This curriculum vitae provides information about Chung-Chau Hon's education, positions, areas of expertise, publications, and skills. It summarizes that Hon has a PhD in Population Genetics of Viruses from the University of Hong Kong and is currently a postdoctoral fellow in France studying the genomics and transcriptomics of protozoan parasites using next-generation sequencing techniques. Hon has published over 30 papers on topics including viral phylogenetics, pathogen genomics, and computational biology methods.
Biochemistry: A pivotal aspects in forensic scienceVanshikaVarshney5
In the above presentation, you will know the importance of biochemistry in forensic science. Biochemistry is not all about the chemicals, it is about your life, your environment. Basically, it belongs to you.
in this presentation, you can know about the biochemical techniques which are majority used in forensic science and various research occurs in the field of forensic science which is related with biochemistry.
Viral metagenomics is the study of viral genetic material sourced directly from the environment rather than from a host or natural reservoir. The goal is to ascertain the viral diversity in the environment that is often missed in studies targeting specific potential reservoirs.
Biochemistry: A pivotal aspects in forensic scienceVanshikaVarshney5
In the above presentation, you will know the importance of biochemistry in forensic science. Biochemistry is not all about the chemicals, it is about your life, your environment. Basically, it belongs to you.
in this presentation, you can know about the biochemical techniques which are majority used in forensic science and various research occurs in the field of forensic science which is related with biochemistry.
Viral metagenomics is the study of viral genetic material sourced directly from the environment rather than from a host or natural reservoir. The goal is to ascertain the viral diversity in the environment that is often missed in studies targeting specific potential reservoirs.
Next Generation Sequencing for Identification and Subtyping of Foodborne Pat...nist-spin
"Next Generation Sequencing for Identification and Subtyping of Foodborne Pathogens" presentation at the Standards for Pathogen Identification via NGS (SPIN) workshop hosted by National Institute for Standards and Technology October 2014 by Rebecca Lindsey, PhD from Enteric Diseases Laboratory Branch of the CDC.
Course: Bioinformatics for Biomedical Research (2014).
Session: 2.1.3- Next Generation Sequencing. Technologies and Applications. Part III: NGS Applications II.
Statistics and Bioinformatisc Unit (UEB) & High Technology Unit (UAT) from Vall d'Hebron Research Institute (www.vhir.org), Barcelona.
Next Generation Sequencing for Identification and Subtyping of Foodborne Pat...nist-spin
"Next Generation Sequencing for Identification and Subtyping of Foodborne Pathogens" presentation at the Standards for Pathogen Identification via NGS (SPIN) workshop hosted by National Institute for Standards and Technology October 2014 by Rebecca Lindsey, PhD from Enteric Diseases Laboratory Branch of the CDC.
Course: Bioinformatics for Biomedical Research (2014).
Session: 2.1.3- Next Generation Sequencing. Technologies and Applications. Part III: NGS Applications II.
Statistics and Bioinformatisc Unit (UEB) & High Technology Unit (UAT) from Vall d'Hebron Research Institute (www.vhir.org), Barcelona.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
FIDO Alliance Osaka Seminar: The WebAuthn API and Discoverable Credentials.pdf
Cv.hon.chung.chau
1. Curriculum Vitae
A. Basic Information
NAME, SURNAME (EMAIL)
Chung-Chau, HON
chung-chau.hon@pasteur.fr
CURRENT POSITION
BIRTH INFOMATION
Postdoctoral Fellow,
Transcriptome and Epigenome
Platform of Genopole,
& Cellular Biology of
Parasitism Unit,
Pasteur Institute, Paris
22/04/1979
Male, Age: 34, Hong Kong
HOMEPAGE
http://genomebytes.wordpress.com/
EDUCATION and TRANING
Institution (Location)
Degree / Position
Year
Subject
The University of Hong Kong
(Hong Kong)
Bachelor of Science
1998-2001
Molecular Biotechnology, General Bioinformatics
Supervisor: Prof. Frederick Chi-Ching Leung
fcleung@hkucc.hku.hk
The University of Hong Kong
(Hong Kong)
Master of Philosophy
2001-2003
Molecular Virology
Supervisor: Prof. Frederick Chi-Ching Leung
fcleung@hkucc.hku.hk
IBM
Computational Biology Center
(New York, USA)
Computational
biologist (Intern)
2005
Massively parallel molecular dynamics simulations
Supervisor: Dr. Ruhong Zhou
ruhongz@us.ibm.com
The University of Hong Kong
(Hong Kong)
Doctor of Philosophy
2003-2008
Population Genetics of Viruses
Supervisor: Prof. Frederick Chi-Ching Leung
fcleung@hkucc.hku.hk
EXPERTISE by TOPICS (Duration)
•
•
•
•
•
•
•
•
Genomics and transcriptomics of protozoan parasites (3 years);
Designing and analyzing RNA-Seq experiments (3 years);
Gene regulation by small RNA and long non-coding RNA in protozoan parasites (2 years);
Comparative genomics of closely related species (3 years);
Gene expression analyses using microarray and RNA-Seq (5 years);
Phylogenetics and population genetics of viruses (8 years);
Origins of emerging viral diseases (8 years);
Massively parallel molecular dynamics simulations (1 year);
EXPERTISE by TECHNIQUES (Level)
•
•
•
•
•
•
•
•
•
•
•
•
Development of custom scripts (mainly Perl) for analyses of next generation sequencing data (proficient);
Genome-wide mapping of transcription start sites and polyadenylation sites of Pol II transcripts (proficient);
Discovery of cis-regulatory motifs for transcription initiation and polyadenylation (semi-proficient);
Revision of gene models and annotation of antisense transcripts using RNA-Seq (proficient);
Annotation of alternative splicing transcript isoforms using RNA-Seq (proficient);
Characterization of endogenous small RNA populations using RNA-Seq (proficient);
Differential expression and functional enrichment analyses based on next generation sequencing data (semi-proficient);
Weighted gene correlation network analyses using microarray expression data (semi-proficient);
Identification of orthological and syntenic genes between closely related species (proficient);
Application of Bayesian, parsimony and likelihood methods in population genetics (semi-proficient);
Large scale genotyping of viruses (proficient);
Massively parallel molecular dynamics simulations (amateur);
2. B. Postdoctoral Employment
I. Senior Postdoctoral Fellow,
Transcriptome and Epigenome Platform of Genopole, & Cellular Biology of Parasitism Unit,
Institute of Pasteur (Paris)
2011-Now
• Topic: Application of Next Generation Sequencing on Comparative genomics and Transcriptomics of Entamoeba;
• Supervisor: Dr Nancy Guillen; email: nguillen@pasteur.fr and Dr Jean-Yves Coppee; email: jycoppee@pasteur.fr
II. Postdoctoral Fellow,
Cellular Biology of Parasitism Unit,
Institute of Pasteur (Paris)
• Topic: Genomics of Entamoeba;
• Supervisor: Dr Nancy Guillen; email: nguillen@pasteur.fr
2008-2011
C. Competitive External Funds
(Proposals can be found at http://genomebytes.wordpress.com/projects/)
I. Agence Nationale Recherche Genomic Grant 2010
2010-2013
• Title: Understating the Pathogenicity of Entamoeba Using Comparative Transcriptomics and Phylogenomics
• Amount: €641,744 (US$869,258), in total for 3 years;
• Role: Proposal writing, project management, corresponding author, high throughput sequencing data analysis
D. Skill Sets
(Research experiences can be found at http://genomebytes.wordpress.com/research/)
I. Computational Skills (Level)
•
•
•
•
•
•
Perl scripting (proficient);
Unix command line, system maintenance and software compiling and installation (proficient);
Shell scripting (semi-proficient);
Remote working on a server farm (semi-proficient);
Python scripting (amateur);
MySQL database (amateur);
II. Next Generation Sequencing Data Analysis Skills (Level)
•
•
•
•
•
•
•
Basic read data mapping using bowtie, tophat, eXpress, SOAP etc (proficient);
Basic read data format handling using samtools, picard, bamtools, fastqc etc (proficient);
Discovery of transcription start sites and polyadenylation sites using custom scripts (proficient);
Transcriptome assembly using cufflinks and custom scripts (proficient);
Genome-wide discovery of cis-regulatory motifs using MEME suite and custom scripts (proficient);
Annotation of long non-coding and antisense transcripts using custom scripts (proficient);
Annotation of endogenous small RNA populations using custom scripts (proficient);
III. Gene Expression Data and System Biology Analysis Skills (Level)
• Differential expression analyses using DESeq, Cuffdiff, EdgeR etc (proficient);
• Functional enrichment analyses using GSEA, GOSeq, FUNC_hyper, etc (proficient);
• Gene co-expression network analyses using WGCNA, Cytoscape and custom scripts (semi-proficient);
IV. Comparative Genomic Analysis Skills (Level)
• Identification of orthological genes using orthoMCL and inparanoid (proficient);
• Identification of syntenic genes using DAGChainer etc (semi-proficient);
• Genome-wide protein family clustering and classification using spectral clustering (SCPS) (proficient);
V. Phylogenetic and Population Genetics Analysis Skills (Level)
•
•
•
•
Bayesian based molecular clock and coalescent analyses using BEAST (proficient);
Likelihood based selection pressure analyses using PAML and HyPhy (semi-proficient);
Large scale phylogeny reconstruction using PAML, PAUP*, mrBayes, BEAST etc (proficient);
Semi-automatic viral genotyping base on large phylogenies using custom scripts (proficient);
3. D. Publications
(Abstracts can be found at http://genomebytes.wordpress.com/publications/)
I. Genomics and Transcriptomics (13 journal articles & 3 book chapters)
1.
Hon,C.-C., Weber, C., Sismeiro, O., Proux, C., Koutero, M., Deloger, M., Das, S., Agrahari, M., Dillies, M.-A., Jagla,
B., Coppee, J.Y., Bhattacharya, A. and Guillen, N. (2012) Quantification of stochastic noise of splicing and
polyadenylation in Entamoeba histolytica. Nucleic Acids Res, 10.1093/nar/gks1271. (Corresponding and first
author).
2.
Vasquez,J.-J., Hon,C.-C., Vanselow J.T., Schlosser A. and Siegel, T.N (2013). Comparative ribosome-profiling
reveals extensive translational complexity in different Trypanosoma brucei life-cycle stages. Nucleic Acids Res
accepted.
3.
Thibeaux, R., Weber. C., Hon,C.-C., Dillies, M.-A., Copee, J.Y., Labruye, E. and Guillen, N. (2013). Identification
of the virulence landscape essential for Entamoeba histolytica invasion of the human colon. PLoS Pathogens
accepted.
4.
Njoya, E.M., Weber. C., Hernandez-Cuevas. N.A., Hon,C.-C., Janin, Y, Kamini, M.F.G, Moundipa, P.F and Guillén,
N (2013). Bioassay-guided fractionation of Codiaeum variegatum’s aqueous extract killing Entamoeba histolytica
target ceramide biosynthesis. PLoS Negl Trop Dis in press.
5.
Hon,C.-C., Weber,C., Koutero,M., Coppée,J.-Y., Deloger,M and Guillen,N. Surveying Entamoeba histolytica
transcriptome using massively parallel cDNA sequencing. In ‘Amebiasis: Biology and Pathogenesis of Entamoeba’
by SPRINGER In Press. (Corresponding and first author)
6.
Janbon, G., Ormerod, K. L., Paulet , D., Byrnes, E., Chatterjee, G., Yadav, V., Hon,C.-C., A., Cuomo, C. A., Dietrich,
F. S., Billmyre, Brunel, F, Bahn Y.-S., Chen, W., Chen, Y., Chow E. W. L., Coppée, J.Y., Floyd-Averette, A.,
Gaillardin C., Gerik, K. J., Goebels, C., Goldberg, J., Gonzalez-Hilarion S., Gujja, S., Hamlin, J. L., Hsueh, Y.-P.,
Ianiri, G., Jones, S., Kodira, C. D., Lam, W., Marra, M., Mesner, L. D., Mieczkowski, P.A., Moyrand, F., Nielsen, K.,
Proux, C., Rossignol, T., Schein1, J. E., Sun, S., Wood, I. A., Zeng, Q., Neuvéglise, C., Newlon, C. S., Perfect, J. R.,
Lodge, J. K., Idnurm. A., Stajich, J. E., Kronstad, J. W., Sanya, K. Heitman, J., Fraser, J., Cuomo C. A. and Dietrich F.
(2013). The genome sequence of Cryptococcus neoformans var. grubii reveals complex mechanisms of RNA
expression and virulence plasticity. PLoS Genetics in 1st revision.
7.
Siegel, N, Hon,C.-C., Zhang,Q., Lopez-Rubio,J.J., Coppée,J.-Y., Sismeiro,O and Scherf,A. Strand-specific RNA-Seq
reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium
falciparum. BMC Genomics in 2nd revision.
8.
Santi-Rocca,J., Smith,S., Weber,C., Pineda,E., Hon,C.-C., Saavedra,E., Olivos-García,A., Rousseau,S., Dillies,M.-A.,
Coppée,J.-Y. and Guillén, N (2012) Endoplasmic reticulum stress-sensing mechanism is activated in Entamoeba
histolytica upon treatment with nitric oxide. PLoS ONE, 7, e31777.
9.
Marquay Markiewicz,J., Syan,S., Hon,C.-C., Weber,C., Faust,D. and Guillen,N. (2011) A proteomic and cellular
analysis of uropods in the pathogen Entamoeba histolytica. PLoS Negl Trop Dis, 5, e1002.
10. Hon,C.-C., Nakada-Tsukui,K., Nozaki,T. and Guillen,N. (2009) Dissecting the actin cytoskeleton of Entamoeba
histolytica from a genomic perspective. In Anaerobic Parasitic Protozoa: Genomics and Molecular Biology.
Edited by G. C. Clark, P. J. Johnson & A. R.D. Tucson AZ, USA: Caister Academic Press. (First author)
11. Yeung,Y.S., Yip,C.W., Hon,C.-C., Chow,K.Y.C., Ma,I.C.M., Zeng,F. and Leung,F.C.C. (2008) Transcriptional
profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: insights on viral regulation of apoptosis and
proliferation. Virology, 371, 32–43.
12. Wang,Y., Zeng,F., Hon,C.-C., Zhang,Y. and Leung,F.C.C. (2008) The mitochondrial genome of the Basidiomycete
fungus Pleurotus ostreatus (oyster mushroom). FEMS Microbiol Lett, 280, 34–41.
13. Wong,R.T.-Y., Hon,C.-C., Zeng,F. and Leung,F.C.C. (2007) Screening of differentially expressed transcripts in
infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays. J Gen
Virol, 88, 1785–1796.
14. Zeng,F., Hon,C.-C., Sit,W.-H., Chow,K.Y.-C., Hui,R.K.-H., Law,I.K.-M., Ng,V.W.-L., Yang,X.-T., Leung,F.C.C.
and Wan,J.M.-F. (2005) Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human
promyelotic leukemic HL-60 cells using cDNA microarray. Int J Oncol, 27, 513–523.
4. 15. Cheung,K.H., Hon,C.-C., and Leung,F.C.C. (2003) Illustration of Enhanced Features of Visual Genome Explorer
Beta 2.1 by Comparative Analysis of Helicobacter pylori Strains 26695 and J99 Genomes. Biocomputing:
Computer Tools for Biologists.
16. Hon,C.-C., Chow,Y.C., Zeng,F.Y. and Leung,F.C.C. (2003) Genetic authentication of ginseng and other traditional
Chinese medicine. Acta Pharmacol Sin, 24, 841–846. (First author)
II. Phylogenetics and Population Genetics (18 journal articles)
17. Lam,T.T.-Y., Chong,Y.L., Shi,M., Hon,C.-C., Li,J., Martin,D.P., Tang,J.W.-T., Mok,C.-K., Shih,S.-R., Yip,C.W.,
Jiang, J., Hui, R.K., Pybus, O.G., Holmes, E.C., and Leung, F.C.C. (2013) Systematic phylogenetic analysis of
influenza A virus reveals many novel mosaic genome segments. Infect Genet Evol, 10.1016/j.meegid.2013.03.015.
18. Lam,T.T.-Y., Hon,C.-C., Lemey,P., Pybus,O.G., Shi,M., Tun,H.M., Li,J., Jiang,J., Holmes,E.C. and Leung,F.C.C.
(2012) Phylodynamics of H5N1 avian influenza virus in Indonesia. Mol Ecol, 21, 3062–3077.
19. Shi,M., Lam,T.T.-Y., Hon,C.-C., Hui,R.K.-H., Faaberg,K.S., Wennblom,T., Murtaugh,M.P., Stadejek,T. and
Leung,F.C.C. (2010) Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res, 154, 7–17.
20. Li,Y., Ge,X., Hon,C.-C., Zhang,H., Zhou,P., Zhang,Y., Wu,Y., Wang,L.-F. and Shi,Z. (2010) Prevalence and genetic
diversity of adeno-associated viruses in bats from China. J Gen Virol 91, 2601–2609.
21. Shi,M., Lam,T.T.-Y., Hon,C.-C., Murtaugh,M.P., Davies,P.R., Hui,R.K.-H., Li,J., Wong,L.T.-W., Yip,C.W.,
Jiang,J.-W., and Leung,F.C.C. (2010) Phylogeny-based evolutionary, demographical, and geographical dissection of
North American type 2 porcine reproductive and respiratory syndrome viruses. J Virol, 84, 8700–8711.
22. Yuan,J., Hon,C.-C., Li,Y., Wang,D., Xu,G., Zhang,H., Zhou,P., Poon,L.L.M., Lam,T.T.-Y., Leung,F.C.C., and Shi,Z.
(2010) Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of
SARS coronaviruses in humans. J Gen Virol, 91, 1058–1062. (Equally contributed first author)
23. Lam,T.T.-Y., Hon,C.-C., and Tang,J.W. (2010) Use of phylogenetics in the molecular epidemiology and
evolutionary studies of viral infections. Critical Reviews in Clinical Laboratory Sciences, 47, 5–49.
24. Yip,C.W., Hon,C.-C., Shi,M., Lam,T.T.-Y., Chow,K.Y.-C., Zeng,F. and Leung,F.C.C. (2009) Phylogenetic
perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses. Infect Genet Evol, 9, 1185–
1196.
25. Hon,C.-C., Lam,T.T.-Y., Yip,C.W., Wong,R.T.-Y., Shi,M., Jiang,J., Zeng,F. and Leung,F.C.C. (2008) Phylogenetic
evidence for homologous recombination within the family Birnaviridae. J Gen Virol, 89, 3156–3164. (First author)
26. Hon,C.-C., Lam,T.-Y., Shi,Z.-L., Drummond,A.J., Yip,C.W., Zeng,F., Lam,P.-Y. and Leung,F.C.C. (2008) Evidence
of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on
the direct ancestor of SARS coronavirus. J Virol, 82, 1819–1826. (First author)
27. Lam,T.-Y., Hon,C.-C., Wang,Z., Hui,R.K.-H., Zeng,F. and Leung,F.C.C. (2008) Evolutionary analyses of European
H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events. Virus Res, 131, 271–278.
28. Lam,T.T.-Y., Hon,C.-C., Lam,P.-Y., Yip,C.W., Zeng,F. and Leung,F.C.C. (2008) Comments to the predecessor of
human SARS coronavirus in 2003-2004 epidemic. Vet Microbiol, 126, 390–393.
29. Lam,T.T.-Y., Hon,C.-C., Pybus,O.G., Kosakovsky Pond,S.L., Wong,R.T.-Y., Yip,C.W., Zeng,F. and Leung,F.C.C.
(2008) Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia. PLoS Pathog, 4,
e1000130.
30. Ma,C.M., Hon,C.-C., Lam,T.-Y., Li,V.Y.-Y., Wong,C.K.-W., de Oliveira,T. and Leung,F.C.C. (2007) Evidence for
recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China. J Gen Virol, 88,
1733–1737.
5. 31. Hon,C.-C., Lam,T.-Y., Drummond,A., Rambaut,A., Lee,Y.-F., Yip,C.W., Zeng,F., Lam,P.-Y., Ng,P.T.W. and
Leung,F.C.C. (2006) Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious
bursal disease virus and reassortment of its genome segment B. J Virol, 80, 8503–8509. (First author)
32. Guan,Y., Peiris,J.S.M., Zheng,B., Poon,L.L.M., Chan,K.H., Zeng,F.Y., Chan,C.W.M., Chan,M.N., Chen,J.D.,
Chow,K.Y.C. Hon,C.-C., Hui, K.H., Li, J., Li, V.Y.Y., Wang, Y., Leung, S.W., Yuen, K.Y. and Leung F.C. (2004)
Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet, 363, 99–104.
33. Chow,K.Y.-C., Hon,C.-C., Hui,R.K.-H., Wong,R.T.-Y., Yip,C.W., Zeng,F. and Leung,F.C.C. (2003) Molecular
advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Genomics Proteomics
Bioinformatics, 1, 247–262.
34. Zeng,F.Y., Chan,C.W.M., Chan,M.N., Chen,J.D., Chow,K.Y.C., Hon,C.-C., Hui,K.H., Li,J., Li,V.Y.Y., Wang, C.Y.
Hui, K.H., Li, J., Li, V.Y.Y, Wang, C.Y., Wang, P.Y., Guan, Y., Zheng, B., Poon, L.L.M., Chan, K.H., Yuen, K.Y.,
Peiris, J.S.M., and Leung F.C. (2003) The complete genome sequence of severe acute respiratory syndrome
coronavirus strain HKU-39849 (HK-39). Exp. Biol. Med. (Maywood), 228, 866–873.
III. Molecular Virology and Immunology (9 journal articles)
35. Li,K.K.B., Yip,C.W., Hon,C.-C., Lam,C.Y., Zeng,F. and Leung,F.C.C. (2012) Characterisation of animal
angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with
susceptibility of SARS-CoV infection. Hong Kong Med J, 18 Suppl 3, 35–38.
36. Yip,C.W., Hon,C.-C., Zeng,F. and Leung,F.C.C. (2012) Cell culture-adapted IBDV uses endocytosis for entry in DF1 chicken embryonic fibroblasts. Virus Res, 165, 9–16.
37. Chow,K.Y., Yeung,Y.S., Hon,C.-C., Zeng,F., Law,K.M. and Leung,F.C. (2008) SARS coronavirus and apoptosis.
Hong Kong Med J, 14 Suppl 4, 8–13.
38. Yip,C.W., Yeung,Y.S., Ma,C.M., Lam,P.-Y., Hon,C.-C., Zeng,F. and Leung,F.C.C. (2007) Demonstration of
receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Vero cells. Virus Res,
123, 50–56.
39. Yip,C.W., Hon,C.-C., Zeng,F., Chow,K.Y.C., Chan,K.H., Peiris,J.S.M. and Leung,F.C.C. (2007) Naturally occurring
anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant
nucleocapsid protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory
syndrome. Clin. Vaccine Immunol., 14, 99–101.
40. Zeng,F., Hon,C.-C., Yip,C.W., Law,K.M., Yeung,Y.S., Chan,K.H., Malik Peiris,J.S. and Leung,F.C.C. (2006)
Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein
in virus neutralization and blocking of receptor binding: implications for the functional roles of S2 subunit. FEBS
Lett, 580, 5612–5620.
41. Chow,K.Y.C., Yeung,Y.S., Hon,C.-C., Zeng,F., Law,K.M. and Leung,F.C.C. (2005) Adenovirus-mediated
expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.
FEBS Lett, 579, 6699–6704.
42. Yip,C.W., Hon,C.-C., Zeng,F., Chow,K.Y.C. and Leung,F.C.C. (2004) Prevalence of non-pneumonic infections with
SARS-correlated virus. Lancet, 363, 1825–author reply 1826–7.
43. Zeng,F., Chow,K.Y.-C., Hon,C.-C., Law,K.M., Yip,C.W., Chan,K.H., Peiris,J.S.M. and Leung,F.C.C. (2004)
Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene
fragments. Biochem Biophys Res Commun, 315, 1134–1139.
IV. Massively Parallel Molecular Dynamics Simulations (1 journal article)
44. Zhou,R., Eleftheriou,M., Hon,C.-C., Germain,R.S., Royyuru,A.K. and Berne,B.J. (2008) Massively parallel
molecular dynamics simulations of lysozyme unfolding. Ibm J Res Dev, 52, 19–30.