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1. Thesis Plan submitted to MGUMST, Jaipur
July 2022 session
THE ASSOCIATION BETWEEN DYSELECTROLYTEMIA
AND ACUTE EXACEBRATION OF CHRONIC
OBSTRUCTIVE PULMONARY DISEASE
By
DR AKANSHU JAIN
Under the guidance of
DR DEEPAK GUPTA
(Proffesor)
Department of General Medicine
Mahatma Gandhi Medical College & Hospital, Jaipur

2. Mahatma Gandhi Medical College & Hospital, Jaipur
To,
The Principal & Controller
Mahatma Gandhi Medical College & Hospital
Jaipur.
Sub.- Submission of thesis plan
I , Dr AKANSHU JAIN registered for MD – GENERAL MEDICINE ( March 2022 session ) ), hereby submit my thesis plan titled,
THE ASSOCIATION BETWEEN DYSELECTROLEMIA AND ACUTE EXACEBRATION OF CHRONIC OBSTRUCTIVE
PULMONARY DISEASE AT MAHATMA GANDHI MEDICAL COLLEGE , JAIPUR to be done under the guidance of DR
DEEPAK GUPTA SIR .
Signature of PG Student Signature of PG Guide
Signature of Head of Department

3. Name of the institution:- MGUMST,JAIPUR,RAJASTHAN
Corse of study and subject :- 3 years M.D. GENERAL MEDICINE
Date of admission to course:-07/03/2022
Due date of final exam:- 2025
Title of the topic :- THE ASSOCIATION BETWEEN DYSELECTROLEMIAAND
ACUTE EXACEBRATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT
MAHATMA GANDHI MEDICAL COLLEGE , JAIPUR

4. INDEX
•
1. Introduction
2. Aims and Objectives
3. Materials and Methods
4. Performa
5. Consent form

5. INTRODUCTION
• Chronic obstructive pulmonary disease (COPD) is defined as a disease state characterized
by persistent respiratory symptoms and airflow obstruction.
• There is a lack of studies on the association of COPD with disorders of serum sodium and
potassium. Hypokalemia may be a complication of AECOPD due to decreased nutritional
intake in acute illness or increased renal loss, especially in case of concomitant
decompensated heart failure.
• Reduced general state of health in acute illness such as acute exacerbation of COPD
might lead to impairment of thirst sensation for example due to fever, confusion or
inflammation. Furthermore, patients might suffer from weakness or even immobility
limiting their free access to water even with intact thirst sensation. Both conditions
might increase the risk for hypernatremia in these patients.
• This study aims at evaluating serum electrolyte levels in acute exacerbation of COPD.

6. AIMS AND OBJECTIVES
• To establish relationship between Acute Exacerbation of COPD and
Electrolyte Imbalance
• Prognosis of hyponatremia/hypernatremia and
hypokalemia/hyperkalemia with acute exacerbation of COPD

7. MATERIALS AND METHODS
• Type of Study: A cross sectional observational study
• Period of Study: July 2022 to August 2023
• Place of Study: Mahatma Gandhi Medical College & Hospital, Jaipur
• SAMPLE SIZE. : All patient admitted in hospital during above period
meeting the inclusion criterion

8. INCLUSION CRITERION
• All cases of COPD patients presenting to outpatient department or
emergency with acute exacerbation.
• Age of patient between 18 -65 yrs of age

9. EXCLUSION CRITERION
• 1. COPD patients admitted for causes other than COPD exacerbation
• 2. COPD patients requiring mechanical ventilation
• 3. Patients with pre-existing renal, hepatic, endocrinal or cardiac
illness.
• 4. All patients not willing to give consent

10. METHODOLOGY
• Patients admitted under General Medicine of Mahatma Gandhi
Medical College and Hospital, will undergo a detailed medical history
and a thorough physical examination
• All routine blood parameters including, complete blood count, serum
electrolytes , erythrocyte sedimentation rate (ESR) ,C reactive protein
(CRP),renal function test, liver function test, ABG , chest xray .
• COPD diagnosis will be confirmed by clinical history and
investigations, spirometry if and when required .

11. PROFORMA
• Patient name : Age: Sex:
• DOA : DOD :
• Address :
• Occupation : Phone No :
• IP No. : Ward and Unit :
• Clinical Details-
• Date of onset of illness : Duration of illness :

12. Presenting Complaints :
• Shortness of breath
• Cough with / without expectoration
• Swelling of legs/ ankle
• Chest tightness
• Fatigue

13. INVESTIGATIONS
• Complete Haemogram
• CRP
• ESR
• Serum Electrolytes
• Chest X-RAY
• Arterial Blood Gas Analysis
• RFT
• LFT

14. Format C
Informed Consent Form (English)
Study Title :- Prevelance and clinical relevance of skin prick test and its correlation with
pulmonary function test with asthma severity at mahatma gandhi hospital,
jaipur, Rajasthan”
Subject’s Name :- .......................................................................................
Date of Birth/ Age (Years) :- ............................... Sex :- ..............................
Please √ the
box given here
(1) I confirm that I have been explained the purpose and the
methodology of the study and I have cleared every doubt about the
study.
[ ]
(2) I understand that my participation in the study is voluntary and that I
am free to withdraw at any time, without giving any reason, without
my medical care or legal rights being affected.
[ ]
(3) I have been informed that this study is purely a research study and
participation in the above study would not be of any direct benefit or
risk to me and results of this study may be of help in future for the
society.
[ ]
(4) I understand that the investigator of this study and others working on
the investigator’s behalf, the Institutional Ethics Committee will not
need my permission to look at my health records both in respect to
current study and any future research study that may be conducted in
relation to it.
[ ]
(5) I understand that my identity will not be revealed in any information
released to third parties or Published. [ ]
(6) I agree not to restrict the use of any data or result that arise from this
study provided such a use is only for scientific purpose(s). [ ]
(7) I agree to take part in the above study [ ]
Name of the subject: ................................................................................
Signature of the subject: ..................................... Date: ....../......./.........
Name of the Investigator: ........................................................................
Signature of the Investigator: .............................. Date: ....../....../..........
Name of the witness: ...............................................................................
Signature of the witness: ....................................... Date: ....../....../........

15. REFERENCES
• Harshavardhan L, Chikkahonnaiah P. Serum Electrolyte Profile in
Subjects Admitted with Acute Exacerbation of Chronic Obstructive
Pulmonary Disease. Int J Sci Stud 2016;4(9):31-33.

16. •THANKYOU