1) This study investigated the effects of ginger powder supplementation on inflammatory markers in elderly patients with knee osteoarthritis over 12 weeks.
2) 120 patients were randomly assigned to either a ginger group that received 500 mg ginger powder capsules daily or a placebo group that received 500 mg starch capsules.
3) After 12 weeks, serum levels of nitric oxide and C-reactive protein (markers of inflammation) decreased more in the ginger group compared to the placebo group, indicating that daily ginger powder supplementation may help reduce inflammation in patients with knee osteoarthritis.
Efficacy,and safety of intravenous zoledronic acid in treatment+of+pediatric+...Abdulmoein AlAgha
Zoledronic acid is an effective treatment for pediatric osteoporosis. A 13-year study of 131 children with primary or secondary osteoporosis found that intravenous zoledronic acid significantly reduced fractures, bone pain, and bone turnover markers. While acute side effects like fever and hypocalcemia occurred after the first infusion, no chronic adverse events were reported. Zoledronic acid should be considered as an important treatment for improving outcomes in pediatric osteoporosis.
Effect of Walking on Fasting Blood Sugar in Type 2 Diabetesiosrjce
This study examined the effect of 30 minutes of walking on fasting blood sugar levels in 25 male and female adults with type 2 diabetes who were on regular treatment for over one year. Fasting blood sugar levels were measured before and after 30 minutes of walking. The results found a significant decrease in fasting blood sugar levels after 30 minutes of walking compared to without walking, with a p-value of less than 0.001. The study concluded that 30 minutes of walking a day can help control blood sugar levels and plays an important role in managing type 2 diabetes.
THERAPEUTIC EFFECT OF SOYA BEAN CHUNKS SUPPLEMENTION DURING HEMODIALYSISNeeleshkumar Maurya
This document summarizes a study on the therapeutic effects of soybean chunk supplementation during hemodialysis. The study involved 30 chronic kidney disease patients undergoing hemodialysis, who were divided into two groups. The first group received standard hemodialysis treatment, while the second group received hemodialysis treatment plus dietary counseling to consume 50g of soybean chunks daily, which are a rich source of protein and nutrients. Biochemical parameters like hemoglobin, serum albumin, cholesterol, and triglycerides significantly improved in the group that received soybean chunk supplementation compared to those who only received standard hemodialysis treatment. The results indicate that providing nutrient-enriched foods like soybean chunks and dietary counseling can
Chief Co ordinator Dr.Maninder Ahuja
These six modules from 2-7 are on mid life health care of women and were made with intention of training general gynecologist and other speciality into care of mid life women and have Mid Life OPD cards as mainstay of care.
Introduction: Progress in management of Nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal toxicity requires the availability of appropriate experimental animal models that are as close to humans as feasible. Our objective was to develop a rat model for NSAID-induced gastroenteropathy and also to simulate the common clinical scenario of co-administration of NSAID and proton pump inhibitor (PPI) to explore if PPI contribute to exacerbation of NSAID-enteropathy. Methods: Rats were treated twice daily with pantoprazole sodium (PTZ; 10 mg/kg peroral) or vehicle for a total of 10 days. In some experiments, Diclofenac sodium (DCF; 9 mg/kg) or vehicle was administered orally twice daily for the final 5 days of PTZ/vehicle administration. After the last dose on 9th day, rats in all the groups were fasted but water was provided ad libitum. 12 hours after the last dose on 10th day, rats in all the groups were euthanized and their gastrointestinal tracts were assessed for haemorrhagic lesions, lipid peroxidation, intestinal permeability and gastrointestinal luminal pH alterations. Changes in haemoglobin, haematocrit and serum levels of albumin, total protein, ALT and bilirubin were calculated. Results: The macroscopic and histological evidence suggested that administration of DCF resulted in significant gastroenteropathic damage and co-administration of PTZ resulted in significant exacerbation of NSAID enteropathy, while attenuation of NSAID induced gastropathy was observed. Our results were further supported by the significant decrease in haemoglobin and haematocrit levels and serum levels of albumin and total proteins, an increase in oxidative stress and intestinal permeability with the use of DCF either alone or in combination with PTZ. Conclusions: This model was developed to simulate the human clinical situation during NSAID therapy and indeed the present DCF regimen caused both gastric and small bowel alterations, such as multiple erosive lesions, together with a decrease in haemoglobin, haematocrit, serum albumin, serum total protein levels and IP alteration, known to occur in patients receiving NSAIDs. Additionally, this paper provides yet another evidence for PPI induced exacerbation of NSAID enteropathy.
Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Ser...Haleh Hadaegh
1) This randomized controlled trial examined the effects of consuming synbiotic, probiotic, or control bread on insulin metabolism and inflammation markers in 81 diabetic patients over 8 weeks.
2) Patients who consumed synbiotic bread had a significant reduction in insulin levels, insulin resistance scores, and beta-cell function compared to the probiotic and control bread groups.
3) The synbiotic bread, containing Lactobacillus sporogenes and inulin, improved insulin metabolism but did not significantly affect other measures like blood glucose, insulin sensitivity, or CRP levels compared to the other breads.
Closed or ready-to-hang enteral nutrition systems have several benefits over open systems including reduced risk of contamination, easier administration requiring less nursing time, and improved delivery of nutrients. Major guidelines recommend the use of ready-to-hang liquid nutrition as the preferred method where possible. Using closed systems can improve patient outcomes and reduce healthcare costs.
Efficacy,and safety of intravenous zoledronic acid in treatment+of+pediatric+...Abdulmoein AlAgha
Zoledronic acid is an effective treatment for pediatric osteoporosis. A 13-year study of 131 children with primary or secondary osteoporosis found that intravenous zoledronic acid significantly reduced fractures, bone pain, and bone turnover markers. While acute side effects like fever and hypocalcemia occurred after the first infusion, no chronic adverse events were reported. Zoledronic acid should be considered as an important treatment for improving outcomes in pediatric osteoporosis.
Effect of Walking on Fasting Blood Sugar in Type 2 Diabetesiosrjce
This study examined the effect of 30 minutes of walking on fasting blood sugar levels in 25 male and female adults with type 2 diabetes who were on regular treatment for over one year. Fasting blood sugar levels were measured before and after 30 minutes of walking. The results found a significant decrease in fasting blood sugar levels after 30 minutes of walking compared to without walking, with a p-value of less than 0.001. The study concluded that 30 minutes of walking a day can help control blood sugar levels and plays an important role in managing type 2 diabetes.
THERAPEUTIC EFFECT OF SOYA BEAN CHUNKS SUPPLEMENTION DURING HEMODIALYSISNeeleshkumar Maurya
This document summarizes a study on the therapeutic effects of soybean chunk supplementation during hemodialysis. The study involved 30 chronic kidney disease patients undergoing hemodialysis, who were divided into two groups. The first group received standard hemodialysis treatment, while the second group received hemodialysis treatment plus dietary counseling to consume 50g of soybean chunks daily, which are a rich source of protein and nutrients. Biochemical parameters like hemoglobin, serum albumin, cholesterol, and triglycerides significantly improved in the group that received soybean chunk supplementation compared to those who only received standard hemodialysis treatment. The results indicate that providing nutrient-enriched foods like soybean chunks and dietary counseling can
Chief Co ordinator Dr.Maninder Ahuja
These six modules from 2-7 are on mid life health care of women and were made with intention of training general gynecologist and other speciality into care of mid life women and have Mid Life OPD cards as mainstay of care.
Introduction: Progress in management of Nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal toxicity requires the availability of appropriate experimental animal models that are as close to humans as feasible. Our objective was to develop a rat model for NSAID-induced gastroenteropathy and also to simulate the common clinical scenario of co-administration of NSAID and proton pump inhibitor (PPI) to explore if PPI contribute to exacerbation of NSAID-enteropathy. Methods: Rats were treated twice daily with pantoprazole sodium (PTZ; 10 mg/kg peroral) or vehicle for a total of 10 days. In some experiments, Diclofenac sodium (DCF; 9 mg/kg) or vehicle was administered orally twice daily for the final 5 days of PTZ/vehicle administration. After the last dose on 9th day, rats in all the groups were fasted but water was provided ad libitum. 12 hours after the last dose on 10th day, rats in all the groups were euthanized and their gastrointestinal tracts were assessed for haemorrhagic lesions, lipid peroxidation, intestinal permeability and gastrointestinal luminal pH alterations. Changes in haemoglobin, haematocrit and serum levels of albumin, total protein, ALT and bilirubin were calculated. Results: The macroscopic and histological evidence suggested that administration of DCF resulted in significant gastroenteropathic damage and co-administration of PTZ resulted in significant exacerbation of NSAID enteropathy, while attenuation of NSAID induced gastropathy was observed. Our results were further supported by the significant decrease in haemoglobin and haematocrit levels and serum levels of albumin and total proteins, an increase in oxidative stress and intestinal permeability with the use of DCF either alone or in combination with PTZ. Conclusions: This model was developed to simulate the human clinical situation during NSAID therapy and indeed the present DCF regimen caused both gastric and small bowel alterations, such as multiple erosive lesions, together with a decrease in haemoglobin, haematocrit, serum albumin, serum total protein levels and IP alteration, known to occur in patients receiving NSAIDs. Additionally, this paper provides yet another evidence for PPI induced exacerbation of NSAID enteropathy.
Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Ser...Haleh Hadaegh
1) This randomized controlled trial examined the effects of consuming synbiotic, probiotic, or control bread on insulin metabolism and inflammation markers in 81 diabetic patients over 8 weeks.
2) Patients who consumed synbiotic bread had a significant reduction in insulin levels, insulin resistance scores, and beta-cell function compared to the probiotic and control bread groups.
3) The synbiotic bread, containing Lactobacillus sporogenes and inulin, improved insulin metabolism but did not significantly affect other measures like blood glucose, insulin sensitivity, or CRP levels compared to the other breads.
Closed or ready-to-hang enteral nutrition systems have several benefits over open systems including reduced risk of contamination, easier administration requiring less nursing time, and improved delivery of nutrients. Major guidelines recommend the use of ready-to-hang liquid nutrition as the preferred method where possible. Using closed systems can improve patient outcomes and reduce healthcare costs.
As a newly emphasized modality to treat infectious complications and also to folloew non-antibiotic regimens against infection, Probiotics has recieved more and more attention now a days.
П. Сутерс "Проявления инсулинорезистентности и гликемический контроль в интен...rnw-aspen
Доклад с 15 Межрегиональной научно-практической конференции "Искусственное питание и инфузионная терапия больных в медицине критических состояний" 21-22 мая 2015 г
Bariatric surgery leads to long-term weight loss and improved health outcomes through physiological rather than mechanical mechanisms. It alters gastrointestinal signals that change the body's defended fat mass set point and regulate appetite and metabolism. Specifically, surgery modifies the luminal environment and gut microbiota composition, increasing circulating bile acids and triggering hormonal and neuronal signals that decrease hunger and food reward while increasing energy expenditure. This physiological reprogramming opposes the effects of dieting and underlies the durable benefits of bariatric procedures.
This document provides information on various nutraceutical products and their functions, including krill oil, phosphatidylserine, Gastro-AD, and pyrroloquinoline quinone. Krill oil contains omega-3 fatty acids and antioxidants that may improve cognition, reduce inflammation, and support joint, liver, and PMS health. Phosphatidylserine may enhance cognition, decrease stress, improve skin health, and support sports performance. Gastro-AD, containing L. delbrueckii bacteria, can relieve heartburn and heal stomach lining. Pyrroloquinoline quinone is an essential bacterial co-factor important for growth, immunity, and reproduction.
This document discusses the importance of nutrition training for hospital staff. It aims to help nursing staff and canteen staff appropriately utilize the dietetics department to improve nutritional care for patients. The document outlines how malnutrition is common in hospitals, affecting health outcomes. It emphasizes the roles of various staff in nutritional screening, care planning, and meeting patients' nutritional needs through normal foods, supplements, and enteral/parenteral feeding if needed. The importance of education and training for staff on nutritional care is also highlighted.
This document summarizes the results of a clinical trial investigating the efficacy of oral low molecular weight hyaluronic acid (HA) in improving symptoms and function in patients with knee osteoarthritis. The study was a randomized, double-blind, placebo-controlled trial involving Taiwanese patients with knee OA. Patients received either an oral liquid containing low molecular weight HA, glucosamine, and chondroitin, or a placebo daily for 8 weeks. Outcome measures including the WOMAC scale and SF-36 questionnaire showed significant improvements in pain, physical function, and quality of life in the HA group compared to the placebo group. The study demonstrated oral low molecular HA was effective in relieving symptoms of mild knee O
The use of bisphosphonate for patients on glucocorticoid therapy for the prev...sara_abudahab
This document summarizes two meta-analyses on the use of bisphosphonates for patients on glucocorticoid therapy. The first analysis from 2013 found bisphosphonates reduced the risk of vertebral fractures and increased bone mineral density. Prevention trials had greater benefits than treatment trials. The second 2016 analysis also found bisphosphonates reduced vertebral fractures and increased bone mineral density, with high certainty for fractures and moderate certainty for bone mineral density. It found low certainty of effect on non-vertebral fractures and serious adverse events. Both analyses support the use of bisphosphonates to reduce fractures and treat glucocorticoid-induced bone loss.
Biomedical big data and research clinical application for obesityHyung Jin Choi
1. What is Biomedical Big Data?
2. Biomedical Big Data
1) Genetic Data
2) Electrical Health Records
3) National Healthcare Data
4) Medical Images
5) Sensor/Mobile Data
6) Data Integration
3. Biomedical Big Data + Artificial Intelligence
4. Research/Clinical Application for Obesity
1) Three ayurvedic publications on herbal medicines for obesity were systematically reviewed. Ephedra and caffeine were found to reduce body weight and fat over 12 weeks without serious side effects.
2) Several herbal supplements including Cissus quadrangularis, ephedra and caffeine, and extracts of ginger and other plants were found to reduce body weight, fat levels, and waist circumference in human studies on obesity.
3) Terminalia arjuna bark powder was found to have antioxidant effects comparable to vitamin E and significantly reduced cholesterol levels in patients with coronary heart disease.
Dr Emma Ridley is a senior research fellow and ICU dietitian who has published extensively in the field of nutrition. She discloses research funding from Baxter Healthcare and having received speaking fees from them. Her top 5 publications focus on characterizing the metabolic phenotype during critical illness, investigating the effects of very high protein enteral nutrition, examining how pre-existing kidney function impacts outcomes with IV amino acid supplementation, comparing enteral versus parenteral nutrition in shock patients, and a large trial investigating energy-dense versus routine enteral nutrition.
This study examined the effects of 6 consecutive days of breakfast skipping on energy metabolism and blood glucose levels in 10 healthy young Japanese males. The results showed that repeated breakfast skipping slightly increased blood glucose levels and fluctuations when subjects engaged in sedentary behavior. However, 6 days of breakfast skipping did not significantly affect 24-hour energy expenditure or substrate oxidation. Sedentary lifestyle combined with repeated breakfast skipping may cause abnormal glucose fluctuations.
This study examined the association between serum albumin levels and muscle mass in 275 elderly men and women aged 60-95 years. The study found that after controlling for age, protein intake, physical activity, and comorbidities:
1) Serum albumin levels were significantly associated with muscle mass in both men and women, suggesting decreases in serum albumin with age are associated with sarcopenia.
2) This association between serum albumin and muscle mass was independent of other factors that could affect muscle mass or albumin levels.
3) The findings suggest that increased risk of disability seen in elderly people with low serum albumin may actually reflect an association with sarcopenia.
This document discusses sarcopenia and muscle loss in older adults. It provides definitions of sarcopenia from various international organizations and diagnostic criteria. It also reviews research on the role of nutrition, including protein and vitamin D supplementation, resistance training, and multimodal exercise programs in preventing and treating sarcopenia. References are provided for 38 studies and reviews on topics related to sarcopenia in older adults.
Feasting or fasting in ICU? by Professor Marianne ChapmanSMACC Conference
This document summarizes the current evidence and ongoing research regarding optimal calorie delivery for critically ill patients in the ICU. It discusses previous studies that have shown conflicting results regarding whether aiming for full calorie delivery leads to better outcomes compared to permissive underfeeding or usual care. The document concludes that high-quality evidence is still needed to guide practice and describes the ongoing TARGET trial, a large multicenter randomized controlled trial aiming to determine if full calorie delivery improves survival in critically ill patients.
Case study on Holistic Diabetic Care using Diet, Yoga, Resisted Exercises usi...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
This document discusses nutritional support in the prevention and treatment of pressure ulcers. It notes that pressure ulcers pose a significant burden through increased healthcare costs and prolonged hospital stays. Nutrition plays an important role both in preventing pressure ulcers in at-risk patients and in aiding the healing of existing ulcers. Several studies are summarized that have found protein and mineral supplements like zinc and vitamin C to help reduce pressure ulcer size and improve healing rates compared to standard care or placebo, though the evidence for zinc supplements alone is mixed.
Role of meal replacement in type 2 diabetesAmogh lotankar
This document discusses several studies on the relationship between obesity, diabetes, and meal replacements. It finds that modest weight loss through calorie reduction and physical activity can improve insulin sensitivity. Meal replacements as part of a structured diet plan are emerging as a cost-effective solution for weight management in type 2 diabetes patients. Clinical trials show meal replacements result in greater weight loss and improved cardiovascular risk factors compared to usual diets. Liquid meal replacements are a safe and effective tool for weight loss in obese type 2 diabetes patients, resulting in improved body weight, glucose, and lipid levels.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
This presentation was held during the 5th GIB Summit, May 27-28 2015.
The presentation and more information on the Global Infrastructure Basel Foundation are available on www.gib-foundation.org
As a newly emphasized modality to treat infectious complications and also to folloew non-antibiotic regimens against infection, Probiotics has recieved more and more attention now a days.
П. Сутерс "Проявления инсулинорезистентности и гликемический контроль в интен...rnw-aspen
Доклад с 15 Межрегиональной научно-практической конференции "Искусственное питание и инфузионная терапия больных в медицине критических состояний" 21-22 мая 2015 г
Bariatric surgery leads to long-term weight loss and improved health outcomes through physiological rather than mechanical mechanisms. It alters gastrointestinal signals that change the body's defended fat mass set point and regulate appetite and metabolism. Specifically, surgery modifies the luminal environment and gut microbiota composition, increasing circulating bile acids and triggering hormonal and neuronal signals that decrease hunger and food reward while increasing energy expenditure. This physiological reprogramming opposes the effects of dieting and underlies the durable benefits of bariatric procedures.
This document provides information on various nutraceutical products and their functions, including krill oil, phosphatidylserine, Gastro-AD, and pyrroloquinoline quinone. Krill oil contains omega-3 fatty acids and antioxidants that may improve cognition, reduce inflammation, and support joint, liver, and PMS health. Phosphatidylserine may enhance cognition, decrease stress, improve skin health, and support sports performance. Gastro-AD, containing L. delbrueckii bacteria, can relieve heartburn and heal stomach lining. Pyrroloquinoline quinone is an essential bacterial co-factor important for growth, immunity, and reproduction.
This document discusses the importance of nutrition training for hospital staff. It aims to help nursing staff and canteen staff appropriately utilize the dietetics department to improve nutritional care for patients. The document outlines how malnutrition is common in hospitals, affecting health outcomes. It emphasizes the roles of various staff in nutritional screening, care planning, and meeting patients' nutritional needs through normal foods, supplements, and enteral/parenteral feeding if needed. The importance of education and training for staff on nutritional care is also highlighted.
This document summarizes the results of a clinical trial investigating the efficacy of oral low molecular weight hyaluronic acid (HA) in improving symptoms and function in patients with knee osteoarthritis. The study was a randomized, double-blind, placebo-controlled trial involving Taiwanese patients with knee OA. Patients received either an oral liquid containing low molecular weight HA, glucosamine, and chondroitin, or a placebo daily for 8 weeks. Outcome measures including the WOMAC scale and SF-36 questionnaire showed significant improvements in pain, physical function, and quality of life in the HA group compared to the placebo group. The study demonstrated oral low molecular HA was effective in relieving symptoms of mild knee O
The use of bisphosphonate for patients on glucocorticoid therapy for the prev...sara_abudahab
This document summarizes two meta-analyses on the use of bisphosphonates for patients on glucocorticoid therapy. The first analysis from 2013 found bisphosphonates reduced the risk of vertebral fractures and increased bone mineral density. Prevention trials had greater benefits than treatment trials. The second 2016 analysis also found bisphosphonates reduced vertebral fractures and increased bone mineral density, with high certainty for fractures and moderate certainty for bone mineral density. It found low certainty of effect on non-vertebral fractures and serious adverse events. Both analyses support the use of bisphosphonates to reduce fractures and treat glucocorticoid-induced bone loss.
Biomedical big data and research clinical application for obesityHyung Jin Choi
1. What is Biomedical Big Data?
2. Biomedical Big Data
1) Genetic Data
2) Electrical Health Records
3) National Healthcare Data
4) Medical Images
5) Sensor/Mobile Data
6) Data Integration
3. Biomedical Big Data + Artificial Intelligence
4. Research/Clinical Application for Obesity
1) Three ayurvedic publications on herbal medicines for obesity were systematically reviewed. Ephedra and caffeine were found to reduce body weight and fat over 12 weeks without serious side effects.
2) Several herbal supplements including Cissus quadrangularis, ephedra and caffeine, and extracts of ginger and other plants were found to reduce body weight, fat levels, and waist circumference in human studies on obesity.
3) Terminalia arjuna bark powder was found to have antioxidant effects comparable to vitamin E and significantly reduced cholesterol levels in patients with coronary heart disease.
Dr Emma Ridley is a senior research fellow and ICU dietitian who has published extensively in the field of nutrition. She discloses research funding from Baxter Healthcare and having received speaking fees from them. Her top 5 publications focus on characterizing the metabolic phenotype during critical illness, investigating the effects of very high protein enteral nutrition, examining how pre-existing kidney function impacts outcomes with IV amino acid supplementation, comparing enteral versus parenteral nutrition in shock patients, and a large trial investigating energy-dense versus routine enteral nutrition.
This study examined the effects of 6 consecutive days of breakfast skipping on energy metabolism and blood glucose levels in 10 healthy young Japanese males. The results showed that repeated breakfast skipping slightly increased blood glucose levels and fluctuations when subjects engaged in sedentary behavior. However, 6 days of breakfast skipping did not significantly affect 24-hour energy expenditure or substrate oxidation. Sedentary lifestyle combined with repeated breakfast skipping may cause abnormal glucose fluctuations.
This study examined the association between serum albumin levels and muscle mass in 275 elderly men and women aged 60-95 years. The study found that after controlling for age, protein intake, physical activity, and comorbidities:
1) Serum albumin levels were significantly associated with muscle mass in both men and women, suggesting decreases in serum albumin with age are associated with sarcopenia.
2) This association between serum albumin and muscle mass was independent of other factors that could affect muscle mass or albumin levels.
3) The findings suggest that increased risk of disability seen in elderly people with low serum albumin may actually reflect an association with sarcopenia.
This document discusses sarcopenia and muscle loss in older adults. It provides definitions of sarcopenia from various international organizations and diagnostic criteria. It also reviews research on the role of nutrition, including protein and vitamin D supplementation, resistance training, and multimodal exercise programs in preventing and treating sarcopenia. References are provided for 38 studies and reviews on topics related to sarcopenia in older adults.
Feasting or fasting in ICU? by Professor Marianne ChapmanSMACC Conference
This document summarizes the current evidence and ongoing research regarding optimal calorie delivery for critically ill patients in the ICU. It discusses previous studies that have shown conflicting results regarding whether aiming for full calorie delivery leads to better outcomes compared to permissive underfeeding or usual care. The document concludes that high-quality evidence is still needed to guide practice and describes the ongoing TARGET trial, a large multicenter randomized controlled trial aiming to determine if full calorie delivery improves survival in critically ill patients.
Case study on Holistic Diabetic Care using Diet, Yoga, Resisted Exercises usi...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
This document discusses nutritional support in the prevention and treatment of pressure ulcers. It notes that pressure ulcers pose a significant burden through increased healthcare costs and prolonged hospital stays. Nutrition plays an important role both in preventing pressure ulcers in at-risk patients and in aiding the healing of existing ulcers. Several studies are summarized that have found protein and mineral supplements like zinc and vitamin C to help reduce pressure ulcer size and improve healing rates compared to standard care or placebo, though the evidence for zinc supplements alone is mixed.
Role of meal replacement in type 2 diabetesAmogh lotankar
This document discusses several studies on the relationship between obesity, diabetes, and meal replacements. It finds that modest weight loss through calorie reduction and physical activity can improve insulin sensitivity. Meal replacements as part of a structured diet plan are emerging as a cost-effective solution for weight management in type 2 diabetes patients. Clinical trials show meal replacements result in greater weight loss and improved cardiovascular risk factors compared to usual diets. Liquid meal replacements are a safe and effective tool for weight loss in obese type 2 diabetes patients, resulting in improved body weight, glucose, and lipid levels.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
This presentation was held during the 5th GIB Summit, May 27-28 2015.
The presentation and more information on the Global Infrastructure Basel Foundation are available on www.gib-foundation.org
This presentation was held during the 5th GIB Summit, May 27-28 2015.
The presentation and more information on the Global Infrastructure Basel Foundation are available on www.gib-foundation.org
Michael Falaschetti is a welder from Dyer, IN who has over 7 years of experience in mig and stick welding. He has worked as a welder for Latallier from 2011 to 2012 and for U-Haul in Schererville, IN from 2010 to 2011, where his responsibilities included welding truck sub-frames to create moving vans. Mr. Falaschetti completed welding training at 597 Pipe Welding School in 2010 and is authorized to work in the US for any employer.
This document discusses sources of error in finite element analysis, including modeling errors due to simplifying assumptions, discretization errors from approximating solutions, and numerical errors from limited computer precision. It provides examples of common mistakes that can cause incorrect results, such as incorrect material properties or insufficient boundary constraints. It also discusses best practices for verifying models, such as element testing, mesh refinement studies, and checking results against analytical solutions or boundary conditions.
Wearable Summit 2015 ICEMD ZERINTIA Digital Home hueJosé Luis Ferrero
This document discusses the concept of the digital home and connected devices. It covers several key points:
1. Major players in the digital home space like Amazon, Google, and Apple are developing platforms for connected devices.
2. Philips' Hue lighting system is highlighted as an example of a digital home product. It allows users to control lighting for ambient effects, security, and reminders using a smartphone app.
3. There are over 190 apps that are compatible with Hue lights through its open ecosystem, and the Hue product line is expanding to include different types of lights and control accessories.
Aυθορμητο Σπασιμο Συμμετριας και Μηχανισμος Higgs (new)John Fiorentinos
Στις θεωρίες που έχουμε αυθόρμητο σπάσιμο (συνεχούς) συμμετρίας (spontaneous symmetry breaking of continuous symmetry), το θεώρημα Goldstone μας λέει ότι εμφανίζεται ένα άμαζο σωματίδιο μηδενικού spin (Nambu – Goldstone) που ονομάζουμε Goldstone boson.
Τώρα αν η θεωρία μας είναι αναλλοίωτη σε κάποιο τοπικό μετασχηματισμό βαθμίδας (local gauge invariance), το άμαζο σωματίδιο Goldstone, απορροφάται από το μποζόνιο βαθμίδας, οδηγώντας στην εμφάνιση ενός (επί πλέον) “διάμηκους” βαθμού ελευθερίας για το μποζόνιο βαθμίδας, δηλαδή πλέον το gauge bozon αποκτά μάζα. (Το άμαζο μποζόνιο βαθμίδας …«τρώει» το Goldstone…και βαραίνει!)-
Smart Money, Exit Anytime and access to a larger investor networkSociety3 Grp.
Society3, the startup accelerator and accredited investor platform for investing in startups and Exit Anytime organized a special startup night with amazing startups presenting their business. Part of the event was Axel's presentation about fundraising and the new exit anytime paradigm.
An excellent blend of fresh mint pineapple tasting supplement, providing several health maintenance and disease prevention ingredients based on scientific data available only from Richard Clement Nutrition.
Manufactured in the USA in a GMP plant
The document evaluates LRRC17 and periostin biomarkers in osteoporosis patients. The study aimed to detect these biomarkers in osteoporosis patients and examine their association with physiological status. It found significantly higher levels of both LRRC17 and periostin in osteoporosis patients compared to controls. LRRC17 and periostin levels were also higher in older osteoporosis age groups compared to corresponding control groups. The study concludes that LRRC17 and periostin may be useful for early diagnosis of osteoporosis cases.
1) Dietary supplements like glucosamine, chondroitin sulfate, vitamins, omega-3 fatty acids, and herbal extracts are commonly used to treat osteoarthritis (OA) symptoms, but their efficacy is unclear due to a lack of conclusive evidence.
2) Nutrigenomics research aims to define how genes and nutrients interact to influence health and disease, with the goal of developing personalized nutrition plans.
3) Curcumin and resveratrol show potential for treating OA by reducing inflammation and suppressing cartilage degradation, but more research is still needed, including well-designed clinical trials.
The Effects Of Soy Isoflavone On Bone Mineral Density In Pre And Postmenopau...jnnfrwyckoff
This document discusses the effects of soy isoflavones on bone mineral density in pre- and postmenopausal women. It provides background on osteoporosis and risk factors like menopause. Soy isoflavones like genistein and daidzein are phytoestrogens that may help maintain bone density by acting similarly to estrogen. Several studies summarized found that soy isoflavone intake increased bone mineral density in the spine and helped prevent postmenopausal osteoporosis, especially when consuming around 90 mg per day. One study also found benefits of soy consumption for bone health in young Korean women over 2 years.
This document summarizes research on inulin, a type of soluble fiber. Inulin is found naturally in various plants and foods. It acts as a prebiotic that feeds beneficial gut bacteria, and fermentation of inulin by these bacteria produces compounds that may impact health. The document reviews studies showing inulin can positively influence risk factors for cardiovascular disease like obesity, dyslipidemia and blood sugar levels. While human studies have been limited and conflicting, regular inclusion of inulin in the diet may help manage these risk factors.
This study explored the safety and efficacy of intra-articular injections of autologous platelet lysate (PL) for the treatment of early and intermediate knee osteoarthritis. 48 patients received 3 injections of autologous PL over 12 weeks. Patients reported significant improvements in symptoms, stiffness, pain, daily living activities, and sports scores at 32 and 52 weeks post-treatment compared to baseline, as measured by the KOOS questionnaire. Three patients experienced minor bleeding in the joint but no other complications. The study demonstrated that intra-articular PL injections improved osteoarthritis symptoms and were found to be safe based on the absence of adverse events.
2010 effect of pistachio diet on lipid parameters, endothelial functionAgrin Life
This study investigated the effects of consuming a pistachio-enriched Mediterranean diet on cardiovascular risk factors in 32 healthy young men. Compared to a standard Mediterranean diet, the pistachio diet for 4 weeks significantly decreased blood glucose, LDL cholesterol, total cholesterol, and triglycerides. It also significantly improved endothelial function and decreased markers of inflammation and oxidative stress. The findings suggest that pistachios may have beneficial effects beyond lipid lowering and cardiovascular health.
I have an article about bioactives in blueberries along with the req.docxbillylewis37150
I have an article about bioactives in blueberries along with the requirements page that has questions to be answered. There are specific questions that have to be answered. The paper has to be 2-4 pages in APA format. It is due at 3pm eastern time today.
I copied both papers, the article and requirements page on here along with also uploading them.
The article is:
Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women1–4
April J. Stull, Katherine C. Cash, William D. Johnson, Catherine M. Champagne, and William T. Cefalu*
Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808
Abstract
Dietary supplementation with whole blueberries in a preclinical study resulted in a reduction in glucose concentrations over time. We sought to evaluate the effect of daily dietary supplementation with bioactives from blueberries on whole-body insulin sensitivity in men and women. A double-blinded, randomized, and placebo-controlled clinical study design was used. After screening to resolve study eligibility, baseline (wk 0) insulin sensitivity was measured on 32 obese, nondiabetic, and insulin-resistant subjects using a high-dose hyperinsulinemic-euglycemic clamp (insulin infusion of 120 mU(861 pmol)×m22×min21). Serum inflammatory biomarkers and adiposity were measured at baseline. At the end of the study, insulin sensitivity, inflammatory biomarkers, and adiposity were reassessed. Participants were randomized to consume either a smoothie containing 22.5 g blueberry bioactives (blueberry group, n = 15) or a smoothie of equal nutritional value without added blueberry bioactives (placebo group, n = 17) twice daily for 6 wk. Both groups were instructed to maintain their body weight by reducing ad libitum intake by an amount equal to the energy intake of the smoothies. Participants’ body weights were evaluated weekly and 3-d food records were collected at baseline, the middle, and end of the study. The mean change in insulin sensitivity improved more in the blueberry group (1.7 6 0.5 mg×kg FFM21×min21) than in the placebo group (0.4 6 0.4 mg×kg FFM21×min21)(P = 0.04). Insulin sensitivity was enhanced in the blueberry group at the end of the study without significant changes in adiposity, energy intake, and inflammatory biomarkers. In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants. J. Nutr. 140: 1764–1768, 2010.
Introduction
Increased consumption of berries has been shown to improve cognitive function, risk of cardiovascular disease, and cancer (1,2). Studies have also reported that specific berries, i.e., blueberries, have antidiabetic effects. Specifically, a study performed in mice (3) found that supplementation with
whole blueberries reduced the blood glucose area under the curve (AUC)5 in vivo and cell cul.
This document discusses nutrigenomics, an emerging field that examines the relationship between nutrients and the human genome using modern "omics" technologies like transcriptomics, metabolomics, epigenomics, and proteomics. It provides an overview of nutrigenomics and related fields like nutrigenetics, describes some of the experimental approaches and technologies used in nutrigenomics research, and gives examples of specific research findings like how coffee and cigarettes may help combat rare liver diseases.
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Br J Sports Med 2012;46:618–620. doi:10.1136/bjsports-2012-091198618
Nutritional supplement series
INTRODUCTORY REMARKS
Quercetin was fi rst introduced to our A–Z series
in the article on fl avonoids.1 In Part 33, the author
of the fl avonoid review, Dr Nieman, updates this
topic. We also cover another intriguing plant-
based compound with proposed benefi ts as an
antioxidant and stimulator of mitochondrial bio-
genesis, resveratrol. Rhodiola rosea, a claimed adap-
togen, concludes this issue.
QUERCETIN
D C Nieman
Epidemiological studies support multiple disease
prevention benefi ts for individuals consuming foods
rich in the fl avonol quercetin. In vitro and animal
studies indicate that quercetin is a strong antioxi-
dant and anti-infl ammatory agent, and exerts anti-
pathogenic and immune regulatory infl uences.2
Quercetin supplementation studies in community-
dwelling humans do not refl ect these positive bene-
fi ts, but research is continuing in order to determine
the proper outcome measures, dosing regimen and
adjuvants that may amplify any perceived bioactive
effects of quercetin in vivo.
Quercetin supplementation studies in athletes
have focused on potential infl uences on post-exer-
cise infl ammation, oxidative stress and immune
dysfunction, illness rates following periods of
physiological stress and exercise performance.
Results thus far have been negative for quer-
cetin’s countermeasure effects on postexercise
physiological stress indicators, such as immune
perturbations.3–5 However, when quercetin sup-
plementation is combined with other polyphenols
and food components such as green tea extract,
isoquercetin and fi sh oil, a substantial reduction
in exercise-induced infl ammation and oxidative
stress occurs in athletes, with augmentation of
innate immune function.6
Quercetin exerts strong antiviral activities when
cultured with a wide variety of pathogens. In mice,
quercetin supplementation for 7 days before inoc-
ulation with infl uenza virus and a 3-day period
of heavy exertion partially reduced the exercise-
induced increase in morbidity and mortality.7
A 12-week community trial showed a modest
reduction in upper respiratory tract infections
(URTI) among physically active subjects between
the ages of 40 and 85 years consuming 1000 mg
quercetin per day, but not among younger adults.8
Cyclists randomised to 1000 mg/day quercetin or
placebo for fi ve weeks experienced reduced URTI
incidence during the two-week period following
three days of exhaustive exercise.3
Quercetin supplementation over 7 days induces
an increase in mitochondrial biogenesis and tread-
mill endurance performance (37%) and running
distance in wheels in mice.9 The quercetin-related
effects on performance in untrained humans are
mo ...
CLINICAL EVALUATION OF THE EFFECT OF OMEGA-3 FATTY ACIDS ON OSTEOPOROTIC FEMA...Mohamed A. Galal
Mohamed A. Galal ; Mushira A. Dahaba, ; Basma M. Zaki
and Hanaa M. Elshenawy. CLINICAL EVALUATION OF THE EFFECT OF OMEGA-3 FATTY ACIDS ON OSTEOPOROTIC FEMALES HAVING CHRONIC PERIODONTITIS. Cairo Dental Journal (30)Number (1), 1:10January, 2014.
This study examined the relationship between urine protein levels and liking of lentils in 97 students. Urine protein was measured using dipstick tests, and students reported their lentil preferences. The results found that 17.65% of males and 6.90% of females had urine protein and liked lentils, while 82.35% of males and 93.10% of females did not have urine protein and liked lentils. Additionally, 1.82% of females had urine protein and disliked lentils, while 81.82% of females did not have urine protein and disliked lentils. The conclusion was that there was no correlation between the presence of urine protein and preferences around lentils.
Osteoarthritis is the most common disease of women after menopause. There are many factors to develop the disease. Hormones play important role to in this context. The objective of the present study is to determine whether the levels of thyroid and sex hormones are associated with osteoarthritis (OA) in postmenopausal women. Forty three patients suffering from OA and twenty control subjects were included in this study. Thyroid and sex hormones were measured in the serum by enzyme linked immunosorbent assay technique. In OA patients serum estrogen levels were low as compared to control subjects(p<0.001), but these patients did not show any significant change in thyroid hormones and progesterone hormone levels when compared with control subjects. The findings suggest that estrogen deficiency after menopause may contribute to develop OA in postmenopausal women.
Pyridoxine supplementation led to a significant decrease in migraine attack severity, duration, and headache diary results compared to placebo, but did not significantly impact attack frequency. A double-blind randomized clinical trial of 66 migraine patients with aura found that those receiving 80 mg of pyridoxine per day experienced greater reductions in severity (-2.20 vs -1), duration (-8.30 hours vs -1.70 hours), and headache diary results (-89.70 vs -6.10) compared to the placebo group after 12 weeks. However, pyridoxine did not significantly decrease attack frequency more than placebo.
The document discusses optimal nutrition for intensive care unit (ICU) patients, specifically the role of protein delivery. It summarizes recent studies showing:
1) Short-term high-level amino acid infusions can change protein balance in critically ill patients from negative to positive.
2) This positive effect on protein balance from supplemental amino acid infusions can last for at least 24 hours.
3) More research is still needed to determine if improving protein balance through nutrition can change patient outcomes and whether the same strategies apply to all heterogeneous ICU patients.
Effects of yogic practices on polypharmacy Dr. Balaji P.A Dr. smitha r varne.pdfDrBalaji8
The occurrence and concurrency of Noncommunicable chronic diseases increase
with age, and therefore, the number of medications used increases
correspondingly. Polypharmacy is a scenario in which five medications or more
are consumed concurrently (regardless of dose and duration of consumption),
which leads to reduced quality of life, physical problems, increased drug
interactions, adverse effects, and medical complications and increases the cost
of treatment. Moreover, polypharmacy increases the incidence of falls, frequency
of hospital admission, length of stay, and the death rate among patients, especially
in the elderly population. This would allow therapies like Yoga, pranayama,
and meditation to act as an effective mainstay or adjunctive or alternative therapy
for many disorders, as it can be cost-effective, patient-compliant, and clinically
efficacious with the most negligible side effects. However, very few studies
have focused on the impact of yogic practices on reducing drug dosage or
polypharmacy among patients. Hence, a Medline English literature search was
planned to review all the studies demonstrating a dose-response effect between
yogic practices and the number/dosage of medication reduction in different
disorders. Data extracted and analyzed depicted that the practice of Yoga,
pranayama, and meditation can result not only in reducing the number of
medications but also the dosages in hypertension, type 2 diabetes mellitus,
bronchial asthma, arthritis, sleep disorders, obsessive-compulsive disorder
(OCD), gastrointestinal disorders like constipation and irritable bowel syndrome
This document summarizes a study that investigated the effects of aged black garlic extract (ABG) on obesity and hyperlipidemia in rats fed a high-fat diet. The study found that ABG extract significantly lowered body weight and fat pad weight in rats compared to controls. It also improved lipid profiles by decreasing serum triglycerides and hepatic total cholesterol. ABG extract increased the glutathione to oxidized glutathione ratio in serum and the liver, and decreased serum lipid peroxidation levels. The results suggest that ABG extract may help reduce obesity and dyslipidemia by decreasing body fat accumulation and regulating lipid profiles and antioxidant defenses.
The document summarizes research on the effects of black garlic (aged garlic) extracts on the immune system. Key findings include:
1) Black garlic extracts enhanced cellular immunity by increasing the activity of natural killer (NK) cells in spleen cells from treated mice.
2) Cytokines associated with enhanced immunity, such as nitric oxide (NO), interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-α) were preferentially generated from spleen cells of extract-treated mice, while interleukin-4 (IL-4) levels decreased.
3) The active compounds in black garlic extracts that may enhance immunity are S-ally
1) The study examined the effects of aged garlic extract (AGE) on quality of life (QOL) and immune function in patients with advanced cancer.
2) 50 patients with inoperable liver, pancreatic, or colon cancer were randomly assigned to receive either AGE or a placebo for 6 months.
3) While no difference was seen in QOL scores, the group receiving AGE showed a significant increase in the number and activity of natural killer (NK) cells, which are important for immune function. No adverse effects were reported for either group.
FermaPro® Black Garlic is a fermented form of garlic that provides enhanced antioxidant and cardiovascular benefits compared to raw garlic. The fermentation process increases levels of the antioxidant compound S-allyl cysteine (SAC) and creates new antioxidant compounds. Human clinical trials show that black garlic supports cardiovascular health by maintaining healthy cholesterol and blood pressure levels. It also supports immune function by increasing natural killer cell activity. Black garlic is well-suited for use in dietary supplements due to its stability and bioavailability.
Black garlic extract enhance the immune systemCong Tai
The document summarizes research on the effects of black garlic (aged garlic) extracts on the immune system. Key findings include:
1) Black garlic extracts enhanced cellular immunity by increasing the activity of natural killer (NK) cells in spleen cells from treated mice.
2) Cytokines associated with enhanced immunity, such as nitric oxide (NO), interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-α) were preferentially generated from spleen cells of extract-treated mice, while interleukin-4 (IL-4) levels decreased.
3) Compounds in black garlic extracts like S-allyl-L-c
This study investigated the toxicity and genotoxicity of lemongrass (Cymbopogon citratus) essential oil in mice after repeated oral intake over 21 days. The researchers found no evidence of toxicity based on measurements of body and organ weights, histological examination of tissues, urinalysis, and clinical biochemistry. Additionally, lemongrass essential oil reduced blood cholesterol levels at the highest dose tested. The comet assay also showed no genotoxic effects. The study concluded that lemongrass intake at the doses used in traditional medicine is safe, and may have beneficial effects in reducing blood cholesterol.
chức năng chống oxy hóa và kháng khuẩn của cây sảCong Tai
This document describes a study that evaluated the antioxidant and antibacterial activity of lemongrass plant (Cymbopogon citratus) extracts obtained using different solvents. Leaf extracts from C. citratus were tested against various human pathogens using disc diffusion assays and DPPH radical scavenging assays. The results showed that chloroform, methanol, and water extracts of C. citratus exhibited maximum inhibition zones against Bacillus subtilis, Pseudomonas aeruginosa, and Proteus vulgaris. The extracts also demonstrated antioxidant effects by scavenging DPPH radicals and protecting DNA from oxidative damage. The study suggests that lemongrass plant extracts have antimicrobial and antioxidant properties that could offer health benefits.
1) Five randomized clinical trials were included in a meta-analysis examining the effects of ginger supplementation on blood glucose levels and diabetes symptoms in patients with type 2 diabetes.
2) The meta-analysis found that ginger supplementation significantly lowered fasting blood glucose concentrations and HbA1c levels, which is a measure of long-term blood sugar control. However, ginger did not significantly lower fasting blood insulin levels or insulin resistance.
3) Four of the five studies were considered high quality, while one study of only 30 days duration was deemed lower quality. The results provide evidence that ginger supplementation may help manage type 2 diabetes by lowering blood sugar levels when combined with lifestyle interventions.
This study analyzed 31 Thai medicinal plant species commonly used in traditional medicine in northeast Thailand. The plants were grouped into digestive tonic, diarrheal relief, anti-tussive, and anti-inflammation categories based on their traditional uses. The study determined total antioxidant activity, free radical scavenging activity, total phenolic content, ascorbic acid content, and levels of some phytochemicals for the plants. The results showed variation in these biochemical parameters among the different plant groups. Anti-tussive plants generally had higher total antioxidant activity and phenolic/ascorbic acid levels than diarrheal relief and anti-inflammation plants. Digestive tonic plants exhibited strong free radical scavenging activity.
best authentic mexico food in houston.pdftilas9653
Looking for the best authentic Mexican food in Houston? Discover vibrant flavors and traditional recipes at our renowned Mexican restaurant. We offer a diverse menu featuring classic dishes like tacos, enchiladas, tamales, and guacamole, all made with fresh, locally-sourced ingredients.
Mint Progressive Indian, located in downtown Seattle, offers a unique dining experience by blending traditional Indian flavors with modern culinary techniques. Our menu features innovative dishes crafted from the freshest ingredients, served in a chic and inviting atmosphere. Perfect for casual meals, romantic dinners, and special events, we pride ourselves on exceptional service and a vibrant dining experience. Join us at Mint Progressive Indian to explore the future of Indian cuisine. Visit Mint Progressive Indian for more information and reservations.
Science Text Book characteristics and libraryJerslin Muller
This ppt contains qualities of a good Science Text Book, need for text book, importance of text book, criteria of a science text book, text book analysis, content analysis, Hunter's score card, library, utilization of library.
Exploring_Karnali_Region_of_Nepal_(Food, Culture and People).pptxLincoln University
Largest province in Nepal, Mountain landscape with 47% of an area located above 4000 masl, Characterized by its unique cultural heritage, diverse geography, and traditional farming practices
Traditional Agriculture: Subsistence farming on terraced fields (rice, wheat, millet, bean, potato and barley)
Fruits: Apple, walnut, orange, etc.
Livestock Rearing: Transhumance system of animal husbandry (goats, sheep, and cattle)
Dietary Staples: Rice, lentils, vegetables, and dairy products
Food Preparation: Often prepared using locally grown ingredients with traditional cooking methods
Religious Practices: Hinduism and Buddhism
Social Customs: Strong community bonds, traditional attire and customs are upheld during festivals
Environmental Connection: Respect for nature and reverence for sacred sites
Historical Context: Farming techniques shaped by the region's rugged terrain, climate, and historical interactions
Cultural Influence: Food preferences, agricultural rituals, and farming practices have been influenced by a blend of indigenous traditions, Hindu and Buddhist beliefs, and trade routes
Enhancing Agricultural Practices: Introducing modern farming techniques without compromising traditional values
Access to Education and Resources: Investing in education and providing access to agricultural inputs
Promoting Sustainable Tourism: Leveraging the region's cultural richness and natural beauty
Intersection of culture, agriculture, and tradition
Embracing sustainable development practices and honoring cultural heritage
Enhance the lives of its people while safeguarding their unique way of life
Agriculture Market : Global Trends and Forecast Analysis (2023-2032)PriyanshiSingh187645
The global agriculture market is anticipated to grow at a substantial CAGR of 9.60% in the upcoming years. The global agriculture industry was estimated to be worth USD 13.5 billion in 2022 and was expected to be worth USD 25.6 billion by 2030.
From mastering essential life skills like meal planning and budgeting to fostering independence and creativity, teens can embark on a culinary journey that prepares them for a healthier, more self-sufficient future. Join the cooking adventure today!
Smoking as a preservation and processing method for food, Food preservation, food processing, smoking, meat and meat products, methods of food smoking, application, cold smoking, hot smoking, warm smoking, liquid smoking, food industry and business, offset smokers, upright drum smokers, Vertical water smokers, Propane smokers, Electrical smokers and related health concerns.
Discover the Magic 7 Fruits for Weight Loss You Need to Know About!.pdfRapidLeaks
Fruits, a.k.a, nature’s candy are beneficial for tons of reasons. They’re filled with vitamins and nutrients that are not just healthy but delicious too. And, some have officially been identified as fruits for weight loss, which makes them ideal for any and every kind of diet you are currently experimenting with.
Also read: https://rapidleaks.com/lifestyle/food-drink/fruits-weight-loss/
2. adverse cardiovascular and gastrointestinal events.12
Moreover,
findings of two in vitro studies demonstrated that naproxen,
indomethacin, and ibuprofen, which are the most frequently pre-
scribed nonsteroidal anti-inflammatory drugs, block the synthesis
of human cartilage matrix, and this is likely to increase the rate of
degeneration of articular cartilage in OA.13,14
This has led many
researchers to attempt to find a remedy or modalities with negli-
gible side effects and significant improvement in the symptoms.15
Ginger (生薑 sheng jiang) is an underground rhizome of the plant
Zingiber officinale, belonging to the family Zingiberaceae, which is
one of the most popular herbs used in traditional medicine to
remedy diseases such as pregnancy-induced nausea and vomiting,
motion sickness, and arthritic conditions. It is thought that ginger
might be useful to human health owing to its anti-inflammatory
properties. The mechanism of its action is not clear, but it seems
to inhibit the activation of tumor necrosis factor-alpha (TNF-a),
interleukin-1b (IL-1b), and inducible nitric oxide synthase (iNOS).16
C-reactive protein (CRP) is a plasma protein that increases in the
systemic response to inflammatory events. Its rapid increase in
synthesis within hours after tissue injury or infection suggests that
it contributes to host defense and that it is part of the innate im-
mune response. There is an association between elevation of this
protein and future major cardiovascular events.17
Considering the
role of ginger in reducing inflammation and given the fact that we
could not find any study in the literature on the long-term effects of
ginger on inflammation, this study was designed to determine the
effect of daily supplementation of 1 g ginger powder for 3 months
on inflammatory markers in older patients with knee OA.
2. Materials and methods
2.1. Study design and participants
This study was a double-blind randomized placebo-controlled
clinical trial, with a 3-month follow-up, of 120 patients with knee
OA visiting Khatam-ol-anbia Polyclinic in the city of Yazd in Iran.
This study was performed in the period spanning November 2011
to May 2012.
Criteria for inclusion were age (between 50 years and 70 years)
and diagnosis of OA verified by a rheumatologist according to the
classification criteria of the American College of Rheumatology.18
Patients with any of the following were excluded: rheumatoid
arthritis, inflammatory diseases, metabolic disorders (such as dia-
betes, cancer, or other serious diseases), signs or history of liver or
kidney failure, treatment with oral corticosteroids within a period
of 4 weeks prior to the trial, corticosteroids injection within 6
months prior to the experiment, fever 38C at screening, per-
manent consumption of ginger (生薑 sheng jiang), allergy to ginger,
unwillingness to continue the protocol, avoidance of consumption
of 20% of the ginger supplements, any serious complications,
consumption of multivitamin, minerals, or other nutritional sup-
plements, and consumption of analgesic medications.
A total of 120 patients meeting the above-mentioned criteria
were randomly assigned to two groups (n ¼ participants each):
ginger group (GG) and placebo group (PG). Randomization was
done via tables of random numbers that were sequential list pre-
pared. The patients were asked to take two 500-mg capsules per
day for 3 months. The GG and PG capsules contained powdered
ginger and starch, respectively. Placebo and ginger capsules were
similar in terms of color, odor, weight, and packing. All the capsules
were manufactured in the Institute of Medicinal Plants in Tehran,
Iran. Patients were examined at the beginning of the study and then
again after 3 months in order to measure anthropometric indices.
Moreover, the participants filled out a researcher-made question-
naire with questions on age, occupation, education, and obesity
status. The patients were asked not to change their normal diet. The
patients were also instructed to keep their daily use of the stairs to a
minimum. Furthermore, a rheumatologist taught them some kinds
of knee exercises.
2.2. Measurements
Anthropometric indices were obtained by a trained dietitian.
The patients' weights were measured using digital scales with a
readability of 0.1 kg and with the patients being minimally clothed,
without shoes. Height was measured using a stadiometer with a
readability of 0.5 cm and with the patients being in a standing
position without shoes. To determine the obesity status, the BMI
was calculated as weight (kg) divided by the square of height (m).
All anthropometric measurements were obtained on the same day
when blood specimens were taken.
2.3. Biochemical assessment
Both at the start of and 3 months after the experiment, 5 mL
peripheral blood was taken from each patient in a nonfasting state
through venipuncture of an antecubital vein (Suha, Iran). Serum
samples were stored at À70C until the end of the study. Serum CRP
concentrations were measured using enzyme-linked immunosor-
bent assay kits (Biocore, Hamburg, Germany). Serum concentration
of nitric oxide was measured using a colorimetric assay kit
(Biocore).
2.4. Dietary assessment
Dietary intake was assessed by trained dietitians. Data on
24-hour recalls were collected from all 120 participants prior to and
after the intervention. The 24-hour recall is based on actual intake
and may be used to estimate absolute rather than relative intake.19
However, this method is susceptible to recall bias, both for identi-
fication of foods eaten and for quantification of portion sizes. In
order to reduce this type of error in this study, dietary data were
collected by highly trained interviewers.20
Individuals were asked
whether the day of recalls was a usual day or not. To enter the data
into the computer, standard reference tables were used to convert
household portions to grams.21
After coding, the dietary recall form
was linked to a nutrient database (Nutritionist IV, Bruno, CA, USA).
For mixed dishes, food groups were calculated taking account of
their ingredients. The data related to Nutritionist IV were modified
in accordance with the Iranian Food Composition Table.
2.5. Ethical considerations
The protocol was explained to all patients. The participants
volunteered to participate in this study and had the possibility of
withdrawing from the study at any moment. The Ethics-in-
Research Commission of Shahid Sadoughi University of Medical
Sciences, Yazd, Iran approved the study, and all patients gave
written informed consent.
2.6. Statistical analysis
Data were submitted to SPSS 16.0.2 (2008; SPSS Inc., Chicago, IL,
USA).22
Prior to the statistical comparison, a KolmogoroveSmirnov
test was used to demonstrate the distribution of quantitative data.
Furthermore, the t test was used to draw a comparison between the
data obtained from the two groups (i.e., between-groups compar-
ison). In addition, Student t test was used for comparing the data
obtained from each group before and after the intervention (i.e.,
within-groups comparison). The results of the protocol are
Z. Naderi et al. / Journal of Traditional and Complementary Medicine xxx (2015) 1e52
Please cite this article in press as: Naderi Z, et al., Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee
osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial, Journal of Traditional and Complementary
Medicine (2015), http://dx.doi.org/10.1016/j.jtcme.2014.12.007
3. reported as mean ± standard deviation because the distribution of
the quantitative data was normal. All analyses were performed at
the 0.05 level of significance (2-tailed).
3. Results
At the beginning of the study,120 patients participated and were
randomized. During the protocol, 20 patientsd10 receiving ginger
(生薑 sheng jiang) and 10 receiving placebodwere excluded: eight
of the participants withdrew because of a trip, eight due to loss of
follow-up, and four for undisclosed reasons. Therefore, 100 patients
completed the trial without protocol violations (Fig. 1).
Table 1 illustrates the baseline characteristics of the participants
prior to the intervention in both groups. As shown, the patients
were predominantly women, but the frequency of men and women
between groups was statistically insignificant (p ¼ 0.83). There was
no significant difference between the two groups in terms of age,
weight, height, and BMI. Similarly, the two groups were not
significantly different in terms of sex, obesity, education, and
occupational status.
Table 2 presents the effect of ginger and starch on CRP and NO of
the patients at the beginning of and 3 months after the study. As
can be seen, there was no significant difference between the two
groups in CRP and NO concentration prior to the intervention.
However, after supplementation of ginger, a significant decrease
was observed in serum concentration of CRP and NO in the GG, but
not in the other group. At the end of the study, CRP and NO
concentration decreased more in the experimental group than in
the control group.
Table 2 also gives the means for some daily dietary intake in the
two groups prior to and after the intervention. No statistically
Fig. 1. Study flowchart.
Table 1
Comparison of baseline characteristics for the variables under investigation in
ginger and placebo groups.
Variables Ginger group
(n ¼ 50)
Placebo group
(n ¼ 50)
p
Age (y) 57.98 ± 6.2 59.1 ± 6.1 0.3
Weight (kg) 67.94 ± 7.0 66.3 ± 5.9 0.21
Height (cm) 161.4 ± 6.4 161.2 ± 7.0 0.9
BMI (kg/m2
) 26.1 ± 2.9 25.5 ± 2.0 0.2
Sex
Men 3 (6) 7 (14) 0.31
Women 47 (94) 43 (86)
Obesity status
Obese 31 (62) 33 (66) 0.83
Nonobese 19 (38) 17 (34)
Education
Illiterate 20 (40) 18 (36) 0.60
Elementary school graduate 10 (20) 12 (24)
Middle and high school graduate 15 (30) 18 (36)
University graduate 5 (10) 2 (4)
Occupational status
Employed 18 (36) 20 (40) 0.40
Unemployed 32 (64) 30 (60)
Data are presented as n (%) or mean ± SD.
BMI ¼ body mass index.
Z. Naderi et al. / Journal of Traditional and Complementary Medicine xxx (2015) 1e5 3
Please cite this article in press as: Naderi Z, et al., Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee
osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial, Journal of Traditional and Complementary
Medicine (2015), http://dx.doi.org/10.1016/j.jtcme.2014.12.007
4. significant difference was found between pre- and postintervention
figures for daily energy and fiber and cholesterol intake. In other
words, between-group and within-group comparisons did not
show any significant difference in daily energy and fiber and
cholesterol intake.
4. Discussion
This study found that, in the patients who suffered from mod-
erate knee OA, the serum concentration of CRP and NO 3 months
after ginger (生薑 sheng jiang) supplementation was significantly
different from the data obtained at the beginning of the study. This
finding is consistent with that of recent studies on ginger supple-
mentation on anti-inflammatory mediators. Lee et al23
found that
6-gingerol had an anti-inflammatory effect on mouse macrophages.
This active constituent of ginger decreased iNOS and TNF-a
expression by inhibiting I-kappaB alpha phosphorylation, nuclear
factor-kappa B (NF-kB) nuclear activation, and protein kinase C-
alpha translocation.
In another study, Jung et al24
showed that ginger hexane extract
(GHE) significantly inhibited the excessive production of NO, pro-
tein, and mRNA expression of iNOS in lipopolysaccharide (LPS)-
stimulated BV-2 cells, a mouse microglial cell line, and attenuated
their gene expressions. Furthermore, GHE inhibited mRNA
expression and protein induction of COX-2 in BV-2 cells stimulated
through LPS. The only thing that was not affected by GHE was the
production of PGE2 or COX-2 expression in microglial cells. Also,
GHE significantly suppressed the production of TNF-a and IL-1b
and reduced their gene expressions in these cells.24
In another in vitro study carried out by Shimoda et al25
to
evaluate the anti-inflammatory activity of red ginger extract (RGE),
Z. officinale var. Rubra in mouse leukemic monocytes (RAW 264.7
cells) stimulated by LPS, it was found that RGE (100 mg/mL)
significantly inhibited NO production. Moreover, dosage of 3 mg/mL
and 10 mg/mL significantly inhibited PGE2 production. Separation
of RGE by means of bioassay showed that [6]-shogaol and ginger-
diols were capable of inhibiting NO production.25
After 10 weeks of ginger supplementation and resistance
training, Atashak et al26
reported significant decreases in the mean
values of CRP in three of the groups in their experiment: resistance
training plus ginger (RTGI), resistance training plus placebo (RTPL),
and ginger (GI). CRP concentration declined 35.1%, 28.3%, and 21.2%
in RTGI, RTPL, and GI groups, respectively.26
A recent study by Han et al27
found that treatment of Raw 264.7
cells, a murine macrophage-like cell line, with 150 ng/mL and
200 ng/mL of 12-dehydrogingerdione significantly suppressed LPS-
stimulated production of NO. Moreover, this treatment suppressed
the LPS-stimulated increase in iNOS levels. However, treatment of
cells with LPS without 12-dehydrogingerdione significantly
increased NO production.
In another study, daily supplementation of 2 g ginger for 2
months was found to significantly decrease serum concentration of
hs-C reactive protein (hs-CRP), TNF- a, and IL-6 in the GG compared
with the baseline in type 2 diabetes patients.28
These factors did not
change in the PG during the protocol. In other words, covariance
analysis revealed that the level of hs-CRP and TNF- a lowered more
in the blood of the group receiving ginger than in the blood of the
placebo-receiving patients. However, the level of IL-6 remained
unchanged in both groups.
The results of the present research do not concur with the
findings of a few similar studies. Ueda et al22
studied the in vitro
effect of ginger extract on cytokines produced from a macrophage-
like cell line. After an oral administration of 100e1000 mg/mL
squeezed ginger extract (SGE) to mice, the production of TNF-a and
IL-6 and MCP-1 increased in mice cells. When the mice were orally
administered with the SGE or its ethanol-insoluble for a single time
or two, TNF-a production increased in peritoneal cells; however,
administration for more than four times had opposite results. In
addition, oral administration of the SGE for several times increased
immune resistance but caused an anti-inflammatory activity.
A possible mechanism whereby ginger reduces inflammation in
patients with OA is as follows: activation of synovial cells in the
joints leads to the release of two key cytokines involved in the
inflammation and degradation of joints, TNF-a and IL-1b. Both
mediators induce NF-kB, which is a ubiquitous eukaryotic tran-
scription factor with a pivotal role in inflammatory pathways.29
This nuclear factor brings about inflammation by activating iNOS,
COX-2 pathway, and lipoxygenase pathway and by inducing the
secretion of inflammatory cytokines.
Ginger contains gingerols and shogaols, which are pungent
phenolic compounds with anti-inflammatory properties.30,31
These
substances decrease the two proinflammatory factors of TNF-a and
IL-1b in osteoarthritic cartilage. In synoviocytes, these compounds
decrease the IL-1b- or TNF-a-induced expression of TNF-a mRNA
and protein, the TNF-a-induced production of COX2, and the TNF-
a-induced activation of the NF-kB. In addition, these crucial com-
pounds suppress the synthesis of prostaglandin and leukotriene by
inhibiting the COX-2 and lipoxygenase pathways and also
inflammation-involved pathways.32,33
This way, they can diminish
the inflammation.
5. Conclusion
The present work is significant in three ways. (1) We examined
the long-term effect of supplementation of ginger powder on in-
flammatory markers in patients with knee OA. (2) The study was a
double-blind randomized clinical trial, meaning that neither the
researchers nor the patients were aware of the content of capsules.
(3) The protocol involved a control group that was similar to the GG
in all measurements.
It is also important to note the limitation in that the present study
did not measure neuronal sensitization, Immunoglobulin G (IgG),
Table 2
Comparison of mean of NO and CRP concentration in both ginger and placebo groups
prior to and after intervention.
Variables Ginger group Placebo group pa
Energy (kcal/d)
Prior to 1904.2 ± 325.4 1859.7 ± 272.2 0.6
After 2010.4 ± 401.0 1997.4 ± 213.1 0.3
pb
0.9 0.2
Fiber (g/d)
Prior to 9.2 ± 4.2 10.9 ± 9.9 0.5
After 12.3 ± 5.9 7.8 ± 8.2 0.9
p 0.8 0.6
Cholesterol (mg/d)
Prior to 302.02 ± 102.82 310.21 ± 123.02 0.08
After 295.02 ± 87.82 301.02 ± 95.12 0.6
p 0.7 0.5
NO (mmol/L)
Prior to 29.02 ± 0.82 29.21 ± 1.02 0.53
After 26.02 ± 1.82 27.02 ± 0.32 0.001
Change À3.0 ± 0.72 À2.01 ± 0.19 0.001
p 0.001 0.001
CRP (mg/L)
Prior to 11.06 ± 1.43 11.21 ± 1.20 0.56
After 8.47 ± 1.62 9.66 ± 1.31 0.001
Change À2.58 ± 1.47 À1.54 ± 1.12 0.001
p 0.001 0.001
CRP ¼ C-reactive protein; NO ¼ nitric oxide.
a
Student t test.
b
Paired t test.
Z. Naderi et al. / Journal of Traditional and Complementary Medicine xxx (2015) 1e54
Please cite this article in press as: Naderi Z, et al., Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee
osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial, Journal of Traditional and Complementary
Medicine (2015), http://dx.doi.org/10.1016/j.jtcme.2014.12.007
5. Immunoglobulin M (IgM), and did not determine ginger capsule's
formulation. Sample attrition resulting from patient withdrawal
may be regarded as another limitation of the protocol. Further
research into this topic could evaluate the effect of supplementation
of 1 g/d ginger capsule on lipid profile, coagulation factors, other
inflammatory mediators, and neuronal sensitization. Future
research can also consider the effect of 1 g/d ginger capsule on
oxidative stress-related parameters.
Conflicts of interest
The authors declare that they have no conflict of interest.
Acknowledgments
We thank the patients who took part in this project. Special
thanks to the chancellor of Yazd Central laboratory, Dr Akhavan and
staff in this laboratory, particularly, Mr Khajeh Afzali and Mr Salimi
for their cooperation in blood sampling and performing biochem-
ical tests.
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Z. Naderi et al. / Journal of Traditional and Complementary Medicine xxx (2015) 1e5 5
Please cite this article in press as: Naderi Z, et al., Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee
osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial, Journal of Traditional and Complementary
Medicine (2015), http://dx.doi.org/10.1016/j.jtcme.2014.12.007