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Decreased Immune Response: Susceptibility to Infection C Washington RN, MSNEd
Infection Host organism’s  response to a  pathogen or disease causing substance
Infection Tissue destroying microorganisms enter & multiply in the body
Invasion of the body by pathogenic organisms that multiply and produce injurious effects
Four types of microorganisms can enter the body & cause infection
Harmless Organisms Resident flora  	-E Coli (intestine) 	-Staph aureus (skin) Colonization 	-microorganisms     become resident     flora Intestinal flora help synthesize vitamin K
Harmful Actions of Microorganisms # of organism present Ability of organism to cause disease Person’s immune system Length of contact between person & organism
Climate for Infection Poor nutrition Stress Humidity Poor sanitation Crowded living conditions Pollution Dust Medications
Opportunistic infections Risk for Infection Inhalation
Risk for Infection Direct contact
Ingestion Insect or animal bite
Controlling Microorganism  Medical Asepsis  ,[object Object]
Limit #, growth, & transmission of microorganisms
Handwashing
Barrier techniques
Environmental cleaning Surgical Asepsis  Sterile technique Completely free of microorganisms
The Spread of Infection ,[object Object]
Frequent uncontrolled diarrhea stools; the nurse provided excellent care to maintain cleanliness & comfort.
After one episode of cleaning the pt & changing the bed linen, the nurse went over to a second pt to adjust foleycath tubing.
The nurse’s hands were not washed before assisting the second patient.,[object Object]
Nosocomial Infections Drug Resistant Organisms Vancomycin-resistant enterococcus (VRE)
Methicillin-resistant Staph aureus (MRSA)
Clostridium difficile (C Diff)
Nosocomial Infections Pneumonia 	-Pseudomonas 	-Improper suctioning 	 technique
Nosocomial Infections Bloodstream 	-Staph aureus 	-Improper IV site care
Nosocomial Infections Surgical Site 	-Enterococcus 	-Improper dsg      change
Nosocomial Infections Urinary Tract 	-E Coli 	-Poor cath care
Preventing Nosocomial Infections
Transmission Based Precautions Droplet precautions (pneumonia, meningitis) 	-Private room/mask <3 ft from pt
Transmission Based Precautions Airborne precautions (measles, TB) 	-Private neg airflow room 6 air exchanges/hr
Transmission Based Precautions Contact precautions 	-Direct (kissing, bathing, toughing) 	-Indirect (instruments, needles, dressing)
Transmission Based Precautions Protective Precautions
What might you NOTICE (subjective & objective) if the patient has inadequate protection as a result of infection or infectious disease?
What should you ASSESS for a patient with inadequate protection as a result of infection or infectious disease?
How should you INTERVENE for a patient with inadequate protection as a result of infection or infectious disease?
What should you EVALUATE when a patient is being treated for an infection or infectious disease
2 days post-op below-the-knee amputation Reports feeling hot and sweaty VS 100-98-30 156/88 What is your best action at this time
Adm from nursing home H/O Stroke MRSA urine Incontinent of urine & stool No private room available Semi private bed with older pt with fractured leg
Immune Response   recognize foreign substances  neutralize, eliminate, or metabolize them with or without injury to the body's own tissues.
Functions of the Immune System ,[object Object]
Homeostasis: removal of worn out or damaged components (e.g., dead cells)
Surveillance:  ability to perceive or destroy mutated cells or nonself cells. ,[object Object]
Hypofunction:  Immunosuppression with increased susceptibility to infection (neutropenia, AIDS, immunosuppression
Hyperfunction:  Inappropriate and abnormal response to external antigens; an allergy,[object Object]
Hypofunction:  No known effect
Hyperfunction:  Abnormal response where antibodies react against normal tissues and cells; an autoimmune disease,[object Object]
Hypofunction:  Inability of the immune system to perceive and respond to mutated cells, suspected mechanism in cancer
Hyperfunction:  No known effect,[object Object]
Inflammatory Response:  Cause Physical irritants (e.g., trauma or a foreign body)  Chemical irritants (e.g., strong acids or alkalis)  Microorganisms (e.g., bacteria and viruses)
Inflammatory Response: Local Pain Swelling Heat Redness impaired function of part   *five cardinal signs of inflammation
Inflammatory Response: Systemic appear with moderate to severe response Fever Leukocytosis Chills sweating  Anorexia weight loss general malaise
Types of Immunity
Test Yourself A baby is born temporarily immune to the diseases to which the mother is immune.  The nurse understands that this is an example of which type of immunity?
Test Yourself A mother brings her children into the clinic & they are diagnosed with chicken pox The mother had chicken pox as a child and is not concerned with contracting the disease when caring for her children What type of immunity does this mother have?
Factors Influencing Immunity Age Sex Nutritional Status Stress Treatment Modalities
Nursing History Present illness ,[object Object]
Location
Radiation
Intensity
Duration
Frequency
Precipitating & alleviating factorsChief complaint Lack of energy Light-headedness Frequent infections Bruising Slow wound healing
Nursing History Medical history ,[object Object]
Allergies
Childhood diseases
Recurrent infections
Innumizations
Rashes
Visual disturbancesPresent illness Prescription drugs Over the counter drugs Herbal remedies Vitamins & nutritional supplements Alternative therapies
Nursing History Medical history Fever Changes in elimination h/o immune disorders Menstural patterns Family history Recurrent infections Allergies Cancer
Nursing History Social history ,[object Object]
Exercise
Diet
Recreational drugs & alcohol
Hobbies
Stress
Support systems
Coping mechanisms,[object Object]
Physiologic Responses Immunologic Dysfunction Angioedema    Generalized swelling
Physiologic Responses Immunologic Dysfunction Conjunctivitis Inflammation of membranes of eyelids
Physiologic Responses Immunologic Dysfunction Bronchoconstriction Swelling of airway
Physiologic Responses to Immunologic Dysfunction Pruritis Associated with erythema & urticaria Hypotension
Physiologic Responses Immunologic Dysfunction Leukocytopenia Abnormal decrease in WBCs
Physiologic Responses Immunologic Dysfunction
Hypersensitive Immune Responses Allergies Anaphylaxis Transfusion reactions Transplant rejection Latex allergy
Allergies Allergic disorders are the result of a hypersensitivity (excessive reaction to a stimulus) of the immune system to allergens  (a type of antigen commonly found in the environment).
Allergies A pt has allergic rhinitis.   If the pt does not remain compliant with the treatment regime, the patient is at risk for developing an infection  Such as Sinusitis
Anaphylaxis A systemic reaction to allergens and the most serious type of allergic reaction. Foods, drugs, hormones, insect bites, blood, and vaccines are all associated with anaphylactic reactions.
Anaphylaxis
Anaphylactic Reaction A patient is being given PCN via IVPB. Develops an anaphylactic reaction What would you do first? What symptom may the pt be experiencing? What is the medication of choice for anaphylaxis?
Transfusion Reactions ,[object Object]
Five types: febrile nonhemolytic; allergic urticarial; delayed hemolytic; acute hemolytic; and anaphylactic.,[object Object]
Transplant Rejection Even with the use of immunosuppressive medications, 10% to 15% of transplanted organs fail.

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Decreased Immune Response Infection Immunity

Editor's Notes

  1. Infections or disease occur
  2. If infections are not treated or adequately treated patient can develop:SepticemiaSeptic ShockDisseminated intravascular coagulation (DIC)POOR HAND HYGIENE APPLIES TO ALL
  3. Handwashing and alcohol based hand rubs are two methods of hand hygieneCDC bans artificial figernails for healthcare professionaal when they are caring for patients at high risk for infection