Chromosomes carry genes that determine traits like height and eye color. Humans have 22 chromosome pairs and two sex chromosomes that determine biological sex. Abnormalities in chromosomes can occur through changes in number, structure, or arrangement of chromosomes and genes. Examples of genetic disorders caused by recessive genes include sickle cell anemia and Tay-Sachs disease. Fragile X syndrome is a rare inherited disorder caused by a faulty X chromosome that progressively destroys neurons in the brain and spinal cord.