Defitelio is indicated for the treatment of hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT). It is administered as a 2-hour intravenous infusion at 6.25 mg/kg every 6 hours for a minimum of 21 days or until signs and symptoms of VOD resolve. The most common adverse reactions reported are hypotension, diarrhea, vomiting, nausea and epistaxis. Defitelio protects endothelial cells from damage and increases fibrinolysis while decreasing endothelial cell activation.