Cobix Capsules (Generic Celecoxib Capsules)

Cobix Capsules (Generic Celecoxib Capsules)
© The Swiss Pharmacy

Cobix (Generic Celecoxib Capsules) is used for the
management of the signs and symptoms of Osteoarthritis
(OA), for the management of the signs and symptoms of
Rheumatoid Arthritis (RA), for the management of the signs
and symptoms of Juvenile Rheumatoid Arthritis (JRA) in
patients 2 years and older , for the management of the signs
and symptoms of Ankylosing Spondylitis (AS), for the
management of acute pain in adults and for the
management of primary dysmenorrhea.

Cobix Capsules (Generic Celecoxib Capsules) are
manufactured by Cipla Limited, India in the strengths of 100
mg and 200 mg.

Chemical Structure

The active pharmaceutical ingredient contained in
Cobix capsules is Celecoxib. Each hard gelatin
Cobix capsule contains 100 mg or 200 mg of
Celecoxib.

Uses of Cobix 100 mg and 200 mg Capsules:
Cobix (Generic Celecoxib Capsules) is is a nonsteroidal anti-
inflammatory drug (NSAID) used in adults for the relief of signs and
symptoms of rheumatoid arthritis, osteoarthritis, juvenile rheumatoid
arthritis and ankylosing spondylitis. However, this medicine does not
cure arthritis and will help you only as long as you continue to take it.
Celecoxib is also used to treat ankylosing spondylitis, which is a type
of arthritis that affects the joints in the spine. This medicine may also
be used to treat acute pain and menstrual cramps.
Celecoxib is also used to treat acute migraine headaches with or
without aura. However, this medicine is not used to prevent
migraines.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9901_Cobix-Capsules.html

Uses of Cobix 100 mg and 200 mg Capsules:
Your body makes prostaglandins that may cause pain and
inflammation. In conditions such as rheumatoid arthritis and
osteoarthritis your body makes more of these. Celecoxib acts by
reducing the production of prostaglandins, thereby reducing the pain
and inflammation.
You should expect your medicine to start working within hours of
taking the first dose, but you may not experience a full effect for
several days.

Recommended Adult Dosage
Use the lowest effective Cobix Capsules (Generic Celecoxib
Capsules) dosage for shortest duration consistent with individual
patient treatment goals. The dosage for the various indications is given
below:
Osteoarthritis (OA): 200 mg once daily or 100 mg twice daily.
Rheumatoid Arthritis (RA): 100 mg to 200 mg twice daily.
Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older: 50 mg
twice daily in patients 10-25 kg. 100 mg twice daily in patients more
than 25 kg.
Ankylosing Spondylitis (AS): 200 mg once daily single dose or 100 mg
twice daily. If no effect is observed after 6 weeks, a trial of 400 mg
(single or divided doses) may be of benefit.

Recommended Adult Dosage
Acute Pain (AP) and Primary Dysmenorrhea (PD): 400 mg initially,
followed by 200 mg dose if needed on first day. On subsequent days,
200 mg twice daily as needed.
Hepatic Impairment: Reduce daily dose by 50% in patients with
moderate hepatic impairment (Child-Pugh Class B).Consider a dose
reduction by 50% (or alternative management for JRA) in patients who
are known or suspected to be CYP2C9 poor metabolizers.

Contraindications
➔
Cobix Capsules are contraindicated in patients with a known
hypersensitivity to Celecoxib, Sulfonamides or any component
of the tablet.
➔
Cobix capsules must not be used in patients with a history of
asthma, urticaria, or other allergic-type reactions after taking
aspirin or other NSAIDs.
➔
Use of Cobix capsules during the perioperative period in the
setting of coronary artery bypass graft (CABG) surgery is
contraindicated.

Storage Instructions
Cobix Capsules (Generic Celecoxib Capsules) have
to be stored at controlled room temperature i.e. from
20°C to 25°C (68°F to 77°F) with excursions permitted
between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Hepatotoxicity: Inform patients of warning signs and symptoms of
hepatotoxicity. Discontinue if abnormal liver tests persist or worsen or if
clinical signs and symptoms of liver disease develop.
Hypertension: Patients taking some antihypertensive medications may
have impaired response to these therapies when taking NSAIDs.
Monitor blood pressure.
Heart Failure and Edema: Avoid use of Celecoxib in patients with
severe heart failure unless benefits are expected to outweigh risk of
worsening heart failure.

Warnings
Renal Toxicity: Monitor renal function in patients with renal or hepatic
impairment, heart failure, dehydration, or hypovolemia. Avoid use of
Celecoxib in patients with advanced renal disease unless benefits are
expected to outweigh risk of worsening renal function.
Anaphylactic Reactions: Seek emergency help if an anaphylactic
reaction occurs.
Exacerbation of Asthma Related to Aspirin Sensitivity: Celecoxib is
contraindicated in patients with aspirin-sensitive asthma. Monitor
patients with preexisting asthma (without aspirin sensitivity).
Serious Skin Reactions: Discontinue Celecoxib at first appearance of
skin rash or other signs of hypersensitivity.

Warnings
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS):
Discontinue and evaluate clinically.
Fetal Toxicity: Limit use of NSAIDs, including Celecoxib, between about
20 to 30 weeks in pregnancy due to the risk of oligohydramnios/fetal
renal dysfunction. Avoid use of NSAIDs in women at about 30 weeks
gestation and later in pregnancy due to the risks of oligohydramnios
/fetal renal dysfunction and premature closure of the fetal ductus
arteriosus.
Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients
with any signs or symptoms of anemia.

Driving And Using Machines
You should be aware of how you react to Celecoxib (Cobix
capsules) before you drive or operate machinery. If you feel
dizzy or drowsy after taking Celecoxib, do not drive or
operate machinery until these effects wear off.

Possible Side Effects
The Most common Side Effects of Celecoxib capsules
(Cobix capsules) during arthritis trials with an incidence
rate of 2% and greater and more than placebo are:
abdominal pain, diarrhea, dyspepsia, flatulence, peripheral
edema, accidental injury, dizziness, pharyngitis, rhinitis,
sinusitis, upper respiratory tract infection, rash.

Cobix Capsules Overdosage
Symptoms following acute NSAID overdosages have been typically
limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain,
which have been generally reversible with supportive care.
Gastrointestinal bleeding has occurred. Hypertension, acute renal
failure, respiratory depression, and coma have occurred, but were rare.
No overdoses of Celecoxib capsules (Cobix capsules) were reported
during clinical trials. Doses up to 2400 mg/day for up to 10 days in 12
patients did not result in serious toxicity. No information is available
regarding the removal of Celecoxib by hemodialysis, but based on its
high degree of plasma protein binding (greater than 97%) dialysis is
unlikely to be useful in overdose.

Treatment of Cobix Capsules Overdosage
Manage patients with symptomatic and supportive care following an
NSAID overdosage. There are no specific antidotes. Consider emesis
and/or activated charcoal (60 to 100 grams in adults, 1 to 2 grams per
kg of body weight in pediatric patients) and/or osmotic cathartic in
symptomatic patients seen within four hours of ingestion or in patients
with a large overdosage (5 to 10 times the recommended dosage).
Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion
may not be useful due to high protein binding..

Cobix Capsules During Pregnancy
Celecoxib (Cobix capsules) is classified by the US FDA as Pregnancy
Category C prior to 30 weeks gestation and Pregnancy Category D
starting at 30 weeks gestation.
Celecoxib must not be used by women who are pregnant or can
become pregnant (i.e. women of child bearing potential who are not
using adequate contraception) during ongoing treatment.
If you become pregnant during treatment with Celecoxib you should
discontinue the treatment and contact your doctor for alternative
treatment.

Cobix Capsules During Pregnancy
Use of NSAIDs, including Celecoxib (Cobix capsules), can cause premature
closure of the fetal ductus arteriosus and fetal renal dysfunction leading to
oligohydramnios and, in some cases, neonatal renal impairment. Because of
these risks, limit dose and duration of Celecoxib capsules use between about
20 and 30 weeks of gestation and avoid Cobix use at about 30 weeks of
gestation and later in pregnancy.
Use of NSAIDs, including Celecoxib (Cobix capsules), at about 30 weeks
gestation or later in pregnancy increases the risk of premature closure of the
fetal ductus arteriosus.
Use of NSAIDs at about 20 weeks gestation or later in pregnancy has been
associated with cases of fetal renal dysfunction leading to oligohydramnios,
and in some cases, neonatal renal impairment.

Cobix Capsules (Generic Celecoxib Capsules) are
manufactured by Cipla Limited, India.

Cobix Capsules (Generic Celecoxib Capsules)

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