A cold chain is a refrigerated supply chain network that maintains the quality of temperature-sensitive products by keeping them within a specific low-temperature range during production, storage, and distribution. There are three types of cold chain packaging systems - active, passive, and hybrid - and the standard cold chain temperature for vaccine transport and storage is between 35°F and 45°F. In public health centers, an ice-lined refrigerator and backup generator are used at cold chain points to store vaccines and prepare frozen ice packs for maintaining the proper temperature range.