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Complex regional pain syndrome
1. Complex Regional Pain Syndrome
(CRPS)
Presenter :Dr pankaj bhosale
Moderator : Dr Jesto
2. CRPS
Is a debilitating painful condition in a limb
Associated with sensory, motor, autonomic, skin and bone
abnormalities
PAIN is the leading symptom
Often associated with limb dysfunction
Psychological Distress
4. It commonly arises after injury to a limb (sometimes trivial)
CRPS
Type 2Type 1
Absence of a major nerve lesion Presence of a major nerve lesion
(Reflex sympathetic dystrophy
Sudeck’s Atrophy )
(Causalgia)
5. Historical Background
First described by Weir Mitchell after the American Civil War
in 1872
When he encountered soldiers who were injured by gun-shot wounds
exhibiting “bizarre” symptoms and coined the term “Causalgia”
Early 20th century Peter Sudeck
Described features of pain, swelling, atrophy etc. following minor
injury to limbs – hence this phenomenon came to be called “Sudeck’s
atrophy”
A few years on – its association with the sympathetic nervous
system was recognized and hence the term “reflex
sympathetic dystrophy” was increasingly used
6. IASP Consensus group - in 1994
The presence of an initiating noxious
event, or a cause for immobilization
Continuing pain and allodynia which
is disproportionate to any inciting
event
Evidence at some time of oedema,
changes in skin blood flow, abnormal
sudomotor activity in the region of
pain
The diagnosis is excluded by the
existence of other conditions that can
account for the degree of pain and
dysfunction
Criteria 2-4 must be satisfied
Continuing pain, allodynia, or
hyperalgesia after nerve injury, not
necessarily limited to the distribution
of the injured nerve
Evidence at some time of oedema,
changes in skin blood flow, abnormal
sudomotor activity in the region of
pain
The diagnosis is excluded by the
existence of other conditions that can
account for the degree of pain and
dysfunction
All 3 Criteria must be satisfied
Complex Regional Pain Syndrome
TYPE I TYPE II
7. 1994 IASP Criteria
Proved to be extremely
sensitive
Insufficiently specific
Over diagnoses of the
syndrome
Difficult to validate
In 2003, a workshop was
held in Budapest
Published in 2007
Modified diagnostic criteria
Better discrimination
between CRPS and Non-
CRPS neuropathic pain
8. IASP revised criteria – “Budapest criteria”
Continuing pain that is disproportionate to any inciting event
At least one symptom reported in at least 3 of the following
categories
Sensory: Hyperesthesia or allodynia
Vasomotor: Temperature asymmetry, skin colour changes,
skin colour asymmetry
Sudomotor/ Oedema, sweating changes or sweating oedema
asymmetry
Motor / Trophic Decreased range of motion, motor
dysfunction (E.g. weakness, tremor, dystonia),
or trophic changes (e.g. hair, skin, nails)
9. Criteria continued ……………
At least one sign at time of evaluation in at least two of the
following categories
Sensory: Evidence of hyperalgesia (to pinprick), allodynia
(to light touch), temperature sensation, deep
somatic pressure or joint movement
Vasomotor: Evidence of temperature asymmetry (>1°C), skin
colour changes or symmetry
Sudomotor/ Evidence or oedema, sweating changes, or Oedema
sweating asymmetry
Motor/Trophic Evidence of deceased range of movement,
motor dysfunction (E.g. weakness, tremor,
dystonia), trophic changes (E.g. nail, skin, hair)
No other diagnosis explaining the signs and symptoms
10. More stringent criteria in a research setting: to increase
specificity
At least one SYMPTOM in Three ‘SYMPTOM’ categories
At least one SIGN in Three ‘SIGN’ categories
For diagnosis of CRPS in a Research Setting
11. Epidemiology
A population study from the Netherlands showed
Incidence of 26 in 100,000;
Female : Male ratio of 3.5:1
Peak incidence in the age group of 55-70 years
Upper limb more common than the lower
Fracture was the most common precipitating factor
CRPS I more common than CRPS II
(de Mos M et al. Pain 2007; 129:12-20)
This was 4 times that of a previous population study in the
US – 5.5 / 100,000
12. Pathophysiology
Not well understood for many years
Renewed research interest
Revised diagnostic criteria
Availability of animal models of CRPS
Pain 2015; 156: S94-S103
13. Inciting event –
Trivial injury to the limb or injury to a peripheral nerve
Inflammation is exaggerated for yet unclear reasons
inflammatory mediators leading to swelling, changes in colour,
increased skin temperature
Pain and hyperalgesia
Hyperhidrosis / hypohidrosis due to mediators such as neuropeptides
(Substance P, CGRP, bradykinin)
Trophic changes due to cytokines
Motor function is also impaired by peripheral inflammation
Increased levels of TNF-α, with a decrease in anti-
inflammatory cytokines
14. Neuropeptides – released by sensitized peptidergic
nociceptors ( neurogenic inflammation)
Endothelin-1 – potent vasoconstrictor (hyperalgesia)
Autoantibodies on surface structures of β2-adregeric
receptors and m2-cholinergic receptors (which provides a link
to the sympathetic nervous system)
In a significant subset of patients, CRPS gradually “centralizes”
– (time frame varies with individuals)
Mechanical hyperalgesia
Non-dermatomal sensory deficits
Body perception disturbances
Movements disorders
16. Conceptual model of CRPS -
• Enhanced anti-dromic secretion of
Neuropeptides
• Enhanced release of Immune
mediators
• Surface binding auto-antibodies
• Contributes to changes in sensory nerve
function and axonal degeneration
• Viscous cycle is set in motion
19. Clinical Features are a continuum
Stage One (acute stage – 6-8 weeks after injury)
Warmth, coolness, burning pain, oedema, increased sensitivity to
touch, increased pain with hyperalgesia, accelerated hair / nail growth,
tenderness or stiffness of joints, spasm, bone changes on X-ray
Decreased sympathetic activity
20. Clinical Features of CRPS
Stage Two: Dystrophic phase ( can last several months)
Pain is constant – throbbing, burning, aching, exaggerated by stimuli
Affected limb may still have oedema, cool, mottled appearance
Nails – brittle and ridged
Pain and stiffness of joints persist
Muscles – tremors, signs of wasting
Psychological distress sets in (mainly from lack of
pain relief)
Changes in body perception (limbs)
Increased sympathetic activity
21. Stage 3 – Atrophic phase (unlimited amount of time)
Typically the patient has had CRPS for 3+ years
Pain is still constant (varies in degree depending on the
patient)
Skin is cool, thin and shiny
Atrophy of limb – with contractures of joints
Muscle wasting
Increase in osteoporosis
Unlikely for sympathetic blocks to be effective
Central changes
CRPS features can extend beyond the original region
22. Diagnosis
Clinical – There are no specific tests
Differential diagnosis needs to be considered and excluded
• 53 year old male patient
• Clinical features of pain and allodynia
• Limited to the fourth and fifth fingers
• Bluish and significantly cooler
• Thermography showed only the innervation
of the ulnar nerve was colder
• Traumatic ulnar paresis
• Diagnosis : Posttraumatic neuralgia
26. Early Recognition is the key to Management
• Patients may be first seen by a
host of different specialists
• It is important to create
awareness about CRPS in
these groups
• Early recognition and referral
for appropriate therapy can
improve chances for better
management
29. Pain Relief
Corticosteroids
Calcium-regulating drugs
Calcitonin, Alendronate
Opioids
Anti Neuropathic drugs
Ketamine
Sodium channel blockers
Lignocaine
Clonidine
Very little consistent information is
available for these pharmacological
agents
In early CRPS – may be useful
Has been tried
Intravenous immunoglobulins 0.5 g/kg
When others fail to provide pain relief
TCA, gabapentin, pregabalin
Ketamine ( Low dose infusions have been
tried with mixed results)
Dimethyl sulfoxide and n-acetyl cystiene
Pain relief – so that patients are able to
comply with physical therapy, which is the
KEY to management
Medications
38. In Conclusion
CRPS is a chronic debilitating painful condition
There has been significant advances in our understanding of
its Pathophysiology
Early diagnosis and management – is essential to help
patients and reduce suffering
The Budapest Criteria should help while excluding others
A Multidisciplinary Approach to Management has been shown
to be beneficial
With particular emphasis on Patient Education and Support
Debilitating means a disease which makes one individual very weak or infirm
Allodynia…any normal painless stimuli such as touch is perceived as a painful stimuli
These are the mechanisms by which crps has been thought to occur ,rather they are all retrospectively and objectively studied mechanisms in patients of crps.
Compared to unaffected limb…altered cutaneous innervation
central sensitisation:Persistent or intense noxious input resulting from tissue
damage or nerve injury triggers increased excitability of nociceptive
neurons in the spinal cord, a phenomenon termed
central sensitization. An objective
measure associated with central sensitization is windup,
which is reflected in increased excitability of spinal cord
neurons that is evoked by repeated brief mechanical or
thermal stimulation occurring at a frequency similar to
the natural firing rate of nociceptive fibers
So before we conclude dat dis can be a crps…these test can help us confirm our diagnosis by exclusion
Budapest diagnostic criteria (A–D must apply). Note that it is possible to distinguish between CRPS-1 (without damage to major nerves) and CRPS-2 [associated with (yet not causing) damage to a major nerve, a very rare presentation], but there is currently no RCT-derived evidence that this distinction has any consequence for treatment. aThe reflected understanding of allodynia as painful sensation to a number of normally non-painful stimuli is under review by the IASP taxonomy group. Some experts suggest that the term allodynia should be reserved only for brush-stroke evoked pain (dynamic mechanical allodynia). bHyperalgesia is exaggerated pain to a painful stimulus such as a pinprick. cFor example, raised systemic inflammatory markers are not associated with CRPS, even in the initial inflammatory phase; such a finding of raised markers would lead to a search for an alternative or concomitant cause. Abnormal nerve conduction studies do not exclude CRPS, but the primary cause of the observed abnormality must be clarified: CRPS, by definition is always secondary, its presence cannot explain major nerve damage. Figure adapted from Ref. [4].
This calcitonin : antinociceptive effects of calcitonin have not been clearly elucidated. Numerous explanations have been proposed including serotoninergic and catecholaminergic mechanisms, Ca2þ fluxes, protein phosphorylation, endorphin production, cyclooxygenase inhibitionthere was a study done by sahin f et al which was published in the journal of clinical rheumatology which compared calcitonin obtained form salmon fish and paracetamol the results of which showed no significant difference .sothey concluded that calcitonin is not very effective .
Anitneuropathic drugs are…tricyclic antidepressants
Biphosphonates:assumption that the antinociceptive effect of bisphosphonates is primarily due to their capacity to inactivate osteoclasts and antagonize osteoclastogenesis may be simplistic
Dimethyl sulfoxide …organosulfur compound.obtained from the wood industry.used basically as a solvent.but has found to be medicinal.it cn b given iv orally or topically n used for many painful conditions to skin infections.
Spinal Cord Stimulation • Consists of implanted electric wires (leads) connected to a power supply (pulse generator) • Delivers pulsed electrical signals to spinal cord • Neurophysiology – may be different for differing pain physiology • Alteration in the cord neurochemistry in the dorsal horn, suppressing hyperexcitability of neurons by stimulating/suppressing neurotransmitters