1) A coma is an extremely altered state of consciousness where the person does not relate to ordinary reality and exhibits no voluntary movements or behaviors, even in response to painful stimuli. 2) Comas are caused by conditions that interfere with the functioning of the brain structures responsible for consciousness, such as disruptions to the physical brain architecture or changes in the brain's chemical environment from things like toxins, drugs, or metabolic disorders. 3) Treatment of a coma focuses first on maintaining respiration and circulation, and determining and treating the underlying reversible cause to end the coma state.