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Wolfgang G. Voelckel
AUVA Traumacenter
Salzburg
ÖAMTC Air Rescue
Vienna
ETD	
ETA	
CODE	RED	è
MEDIAN TIME TO HAEMORRHAGIC DEATH
PROPPR study
1.9h
Admission 1h 2h 3h 4h 5h
PROMMIT study
2.6 h
Dutton study
2h
Dutton R. J Trauma 2010
Holcomb J. JAMA 2015
Holcomb J, JAMA Surg 2013
immediate	
early	52	min		
PEAK	MORTALITY	<	1	H	AFTER	ADMISSION	
De	Knegt	Injury	2008	
CHANGING	EPIDEMIOLOGY	OF	TRAUMA	DEATHS	
Gunst	Academic	OneFile	Web	2016
Systolic	blood	pressure	<	110	mmHg	is	associated	
increase	in	mortality	in	blut	trauma	patients	
SBP	mmHG 	 	 	 	 	Mortality	
<	100		 	 	 	 	 	 	 	 		2x	
<	90	 	 	 	 	 	 	 	 	 		3x	
<	70 	 	 	 	 	 	 	 				5-6x	
...all	blunt	trauma	patients	with	an	SBP	<	110	mmHg	
should	be	triaged	to	resuscitation	areas...	
Hasler	R	Resuscitation	2011
Drivers	of	Mortality	
Parameter	 Definition	 Prevalence	 Mortality	
LOC	 GCS	<	8	 35	%	 38	%	
Shock	 SBP<90	mmHg	 32	%	 35	%	
Acidosis	 BE	≤	-6	 25	%	 38	%	
Coagulopathy	 PTT≥40s,	PT<60	 27	%	 37	%	
Age	 ≥	70	years	 13	%	 38	%	
Lefering	R		J	Trauma	Acute	Care	Surg	2014
www.doctorlib.info/physiology
CODE	RED	è	FLUIDS	&	DRUGS
...continuing uncertainty about the best fluid administration
strategy in bleeding trauma patients.
TIMING	AND	VOLUME	OF	FLUID	ADMINISTRATION	
FOR	PATIENTS	WITH	BLEEDING	(REVIEW)	
Kwan I Cochrane Library 2014
Sperry L J Trauma 2008
Early
vasopressor
12 h
24 h
Aggressive
volume
resuscitation
12 h
24 h
HR for mortality (95% CI) HR for mortality (95% CI)
Early
vasopressor
Phenylephrin
Norepinephrin
Dopamin
Vasopressin
0,5 1,0 5 0,5 1,0 5
EARLY	USE	OF	VASOPRESSORS	AFTER	INJURY:	
CAUTION	BEFORE	CONSTRICTION
CODE	RED	è	HEMOSTATIC	RESUSCITATION
FIBRINOGEN	CONCENTRATE	
Rossaint	R		Crit	Care	2010	
Schöchl	H	Curr	Opin	Anaesthesiol	2013	
Fibrinogen	concentration:	1.5–2	g/L		
FIBTEM®:	10–12	mm	
è	50	mg	/	kg	BW	
TXA	–	1A	RECOMMENDATION	
è	1	g	(10	min)	1	g	(8hrs)
Improved	global	clot	stability	and	clotting	time	
Improved	Fibtem	 Courtesy	D.	Fries
CODE	RED	è	MASSIVE	TRANSFUISON	
E.Kilby	Flickr.com
EXTEM CA10
mm
RBC(U)
0-25 26-35 36-45 ≥45
0
5
10
15
20
** ***ns
FIBTEM CA10 (mm)
mm
RBC(U)
0-3 4-7 8-11 ≥12
0
5
10
15
20 **** **** ****
0
5
10
15
20
25
BD <2 BD >2-6 BD >6-10 BD >10
PC FFP RBC
BD	<2 				>2-6 		>6-10				>10	 mm					0-3 				4-7 		8-11				>12	
ABGA:	Base	Deficit	 ROTEM:	FIBTEM	
MASSIVE	TRANSFUSION	-	IN-HOSPITAL	TRIGGER	
Schöchl	H	Crit	Care	2011	Mutschler	M	Crit	Care	2013
EUROPEAN	CODE	RED	GUIDELINE	
Spahn	D.		Crit	Care.	2013	
Plasma	(1B)	or	Fibrinogen	(1C)	
Optimal	FFP	:	RBC	Ratio	at	least	1:2	(2C)	
No	Plasma	without	substantial	bleeding	(1B)
VENTILATION IN SHOCK
	
n Hypovolemia:	IPPV	è CO		ê
n No	or	low	PEEP	in	shock	
n Respiratory	rate	ê	in	shock	
0
10
20
30
40
50
60
70
80
90
100
ITP syst BP
Pepe	P,Crit	Care	Med		2004;	32:Supp	S417	
Pepe	P.		J	Trauma	2003	
Roppolo	L,		Yearbook	Int	Care	and	Emerg	Med	2004	
Webster	JA.	Can	J	Anaesth	2003	
RR:		12				6				20					30 		6		min
CODE	RED		
TARGET	THERAPY	BUNDLE	
	
	
	
	
TIME	TO	DAMAGE	CONTROL	
FLUIDS	&	VASOPRESSORS	
HEMOSTATIC	RESUSCITATION	
ADVANCED	VENTILATION	
ECMO	
	
35	MINUTES	
70	LIFE	YEARS	SAVED

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Haemostatic resuscitation of haemorrhagic shock: Wolfgang Voelckel