This document discusses various diseases that can affect the buccal cavity and mucosa of different animal species. It covers topics like foreign body stomatitis in dogs, superficial and deep stomatitis including their causes, vesicular and ulcerative stomatitides caused by viruses, and various deep stomatitides like necrobacillosis. It also summarizes diseases of the tonsils, reactive and hyperplastic lesions of the oral cavity, various tumors found in dental and oral tissues, and squamous cell carcinomas and melanomas which are common oral cancers in dogs and cats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Diagnosis of ulcerative, vesicular and bullous lesionHaritha RK
Ulcers, vesicles and bullous lesions are seen in the oral cavity as well. They sometimes are the first signs of skin diseases and is essential to diagnose them early for better prognosis.
Emerging and Re-emerging Infectious DiseasesFarooq Khan
Overview of literature around the following emerging and re-emerging infectious diseases relevant to Canadian Emergency Physicians in terms of their epidemiology, recognition, and treatment:
- Community-acquired MRSA
- Non-vaccine serotype Pneumococcus
- Fusobacterium Necrophorum
Diagnosis of ulcerative, vesicular and bullous lesionHaritha RK
Ulcers, vesicles and bullous lesions are seen in the oral cavity as well. They sometimes are the first signs of skin diseases and is essential to diagnose them early for better prognosis.
Emerging and Re-emerging Infectious DiseasesFarooq Khan
Overview of literature around the following emerging and re-emerging infectious diseases relevant to Canadian Emergency Physicians in terms of their epidemiology, recognition, and treatment:
- Community-acquired MRSA
- Non-vaccine serotype Pneumococcus
- Fusobacterium Necrophorum
-Salivary glangs - totall.Description and managementEdouardMudekereza
Observation by an assistant and notation of facial switching and motion and its location generlly are more helpful than the use of a facial nerve stimulator.
8- Aciod making the posterior portion of the flap in the infraauricular area too thin or too long to prevent skin necrosis.
9- infection after parotidectomy is rare: preoperatively, anitibiotics are only needed with a pre-existing history of sialadenitis. 1- Use of a facial nerve stimulator is unnecessary except in reoperations.
2-Reoperating in the parotid bed should with the aid of intraperative faical nerve monitoring.
3- Key landmarks for identifying the facial nerve include the cartilaginous pointer, the mastiod tip, and the posterior belly of the digstric muscle. Observation by an assistant and notation of facial switching and motion and its location generlly are more helpful than the use of a facial nerve stimulator.
8- Aciod making the posterior portion of the flap in the infraauricular area too thin or too long to prevent skin necrosis.
9- infection after parotidectomy is rare: preoperatively, anitibiotics are only needed with a pre-existing history of sialadenitis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Feed in mouth of cadaver is abnormal except Ruminants
In horses indicate encephalitis, leukoencephalo- malacia,
hepatic encephalopathy.
Feed poorly masticated
Bones indicate pica
Foreign body stomatitis in dog occur due to plant fibers,
burrs or quills, especially in long hair breeds
Sharp foreign bodies induce laceration, necrotic deep
stomatitis
Foreign bodies
3.
4. Pharyngitis
Glossitis
Gingivitis
Tonsillitis
Superficial (only mucosa involved) or deep
(connective tissue involved)
5. Paraquat, erosive stomatitis, dogs
Dieffenbachia Plant
Actinomyces, Fusobacterium, and spirochetes normal flora
Oral mucosa resistant to infection because
Squamous mucosa
Antimicrobial salivary contents e.g. lysozyme
Immunoglobulins e.g. IgA
Rich submucosal vascular network
Inflammatory cells
Superficial stomatitis
6. Usually involve caudal fauces, gingivitis
often develops in the course of debilitating diseases.
Hyperemia, edema, lymphoid tissue proliferation
Thrus/oral candidiasis occur in dog, foals,pigs
Patchy pale-gray pseudomembranous material on oral
mucosa and back of tongue
Stachybotrys alternans causes catarrhal & necrotic
stomatis
Catarrhal stomatitis
7. Vesicles, bullae, erosion
Virus e.g. FMD virus,
Rinderpest, BVD, MCF produce erosive/ulcerative lesions
Bullous immune skin diseases do have oral lesions e.g
pemphigus vulgaris (desmoglein 3, suprabasilar acantholysis,
clefts,bullae)
Bullous pemphigoid; Subepidermal blistering/cleft; IgG, IgE
against basement membrane antigens
Mucous membrane pemphigoid most common.
Collagen XVII or laminin-5, and basement membrane-
fixed immunoglobulin
Vesicular stomatitides
8.
9.
10.
11.
12.
13. Feline calicivirus
Erosive and ulcerative stomatitides
Phenylbutazone intoxication in horses may cause oral
ulcers
Feline ulcerative stomatitis and glossitis; cause unknown
Feline plasma cell gingivitis-pharyngitis: Raised
erythematous, proliferative lesions, plasma cell infiltration,
elevated polyclonal serum gamma-globulin level
14. Oral eosinophilic granuloma, dog, young Siberian
Huskies.
Ulcerated raised plaques, yellow exudate, on lateral
or ventral surface of tongue
Microscopically foci of collagenolysis, histiocytic
granulomatous infiltration, giant cells, eosinophils.
Feline rhinotracheitis and uremia (dirty gray
brown)also induce ulcerative stomatitis
18. Fusobacterium necrophorum
Necrotizing lesions in upper, lower alimentary tract &
liver as well
Occurs as a secondary invader
Endotoxins: leukocidins, hemolysins, and a
cytoplasmic toxin
Coagulative necrosis
19. Calf diphtheria: Necrotizing, ulcerative inflammation
of oral cavity, pharynx and necrotizing laryngitis
Trauma, infectious bovine rhinotracheitis, and papular
stomatitis are predisposing factors
Fatal in youngs, localized in adults
Early lesions:Large, well-demarcated, yellow-gray, dry
areas of necrosis, surrounded by a zone of hyperemia.
20.
21. Necrotic tissue slightly raised, friable, adherent
Histologically: Necrotic tissue surrounded by vascular
reaction, thin rim of leucocytes & encapsulating
granulation tissue
Bacteria arranged in long filaments at leading edge of
lesion
Aspiration penumonia (due to spread from oral foci),
septicemia, pituitary and cerebral abscessation
22. Fusobacterium necrophorum : Another syndrome in
calves with necrotic stomatitis, enteritis, and
granulocytopenia
Nonregenerative anemia, leukopenia, neutropenia,
hypoproteinemia, and increased fibrinogen levels
Along with characteristic oral lesions marked
depletion of lymphoid tissues and necrotic enteritis.
23. Rapidly spreading Pseudomembranous/gangerenous
stomatitis
Normal flora e.g. fusobacteria and spirochetes
Predisposing: Mucosal trauma, debility
Small tattered ulcer of the cheek or gum, spread
rapidly
Intensely fetid, necrotic area surrounded by acute
inflammatory cells
Noma
24. Cattle, sheep, and pigs
Stomatitis, glossitis, lymphadenitis, sometimes
pyogranulomas in the wall of the forestomachs
Actinobacillus lignieresi
Pyogranulomatous inflammatory loci centered on
club colonies containing gram-negative coccobacilli.
Arcanobacterium pyogenes, Actinomyces bovis,
Staphylococci, Nocardia may also cause
pyogranulomas.
Actinobacillosis
25. Typically a disease of soft tissue, spreading as a
lymphangitis, lymph nodes
wooden tongue
Grossly: Individual inflammatory focus appear as a
nodular, firm, pale, fibrous mass a few millimeters to 1
cm in diameter, containing in the center minute
yellow "sulfur" granules, which are the club colonies.
26.
27.
28. Microscopically: Pyogranuloma, centered on a mass
of coccobacilli, surrounded by radiating eosinophilic
clubs made up of immune complexes.
Club colonies surrounded by neutrophils,
macrophages, giant cells
Lymphocytes, plasmacytes in surrounding fibrous
reactive stroma
29. Dermatophilus congolensis
Exudative dermatitis in many spp but in cat oral
granulomas
Tongue and tonsillar crypt
DDX: SCC
Oral dermatophitosis of cats
30. Sarcosporidiosis
Cysticercosis
Trichinella spiralis
Gongylonema spp
Gasterophilus spp. in the horse
Oestrus ovis in sheep
Halicephalobus gingivalis
Parasitic diseases of the oral cavity
31. Prominent and protrude slightly from the tonsillar
fossa in the dog and cat.
In horses tonsillar tissues are dispersed over
pharyngeal and epiglottic mucosal surfaces
Immune surveillance in the oropharynx
Tonsillitis may occur include pasteurellosis in sheep
and pigs, Actinomyces and Tonsillophilus in tonsils of
swine, and necrobacillosis in all species
Diseases of the tonsils
32. Scrapie-associated prion protein in the center of
primary and secondary lymphoid follicles
Primary replication site for Pseudorabies (Aujeszky's
disease)
Involution of B-dependent tonsillar lymphoid follicles
due to viral lymphocytolysis in many viral infections
e.g. feline panleukopenia, canine parvoviral enteritis,
CD, BVD, RP virus,
33.
34. Epulis is a generic clinical term for tumor-like masses on
the gingiva
Pyogenic granuloma: Bright red or blue mass on the
gums of dogs
Extremely vascular granulation tissue covered by
gingival epithelium
Exaggerated response to local irritation and infection
Reactive and hyperplastic lesions
35. Peripheral giant cell granuloma; Gingival masses
dogs and cats
Red, smooth, sessile,or pedunculated
Gingival epithelium is hyperplastic or ulcerated, extends deeply
into the underlying mass
Fibrous hyperplasia: Generalized and diffuse, or focal, localized
to one or more teeth
Mature fibrous tissue with low cellular density, foci of hard
tissue and epithelial nests may be present
Plasma cells band in the gingival stroma adjacent to epithelium
36.
37. Benign epithelial tumors ("warts") in dogs, cats, and cattle
Papillomaviruses
The virus is host- and fairly site-specific
Infection of basal epithelium of the squamous mucosa,
mitosis
viral genome replicates in the differentiating keratinocytes
of the stratum spinosum and granulosum, viral assembly
and expression in superficial squamous layers
Oral papillomatosis
38.
39.
40. Incubation period 2 months
Multiple, proliferative cauliflower like,firm, white to
gray growths
Microscopically: Lesions is typically verrucous,
Thick keratinizing squamous epithelium covering
thin, branching, often pedunculated cores of
vascularized proprial papillae.
Basophilic intranuclear viral inclusions may be found in
cells in the outer spinose layers
41.
42. Ameloblastoma is a slowly progressive invasive but
nonmetastatic tumor, consisting of proliferating
odontogenic epithelium in a fibrous stroma
Amyloid-producing odontogenic tumors: characterized by
dental epithelium, with deposits of amyloid
Acanthomatous ameloblastoma:Tumor arising from the
mucosal epithelium or epithelial rests of the
gingiva of dogs
gray-pink papillary to sessile gingival masses,
Tumors of dental tissue
43. Histologically: Sheets, nodules, and anastomosing
cords of polyhedral epithelium bordered by a row of
cuboidal to columnar cells with round to oval nuclei
and moderate amounts of cytoplasm
44. Feline inductive odontogenic tumor: Osteolytic
masses in the rostral maxilla, causing tooth loss or
facial distortion
Complex and compound odontomas
Fibromatous epulis of periodontal ligament origin;
Peripheral odontogenic neoplasm
Indistinguishable clinically from fibrous hyperplasia,
Most common in dogs, stromal tumor with interwoven
bundles of cellular fibroblastic tissue.
45.
46. Most common oral malignancy in cats
Occur on the ventral surface of the tongue and
gingiva
Locally invasive, especially into bone and local soft
tissues
Grossly: Irregular, slightly nodular, red-gray, friable
masses, often with an ulcerated surface that bleeds
easily
In dog, occur in tonsils
Squamous cell carcinomas
47.
48. Most common oral tumors in dogs
Malignant, spread to regional lymph nodes
Arise from melanocytes in the mucosa or superficial
stroma, mainly on the gingiva and labia
Histologically: Melanomas varies greatly, from a fairly
well differentiated heavily pigmented type, to a highly
anaplastic amelanotic type
Anaplastic cells show junctional activity
Melanomas
49.
50. Round or polyhedral cells with a large nucleus and
extensive cytoplasm with well-demarcated borders
Some have spindle shaped cells with oval nuclei
containing small nucleoli
Most frequently there is a characteristic mixture of
epithelial-like and spindle-shaped cells, which have a
marked tendency to form nests
DOPA-positive, vimentin 100%, melan A >90%
Editor's Notes
found on the sides or dorsal groove of the tongue, on the
cheeks, gums, palate, and pharynx, especially the recesses beside the
larynx.
Junctional activity of anaplastic cells infiltrating the junction between the basilar epithelial
cells and the submucosa