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The Cytoskeleton
Figure 3.5
Figure 3.1
The Diversity of Cells
MreB
actin like
FtsZ
tubulin like
Crescentin
intermediate
filament like
FtsZ
tubulin like
in mitochondrias
chloroplasts
Fig. 4-22b, p. 98
(b) Fluorescent LM showing microtubules in green. A
microtubule-organizing center (pink dot) is visible beside
or over most of the cell nuclei (blue).
50 μm
MT axonémicos MT citoplásmicos
Acetilaciones de las tubulinas
estabilizan los MT
Colchicine
Nocadozole
Vinblastine
Vincristine
Taxol
Paclitaxel
Centrioles
Centrioles
Fig. 4-24b, p. 99
(b) Note the 9 x 3 arrangement of microtubules.
The centriole on the right has been cut transversely.
Centrioles and Cilia
Figure 3.6
+ -
Tau en las neuritas y axones
Neurofibrillary tangles
(tauopathies)
Centrioles and Cilia
Figure 3.6
Cilia
Fig. 4-26b, p. 101
(b) Many bundles of microfilaments (green) are evident in this
fluorescent LM of fibroblasts, cells found in connective tissue.
100 μm
Microfilaments
Citochalasin
Phaloidin
Fiber Shortening
• As sarcomeres shorten, muscle pulls together,
producing tension
Figure 10–13
Skeletal Muscle Innervation
Figure 10–10a, b (Navigator)
Figure 10–3
A Thick Filament
Figure 10–7c
Figure 10–11
Intermediate
Filaments
Cytokeratin
Vimentin (mesenchymal)
NF-H-pind (green) and Glial Fibrillary Acidic Protein (GFAP) (red)
Progeria
Cell Junctions
• Anchoring junctions
– Hemidesmosomes- between cells in sheets of tissue
– Desmosomes- spot-weld animal cells together
• Adhering junctions- cement cells together formed by
cadherins
Superfamilia de immunoglobulinas
N-CAM y L1-CAM
Retardación y defectos en
cuerpo calloso
Células cancerosas bajan las
cantidades de cadherinas.
Desmosomes
Cell recognition
Fibroblasts
Tight Junctions
Attachment to Basal Lamina
• Hemidesmosomes
Figure 4–2e
Extracellular Matrix
ECM
• Extracellular matrix (ECM)
– Surrounds many animal cell
– Carbohydrates and protein
• Fibronectins
– glycoproteins of ECM
– bind to integrins
• Integrins
– receptor proteins in plasma membrane
Proteoglycans Cartilage
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
Citoesqueleto matriz excl 429
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