The document provides an introduction to the Distributed Annotation System (DAS), including its query model, data model, design principles, documentation resources, and examples of DAS clients and servers. DAS allows for distributed genomic and protein annotation data to remain hosted by individual data providers while still being integrated and accessed through a common protocol. It uses a simple REST-based query language and returns lightweight XML data that can be consumed by various client applications. Major bioinformatics resources like Ensembl, Protein Databank, and UniProt provide data via DAS to allow interoperability across different tools and browsers.