You can disable access to USB ports on a Windows PC through the registry to prevent unauthorized data transfer or virus spreading via USB drives. This involves navigating the registry editor, opening the usbstor key, changing the Start value from 3 to 4, and refreshing the desktop. Re-enabling USB ports requires changing the Start value back to 3.

1. Disable USB ports on Windows PC via Registry
With this trick, you can disable access to your USB(Universal Serial Bus) ports in your Windows based
PC to prevent people from taking out data from your personal computer without permission or
spreading viruses through the use of USB(pen and flash) drives.
To use this trick to disable USB ports, follow the steps given below:1. Click on Start.
2. Click on Run. If you cannot find RUN, type it in the search box.
3. Type "regedit" without quotes. This will launch the Registry Editor.
4. Navigate to HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesusbstor.
5. In the work area, double click on Start.
6. In the Value Data box, enter 4.
7. Click on OK.
8. Close Registry Editor and refresh your desktop.
9. To re-enable access to your USB ports, enter 3 in the Value Data box in Step 6.