Factor VII is a protein involved in the coagulation cascade that causes blood to clot. It is encoded by a gene on chromosome 13. Factor VII deficiency is a rare, recessive bleeding disorder. Factor VII is used medically to treat and prevent bleeding episodes in patients undergoing surgery or invasive procedures, including those with hemophilia, congenital Factor VII deficiency, and Glanzmann's thrombasthenia. It is administered intravenously under physician supervision and can cause side effects.

1. FACTOR VII
Trade names NovoSeven, AryoSeven
Dr Ali Hammosh
Benghazi Medical University

2. IS ONE OF THE PROTEINS THAT
CAUSES BLOOD TO CLOT IN
THE COAGULATION CASCADE
This treatment results in
activation of the extrinsic
pathway of blood coagulation

3. THE GENE FOR FACTOR VII IS LOCATED
ON CHROMOSOME 13 (13Q34)
Deficiency is rare (congenital proconvertin deficiency)
and inherits recessively. Factor VII deficiency
presents as a hemophilia-like bleeding disorder

4. MEDICAL USES
hemophilia(with Factor VIII or IX deficiency)-
- It has also been used in the setting of uncontrollable
treatment and prevention from bleeding episodes in those
undergoing
surgery or invasive procedures in the following patients:
• In patients with congenital haemophilia
• In patients with congenital haemophilia who are expected to have a
high anamnestic response to factor VIII or factor IX administration
• In patients with acquired haemophilia
• In patients with congenital FVII deficiency
• In patients with Glanzmann’s thrombasthenia with antibodies to GP
IIb - IIIa and/or HLA, and with past
or present refractoriness to platelet transfusionshemorrhage
Glanzmann's thrombasthenia-

5. ROUTE OF ADMINISTRATION
ADMINISTERED INTRAVENOUSLY (IV) UNDER
PHYSICIAN SUPERVISION.

6. SIDE EFFECTS

8. THANX