The document evaluates LRRC17 and periostin biomarkers in osteoporosis patients. The study aimed to detect these biomarkers in osteoporosis patients and examine their association with physiological status. It found significantly higher levels of both LRRC17 and periostin in osteoporosis patients compared to controls. LRRC17 and periostin levels were also higher in older osteoporosis age groups compared to corresponding control groups. The study concludes that LRRC17 and periostin may be useful for early diagnosis of osteoporosis cases.
This study explored the safety and efficacy of intra-articular injections of autologous platelet lysate (PL) for the treatment of early and intermediate knee osteoarthritis. 48 patients received 3 injections of autologous PL over 12 weeks. Patients reported significant improvements in symptoms, stiffness, pain, daily living activities, and sports scores at 32 and 52 weeks post-treatment compared to baseline, as measured by the KOOS questionnaire. Three patients experienced minor bleeding in the joint but no other complications. The study demonstrated that intra-articular PL injections improved osteoarthritis symptoms and were found to be safe based on the absence of adverse events.
The document discusses biochemical markers of bone turnover. It notes that in adults, bone undergoes constant remodeling through resorption by osteoclasts and formation by osteoblasts. Biochemical markers measure bone formation or resorption products in blood and urine, allowing serial assessment of bone turnover. Formation markers include osteocalcin and procollagen peptides, while resorption markers include collagen telopeptides and hydroxypyridinium cross-links. These markers can help evaluate treatment response, predict fracture risk and bone loss, and select patients who may benefit most from treatment. However, markers have limitations due to biological and analytical variability.
A randomized controlled_trial_of_four_doses_of_transdermal_estradiol_for_prev...manelle gutierrez
This randomized controlled trial tested the effects of four doses of transdermal estradiol (0.025 mg/day, 0.05 mg/day, 0.06 mg/day, and 0.1 mg/day) on preventing bone loss in postmenopausal women compared to a placebo. At 24 months, all doses of estradiol resulted in statistically significant increases in bone mineral density at the spine and hip compared to decreases seen with placebo. The lowest dose of 0.025 mg/day increased spine bone mineral density by 2.37% and hip bone mineral density by 0.26% compared to decreases of 2.49% and 2.04% respectively with placebo. This study demonstrates that even the
Research proposal &administration issuesFarragBahbah
This study aims to evaluate the long-term effects of parathyroidectomy (PTX) on bone histology, coronary artery calcification, and other biomarkers in hemodialysis patients with severe secondary hyperparathyroidism. A prospective observational study will follow 50 patients undergoing PTX for 12 months, assessing bone biopsies, calcium scoring via CT, and serum biomarkers at baseline and 12 months. The study hypothesizes that PTX will improve bone turnover and mineralization while reducing vascular calcification, aiming to provide insights into long-term PTX outcomes in this patient population.
Research proposal &administration issuesFarragBahbah
This study aims to evaluate the long-term effects of parathyroidectomy (PTX) on bone histology, coronary artery calcification, and other biomarkers in hemodialysis patients with severe secondary hyperparathyroidism. The study will prospectively observe 50 patients undergoing PTX, collecting clinical data and samples at baseline and 12 months post-surgery. Outcome measures include bone biopsy analyses, coronary artery calcium scoring via CT scan, and serum levels of 11 biomarkers related to bone and mineral metabolism. Statistical analyses will compare results before and after PTX to determine PTX's long-term impacts.
EVALUATION OF THE EFFICIENCY OF BISPHOSPHONATES IN THE TREATMENT OF OSTEOPORO...indexPub
Osteoporosis (OP) is a widespread metabolic disease of the skeleton, leading to decreased bone strength and increased risk of fractures. OP is a disease of varying nature that affects all age groups, but is most common in older people. For a long time, doctors did not have serious tools to treat this insidious disease and mainly dealt with its consequences - fractures.
Cong dung cua gung trong dieu tri dau khop xuong man tinh nguoi giaCong Tai
1) This study investigated the effects of ginger powder supplementation on inflammatory markers in elderly patients with knee osteoarthritis over 12 weeks.
2) 120 patients were randomly assigned to either a ginger group that received 500 mg ginger powder capsules daily or a placebo group that received 500 mg starch capsules.
3) After 12 weeks, serum levels of nitric oxide and C-reactive protein (markers of inflammation) decreased more in the ginger group compared to the placebo group, indicating that daily ginger powder supplementation may help reduce inflammation in patients with knee osteoarthritis.
This study evaluated the effectiveness of Osteobios and Guna-Fem supplements for treating early postmenopausal osteoporosis compared to calcium and vitamin D supplements. 70 postmenopausal women with osteoporosis were divided into two groups. The group treated with Osteobios and Guna-Fem showed greater reductions in pain levels, improvements in quality of life, and decreases in bone resorption markers compared to the calcium/vitamin D group. The results suggest Osteobios and Guna-Fem may be effective alternative or additional therapies for treating osteoporosis and improving patients' quality of life.
This study explored the safety and efficacy of intra-articular injections of autologous platelet lysate (PL) for the treatment of early and intermediate knee osteoarthritis. 48 patients received 3 injections of autologous PL over 12 weeks. Patients reported significant improvements in symptoms, stiffness, pain, daily living activities, and sports scores at 32 and 52 weeks post-treatment compared to baseline, as measured by the KOOS questionnaire. Three patients experienced minor bleeding in the joint but no other complications. The study demonstrated that intra-articular PL injections improved osteoarthritis symptoms and were found to be safe based on the absence of adverse events.
The document discusses biochemical markers of bone turnover. It notes that in adults, bone undergoes constant remodeling through resorption by osteoclasts and formation by osteoblasts. Biochemical markers measure bone formation or resorption products in blood and urine, allowing serial assessment of bone turnover. Formation markers include osteocalcin and procollagen peptides, while resorption markers include collagen telopeptides and hydroxypyridinium cross-links. These markers can help evaluate treatment response, predict fracture risk and bone loss, and select patients who may benefit most from treatment. However, markers have limitations due to biological and analytical variability.
A randomized controlled_trial_of_four_doses_of_transdermal_estradiol_for_prev...manelle gutierrez
This randomized controlled trial tested the effects of four doses of transdermal estradiol (0.025 mg/day, 0.05 mg/day, 0.06 mg/day, and 0.1 mg/day) on preventing bone loss in postmenopausal women compared to a placebo. At 24 months, all doses of estradiol resulted in statistically significant increases in bone mineral density at the spine and hip compared to decreases seen with placebo. The lowest dose of 0.025 mg/day increased spine bone mineral density by 2.37% and hip bone mineral density by 0.26% compared to decreases of 2.49% and 2.04% respectively with placebo. This study demonstrates that even the
Research proposal &administration issuesFarragBahbah
This study aims to evaluate the long-term effects of parathyroidectomy (PTX) on bone histology, coronary artery calcification, and other biomarkers in hemodialysis patients with severe secondary hyperparathyroidism. A prospective observational study will follow 50 patients undergoing PTX for 12 months, assessing bone biopsies, calcium scoring via CT, and serum biomarkers at baseline and 12 months. The study hypothesizes that PTX will improve bone turnover and mineralization while reducing vascular calcification, aiming to provide insights into long-term PTX outcomes in this patient population.
Research proposal &administration issuesFarragBahbah
This study aims to evaluate the long-term effects of parathyroidectomy (PTX) on bone histology, coronary artery calcification, and other biomarkers in hemodialysis patients with severe secondary hyperparathyroidism. The study will prospectively observe 50 patients undergoing PTX, collecting clinical data and samples at baseline and 12 months post-surgery. Outcome measures include bone biopsy analyses, coronary artery calcium scoring via CT scan, and serum levels of 11 biomarkers related to bone and mineral metabolism. Statistical analyses will compare results before and after PTX to determine PTX's long-term impacts.
EVALUATION OF THE EFFICIENCY OF BISPHOSPHONATES IN THE TREATMENT OF OSTEOPORO...indexPub
Osteoporosis (OP) is a widespread metabolic disease of the skeleton, leading to decreased bone strength and increased risk of fractures. OP is a disease of varying nature that affects all age groups, but is most common in older people. For a long time, doctors did not have serious tools to treat this insidious disease and mainly dealt with its consequences - fractures.
Cong dung cua gung trong dieu tri dau khop xuong man tinh nguoi giaCong Tai
1) This study investigated the effects of ginger powder supplementation on inflammatory markers in elderly patients with knee osteoarthritis over 12 weeks.
2) 120 patients were randomly assigned to either a ginger group that received 500 mg ginger powder capsules daily or a placebo group that received 500 mg starch capsules.
3) After 12 weeks, serum levels of nitric oxide and C-reactive protein (markers of inflammation) decreased more in the ginger group compared to the placebo group, indicating that daily ginger powder supplementation may help reduce inflammation in patients with knee osteoarthritis.
This study evaluated the effectiveness of Osteobios and Guna-Fem supplements for treating early postmenopausal osteoporosis compared to calcium and vitamin D supplements. 70 postmenopausal women with osteoporosis were divided into two groups. The group treated with Osteobios and Guna-Fem showed greater reductions in pain levels, improvements in quality of life, and decreases in bone resorption markers compared to the calcium/vitamin D group. The results suggest Osteobios and Guna-Fem may be effective alternative or additional therapies for treating osteoporosis and improving patients' quality of life.
This study evaluated the effectiveness of Osteobios and Guna-Fem supplements for treating early postmenopausal osteoporosis compared to calcium and vitamin D supplements. 70 postmenopausal women with osteoporosis were divided into two groups. The group treated with Osteobios and Guna-Fem showed greater reductions in pain levels, improvements in quality of life, and decreases in bone resorption markers compared to the calcium/vitamin D group. The results suggest Osteobios and Guna-Fem may be effective treatments for reducing symptoms of early postmenopausal osteoporosis.
Nephrotic syndrome in Sickle Cell Disease of Western Odisha, India: A case re...inventionjournals
Sickle cell disease causes a distinct pattern of glomerular dysfunction. Subjects with sickle cell disease (SCD) are known to develop many potential functional and structural renal abnormalities. Glomerular hypertension and hyper filtration are thought to play a major role in the development of glomerular disease in subjects with SCD. We reported 5 unusual cases of sickle cell disease presenting as nephrotic syndrome. KEYWORDS- Nephrotic syndrome, sickle cell disease
Nephrotic syndrome in Sickle Cell Disease of Western Odisha, India: A case re...inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This study investigated the effects of antioxidant supplementation on oxidative stress in patients with intermittent claudication. 16 patients performed a standard walking test before and after taking daily vitamins E and C for 4 weeks. Biomarkers were measured before, during, and after the tests. The study found that oxidative stress, as measured by the ortho-APOH biomarker, significantly increased during reperfusion after the initial walking test but did not increase after 4 weeks of antioxidant supplementation. This suggests that antioxidants reduce oxidative stress in claudicants caused by ischemia-reperfusion from walking.
Gingival crevicular fluid turnover markers in premenopausal vs postmenopausal...Dr. Anuj S Parihar
1) The study evaluated levels of bone biomarkers RANKL and OPN in the gingival crevicular fluid of 50 women undergoing orthodontic treatment, dividing them into premenopausal (n=25) and postmenopausal (n=25) groups.
2) Baseline levels of RANKL and OPN were significantly different between the two groups but increased similarly with treatment in both.
3) Within each group, biomarker levels increased significantly from baseline to 24 hours after orthodontic force activation.
4) However, the changes in biomarker levels with treatment were not significantly different between the premenopausal and postmenopausal groups.
ABSTRACT- Sickle cell disease (SCD) is an inherited hematological disorder that causes red blood cells to break down continuously. This leads to a rigid, sickle like shape under certain conditions, causing polymerization of the sickled hemoglobin. This study was undertaken to know whether sex hormones (estradiol, progesterone, testosterone and prolactin) exert any effect on the polymerization of sickle cell erythrocytes in vitro and the possibility of these hormones having an effect on the sickling phenomenon. The hemoglobin polymerization test was carried out when hemoglobin S undergoes gelation after it was deprived of oxygen using 2% sodium metabisulphite as reductant. The polymerization inhibition studies were shown that estrogen, progesterone, testosterone and not prolactin had a statistical significant reduction effect (P<0.05) on the polymerization of the sickle cell erythrocytes. The polymerization of the sickle cell erythrocytes was reduced to 50.90%, 62.74%, 67.56% and 92.16% at the concentration of 50.0 pg/ml of estrogen, 5.0 ng/ml of progesterone, 6.0 ng/ml of testosterone and 7.0 ng/ml of prolactin in the same order. This effect was achieved at a low concentration of these hormones. Higher concentrations of the hormones increased polymerization. The result suggests that using the hormones substances at low concentrations can help to ameliorate the intracellular polymerization of sickle cell hemoglobin.
Key-words- Sickle cell, Hormones, Polymerization, Progesterone, Estradiol, Testosterone, Prolactin
Anti-Mullerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor-B super family. This hormone is a sensitive marker of ovarian reserve. The present study aims to measure the Anti-Mullerian hormone in thalassemic females receiving the regular blood transfusion as well as patients of chronic idiopathic thrombocgtopenic purpura and age and sex matched controls. Serum Anti-Mullerian hormone was measured by ELISA and Ferritin were measured by RIA. Clinical evaluation was done for all patients including anthropometric measurements, pubertal staging and history taking. Results of the study were analyzed by appropriate statistical methods. Obtained results revealed that the values of Body Mass Index as well as Anti-Mullerian were significantly higher in controls than thalassemics and chronic idiopathic thrombocytopenic purpura and there was a negative correlation between serum Ferritin and Anti-Mullerian hormone. Moreover, Anti-Mullerian hormone was significantly higher in patients receiving Desferal than in those receiving Deferriprone. Reduced Anti-Mullerian hormone in thalassemics as well as chronic ITP patients are considered an important indicator declines in ovarian function which entail modification in the therapeutic plans for thalassemic and chronic ITP patients.
The document summarizes key points from the 18th International Conference on Co-morbidities and Adverse Drug Reactions in HIV. It discusses findings related to bone health, cardiovascular health, and physical activity levels in people living with HIV. Regarding bone health, studies showed bone mineral density loss with tenofovir-containing antiretroviral therapy and PrEP. Loss was also seen with glucocorticoid use. For cardiovascular health, studies suggested lower risk of atherosclerotic events with NNRTI-based initial ART and possible lower risk with atazanavir. Physical activity levels were associated with comorbidity risk, with higher risk at lower activity levels.
Red Blood Cell Lipids, Serum Trace Elements and Immunological Markers in Pros...ijtsrd
Aim In this study, the red cell lipids, serum trace elements and immunological markers in prostatic disease patients attending the Nephrology Department of Abia state University Teaching Hospital Aba were evaluated.METHODOLOGY A total of one hundred and ten 110 adult males aged 40 80years comprising of 60 prostatic disease patients and fifty 50 normal subjects were recruited. The prostatic disease patients comprised of thirty 30 prostatitis, twenty 20 benign prostatic hyperplasia BPH and ten 10 prostate cancer patients. Red cell lipids, trace elements and immunological markers were determined on blood samples collected from the subjects between January 2017 and December 2020.RESULTS Results obtained following analysis indicated a significant increase in red cell total cholesterol, red cell LDL cholesterol, red cell Triglyceride and red cell phospholipids P 0.05 compared to control subjects whereas red cell HDL cholesterol were significantly decreased compared to control subjects P 0.05 serum trace elements copper were significantly decreased in prostatitis and BPH compared to control subjects P 0.05 but no significant decrease in prostate cancer patients compared to control subjects P 0.05 . Serum iron and lead showed no significant difference in prostatic patients compared to control subjects. Serum manganese levels showed significant increase in BPH patients compared to control subjects P 0.05 whereas prostatitis and prostate cancer patients showed no significant decrease P 0.05 compared to control subjects. Globulin concentrations of prostatatic patients did not show significant increase in prostatic disease patients compared to control subjects P 0.05 .CONCLUSION Lipids serves as a promoter of peroxidation, oxidative stress and oxidative damage which has been implicated in many diseases and immunological markers is an evidence of inflammation which is evidence and risk factors in development of prostatic diseases. Agbugba. N. Agnes | Ohaeri. O. Christopher | Ijioma. N. Solomon | R. T. Uroko | Onyeabo Chimaroke | Achi. K. Ngozi | Nwaokorie Ernest A. "Red Blood Cell Lipids, Serum Trace Elements and Immunological Markers in Prostatic Disease Patients: An Investigative Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-2 , February 2022, URL: https://www.ijtsrd.com/papers/ijtsrd49441.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/49441/red-blood-cell-lipids-serum-trace-elements-and-immunological-markers-in-prostatic-disease-patients-an-investigative-study/agbugba-n-agnes
Osteoarthritis is the most common disease of women after menopause. There are many factors to develop the disease. Hormones play important role to in this context. The objective of the present study is to determine whether the levels of thyroid and sex hormones are associated with osteoarthritis (OA) in postmenopausal women. Forty three patients suffering from OA and twenty control subjects were included in this study. Thyroid and sex hormones were measured in the serum by enzyme linked immunosorbent assay technique. In OA patients serum estrogen levels were low as compared to control subjects(p<0.001), but these patients did not show any significant change in thyroid hormones and progesterone hormone levels when compared with control subjects. The findings suggest that estrogen deficiency after menopause may contribute to develop OA in postmenopausal women.
Efficacy,and safety of intravenous zoledronic acid in treatment+of+pediatric+...Abdulmoein AlAgha
Zoledronic acid is an effective treatment for pediatric osteoporosis. A 13-year study of 131 children with primary or secondary osteoporosis found that intravenous zoledronic acid significantly reduced fractures, bone pain, and bone turnover markers. While acute side effects like fever and hypocalcemia occurred after the first infusion, no chronic adverse events were reported. Zoledronic acid should be considered as an important treatment for improving outcomes in pediatric osteoporosis.
Background: One of the most common disorders in this age group, abnormal uterine bleeding (AUB), is the primary cause of most gynaecological problems in adolescents. Unfortunately, epidemiological data on AUB in teenagers is scarce, especially in the Indian subcontinent. The PALM-COEIN classification, where PALM stands for structural reasons and COEIN for functional causes, was employed in this single-center prospective observational study to evaluate the relative contributions of several etiological factors in AUB. To comprehend the etiological, dermographic, and therapeutic factors affecting menorrhagia in patients going through adolescence. Methods: Enrollment for females with AUB between 10 and 19 occurred between January and December 2022. A thorough history, physical examination, and laboratory evaluation, which in every case comprised standard testing, hormone analysis, and abdominal and pelvic ultrasonography were used to determine the cause of AUB. MRIs and CT scans were performed when needed. Results: There were 190 patients enrolled in total. Functional factors comprised the predominant aetiology of AUB among adolescent females: Adenomyosis=01 (0.52%), Polyp=1 (0.52%). Coagulopathy=2 (1.05%), Leomyoma=01 (0.52%), Malignancy=1 (0.52%), and PALM=4 (2.11%). COEIN=186 (97.89%), ovulation disorder=175 (92.15%), endometrial=01 (0.52%), iatrogenic=6 (3.15%), non-specified=2 (1.05%), and iatrogenic=6 (3.15%). Conclusion: The most frequent cause of AUB in the adolescent population is ovulatory abnormalities. Even though they are extremely rare, structural factors must be ruled out. A helpful technique for evaluating patients with AUB systematically is the PALM-COEIN classification.
Key-words: PALM-COEIN, Leiomyoma, AUB, Polycystic ovarian syndrome, Hormonal therapy
This study compared the mitochondrial capacity of individuals with iron deficiency anemia to non-anemic controls. Blood samples were taken from 6 anemic and 14 control participants to measure hemoglobin and hematocrit levels. While the anemic group had lower hemoglobin and hematocrit levels, there was no significant difference in mitochondrial rate constants between the two groups. The results suggest that mild iron deficiency anemia does not impair energy production in skeletal muscle mitochondria. Future studies should examine individuals with more severe anemia.
Most Recent Studies About Stem Cell & Autoimmune Diseasemeducationdotnet
This document summarizes recent studies on the relationship between stem cell transplants and autoimmune diseases. It discusses how stem cell transplants, particularly mesenchymal stem cell transplants, have shown promise in treating several autoimmune disorders like multiple sclerosis, systemic lupus erythematosus, pemphigus vulgaris, autoimmune hepatitis, and pure red cell aplasia. The document reviews specific studies that have found stem cell transplants can reduce disease activity, induce remission, and improve organ function for these conditions. It also notes that mesenchymal stem cell transplants appear to exert anti-inflammatory and regenerative effects with few adverse side effects reported.
Hematological and Biochemical Reference IntervalsLázaro Nunes
This study aimed to establish reference intervals for hematological and biochemical markers of iron status in young physically active males. The study analyzed 150 male volunteers aged 19 years old who underwent a 4-month controlled exercise program. Blood samples were collected and analyzed for hematological parameters using automated analyzers, and serum was analyzed for iron status biomarkers. Reference intervals were established for various markers according to guidelines. Some markers like C-reactive protein and iron levels differed from non-physically active populations, highlighting the importance of athlete-specific reference intervals.
Current treatments for postmenopausal osteoporosis
suffer from side effects. Safe and natural milk
proteins, ribonuclease, and lactoferrin promote formation
of new capillaries and bone formation.
This study aimed to identify prognostic factors for clinical outcomes following arthroscopic partial meniscectomy. The authors conducted a systematic review and meta-analysis of 24 studies meeting their inclusion criteria. They found strong evidence that a worse long-term clinical outcome is associated with resection of more meniscal tissue, presence of radiological knee osteoarthritis at baseline, and longer duration of complaints prior to surgery. There was no correlation found between clinical outcome and factors like location of meniscal tear, pre-operative sport level, gender, tear type, or acute versus chronic pathology. Conflicting evidence existed for the prognostic value of age, chondromalacia, BMI, and leg alignment.
This study evaluated the effectiveness of Osteobios and Guna-Fem supplements for treating early postmenopausal osteoporosis compared to calcium and vitamin D supplements. 70 postmenopausal women with osteoporosis were divided into two groups. The group treated with Osteobios and Guna-Fem showed greater reductions in pain levels, improvements in quality of life, and decreases in bone resorption markers compared to the calcium/vitamin D group. The results suggest Osteobios and Guna-Fem may be effective treatments for reducing symptoms of early postmenopausal osteoporosis.
Nephrotic syndrome in Sickle Cell Disease of Western Odisha, India: A case re...inventionjournals
Sickle cell disease causes a distinct pattern of glomerular dysfunction. Subjects with sickle cell disease (SCD) are known to develop many potential functional and structural renal abnormalities. Glomerular hypertension and hyper filtration are thought to play a major role in the development of glomerular disease in subjects with SCD. We reported 5 unusual cases of sickle cell disease presenting as nephrotic syndrome. KEYWORDS- Nephrotic syndrome, sickle cell disease
Nephrotic syndrome in Sickle Cell Disease of Western Odisha, India: A case re...inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This study investigated the effects of antioxidant supplementation on oxidative stress in patients with intermittent claudication. 16 patients performed a standard walking test before and after taking daily vitamins E and C for 4 weeks. Biomarkers were measured before, during, and after the tests. The study found that oxidative stress, as measured by the ortho-APOH biomarker, significantly increased during reperfusion after the initial walking test but did not increase after 4 weeks of antioxidant supplementation. This suggests that antioxidants reduce oxidative stress in claudicants caused by ischemia-reperfusion from walking.
Gingival crevicular fluid turnover markers in premenopausal vs postmenopausal...Dr. Anuj S Parihar
1) The study evaluated levels of bone biomarkers RANKL and OPN in the gingival crevicular fluid of 50 women undergoing orthodontic treatment, dividing them into premenopausal (n=25) and postmenopausal (n=25) groups.
2) Baseline levels of RANKL and OPN were significantly different between the two groups but increased similarly with treatment in both.
3) Within each group, biomarker levels increased significantly from baseline to 24 hours after orthodontic force activation.
4) However, the changes in biomarker levels with treatment were not significantly different between the premenopausal and postmenopausal groups.
ABSTRACT- Sickle cell disease (SCD) is an inherited hematological disorder that causes red blood cells to break down continuously. This leads to a rigid, sickle like shape under certain conditions, causing polymerization of the sickled hemoglobin. This study was undertaken to know whether sex hormones (estradiol, progesterone, testosterone and prolactin) exert any effect on the polymerization of sickle cell erythrocytes in vitro and the possibility of these hormones having an effect on the sickling phenomenon. The hemoglobin polymerization test was carried out when hemoglobin S undergoes gelation after it was deprived of oxygen using 2% sodium metabisulphite as reductant. The polymerization inhibition studies were shown that estrogen, progesterone, testosterone and not prolactin had a statistical significant reduction effect (P<0.05) on the polymerization of the sickle cell erythrocytes. The polymerization of the sickle cell erythrocytes was reduced to 50.90%, 62.74%, 67.56% and 92.16% at the concentration of 50.0 pg/ml of estrogen, 5.0 ng/ml of progesterone, 6.0 ng/ml of testosterone and 7.0 ng/ml of prolactin in the same order. This effect was achieved at a low concentration of these hormones. Higher concentrations of the hormones increased polymerization. The result suggests that using the hormones substances at low concentrations can help to ameliorate the intracellular polymerization of sickle cell hemoglobin.
Key-words- Sickle cell, Hormones, Polymerization, Progesterone, Estradiol, Testosterone, Prolactin
Anti-Mullerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor-B super family. This hormone is a sensitive marker of ovarian reserve. The present study aims to measure the Anti-Mullerian hormone in thalassemic females receiving the regular blood transfusion as well as patients of chronic idiopathic thrombocgtopenic purpura and age and sex matched controls. Serum Anti-Mullerian hormone was measured by ELISA and Ferritin were measured by RIA. Clinical evaluation was done for all patients including anthropometric measurements, pubertal staging and history taking. Results of the study were analyzed by appropriate statistical methods. Obtained results revealed that the values of Body Mass Index as well as Anti-Mullerian were significantly higher in controls than thalassemics and chronic idiopathic thrombocytopenic purpura and there was a negative correlation between serum Ferritin and Anti-Mullerian hormone. Moreover, Anti-Mullerian hormone was significantly higher in patients receiving Desferal than in those receiving Deferriprone. Reduced Anti-Mullerian hormone in thalassemics as well as chronic ITP patients are considered an important indicator declines in ovarian function which entail modification in the therapeutic plans for thalassemic and chronic ITP patients.
The document summarizes key points from the 18th International Conference on Co-morbidities and Adverse Drug Reactions in HIV. It discusses findings related to bone health, cardiovascular health, and physical activity levels in people living with HIV. Regarding bone health, studies showed bone mineral density loss with tenofovir-containing antiretroviral therapy and PrEP. Loss was also seen with glucocorticoid use. For cardiovascular health, studies suggested lower risk of atherosclerotic events with NNRTI-based initial ART and possible lower risk with atazanavir. Physical activity levels were associated with comorbidity risk, with higher risk at lower activity levels.
Red Blood Cell Lipids, Serum Trace Elements and Immunological Markers in Pros...ijtsrd
Aim In this study, the red cell lipids, serum trace elements and immunological markers in prostatic disease patients attending the Nephrology Department of Abia state University Teaching Hospital Aba were evaluated.METHODOLOGY A total of one hundred and ten 110 adult males aged 40 80years comprising of 60 prostatic disease patients and fifty 50 normal subjects were recruited. The prostatic disease patients comprised of thirty 30 prostatitis, twenty 20 benign prostatic hyperplasia BPH and ten 10 prostate cancer patients. Red cell lipids, trace elements and immunological markers were determined on blood samples collected from the subjects between January 2017 and December 2020.RESULTS Results obtained following analysis indicated a significant increase in red cell total cholesterol, red cell LDL cholesterol, red cell Triglyceride and red cell phospholipids P 0.05 compared to control subjects whereas red cell HDL cholesterol were significantly decreased compared to control subjects P 0.05 serum trace elements copper were significantly decreased in prostatitis and BPH compared to control subjects P 0.05 but no significant decrease in prostate cancer patients compared to control subjects P 0.05 . Serum iron and lead showed no significant difference in prostatic patients compared to control subjects. Serum manganese levels showed significant increase in BPH patients compared to control subjects P 0.05 whereas prostatitis and prostate cancer patients showed no significant decrease P 0.05 compared to control subjects. Globulin concentrations of prostatatic patients did not show significant increase in prostatic disease patients compared to control subjects P 0.05 .CONCLUSION Lipids serves as a promoter of peroxidation, oxidative stress and oxidative damage which has been implicated in many diseases and immunological markers is an evidence of inflammation which is evidence and risk factors in development of prostatic diseases. Agbugba. N. Agnes | Ohaeri. O. Christopher | Ijioma. N. Solomon | R. T. Uroko | Onyeabo Chimaroke | Achi. K. Ngozi | Nwaokorie Ernest A. "Red Blood Cell Lipids, Serum Trace Elements and Immunological Markers in Prostatic Disease Patients: An Investigative Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-2 , February 2022, URL: https://www.ijtsrd.com/papers/ijtsrd49441.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/49441/red-blood-cell-lipids-serum-trace-elements-and-immunological-markers-in-prostatic-disease-patients-an-investigative-study/agbugba-n-agnes
Osteoarthritis is the most common disease of women after menopause. There are many factors to develop the disease. Hormones play important role to in this context. The objective of the present study is to determine whether the levels of thyroid and sex hormones are associated with osteoarthritis (OA) in postmenopausal women. Forty three patients suffering from OA and twenty control subjects were included in this study. Thyroid and sex hormones were measured in the serum by enzyme linked immunosorbent assay technique. In OA patients serum estrogen levels were low as compared to control subjects(p<0.001), but these patients did not show any significant change in thyroid hormones and progesterone hormone levels when compared with control subjects. The findings suggest that estrogen deficiency after menopause may contribute to develop OA in postmenopausal women.
Efficacy,and safety of intravenous zoledronic acid in treatment+of+pediatric+...Abdulmoein AlAgha
Zoledronic acid is an effective treatment for pediatric osteoporosis. A 13-year study of 131 children with primary or secondary osteoporosis found that intravenous zoledronic acid significantly reduced fractures, bone pain, and bone turnover markers. While acute side effects like fever and hypocalcemia occurred after the first infusion, no chronic adverse events were reported. Zoledronic acid should be considered as an important treatment for improving outcomes in pediatric osteoporosis.
Background: One of the most common disorders in this age group, abnormal uterine bleeding (AUB), is the primary cause of most gynaecological problems in adolescents. Unfortunately, epidemiological data on AUB in teenagers is scarce, especially in the Indian subcontinent. The PALM-COEIN classification, where PALM stands for structural reasons and COEIN for functional causes, was employed in this single-center prospective observational study to evaluate the relative contributions of several etiological factors in AUB. To comprehend the etiological, dermographic, and therapeutic factors affecting menorrhagia in patients going through adolescence. Methods: Enrollment for females with AUB between 10 and 19 occurred between January and December 2022. A thorough history, physical examination, and laboratory evaluation, which in every case comprised standard testing, hormone analysis, and abdominal and pelvic ultrasonography were used to determine the cause of AUB. MRIs and CT scans were performed when needed. Results: There were 190 patients enrolled in total. Functional factors comprised the predominant aetiology of AUB among adolescent females: Adenomyosis=01 (0.52%), Polyp=1 (0.52%). Coagulopathy=2 (1.05%), Leomyoma=01 (0.52%), Malignancy=1 (0.52%), and PALM=4 (2.11%). COEIN=186 (97.89%), ovulation disorder=175 (92.15%), endometrial=01 (0.52%), iatrogenic=6 (3.15%), non-specified=2 (1.05%), and iatrogenic=6 (3.15%). Conclusion: The most frequent cause of AUB in the adolescent population is ovulatory abnormalities. Even though they are extremely rare, structural factors must be ruled out. A helpful technique for evaluating patients with AUB systematically is the PALM-COEIN classification.
Key-words: PALM-COEIN, Leiomyoma, AUB, Polycystic ovarian syndrome, Hormonal therapy
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1. Evaluation of LRRC17 and Periosten
for osteoporosis patients
Noor Ali Nemaha
Colleage of Health and Medical Techniquse /Kufa
Al-Furat Al-Awsat Technical University/Iraq
Supervised by
Prof . Dr. Hanan Jassim Hammod
Babylon Technical Institute/Kufa
Al-Furat Al-Awsat Technical University/Iraq
Abstract
Osteoporosis is a metabolic bone disease that results, at the cellular
level, in osteoporotic bone resorption that is irreplaceable by osteogenesis
of osteoblasts. This leads to weak bones and causes osteoporosis, which
he current study
t
Aim of Study:
.
leads to an increased risk of fractures
aimed to detected biomarkers in patients with osteoporosis and it
association with some physiological status have been a study because
increase incidence of osteoporosis, for both genders which might also
help in early diagnosis of case of osteoporosis to prevent development of
of some biomarkers include
by: Estimation
complication, this achieved
The study,
,
Result
.
Periostin
and
containing 17
-
rich repeat
-
Leucine
2. higher serum periostin levels have been reported to be associated with
The perostin parameter
ased fracture risk in postmenopausal women
incre
in the current study was highly significant increase in osteoporosis age
group (41-50 y) patients (27.81±5.86) than in control age group (41-50 y)
(14.91±0.52) according to p-value (0.002) , demonstrated that
postmenopausal women in the lowest plasma lrrc17 tertile had higher,
The LRRC17 parameter in the current study was highly significant
increase in osteoporosis age group (41-50 y) patients (712.33±60.68) than
in control age group (41-50 y) (311.22±21.64) according to p-value
(0.001).
INTRODUCTION
Osteoporosis is the most common chronic metabolic bone
.
disease, and it is characterized by increasing osteoporosis. It
affects people of all ages, genders, and gender identities, but it
is more common among elderly individuals and women. With
the aging of the population and the extension of life spans,
several variables that impact bones, such as aging and
menopause, are becoming more prevalent. According to the
International Osteoporosis Foundation, one in every three
women over 50 and one in every five men over 50 may suffer a
bone fracture as a result of osteoporosis at some time in their
lives. Osteoporosis is growing more prevalent throughout the
Osteoporosis can be primary or secondary to other
).
14
(
world
diseases that lead to bone loss. Type I osteoporosis in rare
cases, the process of bone formation is normal in this type of
Periostin is
.
13)
osteoporosis, which leads to more bone loss (
an extracellular matrix protein produced by periosteal
osteoblasts and osteoblasts (8). Periostin has been found to
play a role in bone strength and microstructure maintenance. It
3. has a protein structure that includes an amino-terminal EMI
domain, a tandem repeat of four Fas 1 domains, and a
carboxyl-terminal domain with a heparin-binding site .Function
Periostin (POSTN) regulates the recruitment and binding of
bone activators from primary sources such as bone marrow and
containing 17 (LRRc17) is a 37
-
rich repeat
-
Leucine
.
(12)
blood
kDa protein with secretary feature containing five putative LRR
domains. Previous experimental study well characterized the
role of LRRc17 in bone metabolism as an inhibitor of RANKL
induced osteoclast differentiation (6) .
MATERAIL AND METHODE
1-Patients
The research was carried out at Al-Sadr Teaching Hospital's
Physiotherapy Center-Osteoporosis Department from December 1 to
January 9.The study included 90 participants, including 45 osteoporosis
patients and 45 healthy adults who served as controls. Patients were
diagnosed by specialists based on their family histories, age, height,
weight, and a few unambiguous clinical criteria, which were then
confirmed by the DXA (dual-energy x-ray absorptiometry) instrument
and other tests. As shown in Appendix 1, various vitamin D and calcium
laboratory tests
2 -Control
The controls provided blood samples that were equivalent to those of
the patients in terms of sex and age, but they did not have any hereditary
illnesses, infections, or chronic conditions.
3- Exclusion criteria
4. When the samples were taken from patients and controls, some of
them were left out since they could change the results. In this study,
samples with (heart failure, vitamin deficiency, warfarin intake,
chemotherapy, kidney failure, surgery, removal of the small intestine,
drug treatment, cephalosporin antibiotics) were included because these
conditions could affect the results of protein S1P, LRRC17, GSN, and
protein Perostin in the samples.
Methods :
1 -Sample Collection:
Each control and osteoporosis patient had 5 mL of venous blood
drawn in this investigation. Ethyl alcohol was used to sanitize the skin.
The patient was being readied for a blood transfusion at this time. Blood
was drawn and deposited in tubes as follows: The tube included a
separating gel in which 3 ml was poured and left to clot for 10-15 minutes
at room temperature before being centrifuged for 5 minutes at 5000 rpm
to obtain the serum. The serum was collected for testing purposes
(LRRC17 and periosten).
2 -BMI (Body Mass Index)
The BMI is a metric that uses a person's weight and height to assess
how lean or obese they are. It is used to determine the weight of tissue.
3- ELISA (Enzyme Linking Immunosorbent Assay)
The amounts of the proteins LRRC17 and POST in the plasma of
healthy controls and osteoporosis patients were measured using ELISA
kits.
5. 4-Human protein ELISA kit (LRRC17)
The Bioassay Technology Laboratory provided a specific kit for testing
human Leucine-rich Repeat-containing protein 17 concentrations in
serum
5-Human Protein Periostin ELISA Kit
The level of human protein periostin was measured using the enzyme-
linked immunosorbent assay (ELISA) method, as directed by the
manufacturer. Bioassay Technology Laboratory, E3226Hu, China
4. Results and Discussion
4.1 Results:
This study was conducted on a total 90 person composed of two
groups. The first group was the patient group, which consists of 45
patients with Osteoporosis, were collected from patients attended to "
Physiotherapy Center - Osteoporosis Department in AL-Sadder
medical city in Al-Najaf Governorate/ Ministry of Health/Iraq, in the
period from 1st
of December to the 9th
of January. with an age ranging
between (34-68) years old; and The second group is the control group
(Non-osteoporosis), which consists of 45 with no osteoporosis, also from
the same place with age ranging (30-68) years old. Patients were
diagnosed by specialist physicians based on family histories, age, height,
weight and some clear clinical parameters and confirmed by the DXA
(dual-energy x-ray absorptiometry) device.
Table (.1) General characteristics of patients and healthy groups.
Group
Patient Healthy
p-value
N % N %
Gender Male 10 22.2 13 28.9 0.03*
6. Female 35 77.8 32 71.1
Age
20-40 7 15.6 15 33.3
0.04*
41-60 25 55.5 15 33.3
<60 13 28.8 15 33.3
BMI (kg/M2
)
Normal 12 26.7 11 22.4
0.023*
over-weight 17 37.8 13 28.9
Obesity 36 35.6 21 46.7
Smoking
No 28 62.2 24 53.3 0.039*
Yes 17 37.7 21 46.6
Menopause
Pre-menopause 14 31.2 21 65.6
0.001**
Post-menopause 31 68.8 11 34.3
Hypertension
Yes 33 73.3 26 57.7
0.043*
No 12 26.6 19 42.2
*Significant different at(p<0.05)
**Significant different at(p<0.01)
2-Biochemical Results
Table.2: Biochemical parameter in patient and control in study on
osteoporosis.
Group
Parameter
Patient control P-value
LRRC17 ng/ml 739.62±55.30 328.77±12.31 0.0001**
Periosten pg/ml 29.204±3.76 15.45±0.284 0.0001**
BMD ng/ml 0.63±0.014 1.02±0.021 0.0001**
V.D ng/ml 19.67±0.42 33.63±1.93 0.05*
*Significant different at(p<0.05)
**Significant different at(p<0.01)
7. Figure (4-3) Comparisons of serum periosten between patient and control
groups in osteoporosis
The Periosten parameter in the current study was highly significant
increase in osteoporosis patients (739.62±55.30) than in control group
(328.77±12.31) according to p-value (0.0001).
Figure (4-2) Comparisons of serum LRRC17 between patient and control
groups in osteoporosis.
The LRRC17parameter in the current study was highly significant
increase in osteoporosis patients (739.62±55.30) than in control group
(328.77±12.31) according to p-value (0.0001
0
5
10
15
20
25
30
35
40
patient control
Periosten
pg/ml 29.204±3.6*
15.45±0.284
8. Figure (4-5) Comparisons of serum BMD between Patient and control
groups in osteoporosis
Figure (4-6) Comparisons of serum vitamin D between patient and
control groups in osteoporosis
The VitD parameter in the current study was highly significant decrease
in osteoporosis patients (9.67±0.42) than in control group (40.63±1.93)
according to p-value (0.0001).
Table.4: Biochemical parameter in patient and control in study on
osteoporosis as age groups comparison.
Parameter group 20-40 y 41-50 y <60 y
LRRC17 ng/ml
patient 697.92±89.19 712.33±60.68 924.82±214.74
control 360.85±23.72 311.22±21.64 314.24±16.93
P-value 0.001 0.001 0.0001
Periosten
pg/ml
patient 25.71±4.78 27.81±5.86 42.75±13.14
control 15.24±.42 14.91±0.52 16.20±0.49
P-value 0.042 0.002 0.046
BMD g/cm
patient 0.63±0.02 0.63±0.0 0.64±0.02
control 0.95±0.04 1.03±0.03 1.08±0.03
0
0.5
1
1.5
patient control
BMD
g/cm
2
0.63±0.014
1.02±0.021
-20
0
20
40
60
patient control
V.D
ng/ml
9.67±0.42
40.63±1.93
9. P-value 0.0001 0.0001 0.0001
V.D ng/ml
patient 10.23±0.68 9.42±0.64 8.91±0.89
control 37.46±3.59 43.40±3.91 41.01±2.38
P-value 0.0001 0.0001 0.0001
Figure (4-17) Comparisons of serum LRRC17 between patient and
control groups age in osteoporosis
Figure (4-19) Comparisons of serum Periosten between patient and
control groups age in osteoporosis
The LRRC17 parameter in the current study was highly significant
increase in osteoporosis age group (20-40 y) patients (697.92±89.19)
than in control age group (20-40 y) (360.85±23.72) according to p-value
(0.001). The LRRC17 parameter in the current study was highly
significant increase in osteoporosis age group (41-50 y) patients
0
200
400
600
800
1000
1200
31-40 y 41-50 y 51-60 y
LRRC17
ng/ml
patient
control
924.82±214.74
697.92±89.19
712.33±60.68
360.85±23.72 311.22±21.64 314.24±16.93
0
10
20
30
40
50
60
31-40 y 41-50 y 51-60 y
Periosten
pg/ml
patient
control
42.75±13.14
27.81±5.86 25.71±4.78
15.24±.42 14.91±0.52 16.20±0.49
10. (712.33±60.68) than in control age group (41-50 y) (311.22±21.64)
according to p-value (0.001). The current study agreed with a study that
found a significant increase in patients, the LRRC17 parameter in the
current study was highly significant increase in osteoporosis age group
(<60 y) patients (924.82±214.74) than in control age group (<60 y)
The Perostin parameter
value (0.0001).
-
(314.24±16.93) according to p
in the current study was highly significant increase in osteoporosis age
group (20-40 y) patients (25.71±4.78) than in control age group (20-40 y)
(15.24±.42) according to p-value (0.042). The perostin parameter in the
current study was highly significant increase in osteoporosis age group
(41-50 y) patients (27.81±5.86) than in control age group (41-50 y)
(14.91±0.52) according to p-value (0.002). The perostin parameter in the
current study was highly significant increase in osteoporosis age group
(<60 y) patients (42.75±13.14) than in control age group (<60 y)
(0.046)
value
-
(16.20±0.49) according to p
Tabl:3 Biochemical parameter in patient and control in study on
osteoporosis as pre-menopause and post-menopause groups
comparison.
Parameter Cycle Patient Control
LRRC17 ng/ml
Pre 710.30±63.27 307.07±17.35
Post 740.93±157.66 317.66±35.92
P-value 0.421 0.641
Periosten pg/ml
Pre 27.07±4.36 15.16±0.43
Post 37.76±14.57 15.80±0.75
P-value 0.057 0.822
BMD g/cm2
Pre 0.63±0.02 1.01±0.03
Post 0.67±0.03 1.00±0.03
P-value 0.213 0.123
11. Figure Comparisons of serum LRRC17
Figure Comparisons of serum periosten
Figure Comparisons of serum BMD
Discusion:
osteoblasts and
In bone, periostin is mainly expressed by periosteal
The present study shows that hip fracture women had
.
2)
(
osteocytes
higher serum periostin (sPostn) levels. The elevation of sPostn is
associated with bone density loss, yet fracture itself may even increase
The current study agreed
.
(11)
ing phase
sPostn levels during early heal
0.00
200.00
400.00
600.00
800.00
1000.00
1200.00
Patient control
pre
post
710.30±63.27
307.07±17.35 317.66±35.92
0.00
10.00
20.00
30.00
40.00
50.00
60.00
Patient control
pre
post
0.00
0.20
0.40
0.60
0.80
1.00
1.20
1.40
Patient control
pre
post
740.93±157.66
15.80±0.75
15.16±0.43
37.76±14.57
27.07±4.3
6
0.63±0.02
0.67±0.03
1.01±0.03
1.00±0.03
12. which
,
with a study that found a significant increase in patients
to inhibit
RANKL
negatively regulates
LRRC17
that
contradicts his study
demonstrated that postmenopausal
al
et
bone degradation. Later, Kim
fold higher odds ratio for
-
level had a 3.32
LRRC17
lower
women with
osteoporotic fracture and associated with a 46% higher risk of
osteoporotic fracture than the group with higher LRRC17 levels,
.
(7)
suggesting LRRC17's potential as a marker for osteoporotic fracture
The BMD parameter in the current study was highly significant decrease
in osteoporosis patients (0.63±0.014) than in control group (0.63±0.014)
Clinically, BMD is a strong relevant
value (0.0001).
-
according to p
ndicator for its diagnosis and
marker of osteoporosis, as well as a key i
The current study agreed with a study that found a
.
4)
(
treatment
hormone that
-
Vitamin D is a pro
,
significant decrease in patients
regulates Ca and P balance and skeletal structures, and has an adverse
alth and neuromuscular function. Vitamin D
impact on skeletal he
deficiency increases the risk of osteoporosis. Serum 25OHD level lower
than 20 ng/mL was reported to be associated with defective bone
(12)
mineralization
These findings suggest that low circulating lrrc17 level may be a risk
factor for OF. In fact, Hong et al. Demonstrated that postmenopausal
women in the lowest plasma lrrc17 tertile had higher odds ratio (OR) for
OF than those in the highest tertile and that each log-unit decrease in
plasma (3). The study, higher serum periostin levels have been reported
to be associated with increased fracture risk in postmenopausal women
from the Os des Femmes de Lyon cohort study independently of age,
bone turnover markers, and BMD (9) clinical studies have also
demonstrated that circulating periostin levels were positively correlated
with non-vertebral fractures after adjustment for BMD and potential
13. confounders in Korean postmenopausal women (5).There is little if any
change in BMD in midlife pre- or early peri-menopausal women. BMD
loss increases substantially in the late perimenopause and remains rapid
in the first few postmenopausal years. Body weight is an important
determinant of the rates of BMD loss during the menopause transition.
These findings suggest that healthcare providers should consider
screening for osteoporosis when women enter the late stages of the
menopause transition, particularly if they have relatively low body weight
(1).
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Ettinger, B., ... & Neer, R. M. (2008). Bone mineral density changes during the
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