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Bio-CAD modeling and its
applications
in computer-aided tissue
engineering
Hamza Riaz
UW-14-ME-BSC-045
Layout
• Use of CAD in Bio-Medical engineering
• Overview of computer-aided tissue engineering
• Bio-CAD modeling in CATE
• Different structures of unit cells
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 2
Use of CAD in Bio-Medical Engineering
Cad is being used in Bio-Medical Engineering as
• In Clinical medicine
• In tissue engineering
• In Customized medical implant design
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 3
Overview of CATE
CATE embraces three major applications in tissue engineering
• computer-aided tissue modeling, including 3D anatomic
visualization, 3D reconstruction and CAD-based tissue modeling
• computer-aided tissue scaffold informatics and biomimetic
design, including computer-aided tissue classification and
application for tissue identification and characterization at
different tissue hierarchical levels
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 4
Overview of CATE
• Bio-manufacturing for tissue and organ regeneration, including
computer-aided manufacturing of tissue scaffolds, bio-
manufacturing of tissue constructs, bio-blueprint modeling for 3D
cell and organ printing
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 5
Overview of CATE
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 6
Bio-CAD modeling in CATE
• Reconstruction of data obtained from the noninvasive images of
MRI and CT scan in medical reconstructive software MIMICS
and Geomagic.
• Characterization of heterogeneity of tissue structure using
homogenized techniques
• ABAQUS is used to determine the mechanical properties of the
tissues
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 7
Bio-CAD modeling in CATE
• Using CAD solid modeling based Boolean operations unit cells
relating to the internal architecture of candidate’s unit cells are
integrated with the shape of bone
• CAD model of bone tissues scaffolds is made having the same
internal and external properties to that of actual replaced bone.
• Process planning and tool path is generated based on solid
freeform fabrications techniques that would be able to design the
desired tissue structure by using CAM techniques [1]
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 8
Bio-CAD modeling in CATE
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 9
Different structures of unit cells
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 10
Thanks
5/16/2017 7:57 PMDepartment of Mechanical Engineering, WEC 11
References
• [1] Bio-CAD modeling and its applications in computer-aided
tissue engineering
• [1] W. Sun*, B. Starly, J. Nam, A. Darling
5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 12

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Computer aided tissue engineerimg

  • 1. Bio-CAD modeling and its applications in computer-aided tissue engineering Hamza Riaz UW-14-ME-BSC-045
  • 2. Layout • Use of CAD in Bio-Medical engineering • Overview of computer-aided tissue engineering • Bio-CAD modeling in CATE • Different structures of unit cells 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 2
  • 3. Use of CAD in Bio-Medical Engineering Cad is being used in Bio-Medical Engineering as • In Clinical medicine • In tissue engineering • In Customized medical implant design 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 3
  • 4. Overview of CATE CATE embraces three major applications in tissue engineering • computer-aided tissue modeling, including 3D anatomic visualization, 3D reconstruction and CAD-based tissue modeling • computer-aided tissue scaffold informatics and biomimetic design, including computer-aided tissue classification and application for tissue identification and characterization at different tissue hierarchical levels 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 4
  • 5. Overview of CATE • Bio-manufacturing for tissue and organ regeneration, including computer-aided manufacturing of tissue scaffolds, bio- manufacturing of tissue constructs, bio-blueprint modeling for 3D cell and organ printing 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 5
  • 6. Overview of CATE 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 6
  • 7. Bio-CAD modeling in CATE • Reconstruction of data obtained from the noninvasive images of MRI and CT scan in medical reconstructive software MIMICS and Geomagic. • Characterization of heterogeneity of tissue structure using homogenized techniques • ABAQUS is used to determine the mechanical properties of the tissues 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 7
  • 8. Bio-CAD modeling in CATE • Using CAD solid modeling based Boolean operations unit cells relating to the internal architecture of candidate’s unit cells are integrated with the shape of bone • CAD model of bone tissues scaffolds is made having the same internal and external properties to that of actual replaced bone. • Process planning and tool path is generated based on solid freeform fabrications techniques that would be able to design the desired tissue structure by using CAM techniques [1] 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 8
  • 9. Bio-CAD modeling in CATE 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 9
  • 10. Different structures of unit cells 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 10
  • 11. Thanks 5/16/2017 7:57 PMDepartment of Mechanical Engineering, WEC 11
  • 12. References • [1] Bio-CAD modeling and its applications in computer-aided tissue engineering • [1] W. Sun*, B. Starly, J. Nam, A. Darling 5/16/2017 7:57:43 PMDepartment of Mechanical Engineering, WEC 12