curative management.
Holistic concept in treatment of Cerebral Palsy jitendra jain
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it is very difficult to manage cerebral palsy because we cant repair brain damage but we can give good quality of independent life by combination good rehabilitation tool which include advance therapeutic technique, botulinum toxin early age child and SEMLOSSS surgical concept in others. Our aim of management is to take these person to their highest capability and decrease their physical limitation as much as possible. This ppt have brief review about latest concept in mx of cerebral aplsy
Tensor fascia lata[tfl] muscle pedicle grafting for avn hip dr mohamed ashraf...drashraf369
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slide presentation of a very promising surgical technic for a very elusive condition called avascular necrosis of femoral head.good clinical and surgical demo by dr mohamed ashraf,HOD, govt TD medical college ,alleppey,kerala, india
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganongâs Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganongâs Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
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June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMENâS HEALTH: FERTILITY PRESERVATION
- WHATâS NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
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Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
4. Early onset scoliosis (EOS)
ď It is defined as scoliosis that starts before
the age of 5th year.
ď Some other scientists defined EOS as
scoliosis that starts before the age of 10th
years, regardless the cause of the
deformity.
4
5. 5
Allows spine growth and lung
development
EOS is different from late onset
scoliosis
6.
7.
8. Cause of EOS
Congenital
Failure of formation
Failure of segmentation
Mixed
Neuromuscular
Syndromic
e.g. Marfanâs or Morquios
syndromes
Idiopathic
unclassified
10. Treatment options of EOS
ď Standard conservative interventions that include:
⢠Observation
⢠Physical therapy
⢠Bracing
⢠Casting
ďź These options are rarely curative and only indicated:
o In mild curves
o To delay early surgery
11. Surgical management of EOS
2-Non-fusion surgery
Results in negative pulmonary
consequences and most
surgeons now use fusion as the
last resort for EOS.
1-Fusion surgery
12. 2-Non-fusion surgery
Distraction based
Growing rods
(spine based)
VEPTR
(rib based )
Magnetically controlled
growing rods
Guided growth
Luque-trolley
Shilla technique
Tension based
Tether
Staples
13. Advantages of non-Fusion options
⢠When fusion is used the curve of the spine is
improved but growth stops
⢠Fusionless treatments are important for children
especially those under 10
⢠Children under 5 still have up to 12.5 cm of vertical
growth
⢠Lungs do not fully develop till about 8 years old
⢠Fusion does work for patients who are fully grown
14. Common non fusion methods
Growing rods
⢠Traditional
growing rods
⢠Magnetically
controlled
growing rods
VEPTER
⢠Directly treats
TIS
⢠Indirectly
treats EOS
Tethering
⢠Depends on
epiphysiodesis
of the convex
side
Shila technique
ď All techniques have their limitations and complications including:
⢠Rod breakage
⢠Infection
⢠Skin problems due to protruding hardware
⢠Premature fusion
15. Growing Rods
⢠It was first popularized in 1984 (Moe et al., 1984).
⢠Since then many generations were popularized:
o The rods are implanted at the index surgery
o Initial lengthening is done.
o May obtain up to 50% correction of the curve.
⢠This is followed by repeated lengthening every 6 months till
reaching near maturity where definitive fusion can be done
safely.
15
16. ď Growing rods may be:
⢠Spine to spine
⢠Pelvis to spine
⢠Spine to ribs
⢠Pelvis to rib
Either of these may be magnetically controlled or Tradional
growing rods.
16
17. Growing rods
Indication for growing rods include
- Significant axial spine growth potential
remaining
- Progressive deformity more than 50°
- Spinal deformity that is flexible or can be
made flexible after a limited anterior release
18. Growing rods
-The rods are implanted at the index surgery
and initial lengthening is done which may
obtain up to 50% correction of the curve
-This is followed by repeated lengthening every
6 months till reaching near maturity where
definitive fusion can be done safely
19. Pros and Con of Dual Growing Rod
⢠One of the most efficient
ways of treating EOS
⢠Opens up the thorax
preventing many future
pulmonary issues
⢠Continues to allow for
growth
⢠Each patient must receive
an invasive surgery every
six months for a span of a
few years (usually till age
10 for girls and age 13 for
boys)
⢠This leads to more
opportunities to contract
some kind of infection
⢠Very physically and
psychologically grueling
advantages disadvantages
20.
21.
22. Magnetically controlled growing
rod
This is a newly developed technique the idea
of which depends on
-The (interaction between the internal
implant magnets and external remote
control )
-As other growing rods lengthening is done
periodically
23. Magnetically Controlled Growing Rods
(MCRG)
⢠Attached in basically the same way as the dual
growing rods
⢠Lengthened during quick follow-ups in the office
without any invasive surgery every 3-4 months
⢠This allows for the curve to be managed until their
skeletal structure has matured enough for spinal
fusion
⢠The EOS is then tracked using radiographs
[6]
24.
25. MCGR
⢠This technique is new in the United States so
not many hospitals are doing it
⢠The first one was completed in Washington DC
on a ten year old boy
⢠The requirements are a skeletal age of 10
years old or younger and a Cobb angle of 50
degrees or greater
⢠Approved by the FDA in February of 2014
26.
27.
28. Which is better
Many studies compared the effectiveness of
both traditional and magnetic rods
29. Multicenter comparative study results
Major Curve Correction
⢠Very similar with MCGR and TRG patients
⢠Overall it was 32% and 33%
Spinal Height(T1-S1)
⢠MCGR- 8.1mm/year
⢠TGR- 9.7mm/year
⢠This is not considered significantly different
Thoracic Height(T1-T12)
⢠Increase 1.5cm/year in MCGR
⢠Increase 1.9cm/year in TRG
30. Discussion
MCGR âno proper sagittal plane to contouring
because of the actuatorâs position
TRG âbetter results when looking at numbers but
regarding surgeries and complications are it is not
ideal
31. VEPTR
This procedure treats thoracic insufficiency by
-Lengthening and expanding the constricted
hemithorax
-Allowing growth of the thoracic spine and rib
cage
-Correcting scoliosis with no need for spine
fusion
33. Goals of treatment
-Improve thoracic volume and function
-Establish thoracic symmetry by lengthening the
concave, restricted hemithorax
-Avoid growth-inhibiting procedures
-Maintain these improvements throughout the
patientâs growth
-Correct scoliosis
-Maintain spinal alignment and growth
34. Indications
-Primary Thoracic Insufficiency Syndrome (TIS)
-Progressive thoracic congenital scoliosis with concave
fused ribs
-Progressive thoracic congenital scoliosis with flail
chest due to absent ribs
-Progressive thoracic congenital, neurogenic or
idiopathic scoliosis without rib abnormality
36. Indications
-Acquired chest wall defect,
-Chest wall tumor resection
-Traumatic flail chest
-Surgical separation of conjoined twins
-Secondary Thoracic Insufficiency Syndrome due to
lumbar kyphosis (non gibbus)
37.
38. Contraindications
-Inadequate strength of bone (ribs/spine)
-Absence of proximal and distal ribs for attachment
-Absent diaphragmatic function
-Inadequate soft tissue for coverage
-Age beyond skeletal maturity or below 6 months
-Infection at the operative site
42. Complications of VEPTR
-Brachial plexus problems
-direct trauma or
-impingement from an implant placed too cephalad
-compression of the plexus between upper chest
wall and the clavicle
-Campbell advised the upper rib cradle should remain
medial to the scalene muscles and never cephalad
to the second rib
43. -Chest wall problems
-Chest wall scarring
-ribs autofusion
-Shoulder problems
-Shoulder stiffness
-spontaneous fusion of the scapula to the VEPTR
device and rib cage
44. Take home message
-Distraction based surgery is main stay for
management of EOS
-Many options are available
-No one free from complications
-Every patient should get his optimal option