De Quervain's tenosynovitis is inflammation of the tendon sheath of the abductor pollicis longus and extensor pollicis brevis tendons. It is caused by repetitive movements of the wrist and thumb and results in thickening of the tendon sheath and stenosis of the compartment. Patients experience pain on the radial side of the wrist that is worsened by thumb movement. Diagnosis involves tenderness over the radial styloid and a positive Finkelstein's or hitchhiker's sign test. Treatment ranges from corticosteroid injections for mild cases to splinting and possibly surgery to release the tendon sheath for severe or persistent cases.