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Corticosteroids
Document created: 07.24.2021 19:24
Quiz Settings
Setting Value
Passing score: 80%
Total number of questions: 25
Number of questions to ask: 25
Answer submission: Submit one question at a time
Time limit (h:mm:ss): 1:00:00
Number of quiz retries: Unlimited / None
When quiz is finished: Show slide with results
Send quiz results to instructor: mbbsblues@gmail.com
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Intro Slide
Welcome to the MCQ-Learn-Recall-Learn Quiz Session
"%QUIZ_TITLE%"
by Shivankan Kakkar, MD (Gold Medal)
www.doctoru.weebly.com
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Quiz Instructions
Quiz Instructions
 Before attempting, carefully read the question text.
 Then choose the correct answer. (REMEMBER- You have 4 attempts for each question , since
this is a practice session).
 Click on “Submit” to confirm your answer. (On attempting the correct response you get a
feedback, this is for proper understanding and correct recall the next time).
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 Use the Question List in the upper left corner to jump to a certain question.
 Remember you may attempt the quiz any number of times.
Best of luck!
Question Group 1 (25/25 questions)
Question 1. Multiple Choice, 10 points, 4 attempts
Glucocorticoids are contraindicated in all EXCEPT
Correct Choices Feedback
V Organ transplant
Organ transplant is one of the indications
Peptic ulcers Try again!
Hypertension Try again!
Diabetes Mellitus Try again!
Question 2. Multiple Choice, 10 points, 4 attempts
Metyrapone is a selective inhibitor of
4
Correct Choices Feedback
17 alpha
hydroxylase
Try again!
21 alpha
hydroxylase
Try again!
V
11 beta
hydroxylase
Metyrapone
Metyrapone is a relatively selective inhibitor of steroid 11-hydroxylation,
interfering with cortisol and corticosterone synthesis.
This agent has not been widely used in the treatment of Cushing’s syndrome.
However, metyrapone can reduce cortisol production to normal levels in some
patients with endogenous Cushing’s syndrome. Thus, it may be useful in the
management of severe manifestations of cortisol excess while the cause of this
condition is being determined or in conjunction with radiation or surgical
treatment.
Metyrapone is the only adrenal-inhibiting medication that can be administered
to pregnant women with Cushing’s syndrome.
Desmolase Try again!
Question 3. Multiple Choice, 10 points, 4 attempts
Topical steroids can cause
5
Correct Choices Feedback
V Glaucoma
Increased intraocular pressure is common with use of topical steroids, and
secondary glaucoma may be induced.
Cataract Try again!
Corneal
opacities
Try again!
Optic
neuritis
Try again!
Question 4. Multiple Choice, 10 points, 4 attempts
Cortisone and ACTH cause which CNS manifestation
Correct Choices
V Affective disturbance
Delirium
6
Correct Choices
Confusion
Schizophrenia
Feedback
Correct: That's right! You chose the correct response.
Incorrect: You did not choose the correct response.
Try
Again:
You did not choose the correct response. Please try again.
You have %ANSWER_ATTEMPTS% attempts.
Question 5. Multiple Choice, 10 points, 4 attempts
Parenteral steroids can cause
Correct Choices Feedback
V Cataract
Long-term therapy with intermediate- and long-acting steroids is associated
the development of posterior subcapsular cataracts.
Glaucoma Try again!
Corneal
opacity
Try again!
Papilloedema Try again!
Question 6. Multiple Choice, 10 points, 4 attempts
Steroid inhalation side effect
7
Correct Choices
Cushing syndrome
V Oropharyngeal Candidiasis
Sedation
None
Feedback
Correct: That's right! You chose the correct response.
Incorrect: You did not choose the correct response.
Try
Again:
You did not choose the correct response. Please try again.
You have %ANSWER_ATTEMPTS% attempts.
Question 7. Multiple Choice, 10 points, 4 attempts
All of the following glucocorticoid has the least mineralocorticoid activity EXCEPT
8
Correct Choices Feedback
Betamethasone Try again!
Triamcinolone Try again!
V Hydrocortisone
Reference: Katzung
Fluprednisolone Try again!
9
Question 8. Multiple Choice, 10 points, 4 attempts
Long term steroid treatment results in
Correct Choices Feedback
V
Resorption
of bone
matrix
Catabolic and antianabolic effects on bone are the cause of osteoporosis in
Cushing’s syndrome and impose a major limitation in the long-term therapeutic
use of glucocorticoids.
Decreased
vitamin D
activation
Try again!
Dereased
calcium
loss in
Urine
Try again!
Increased
calcium
absorption
from gut
Try again!
Question 9. Multiple Choice, 10 points, 4 attempts
The corticosteroid without any glucocorticoid activity is
10
Correct Choices Feedback
Aldosterone Try again!
Fludrocortisone Try again!
V DOCA
Reference from Katzung: DOCA is Desoxycorticosterone acetate (DOCA- O
C A Zero glucoCorticoid Activity)
Cortisol Try again!
Question 10. Multiple Choice, 10 points, 4 attempts
Which of the following is the most potent mineralocorticoids
11
Correct Choices Feedback
11
deoxycorticosterone
Try again!
Fludrocortisone Try again!
V Aldosterone
The most potent and important naturally occurring mineralocorticoid
is aldosterone.
Triamcinolone Try again!
Question 11. Multiple Choice, 10 points, 4 attempts
All of the following are side effects of steroids EXCEPT
Correct Choices Feedback
Osteoporosis Try again!
V Muscular Hypertrophy
12
Correct Choices Feedback
Cataracts Try again!
Psychosis Try again!
Question 12. Multiple Choice, 10 points, 4 attempts
In which of the following disease is corticosteroids indicated
Correct Choices Feedback
Osteoporosis Try again!
Peptic ulcer Try again!
V Collagen disease
13
Correct Choices Feedback
Tuberculosis Try again!
Question 13. Multiple Choice, 10 points, 4 attempts
In equivalent concentrations, steroids are more potent in which form
Correct Choices Feedback
Gel
Cream
V Ointment
Lotion
Question 14. Multiple Choice, 10 points, 4 attempts
The corticosteroid without mineralocorticoid activity is
14
Correct Choices Feedback
Hydrocortisone Try again!
Prednisolone Try again!
Methylprednisolone Try again!
V Triamcinolone
Question 15. Multiple Choice, 10 points, 4 attempts
Steroids do not cause
15
Correct Choices Feedback
Hypertension Try again!
Diabetes mellitus Try again!
V Osteomalacia
Osteoporosis and NOT osteomalacia
Infection Try again!
Question 16. Multiple Choice, 10 points, 4 attempts
Intermediate acting corticosteroid
16
Correct Choices Feedback
Dexamethasone Try again!
V Triamcinolone
Cortisol Try again!
Betamethasone Try again!
Question 17. Multiple Choice, 10 points, 4 attempts
Glucocorticoid with mineralocorticoid activity is seen in
17
Correct Choices Feedback
Triamcinolone Try again!
Betamethasone Try again!
V Cortisol
Dexamethasone Try again!
Question 18. Multiple Choice, 10 points, 4 attempts
Longest acting glucocorticoid is
18
Correct Choices Feedback
Prednisone Try again!
Prednisolone Try again!
Cortisone Try again!
V Dexamethasone
Question 19. Multiple Choice, 10 points, 4 attempts
Compared to hydrocortisone maximum glucocorticoid action is found in
19
Correct Choices Feedback
Prednisolone Try again!
Methylprednisolone Try again!
Cortisone Try again!
V Dexamethasone
Question 20. Multiple Choice, 10 points, 4 attempts
In Addison’s disease drug to be given is
20
Correct Choices Feedback
V Hydrocortisone
Hydrocortisone
• In chronic adrenal insufficiency or Addison’s disease,
hydrocortisone given orally is the drug of choice.
• Hydrocortisone is a glucocorticoid with maximum mineralocorticoid
action.
Betamethasone Try again!
Prednisolone Try again!
DOCA Try again!
Question 21. Multiple Choice, 10 points, 4 attempts
All are side effects of steroids EXCEPT
21
Correct Choices Feedback
Skin atrophy Try again!
Telengectasia Try again!
Folliculitis Try again!
V Photosensitivity
• Steroids are used for treatment of photosensitivity.
• Other effects i.e. skin atrophy, telangiectasia and folliculitis can
caused by steroids.
Question 22. Multiple Choice, 10 points, 4 attempts
Dose of dexamethasone given to mother in anticipated preterm delivery
Correct Choices Feedback
12 mg 12
hourly 2
doses
Try again!
22
Correct Choices Feedback
12 mg 24
hourly 4
doses
Try again!
6 mg 24
hourly 2
doses
Try again!
V
6 mg 12
hourly 4
doses
Dose of dexamethasone given to mother in anticipated preterm delivery is 6 mg
12 hourly 4 doses.
Question 23. Multiple Choice, 10 points, 4 attempts
All of the following are seen in adrenal insufficiency EXCEPT
Correct Choices Feedback
Hyperkalemia Try again!
Fever Try again!
V Weight gain Adrenal insufficiency results in weight loss.
Postural hypotension Try again!
Question 24. Multiple Choice, 10 points, 4 attempts
Which of the following regimen of antenatal steroids is preferred for fetal lung
maturation?
23
Correct Choices Feedback
V
Dexamethasone
6 mg 12 hourly
4 doses
Dose of dexamethasone is 6 mg 12 hourly for4 doses and dose of
betamethasone is 12 mg 24 hourly for 2 doses.
Betamethasone
6 mg 12 hourly
4 doses
Try again!
Dexamethasone
12 mg 12
hourly 4 doses
Try again!
Betamethasone
12 mg 12
hourly 4 doses
Try again!
Question 25. Multiple Choice, 10 points, 4 attempts
Drug of choice for pregnant female suspected of having a baby with congenital
adrenal hyperplasia is
24
Correct Choices Feedback
V Dexamethasone
To suppress fetal androgen production effectively and consequent
virilization,
dexamethasone must be initiated before 10 weeks of gestation.
Please Note: To treat congenital adrenal hyperplasia in baby
hydrocortisone is used.
Betamethasone Try again!
Hydrocortisone Try again!
Prednisolone Try again!
Quiz Results
Quiz Results, Passed
Congratulations, you passed!
25
Quiz Results, Failed
You did not pass.

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Corticosteroids

  • 1. 1 Corticosteroids Document created: 07.24.2021 19:24 Quiz Settings Setting Value Passing score: 80% Total number of questions: 25 Number of questions to ask: 25 Answer submission: Submit one question at a time Time limit (h:mm:ss): 1:00:00 Number of quiz retries: Unlimited / None When quiz is finished: Show slide with results Send quiz results to instructor: mbbsblues@gmail.com Send quiz results to user: Yes Intro Slide Welcome to the MCQ-Learn-Recall-Learn Quiz Session "%QUIZ_TITLE%" by Shivankan Kakkar, MD (Gold Medal) www.doctoru.weebly.com Click the "Start Quiz" button to proceed
  • 2. 2 User Info Form Enter Your Details, if you require questions and feedback on your email! Optional, you may continue without entering your details. Field name Condition Name Optional Email Optional Quiz Instructions Quiz Instructions  Before attempting, carefully read the question text.  Then choose the correct answer. (REMEMBER- You have 4 attempts for each question , since this is a practice session).  Click on “Submit” to confirm your answer. (On attempting the correct response you get a feedback, this is for proper understanding and correct recall the next time).
  • 3. 3  Use the Question List in the upper left corner to jump to a certain question.  Remember you may attempt the quiz any number of times. Best of luck! Question Group 1 (25/25 questions) Question 1. Multiple Choice, 10 points, 4 attempts Glucocorticoids are contraindicated in all EXCEPT Correct Choices Feedback V Organ transplant Organ transplant is one of the indications Peptic ulcers Try again! Hypertension Try again! Diabetes Mellitus Try again! Question 2. Multiple Choice, 10 points, 4 attempts Metyrapone is a selective inhibitor of
  • 4. 4 Correct Choices Feedback 17 alpha hydroxylase Try again! 21 alpha hydroxylase Try again! V 11 beta hydroxylase Metyrapone Metyrapone is a relatively selective inhibitor of steroid 11-hydroxylation, interfering with cortisol and corticosterone synthesis. This agent has not been widely used in the treatment of Cushing’s syndrome. However, metyrapone can reduce cortisol production to normal levels in some patients with endogenous Cushing’s syndrome. Thus, it may be useful in the management of severe manifestations of cortisol excess while the cause of this condition is being determined or in conjunction with radiation or surgical treatment. Metyrapone is the only adrenal-inhibiting medication that can be administered to pregnant women with Cushing’s syndrome. Desmolase Try again! Question 3. Multiple Choice, 10 points, 4 attempts Topical steroids can cause
  • 5. 5 Correct Choices Feedback V Glaucoma Increased intraocular pressure is common with use of topical steroids, and secondary glaucoma may be induced. Cataract Try again! Corneal opacities Try again! Optic neuritis Try again! Question 4. Multiple Choice, 10 points, 4 attempts Cortisone and ACTH cause which CNS manifestation Correct Choices V Affective disturbance Delirium
  • 6. 6 Correct Choices Confusion Schizophrenia Feedback Correct: That's right! You chose the correct response. Incorrect: You did not choose the correct response. Try Again: You did not choose the correct response. Please try again. You have %ANSWER_ATTEMPTS% attempts. Question 5. Multiple Choice, 10 points, 4 attempts Parenteral steroids can cause Correct Choices Feedback V Cataract Long-term therapy with intermediate- and long-acting steroids is associated the development of posterior subcapsular cataracts. Glaucoma Try again! Corneal opacity Try again! Papilloedema Try again! Question 6. Multiple Choice, 10 points, 4 attempts Steroid inhalation side effect
  • 7. 7 Correct Choices Cushing syndrome V Oropharyngeal Candidiasis Sedation None Feedback Correct: That's right! You chose the correct response. Incorrect: You did not choose the correct response. Try Again: You did not choose the correct response. Please try again. You have %ANSWER_ATTEMPTS% attempts. Question 7. Multiple Choice, 10 points, 4 attempts All of the following glucocorticoid has the least mineralocorticoid activity EXCEPT
  • 8. 8 Correct Choices Feedback Betamethasone Try again! Triamcinolone Try again! V Hydrocortisone Reference: Katzung Fluprednisolone Try again!
  • 9. 9 Question 8. Multiple Choice, 10 points, 4 attempts Long term steroid treatment results in Correct Choices Feedback V Resorption of bone matrix Catabolic and antianabolic effects on bone are the cause of osteoporosis in Cushing’s syndrome and impose a major limitation in the long-term therapeutic use of glucocorticoids. Decreased vitamin D activation Try again! Dereased calcium loss in Urine Try again! Increased calcium absorption from gut Try again! Question 9. Multiple Choice, 10 points, 4 attempts The corticosteroid without any glucocorticoid activity is
  • 10. 10 Correct Choices Feedback Aldosterone Try again! Fludrocortisone Try again! V DOCA Reference from Katzung: DOCA is Desoxycorticosterone acetate (DOCA- O C A Zero glucoCorticoid Activity) Cortisol Try again! Question 10. Multiple Choice, 10 points, 4 attempts Which of the following is the most potent mineralocorticoids
  • 11. 11 Correct Choices Feedback 11 deoxycorticosterone Try again! Fludrocortisone Try again! V Aldosterone The most potent and important naturally occurring mineralocorticoid is aldosterone. Triamcinolone Try again! Question 11. Multiple Choice, 10 points, 4 attempts All of the following are side effects of steroids EXCEPT Correct Choices Feedback Osteoporosis Try again! V Muscular Hypertrophy
  • 12. 12 Correct Choices Feedback Cataracts Try again! Psychosis Try again! Question 12. Multiple Choice, 10 points, 4 attempts In which of the following disease is corticosteroids indicated Correct Choices Feedback Osteoporosis Try again! Peptic ulcer Try again! V Collagen disease
  • 13. 13 Correct Choices Feedback Tuberculosis Try again! Question 13. Multiple Choice, 10 points, 4 attempts In equivalent concentrations, steroids are more potent in which form Correct Choices Feedback Gel Cream V Ointment Lotion Question 14. Multiple Choice, 10 points, 4 attempts The corticosteroid without mineralocorticoid activity is
  • 14. 14 Correct Choices Feedback Hydrocortisone Try again! Prednisolone Try again! Methylprednisolone Try again! V Triamcinolone Question 15. Multiple Choice, 10 points, 4 attempts Steroids do not cause
  • 15. 15 Correct Choices Feedback Hypertension Try again! Diabetes mellitus Try again! V Osteomalacia Osteoporosis and NOT osteomalacia Infection Try again! Question 16. Multiple Choice, 10 points, 4 attempts Intermediate acting corticosteroid
  • 16. 16 Correct Choices Feedback Dexamethasone Try again! V Triamcinolone Cortisol Try again! Betamethasone Try again! Question 17. Multiple Choice, 10 points, 4 attempts Glucocorticoid with mineralocorticoid activity is seen in
  • 17. 17 Correct Choices Feedback Triamcinolone Try again! Betamethasone Try again! V Cortisol Dexamethasone Try again! Question 18. Multiple Choice, 10 points, 4 attempts Longest acting glucocorticoid is
  • 18. 18 Correct Choices Feedback Prednisone Try again! Prednisolone Try again! Cortisone Try again! V Dexamethasone Question 19. Multiple Choice, 10 points, 4 attempts Compared to hydrocortisone maximum glucocorticoid action is found in
  • 19. 19 Correct Choices Feedback Prednisolone Try again! Methylprednisolone Try again! Cortisone Try again! V Dexamethasone Question 20. Multiple Choice, 10 points, 4 attempts In Addison’s disease drug to be given is
  • 20. 20 Correct Choices Feedback V Hydrocortisone Hydrocortisone • In chronic adrenal insufficiency or Addison’s disease, hydrocortisone given orally is the drug of choice. • Hydrocortisone is a glucocorticoid with maximum mineralocorticoid action. Betamethasone Try again! Prednisolone Try again! DOCA Try again! Question 21. Multiple Choice, 10 points, 4 attempts All are side effects of steroids EXCEPT
  • 21. 21 Correct Choices Feedback Skin atrophy Try again! Telengectasia Try again! Folliculitis Try again! V Photosensitivity • Steroids are used for treatment of photosensitivity. • Other effects i.e. skin atrophy, telangiectasia and folliculitis can caused by steroids. Question 22. Multiple Choice, 10 points, 4 attempts Dose of dexamethasone given to mother in anticipated preterm delivery Correct Choices Feedback 12 mg 12 hourly 2 doses Try again!
  • 22. 22 Correct Choices Feedback 12 mg 24 hourly 4 doses Try again! 6 mg 24 hourly 2 doses Try again! V 6 mg 12 hourly 4 doses Dose of dexamethasone given to mother in anticipated preterm delivery is 6 mg 12 hourly 4 doses. Question 23. Multiple Choice, 10 points, 4 attempts All of the following are seen in adrenal insufficiency EXCEPT Correct Choices Feedback Hyperkalemia Try again! Fever Try again! V Weight gain Adrenal insufficiency results in weight loss. Postural hypotension Try again! Question 24. Multiple Choice, 10 points, 4 attempts Which of the following regimen of antenatal steroids is preferred for fetal lung maturation?
  • 23. 23 Correct Choices Feedback V Dexamethasone 6 mg 12 hourly 4 doses Dose of dexamethasone is 6 mg 12 hourly for4 doses and dose of betamethasone is 12 mg 24 hourly for 2 doses. Betamethasone 6 mg 12 hourly 4 doses Try again! Dexamethasone 12 mg 12 hourly 4 doses Try again! Betamethasone 12 mg 12 hourly 4 doses Try again! Question 25. Multiple Choice, 10 points, 4 attempts Drug of choice for pregnant female suspected of having a baby with congenital adrenal hyperplasia is
  • 24. 24 Correct Choices Feedback V Dexamethasone To suppress fetal androgen production effectively and consequent virilization, dexamethasone must be initiated before 10 weeks of gestation. Please Note: To treat congenital adrenal hyperplasia in baby hydrocortisone is used. Betamethasone Try again! Hydrocortisone Try again! Prednisolone Try again! Quiz Results Quiz Results, Passed Congratulations, you passed!