The document discusses work and energy. It defines work as being done when a force causes an object to move, and says work is measured as force times distance. It describes different forms of energy including mechanical, electrical, chemical, and heat. Mechanical energy includes kinetic energy from motion and potential energy from position or condition. The law of conservation of energy is introduced, which states that energy cannot be created or destroyed, only transformed from one form to another. Examples of energy transformations between kinetic and potential energy are provided.
watch video lec of this ppt
https://www.youtube.com/channel/UC7wyHCjg14GieFQmgf3CHCQ
energy types
potential energy
kinetci ebergy
thier equations
mathematical forms
equation derivation
numerical problem on kinetic and potential energy
concept of energy
class 9
o level
1. Define Work
2. Express work in proper units
3. Calculate work done in simple case
4. Define Kinetic Energy
5. Express kinetic Energy in proper units
6. Solve Simple problems based on Kinetic Energy
7. Define Potential Energy
8. Define Gravitational Potential Energy
9. Solve Simple problems based on Gravitational Potential Energy
9. Describe Energy Transformation in daily life
10. Define Power
11. Distinguish between Energy and Power
watch video lec of this ppt
https://www.youtube.com/channel/UC7wyHCjg14GieFQmgf3CHCQ
energy types
potential energy
kinetci ebergy
thier equations
mathematical forms
equation derivation
numerical problem on kinetic and potential energy
concept of energy
class 9
o level
1. Define Work
2. Express work in proper units
3. Calculate work done in simple case
4. Define Kinetic Energy
5. Express kinetic Energy in proper units
6. Solve Simple problems based on Kinetic Energy
7. Define Potential Energy
8. Define Gravitational Potential Energy
9. Solve Simple problems based on Gravitational Potential Energy
9. Describe Energy Transformation in daily life
10. Define Power
11. Distinguish between Energy and Power
Work is done if the object you push changes it direction towards which you are pushing it.
No work is done if the force you exert does not make the object move.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Work is done if the object you push changes it direction towards which you are pushing it.
No work is done if the force you exert does not make the object move.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
1. What do we see?
Moving parts – gears and
cogs that drive cars,
machines, conveyor belts,
et cetera
Is work done by these
moving parts?
Absolutely yes!
2. What do we see here?
A tractor ploughing or
tilling the soil
Is work done here?
Again, a yes!
3. What do we see here?
A car moving on a stretch
of road
Is work done here?
Again, a yes!
Who/what does the
work here?
The engine and pistons in
the car
4. What does this image
tell us?
A man is about to lift a
weight bar
Will work be done
here when he lifts it?
Again, a yes!
5. What do we see now?
A man pushing against a wall
Is work done here?
We would have to say no!
Why so?
Because the wall does not
move and therefore no work
is done
6. What do we see here?
A man pushing a cart with
fruits
Is work done here?
Again, a yes!
By whom or by what?
By the man
8. WHAT IS WORK?
• When a force is applied to
an object due to which the
object is set in motion, then
we say that work is done
• In this image, the force is applied
by the little boy as he kicks the
football
9. FACTS ABOUT WORK
Work is only done when a force acts on an object and causes it to
move some distance
So two conditions that need to be fulfilled for work to be done are:
• A force should be applied on the object
• The applied force should produce a motion of the object in the direction of the
applied force
10. MEASUREMENT OF WORK
Work = force × distance moved in the direction of the force
or W = F × S, where
W = work done
F = applied force
S = magnitude of displacement in the direction of the force
11. UNITS OF WORK
Work = Force × Displacement
SI unit of force is newton (N) and that of displacement is metre
Therefore, SI unit of work is newtonmetre (Nm)
Nm is called joule (J) in honour of the British scientist James Prescott Joule
1 J is the work done when the point where the force of 1 N is applied moves
through a distance of 1 m
12. UNITS OF WORK
Larger units of work are kilojoules (kJ) and megajoules (MJ)
1kJ = 1000 J
1 MJ = 1,000,000 J = 106 J
13. WORKED PROBLEMS ON WORK
Example 1
A boy pushes a box through a distance of 6 m with a force of 50 N. Calculate
the work done by him.
Given force (F) = 50 N and the distance moved is 6 m, then
Work done = F × S = 50 × 6 = 300 J
∴ Work done = 300 J
14. WORKED PROBLEMS ON WORK
Example 2
A man applies a force of 15 N to move a toy car. If the work done by him is
180 J, then calculate the distance through which the car has moved.
Given force (F) = 15 N and the work done by him is 180 J, then using the
formula, Work done = F × S
180 = 15 × S or S = 180/15 = 12 m
∴ Distance through which the car is moved = 12 m
15. FACTORS AFFECTING WORK
• There are 2 factors on which the
amount of work done depends
on:
• The magnitude (size) of the
force that is applied to produce
the motion
• The distance travelled by the
body in the direction of the
force
16. ILLUSTRATION
In the accompanying image,
in the first instance – the boy
pushes a box weighing 40 kg
through 5 m
In the second one he pushes the
same box weighing 40 kg
through 10 m
Where is more work done?
In the second case, as the same object is pushed through a greater
distance
17. CAN WORK DONE BE ZERO OR NEGATIVE?
• Yes , there are conditions when
work done is zero or negative
• When pushing a wall and the wall
does not move, then work done is
zero
• When force is applied on a object
and it moves, but returns to its
original position, then work done
is zero (circular motion)
• When a force is applied and an
object moves, but work done by
friction is negative (as it acts in
the opposite direction)
18. ILLUSTRATION
Now look at the two images – what do we have in
the first image?What do we have in the second?
20. INTRODUCTION
• The food we eat helps us do work, workout, run, play,
et cetera
• What does food provide us?
•ENERGY!!!
• So how do we define energy?
• Energy is defined as the capacity to do work
21. DIFFERENT FORMS OF ENERGY
• We have different forms of energy around us
• Flowing water, falling water, blowing wind, sun’s light
and heat, et cetera
• We have one form of energy being changed into
another
• To account for these changes, we can broadly
categorize all forms of energy into 4 types
22. DIFFERENT FORMS OF ENERGY
• Mechanical energy
• Electrical energy
• Chemical energy
• Heat energy
23. DIFFERENT FORMS OF ENERGY
• Mechanical energy
Energy possessed by a body due to its state of rest,
position or motion is called mechanical energy
• We have 2 forms of mechanical energy:
o Kinetic energy
o Potential energy
24. TYPES OF MECHANICAL ENERGY
• Kinetic energy
Energy possessed by a body
due to its motion is called
kinetic energy
• Examples: a flying aeroplane,
a rolling ball, a speeding train
• Expression for kinetic energy
Kinetic energy (KE) = ½ mv2
25. TYPES OF MECHANICAL ENERGY
• Potential energy
Energy possessed by a body
due to its position or
condition is called potential
energy
• Examples: a stretched rubber
band, a wound up spring of a
clock, a stretched bow
• Expression for kinetic energy
Potential energy (KE) = mgh
26. DIFFERENT FORMS OF ENERGY
• Electrical energy
The energy possessed by a charged
body is known as electrical energy
• Electrical energy is used to run
various appliances such as fans,
refrigerators,TVs, et cetera
• Electrical energy is generated in
large electrical power plants –
thermal, hydro, solar or nuclear
27. DIFFERENT FORMS OF ENERGY
• Chemical energy
The energy stored by every
substance and released during
certain chemical reactions is
known as chemical energy
• Examples of chemical energy
1. Food that we eat
2. Food prepared by green plants
3. Energy from battery cells
28. DIFFERENT FORMS OF ENERGY
• Heat energy
The energy released when we burn
fuels such as coal, wood, and oil is
known as chemical energy
• Heat energy always flows from a
hot object to a cold object
• Heat energy causes a change in the
temperature of any form of matter
30. EXAMPLE OF LAW OF
CONSERVATION OF ENERGY
Energy is transferred from the ball to the pin. No energy is lost!
31. What do we have here?
A juggler’s act with balls
He throws one ball up,
and catches another
What is the
transformation of energy?
KE to PE and back again to
KE
32. What do we have here?
A simple pendulum
with to and fro motion
Max. KE in the mean
position
Max. PE in the extreme
positions