Dr. K. Shiva Rama Prasad's keynote address on the relevance of Charaka's 'Indriya-Sthana' in the modern era discusses its historical significance and the applicability of its prognostic evaluations in contemporary healthcare. The address emphasizes the need for a reevaluation of ancient Ayurvedic practices against current medical understanding, suggesting that many of Charaka's observations, particularly regarding symptoms and diagnostics, are still valid but require contextual adaptation. Various factors such as race, geography, season, age, and genetics are highlighted as influential on health, thus underscoring the importance of individualized patient examination.